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公开(公告)号:US07514564B2
公开(公告)日:2009-04-07
申请号:US11417329
申请日:2006-05-02
申请人: Guoqing Chen , Jeffrey Adams , Jean Bemis , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Qi Huang , Joseph L. Kim , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan , Tae-Seong Kim
发明人: Guoqing Chen , Jeffrey Adams , Jean Bemis , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Qi Huang , Joseph L. Kim , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan , Tae-Seong Kim
IPC分类号: C07D211/94 , C07D211/98 , A61K31/44
CPC分类号: C07D401/14 , A61K31/00 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , Y02A50/401
摘要: Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 选择的胺对于预防和治疗疾病如血管生成介导的疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US20090054405A1
公开(公告)日:2009-02-26
申请号:US12221416
申请日:2008-08-01
申请人: Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang
发明人: Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang
IPC分类号: A61K31/55 , C07D401/14 , C07D401/10 , C07D413/14 , A61P35/00 , A61K31/435 , A61K31/5377 , A61K31/497
CPC分类号: C07D277/82 , C07D413/04 , C07D417/04 , C07D417/14 , C07D513/04
摘要: The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A1, A2, A3, A4, X, R1 and R2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译: 本发明包括能够调节PI3激酶活性的新一类化合物,因此可用于治疗PI3激酶介导的疾病,包括黑素瘤,癌和其它癌症相关病症。 所述化合物具有通式I,其中A1,A2,A3,A4,X,R1和R2各自在本文中定义。 本发明还包括药物组合物,治疗PI3激酶介导的疾病的方法,以及可用于制备本发明化合物的中间体和方法。
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公开(公告)号:US20080280917A1
公开(公告)日:2008-11-13
申请号:US12070309
申请日:2008-02-15
申请人: Brian K. Albrecht , Steven Bellon , Shon Booker , Alan C. Cheng , Derin D'Amico , Noel D'Angelo , Jean-Christophe Harmange , Tae-Seong Kim , Longbin Liu , Mark H. Norman , Aaron C. Siegmund , Markian Stec , Ning Xi , Kevin Yang
发明人: Brian K. Albrecht , Steven Bellon , Shon Booker , Alan C. Cheng , Derin D'Amico , Noel D'Angelo , Jean-Christophe Harmange , Tae-Seong Kim , Longbin Liu , Mark H. Norman , Aaron C. Siegmund , Markian Stec , Ning Xi , Kevin Yang
IPC分类号: A61K31/501 , C07D403/12 , A61K31/4709 , A61P25/00 , A61P35/00 , C07D471/00
CPC分类号: C07D237/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US20080252564A1
公开(公告)日:2008-10-16
申请号:US12081299
申请日:2008-04-14
申请人: In-Ju Choi , Woo-Joon Chung , Seong-Joon Jeong , Tae-Seong Kim
发明人: In-Ju Choi , Woo-Joon Chung , Seong-Joon Jeong , Tae-Seong Kim
IPC分类号: G09G3/28
CPC分类号: G09G3/2927 , G09G3/2022 , G09G2310/066 , G09G2320/0238
摘要: Provided is a method of driving a plasma display panel (PDP) that comprises X electrodes, Y electrodes, and address electrodes, wherein a frame, which is a display cycle, comprises a plurality of subfields for time-divisional gray scale display. Each of the subfields includes a reset period, an address period, and a sustain period. The reset period is one of a main reset period during which both a rising pulse and a falling pulse are applied to the Y electrodes and an auxiliary reset period during which one of the rising pulse and the falling pulse is applied to the Y electrodes, and the main reset period comprises a first pulse time during which a pulse rising to a level of a first voltage and then falling to a level of a second voltage is applied to the Y electrodes and a second pulse time during which a pulse rising to a level of a third voltage and then falling to a level of a fourth voltage is applied to the Y electrodes.
摘要翻译: 提供了一种驱动包括X电极,Y电极和寻址电极的等离子体显示面板(PDP)的方法,其中作为显示周期的框架包括用于时分分割灰度显示的多个子场。 每个子场包括复位周期,地址周期和维持周期。 复位期间是向Y电极施加上升脉冲和下降脉冲的主复位期间和向Y电极施加上升脉冲和下降脉冲之一的辅助复位期间之一, 主复位周期包括第一脉冲时间,在该第一脉冲时间期间,将上升到第一电压的电平然后下降到第二电压的电平的脉冲施加到Y电极和第二脉冲时间,在该第二脉冲时间期间脉冲上升到电平 的第三电压,然后下降到第四电压的电平施加到Y电极。
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公开(公告)号:US20080122753A1
公开(公告)日:2008-05-29
申请号:US11976328
申请日:2007-10-23
IPC分类号: G09G3/28
CPC分类号: G09G3/2932 , G09G3/2942 , G09G2310/06 , G09G2320/0233
摘要: In a plasma display device, an elapsed driving time of the plasma display device is accumulated and calculated, and a scan pulse having a first voltage is supplied to a scan electrode during a first period which is an address period of each subfield in response to the accumulated driving time being less than a reference time, and a scan pulse having a second voltage that is greater than the first voltage is supplied to a scan electrode during a second period which is an address period of each subfield in response to the accumulated driving time being greater than the reference time.
摘要翻译: 在等离子体显示装置中,累积和计算等离子体显示装置的经过的驱动时间,并且在作为响应于每个子场的地址周期的第一周期期间,向扫描电极提供具有第一电压的扫描脉冲 累积的驱动时间小于参考时间,并且具有大于第一电压的第二电压的扫描脉冲在响应于累积的驱动时间的每个子场的寻址周期的第二周期期间被提供给扫描电极 大于参考时间。
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公开(公告)号:US07355565B2
公开(公告)日:2008-04-08
申请号:US10974946
申请日:2004-10-28
申请人: Jin-Sung Kim , Woo-Joon Chung , Seung-Hun Chae , Kyoung-Ho Kang , Tae-Seong Kim
发明人: Jin-Sung Kim , Woo-Joon Chung , Seung-Hun Chae , Kyoung-Ho Kang , Tae-Seong Kim
IPC分类号: G09G3/28
CPC分类号: G09G3/2942 , G09G2330/021 , G09G2360/16
摘要: A method for driving a display panel including a first electrode, a second electrode and an address electrode crossed with the first and second electrodes to form a discharge cell. The method comprises, during a sustain period, alternately applying a voltage pulse to the first and second electrodes, and floating the first or the second electrode and maintaining it at a first voltage level while the voltage pulse is applied to the other electrode.
摘要翻译: 一种用于驱动显示面板的方法,包括与第一和第二电极交叉的第一电极,第二电极和寻址电极,以形成放电单元。 该方法包括在维持周期期间,交替地向第一和第二电极施加电压脉冲,并且在将电压脉冲施加到另一个电极的同时使第一或第二电极浮置并将其保持在第一电压电平。
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公开(公告)号:US20070054903A1
公开(公告)日:2007-03-08
申请号:US11479187
申请日:2006-06-30
申请人: Tae-Seong Kim , Jean-Christophe Harmange , Steven Bellon , Shon Booker , Noel D'Angelo , Celia Dominguez , Ingrid Fellows , Julie Germain , Timothy Harvey , Joseph Kim , Matthew Lee , Longbin Liu , Vinod Patel , Andrew Tasker
发明人: Tae-Seong Kim , Jean-Christophe Harmange , Steven Bellon , Shon Booker , Noel D'Angelo , Celia Dominguez , Ingrid Fellows , Julie Germain , Timothy Harvey , Joseph Kim , Matthew Lee , Longbin Liu , Vinod Patel , Andrew Tasker
IPC分类号: A61K31/538 , A61K31/5377 , A61K31/4709 , C07D403/02 , C07D413/02
CPC分类号: C07D333/38 , C07D217/02 , C07D217/24 , C07D401/10 , C07D401/12 , C07D409/12 , C07D417/10 , C07D417/12
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US07102009B2
公开(公告)日:2006-09-05
申请号:US10197918
申请日:2002-07-17
申请人: Vinod F. Patel , Benny Askew , Shon Booker , Guoqing Chen , Lucian V. DiPietro , Julie Germain , Gregory J. Habgood , Qi Huang , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Rana Nomak , Babak Riahi , Chester Chenguang Yuan , Daniel Elbaum
发明人: Vinod F. Patel , Benny Askew , Shon Booker , Guoqing Chen , Lucian V. DiPietro , Julie Germain , Gregory J. Habgood , Qi Huang , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Rana Nomak , Babak Riahi , Chester Chenguang Yuan , Daniel Elbaum
IPC分类号: C07D401/02 , A61K31/44
CPC分类号: C07D471/04 , A61K31/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要: Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号:US07101868B2
公开(公告)日:2006-09-05
申请号:US10823809
申请日:2004-04-12
申请人: Daniel Elbaum , Benny C. Askew, Jr. , Shon Booker , Julie Germain , Gregory J. Habgood , Michael Handley , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Vinod F. Patel , Chester Chenguang Yuan , Joseph L. Kim , Guolin Cai , Guoqing Chen , Michael Croghan , Lucian V. Di Pietro , Celia Dominguez , Qi Huang , Leon M. Smith, II , Andrew Tasker , Ning Xi , Shimin Xu
发明人: Daniel Elbaum , Benny C. Askew, Jr. , Shon Booker , Julie Germain , Gregory J. Habgood , Michael Handley , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Vinod F. Patel , Chester Chenguang Yuan , Joseph L. Kim , Guolin Cai , Guoqing Chen , Michael Croghan , Lucian V. Di Pietro , Celia Dominguez , Qi Huang , Leon M. Smith, II , Andrew Tasker , Ning Xi , Shimin Xu
IPC分类号: A61K31/33 , A61K31/44 , C07D211/62 , C07D213/72
CPC分类号: C07D213/81 , C04B35/632 , C07D213/82 , C07D237/04 , C07D237/24 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号:US20060176740A1
公开(公告)日:2006-08-10
申请号:US11346520
申请日:2006-02-02
申请人: Tae-Seong Kim , Gyu-Hong Kim
发明人: Tae-Seong Kim , Gyu-Hong Kim
IPC分类号: G11C16/04
CPC分类号: G11C29/021 , G11C16/04 , G11C16/0425 , G11C29/028 , G11C29/789 , G11C29/82
摘要: A flash memory device includes a flash cell array, a first flash fuse cell fusing circuit, a second flash fuse cell fusing circuit, a third flash fuse cell fusing circuit and a plurality of fuse sense amplifying circuits. The first, second and third flash fuse cell fusing circuits all share bit lines with a flash cell array and have flash fuse cells. The first flash fuse cell fusing circuit may be used to control a connection between the flash cell array and an external logic circuit. The second flash fuse cell fusing circuit may be used to change an address of a defective cell into an address of a redundancy cell. The third flash fuse cell fusing circuit may be used to control a DC level for adjusting a reference value used in a manufacturing process of the flash memory device. The fuse sense amplifying circuits are coupled to the bit lines to read data from the bit lines, respectively.
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