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    Attenuated respiratory syncytial virus vaccine compositions
    74.
    发明授权
    Attenuated respiratory syncytial virus vaccine compositions 失效
    减毒呼吸道合胞病毒疫苗组合物

    公开(公告)号：US5922326A

    公开(公告)日：1999-07-13

    申请号：US327263

    申请日：1994-10-21

    申请人： Brian R. Murphy ,  Robert M. Chanock ,  James E. Crowe, Jr. ,  Mark Connors

    发明人： Brian R. Murphy ,  Robert M. Chanock ,  James E. Crowe, Jr. ,  Mark Connors

    IPC分类号： C12N7/00 ,  A61K39/155 ,  A61K39/39 ,  A61P31/12 ,  A61P31/14 ,  C12N7/04 ,  C12N7/08

    CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/543 ,  C12N2760/18534 ,  C12N2760/18561

    摘要： The present invention provides vaccine compositions of attenuated respiratory syncytial virus (RSV). More particularly, the attenuated virus may be a derivative of RSV which has been incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. The invention also provides methods for stimulating the immune system of an individual to induce protection against respiratory syncytial virus by administration of attenuated RSV. The invention also provides pure cultures of attenuated RS virus, wherein the virus has been more completely attenuated by the further derivatization of previously identified incompletely attenuated ts or cp mutants.

    摘要翻译： 本发明提供减毒呼吸道合胞病毒（RSV）的疫苗组合物。 更具体地，减毒病毒可以是RSV的衍生物，其通过冷通道或引入产生具有温度敏感（ts）或冷适应（ca）表型的病毒的突变而不完全减毒。 本发明还提供了刺激个体的免疫系统以通过施用减毒RSV诱导针对呼吸道合胞病毒的保护的方法。 本发明还提供了减毒RS病毒的纯培养物，其中通过进一步衍生以前鉴定的不完全衰减的ts或cp突变体，病毒已被更完全地减毒。

    Temperature-sensitive recombinant mutant viruses and a process for producing same
    76.
    发明授权
    Temperature-sensitive recombinant mutant viruses and a process for producing same 失效
    温度敏感型重组突变病毒及其制备方法

    公开(公告)号：US3992522A

    公开(公告)日：1976-11-16

    申请号：US587974

    申请日：1975-06-18

    申请人： Robert M. Chanock ,  Brian R. Murphy

    发明人： Robert M. Chanock ,  Brian R. Murphy

    IPC分类号： A61K39/145 ,  C12N7/04 ,  C12N15/00 ,  A61K39/18 ,  C12K7/00

    CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/145 ,  C12N15/00 ,  A61K2039/5254 ,  A61K2039/543 ,  C12N2760/16134 ,  C12N2760/16161 ,  Y10S424/821

    摘要： A method and resulting temperature sensitive (ts) recombinants which may be produced by modifying wild-type influenza A viruses by utilization of chemically mutagenized donor viruses possessing ts lesions and shut off temperatures in the area 37.degree.-38.degree. C. Such a recombinant virus has been produced that contains the surface H3 antigen of influenza A/Hong Kong/1968 (H3N2) virus and a temperature-sensitive (ts) lesion derived from a ts mutant of influenza A/Great Lakes/1965 (H2N2) virus. Additional donor viruses include influenza A/Hong Kong/1968-ts-1[A], influenza A double recombinant 10B, and influenza A/Hong Kong/1968-ts-1[E]. When utilized as a vaccine, these temperature-sensitive recombinant viruses have the facility to develop only mild symptoms, but the infection induces complete resistant to influenzal disease produced by challenge with a virulent wild-type virus. The temperature-sensitive donor mutant is prepared chemically by growth of the virus in the presence of 5-fluorouracil (5-FU).

    摘要翻译： 可以通过利用具有ts病变的化学诱变的供体病毒修饰野生型甲型流感病毒并在37℃-38℃的区域关闭温度来产生的方法和得到的温度敏感（ts）重组体。这样的重组病毒 已经生产出含有流感A /香港/ 1968（H3N2）病毒的表面H3抗原和源自A / Great Lakes / 1965（H2N2）型流感病毒的ts突变体的温度敏感性（ts）病变。 额外的供体病毒包括甲型流感/香港/ 1968-ts-1 [A]，甲型双重重组10B和流感A /香港/ 1968-ts-1 [E]。 当用作疫苗时，这些对温度敏感的重组病毒具有仅发展轻微症状的功能，但感染诱导通过用强毒野生型病毒攻击产生的流感病毒完全抗性。 通过在5-氟尿嘧啶（5-FU）存在下生长病毒来化学地制备温度敏感的供体突变体。