公开(公告)号：US11628241B2

公开(公告)日：2023-04-18

申请号：US16624944

申请日：2018-06-22

Applicant: NIPRO CORPORATION

Inventor： Mitsutaka Ueda ,  Hidetoshi Saio

IPC: A61M1/16 ,  A61M1/30 ,  A61M1/34

Abstract: A blood purification apparatus that includes a blood purifier, a vascular access flow path, a cleaning solution flow path, and a drainage flow path. The blood purifier has an inner portion divided by a semi-permeable membrane into a first portion and a second portion. The vascular access flow path is connected to the blood purifier and is in communication with the first portion. The cleaning solution flow path is connected to the blood purifier and is in communication with the first portion. The drainage flow path is connected to the blood purifier and is in communication with the second portion. The cleaning solution flow path is provided with a blood pump capable of bidirectionally feeding a fluid. An open-close valve is provided in each of the vascular access flow path and the drainage flow path.

公开(公告)号：US20230062912A1

公开(公告)日：2023-03-02

申请号：US17918991

申请日：2021-03-23

Applicant: NIPRO CORPORATION

Inventor： Yuki NISHIMURA ,  Yoshikazu SAITO ,  Shuntaro ITO

IPC: A61M25/10 ,  A61B18/24

Abstract: An effortless means for deflating a balloon of a catheter. A catheter system includes a catheter, a circuit for making fluid flow through the catheter, and a drive device having a bidirectionally drivable pump and a controller. The catheter includes an inflatable balloon, and a first lumen and a second lumen that allow the fluid to flow through the balloon. The controller drives the pump in a first direction to make the fluid flow from a buffer tank via a first flow path into the first lumen and to make the fluid flow out from the second lumen via a second flow path to the buffer tank, and drives the pump in a second direction opposite to the first direction to make the fluid flow from the first lumen via the first flow path into the buffer tank.

公开(公告)号：US11589763B2

公开(公告)日：2023-02-28

申请号：US16083919

申请日：2017-03-27

Applicant: NIPRO CORPORATION

Inventor： Yoshihiko Sano ,  Katsuya Miyagawa ,  Natsumi Shimazaki

IPC: A61B5/026 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/00 ,  G01P5/10 ,  G01R19/165 ,  G01R31/52

Abstract: A blood measurement device having high bending rigidity and having excellent propulsion properties and rotational force transmission properties in a blood vessel. A blood measurement device has a tubular shaft having flexibility, a tubular connection portion positioned coaxially with the distal end of the shaft and having an inner diameter larger than the inner diameter of the shaft, a slit communicating the inside and the outside of the connection portion, a tubular tip guide portion having flexibility coaxially connected to the distal end of the connection portion, a core material having flexibility fitted into the connection portion and extending to the distal end in the internal space of the tip guide portion to be connected to the tip guide portion, a measurement element positioned in the internal space of the tip guide portion and measuring the physical quantity of blood, and a signal wire which is extended from the measurement element to be inserted into and passed through the internal space of the shaft through the slit.

公开(公告)号：US20230041953A1

公开(公告)日：2023-02-09

申请号：US17788982

申请日：2019-12-27

Applicant: MDAP CO., LTD. ,  NIPRO CORPORATION

Inventor： Kazuhiko NIIKURA ,  Shinji HAYAKAWA ,  Masahito NAITO ,  Saori HORIUCHI ,  Takanori SAMBUICHI ,  Ryuuya YAMADA

IPC: A61J1/16 ,  B65D81/38

Abstract: In a vacuum heat insulating double walled container 1, adsorbent blocks 30 are formed in block, and each of the adsorbent blocks 30 disposed on the peripheral surface of a sample storage container 25 is placed on a partition plate 27. Moreover, an inner container 10 is hang in an outer container 3 using a connecting tube 20 formed of a thin material having an uneven outer peripheral surface, and a heat insulating tube 40 is disposed on the inner surface of the connecting tube 20. Further, as to a workpiece carrier 50 as a fixing device, a carrier guide 52 is in close contact with the heat insulating tube 40, and a plate-like portion 54 and a workpiece storage portion 51 are disposed in a non-contact state with respect to the sample storage container 25. As a result, it is possible to suppress the amount of heat transferred from the inner container 10 to the outer container 3, and vibration and impact is less likely to applied to a sample in the workpiece storage portion 51 even if an external force such as impact is applied to the vacuum heat insulating double walled container 1.

公开(公告)号：US20220365102A1

公开(公告)日：2022-11-17

申请号：US17764931

申请日：2020-09-02

Applicant: NIPRO CORPORATION

Inventor： Yoshinori KOSOKU ,  Yuka SANO ,  Toshiaki BABA ,  Hiroshi YOSHIDA

IPC: G01N33/68 ,  G01N33/543

Abstract: Two different antibodies that specifically bind to tau protein or phosphorylated tau protein are used. One of the two different antibodies is a first antibody immobilized on a support or labeled with a molecule capable of binding to the support, and the other of the two different antibodies is a second antibody labeled without being immobilized on the support. The tau protein includes an N-terminal domain, a C-terminal domain, and an intermediate domain located between the N-terminal and C-terminal domains. Epitopes recognized by the first and second antibodies are each an amino acid sequence contained in the intermediate domain or an amino acid sequence contained in the N-terminal domain. One of the first and second antibodies is first subjected to an antigen-antibody reaction with the blood sample, and the other of the first and second antibodies is subsequently subjected to an antigen-antibody reaction with the blood sample.

公开(公告)号：US20220332625A1

公开(公告)日：2022-10-20

申请号：US17850101

申请日：2022-06-27

Applicant: NIPRO CORPORATION

Inventor： Kazuhisa MORIUCHI ,  Yoshio INOUE ,  Atsushi ISHIKAWA ,  Yoshihiro KAWAI

IPC: C03B32/00 ,  A61J1/05 ,  C03B23/043 ,  C03B23/09 ,  C03C23/00 ,  C03B29/02 ,  C03B23/045

Abstract: A fire blasting device for manufacturing a medical glass container prevented from breakage and deformation. A glass container is placed on the outer peripheral surface of each of a first roller and a second roller, which are disposed side by side in such a manner that the axis lines are parallel to each other. The axis line of the glass container is parallel to the axis lines of the first roller and the second roller. The entire outer peripheral surface in an inner surface of the glass container corresponding to a region deteriorated by processing is made to abut on the outer peripheral surface of each of the first roller and the second roller. A flame is ejected from a point burner to the region deteriorated by processing in the inner surface of the glass container while rotating the glass container by rotating the first roller and the second roller around the axis lines.

公开(公告)号：US20220257856A1

公开(公告)日：2022-08-18

申请号：US17628996

申请日：2020-07-22

Applicant: NIPRO CORPORATION

Inventor： Shingo Sakamoto

IPC: A61M5/168

Abstract: A drug solution injection controller 10 includes a sub-reservoir 24 connected via a sub-line 26 to a main line 14 for performing continuous administration of a drug solution such that rapid administration of the drug solution from the sub-reservoir 24 by self-operation is enabled, and comprises: a priming flow path 46 configured to perform priming on at least one of the main line 14 and the sub-line 26; a closing mechanism 48 configured to close the priming flow path 46; and a connector holding part 84 holding a terminal connector 18 connected to the main line 14. Holding of the terminal connector 18 by the connector holding part 84 is allowed to be released due to operation of an operation switch 50 configured to activate the closing mechanism 48.

公开(公告)号：US20220218617A1

公开(公告)日：2022-07-14

申请号：US17605860

申请日：2020-04-21

Applicant: NIPRO CORPORATION

Inventor： Yoshio NAKANO ,  Tomohiro HAYASHIDA ,  Yohei HOASHI ,  Keisuke EDAMURA ,  Yuki ICHIKAWA

IPC: A61K9/28 ,  A61K31/352 ,  A61K9/20 ,  A61K31/137

Abstract: Problem to be Solved
Provided is a method for manufacturing a pharmaceutical preparation, which safely and simply enables uniformization of contents of a small amount of a drug.
[Solution]
The method for manufacturing the pharmaceutical preparation includes: using a liquid for dispensing, the liquid containing a drug; and a first application step of applying the drug to a surface of a tablet or a capsule by a dispensing method. In addition, a pharmaceutical preparation according to the present invention includes: a base; and a drug which is applied to a surface of the base by a dispensing method, and the base is a tablet or a capsule.

公开(公告)号：US20220125850A1

公开(公告)日：2022-04-28

申请号：US17429215

申请日：2020-02-07

Applicant: Sapporo Medical University ,  Nipro Corporation

Inventor： Osamu HONMOU ,  Masanori SASAKI ,  Yuko SASAKI ,  Shinichi OKA ,  Masahito NAKAZAKI ,  Rie MAEZAWA

IPC: A61K35/28 ,  A61P9/10

Abstract: The present invention relates to a pharmaceutical composition containing mesenchymal stem cells administered to a patient subjected to stenting. The present invention relates specifically to: a pharmaceutical composition for repairing and regenerating tissue, comprising mesenchymal stem cells, wherein the pharmaceutical composition is administered to a patient subjected to stenting; and the prevention of in-stent neointimal hyperplasia or in-stent restenosis with the pharmaceutical composition.

公开(公告)号：US20210363048A1

公开(公告)日：2021-11-25

申请号：US16956714

申请日：2018-12-21

Applicant: NIPRO CORPORATION

Inventor： Michael DROESSLER

IPC: C03B23/045 ,  C03B23/09 ,  C03B40/00

Abstract: Provided is a method of manufacturing a glass product including the following steps. An intermediate glass product is provided. A portion of the intermediate glass product is heated to a predetermined temperature. A tool and the heated portion of the intermediate glass product are brought into contact. Under a state that a tool contacts the heated portion, at least one of the tool and the intermediate glass product is rotated so that the tool and the intermediate glass product relatively rotate, wherein a part of the tool that contacts the heated portion comprises or is made of glassy carbon.