公开(公告)号：US20080269140A1

公开(公告)日：2008-10-30

申请号：US10586271

申请日：2005-01-18

Applicant: Shaomeng Wang ,  Haiying Sun ,  Zaneta Nikolovska-Coleska ,  Chao-Yie Yang ,  Liang Xu

Inventor： Shaomeng Wang ,  Haiying Sun ,  Zaneta Nikolovska-Coleska ,  Chao-Yie Yang ,  Liang Xu

IPC: A61K38/06 ,  C07K5/083 ,  A61K38/05 ,  C07D487/04 ,  C12N5/06 ,  C12N13/00 ,  A61P35/00

CPC classification number: C07K5/0806 ,  C07D487/04 ,  C07K5/0808 ,  C07K5/0827

Abstract: The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

Abstract translation: 本发明涉及Smac的构象约束模拟物，其作为细胞凋亡蛋白抑制剂的抑制剂。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。

公开(公告)号：US07432300B2

公开(公告)日：2008-10-07

申请号：US11818766

申请日：2007-06-15

Applicant: Shaomeng Wang ,  Jiangyong Chen

Inventor： Shaomeng Wang ,  Jiangyong Chen

IPC: A61K31/225 ,  A61K31/11 ,  A61K31/70

CPC classification number: A61K31/11

Abstract: This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.

Abstract translation: 本发明涉及包含（ - ） - 棉酚与C 1-8 - 羧酸或C 1-8 - 磺酸的共晶体的组合物，其可用作 Bcl-2家族蛋白。 本发明还涉及（ - ） - 棉酚与C 1-8 - 羧酸或C 1-8 - 磺酸的共晶体用于诱导细胞凋亡 细胞和致敏细胞诱导凋亡细胞死亡。

公开(公告)号：US07427689B2

公开(公告)日：2008-09-23

申请号：US10343267

申请日：2001-07-30

Applicant: Shaomeng Wang ,  Dajun Yang ,  Istvan Enyedy

Inventor： Shaomeng Wang ,  Dajun Yang ,  Istvan Enyedy

IPC: C07C205/00

CPC classification number: A61K31/216 ,  A61K31/00 ,  A61K31/192

Abstract: A novel method for erbB-2 kinase inhibition by compounds identifies through computational modeling and data processing and/or rational and de novo drug design is provided the compounds bind erbB-2 kinase molecules and which can be used as erbB-2 kinase agonists or antagonists. These compounds are useful especially in the treatment of cancer, particularly breast cancer, and can be used alone or in combination with other chemotherapeutic agents, particularly with hercetin, a humanized anti-HER-2 antibody, or with radiation therapy. A specific compound which is exemplified is “compound B17”=methyl-(p-nitrophenyl)-2-propynoate.

Abstract translation: 化合物的erbB-2激酶抑制的新方法通过计算建模和数据处理鉴定，和/或合理和从头药物设计提供了化合物结合erbB-2激酶分子，并且其可以用作erbB-2激酶激动剂或拮抗剂 。 这些化合物特别用于治疗癌症，特别是乳腺癌，并且可以单独使用或与其它化学治疗剂，特别是与赫氏原，人源化抗HER-2抗体或放射治疗组合使用。 例示的具体化合物是“化合物B17”=甲基 - （对硝基苯基）-2-丙炔酸酯。

公开(公告)号：US20080125430A1

公开(公告)日：2008-05-29

申请号：US11848089

申请日：2007-08-30

Applicant: Shaomeng Wang ,  Dongguang Qin ,  Jiangyong Chen ,  Shanghai Yu

Inventor： Shaomeng Wang ,  Dongguang Qin ,  Jiangyong Chen ,  Shanghai Yu

IPC: A61K31/5377 ,  C07D209/96 ,  A61K31/407 ,  C07D265/30 ,  A61K31/445 ,  A61P35/00 ,  C07D211/06 ,  C07D241/04 ,  A61K31/497

CPC classification number: C07D487/10 ,  C07D491/10

Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).

Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。

公开(公告)号：US20080021110A1

公开(公告)日：2008-01-24

申请号：US11729638

申请日：2007-03-29

Applicant: Shaomeng Wang ,  Jianyong Chen ,  John Keana ,  Ming Guo

Inventor： Shaomeng Wang ,  Jianyong Chen ,  John Keana ,  Ming Guo

IPC: A61K31/192 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P43/00 ,  C07B57/00 ,  C07C65/01

CPC classification number: C07B57/00 ,  A61K31/192 ,  A61K31/78 ,  C07C45/516 ,  C07C45/79 ,  C07C45/85 ,  C07C47/57 ,  C07C51/487 ,  C07C53/08

Abstract: This invention relates to relates to methods for producing gossypol acetic acid co-crystals and (−)-gossypol acetic acid co-crystals. The invention also relates to pharmaceutical compositions comprising gossypol acetic acid co-crystals and (−)-gossypol acetic acid co-crystals and the use of gossypol acetic acid co-crystals and (−)-gossypol acetic acid co-crystals for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.

Abstract translation: 本发明涉及生产棉酚乙酸共晶体和（ - ） - 棉酚乙酸共晶体的方法。 本发明还涉及包含棉酚乙酸共晶和（ - ） - 棉酚乙酸共晶体的药物组合物，以及使用棉酚乙酸共晶体和（ - ） - 棉酚乙酸共晶体诱导细胞凋亡 细胞和致敏细胞诱导凋亡细胞死亡。

公开(公告)号：US20080021095A1

公开(公告)日：2008-01-24

申请号：US10594200

申请日：2005-03-22

Applicant: Jianyong Chen ,  Zaneta Nikolovska-Coleska ,  Dajun Yang ,  Shaomeng Wang ,  Haiying Sun ,  Liang Xu ,  Zengjian Hu

Inventor： Jianyong Chen ,  Zaneta Nikolovska-Coleska ,  Dajun Yang ,  Shaomeng Wang ,  Haiying Sun ,  Liang Xu ,  Zengjian Hu

IPC: A61K31/353 ,  A61K31/122 ,  A61P35/00 ,  C07C49/603 ,  C07D311/30 ,  C12N5/06

CPC classification number: C07C235/84 ,  C07C50/28 ,  C07C50/30 ,  C07D311/30

Abstract: The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of XIAP family proteins. In particular, the present invention provides embelin and other XIAP inhibitors and methods of using these compounds as antagonists of the anti-apoptotic effects of XIAP family member proteins. The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases).

Abstract translation: 本发明涉及XIAP家族蛋白质的天然存在和化学合成的小分子拮抗剂。 特别地，本发明提供了塞林和其他XIAP抑制剂以及使用这些化合物作为XIAP家族蛋白的抗凋亡作用的拮抗剂的方法。 本发明还提供了治疗疾病和病理（例如肿瘤性疾病）的方法。

公开(公告)号：US07268115B2

公开(公告)日：2007-09-11

申请号：US10412701

申请日：2003-04-10

Applicant: Barbara J. Gour ,  Orest W. Blaschuk ,  Anmar Ali ,  Feng Ni ,  Zhigang Chen ,  Stephanie Denise Michaud ,  Shaomeng Wang ,  Zenjian Hu

Inventor： Barbara J. Gour ,  Orest W. Blaschuk ,  Anmar Ali ,  Feng Ni ,  Zhigang Chen ,  Stephanie Denise Michaud ,  Shaomeng Wang ,  Zenjian Hu

IPC: A61K38/00

CPC classification number: C07K7/06 ,  A61K31/4196 ,  A61K38/00 ,  C07K2299/00

Abstract: Peptidomimetics of cyclic peptides, and compositions comprising such peptidomimetics are provided. The peptidomimetics have a three-dimensional structure that is substantially similar to a three-dimensional structure of a cyclic peptide that comprises a cadherin cell adhesion recognition sequence HAV. Methods for using such peptidomimetics for modulating cadherin-mediated cell adhesion in a variety of contexts are also provided.

Abstract translation: 提供了环肽的肽模拟物，以及包含这种肽模拟物的组合物。 肽模拟物具有基本上类似于包含钙粘着蛋白细胞粘附识别序列HAV的环状肽的三维结构的三维结构。 还提供了使用这种肽模拟物在各种情况下调节钙粘蛋白介导的细胞粘附的方法。

公开(公告)号：US20060247318A1

公开(公告)日：2006-11-02

申请号：US11361149

申请日：2006-02-24

Applicant: Hui Song ,  Renxiao Wang ,  Shaomeng Wang ,  Jiayuh Lin

Inventor： Hui Song ,  Renxiao Wang ,  Shaomeng Wang ,  Jiayuh Lin

IPC: A61K31/12

CPC classification number: A61K31/122 ,  A61K31/12

Abstract: The invention relates to small molecules which function as inhibitors of Stat3. The invention also relates to the use of these compounds for inducing cell death and sensitizing cells to the induction of cell death by anti-cancer drugs.

Abstract translation: 本发明涉及作为Stat3抑制剂起作用的小分子。 本发明还涉及这些化合物用于诱导细胞死亡和使细胞增敏以通过抗癌药物诱导细胞死亡的用途。

公开(公告)号：US20060247305A1

公开(公告)日：2006-11-02

申请号：US11373898

申请日：2006-03-13

Applicant: Shaomeng Wang ,  Ke Ding ,  Guozhi Tang ,  Zaneta Nikolovska-Coleska ,  Renxio Wang ,  Chao-Yie Yang

Inventor： Shaomeng Wang ,  Ke Ding ,  Guozhi Tang ,  Zaneta Nikolovska-Coleska ,  Renxio Wang ,  Chao-Yie Yang

IPC: A61K31/353 ,  C07D405/14

CPC classification number: C07D311/22 ,  C07D311/36 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D409/04 ,  C07D495/04

Abstract: The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.

Abstract translation: 本发明涉及作为抗凋亡Bcl-2家族成员蛋白（例如Bcl-2和Bcl-xL）的抑制剂的小分子。 本发明还涉及这些化合物用于诱导凋亡细胞死亡和使细胞对诱导凋亡性细胞死亡致敏的用途。

公开(公告)号：US5874464A

公开(公告)日：1999-02-23

申请号：US372602

申请日：1995-01-13

Applicant: Victor E. Marquez ,  Jeewoo Lee ,  Rajiv Sharma ,  Shaomeng Wang ,  George W. A. Milne ,  Marc C. Nicklaus ,  Peter M. Blumberg ,  Nancy E. Lewin

Inventor： Victor E. Marquez ,  Jeewoo Lee ,  Rajiv Sharma ,  Shaomeng Wang ,  George W. A. Milne ,  Marc C. Nicklaus ,  Peter M. Blumberg ,  Nancy E. Lewin

IPC: C07D307/58 ,  A61K31/34 ,  C07D307/34

CPC classification number: C07D307/58

Abstract: Conformationally constrained diacylglycerol analogues, pharmaceutical compositions comprising such analogues, and methods of using such analogues as agonists and antagonists of protein kinase C.

Abstract translation: 构成约束的二酰基甘油类似物，包含这种类似物的药物组合物，以及使用这些类似物作为蛋白激酶C的激动剂和拮抗剂的方法。