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公开(公告)号:US08426405B2
公开(公告)日:2013-04-23
申请号:US12733994
申请日:2009-07-02
申请人: John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Thienthong , Nicholas Andrew Vandegraaff , Lisa Jane Winfield
发明人: John Joseph Deadman , Eric Dale Jones , Giang Thanh Le , David Ian Rhodes , Neeranat Thienthong , Nicholas Andrew Vandegraaff , Lisa Jane Winfield
IPC分类号: A61K31/535 , C07D413/14
CPC分类号: C07D513/04
摘要: Compounds of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof are disclosed. Also disclosed are methods of treating a viral infection in a subject by administering to the subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Pharmaceutical compositions comprising a compound of formula (I) are also provided.
摘要翻译: 公开了式(I)化合物或其药学上可接受的衍生物,盐或前药。 还公开了通过向受试者施用有效量的式(I)化合物或其药学上可接受的衍生物,盐或前药来治疗受试者的病毒感染的方法。 还提供了包含式(I)化合物的药物组合物。
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公开(公告)号:US20120168228A1
公开(公告)日:2012-07-05
申请号:US13412297
申请日:2012-03-05
申请人: Richard L. Giroux , Gregory G. Galloway , Tuong Thanh Le , Raymond H. Jackson , Gregory R. Nazzal , James C. Swarr , David J. Brunnert , William M. Beasley , Brent J. Lirette , Albert C. Odell , Jim Terry , Dave McKay , Samir Alkhatib , Mike Wardley
发明人: Richard L. Giroux , Gregory G. Galloway , Tuong Thanh Le , Raymond H. Jackson , Gregory R. Nazzal , James C. Swarr , David J. Brunnert , William M. Beasley , Brent J. Lirette , Albert C. Odell , Jim Terry , Dave McKay , Samir Alkhatib , Mike Wardley
CPC分类号: E21B43/105 , B05B1/002 , E21B7/06 , E21B7/065 , E21B7/18 , E21B7/208 , E21B10/61 , E21B17/14 , E21B21/103 , E21B33/14 , E21B41/0078 , E21B47/01 , E21B2034/002
摘要: Apparatus and methods for drilling with casing. In an embodiment, methods and apparatus for deflecting casing using a diverter apparatus are disclosed. In another embodiment, the apparatus comprises a motor operating system disposed in a motor system housing, a shaft operatively connected to the motor operating system, the shaft having a passageway, and a divert assembly disposed to direct fluid flow selectively to the motor operating system and the passageway in the shaft. In another aspect, methods and apparatus for directionally drilling a casing into the formation are disclosed. Methods and apparatus for measuring the trajectory of a wellbore while directionally drilling a casing into the formation are also described.
摘要翻译: 用套管钻孔的装置和方法。 在一个实施例中,公开了使用分流装置偏转套管的方法和装置。 在另一个实施例中,该装置包括设置在马达系统壳体中的马达操作系统,可操作地连接到马达操作系统的轴,具有通道的轴以及用于将流体流选择性地引导到马达操作系统的转向组件, 轴中的通道。 在另一方面,公开了用于将壳体定向钻入地层的方法和装置。 还描述了在将套管定向钻入地层时测量井眼轨迹的方法和装置。
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公开(公告)号:US20120138298A1
公开(公告)日:2012-06-07
申请号:US13306592
申请日:2011-11-29
申请人: Richard L. Giroux , Gregory G. Galloway , David J. Brunnert , Patrick G. Maguire , Tuong Thanh Le , Albert C. Odell, II , David M. Haugen , Frederick T. Tilton , Brent J. Lirette , Mark Murray , Peter Barnes Moyes
发明人: Richard L. Giroux , Gregory G. Galloway , David J. Brunnert , Patrick G. Maguire , Tuong Thanh Le , Albert C. Odell, II , David M. Haugen , Frederick T. Tilton , Brent J. Lirette , Mark Murray , Peter Barnes Moyes
CPC分类号: E21B7/20 , E21B4/02 , E21B7/203 , E21B17/07 , E21B21/00 , E21B21/08 , E21B21/103 , E21B33/14 , E21B33/143 , E21B43/10 , E21B2021/006
摘要: The present invention relates methods and apparatus for lining a wellbore. In one aspect, a drilling assembly having an earth removal member and a wellbore lining conduit is manipulated to advance into the earth. The drilling assembly includes a first fluid flow path and a second fluid flow path. Fluid is flowed through the first fluid flow path, and at least a portion of which may return through the second fluid flow path. In one embodiment, the drilling assembly is provided with a third fluid flow path. After drilling has been completed, wellbore lining conduit may be cemented in the wellbore.
摘要翻译: 本发明涉及用于衬砌井筒的方法和装置。 在一个方面,操纵具有除尘构件和井眼衬里导管的钻井组件以前进到地球中。 钻井组件包括第一流体流动路径和第二流体流动路径。 流体流过第一流体流动路径,并且其中至少一部分可以通过第二流体流动路径返回。 在一个实施例中,钻井组件设置有第三流体流动路径。 钻井完成后,井眼衬里导管可以在井筒中胶合。
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公开(公告)号:US07989422B2
公开(公告)日:2011-08-02
申请号:US12096771
申请日:2006-12-20
申请人: Wim Meutermans , Declan McKeveney , Johannes Zuegg , Rajaratnam Premraj , Craig Muldoon , Giang Thanh Le
发明人: Wim Meutermans , Declan McKeveney , Johannes Zuegg , Rajaratnam Premraj , Craig Muldoon , Giang Thanh Le
IPC分类号: A61K31/7052 , A61K31/7056 , A61K31/706 , A61K31/416 , C07D235/18 , C07H5/04
CPC分类号: A61K31/34 , A61K31/351 , A61K31/70 , C07D235/30 , C07D235/32 , C07D249/06 , Y02A50/473
摘要: The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as described herein:
摘要翻译: 本发明在一个方面提供了通过使细菌与有效量的至少一种如本文所述的式(1)单糖化合物接触来抑制细菌生长的方法:
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公开(公告)号:US20110177163A1
公开(公告)日:2011-07-21
申请号:US13119583
申请日:2009-09-18
CPC分类号: A61K39/29 , A61K39/12 , A61K2039/5252 , A61K2039/542 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , C12N2770/32434 , Y02A50/464
摘要: The present application provides compositions and methods useful for treating hepatitis A. In particular, while hepatitis A vaccines are currently limited to parenteral administration routes (i.e., intramuscular injection), we have identified compositions that induce a protective response when administered orally.
摘要翻译: 本申请提供了用于治疗戊型肝炎的组合物和方法。特别地,虽然甲型肝炎疫苗目前限于肠胃外给药途径(即肌内注射),但是我们已经鉴定出在口服给药时诱导保护性反应的组合物。
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公开(公告)号:US20110165700A1
公开(公告)日:2011-07-07
申请号:US13047601
申请日:2011-03-14
IPC分类号: G01N33/566
CPC分类号: A61K31/351 , A61K31/70
摘要: A method of inhibiting or effecting the activity of an integrin receptor comprises contacting an integrin with a pyranose of formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译: 抑制或影响整联蛋白受体活性的方法包括使整联蛋白与式I的吡喃糖或其药学上可接受的盐接触。
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公开(公告)号:US20100286478A1
公开(公告)日:2010-11-11
申请号:US12766731
申请日:2010-04-23
申请人: Richard C. EWERS , Barton P. BANDY , Haio FAUSER , Tung Thanh LE
发明人: Richard C. EWERS , Barton P. BANDY , Haio FAUSER , Tung Thanh LE
IPC分类号: A61B1/01
CPC分类号: A61B1/00128 , A61B1/00133 , A61B1/0051 , A61B1/018 , A61B1/273 , A61B17/3421 , A61B90/50 , A61B2017/2906 , A61B2017/3445
摘要: A flexible surgery access and instrument management system includes a base unit and an insertion unit. The base unit provides a platform having a connection mechanism to which the insertion unit is attached. The insertion unit includes an elongated conduit having one or more tubes providing instrument passages, and a connection mechanism adapted to selectively couple with the mating connection mechanism provided on the base unit. The elongated conduit of the insertion unit is preferably steerable. One or more flexible instruments may be inserted through the tubes of the elongated conduit, with the proximal ends of the instruments being attached to the base unit such that the user is able to control and manipulate the instruments.
摘要翻译: 灵活的手术进入和仪器管理系统包括基本单元和插入单元。 基座单元提供具有连接机构的平台,插入单元附接到该平台。 插入单元包括具有一个或多个提供器具通道的管的细长导管,以及适于选择性地与设置在基座单元上的配合连接机构联接的连接机构。 插入单元的细长导管优选是可操纵的。 一个或多个柔性仪器可以穿过细长导管的管插入,仪器的近端附接到基座单元,使得使用者能够控制和操纵仪器。
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78.
公开(公告)号:US20100275968A1
公开(公告)日:2010-11-04
申请号:US12770278
申请日:2010-04-29
申请人: Fredrick Kaiser , Thanh Le , Darren Hoppins
发明人: Fredrick Kaiser , Thanh Le , Darren Hoppins
IPC分类号: H01L31/042
CPC分类号: H01L31/02021 , H02S40/12 , Y02E10/50
摘要: A solar power system for supplying electrical energy to a load based on solar energy comprising at least one solar panel, a power supply, and at least one mode select switch. The at least one solar panel comprises at least one solar cell. The at least one mode select switch is operatively connected to the at least one solar panel, the power supply, and the load. The at least one mode select switch is operable in a first mode and in a second mode. In the first mode, the at least one solar cell is capable of supplying electrical energy to the load. In the second mode, the power supply supplies electrical energy to the at least one solar cell such that the at least one solar cell generates heat.
摘要翻译: 一种用于基于太阳能向负载提供电能的太阳能发电系统,其包括至少一个太阳能电池板,电源和至少一个模式选择开关。 至少一个太阳能电池板包括至少一个太阳能电池。 所述至少一个模式选择开关可操作地连接到所述至少一个太阳能面板,所述电源和所述负载。 所述至少一个模式选择开关可在第一模式和第二模式中操作。 在第一模式中,至少一个太阳能电池能够向负载提供电能。 在第二模式中,电源向至少一个太阳能电池提供电能,使得至少一个太阳能电池产生热量。
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79.
公开(公告)号:US20100239435A1
公开(公告)日:2010-09-23
申请号:US12543736
申请日:2009-08-19
申请人: Kevin D. Le , Thanh Le
发明人: Kevin D. Le , Thanh Le
IPC分类号: F04F5/00
CPC分类号: F04F5/10
摘要: A fluid displacing apparatus, system, and method is provided. The apparatus includes a motor having a first shaft, the motor for rotating the first shaft; a first magnetic element coupled to the first shaft such that rotation of the first shaft causes rotation of the first magnetic element; a second magnetic element coupled to a second shaft, and magnetically coupled to the first magnetic element such that rotation of the first magnetic element causes rotation of the second magnetic element; an input section for receiving a fluid; an output section for outputting the fluid; a channel having first and second openings; and an impeller coupled to the second magnetic element such that rotation of the second magnetic element causes rotation of the impeller, thereby the fluid flows in the input section and out the output section. The flow of the fluid across the second opening of the channel encourages another fluid to flow in the first opening, through the channel, and out the second opening.
摘要翻译: 提供了一种流体移动装置,系统和方法。 该装置包括具有第一轴的马达,用于旋转第一轴的马达; 耦合到所述第一轴的第一磁性元件,使得所述第一轴的旋转引起所述第一磁性元件的旋转; 耦合到第二轴的第二磁性元件,并且磁耦合到所述第一磁性元件,使得所述第一磁性元件的旋转引起所述第二磁性元件的旋转; 用于接收流体的输入部分; 用于输出流体的输出部分; 具有第一和第二开口的通道; 以及联接到所述第二磁性元件的叶轮,使得所述第二磁性元件的旋转引起所述叶轮的旋转,由此所述流体在所述输入部中流出并输出到所述输出部。 流体穿过通道的第二开口的流动促使另一种流体在第一开口中流过通道,并流出第二开口。
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公开(公告)号:US20100126776A1
公开(公告)日:2010-05-27
申请号:US12620581
申请日:2009-11-17
申请人: Jose A. Trevino , Albert C. Odell, II , Eric M. Twardowski , Tuong Thanh Le , Wei Jake Xu , Guy F. Feasey
发明人: Jose A. Trevino , Albert C. Odell, II , Eric M. Twardowski , Tuong Thanh Le , Wei Jake Xu , Guy F. Feasey
CPC分类号: E21B7/208 , E21B3/00 , E21B7/124 , E21B7/20 , E21B17/06 , E21B17/07 , E21B19/002 , E21B23/02 , E21B33/035 , E21B33/143 , E21B34/04 , E21B43/101 , E21B47/06
摘要: A method of forming a wellbore includes providing a drilling assembly comprising one or more lengths of casing and an axially retracting assembly having a first tubular; a second tubular at least partially disposed in the first tubular and axially fixed thereto; and a support member disposed in the second tubular and movable from a first axial position to a second axial position relative to the second tubular, wherein, in the first axial position, the support member maintains the second tubular axially fixed to the first tubular, and in the second axial position, allows the second tubular to move relative to the first tubular; and an earth removal member disposed below the axially retracting assembly. The method also includes rotating the earth removal member to form the wellbore; moving the support member to the second axial position; and reducing a length of the axially retracting assembly.
摘要翻译: 形成井眼的方法包括提供包括一个或多个长度的壳体和具有第一管的轴向回缩组件的钻孔组件; 至少部分地设置在所述第一管状件中并轴向固定到其上的第二管状物; 以及支撑构件,其设置在所述第二管状体中并且可相对于所述第二管状物从第一轴向位置移动到第二轴向位置,其中,在所述第一轴向位置中,所述支撑构件将所述第二管状体轴向固定到所述第一管状物,以及 在第二轴向位置允许第二管状件相对于第一管状件移动; 以及设置在所述轴向收缩组件下方的除土构件。 该方法还包括旋转除尘构件以形成井眼; 将支撑构件移动到第二轴向位置; 并减小轴向回缩组件的长度。
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