公开(公告)号：US20080203852A1

公开(公告)日：2008-08-28

申请号：US12065708

申请日：2006-09-04

申请人： Bernhard Gottlieb ,  Andreas Kappel ,  Tim Schwebel ,  Carsten Wallenhauer

发明人： Bernhard Gottlieb ,  Andreas Kappel ,  Tim Schwebel ,  Carsten Wallenhauer

IPC分类号： H01L41/00 ,  H03K3/00

CPC分类号： H02N2/065 ,  H02N2/105 ,  H02N2/145

摘要： A circuit for analogously controlling a capacitive charge, has a drive source used to provide an operating voltage or an operating flow used to charge the capacitive charge, a circuit arrangement used to charge and discharge the charge, and a storage capacity used to intermediately store the charge of the charge during the discharge of the charge and to emit intermediately stored charge to the charge during charging of the charge. In a method for analogously controlling a capacitive charge by applying a operational voltage or an operating flow of a drive source in order to charge the capacitive charge onto the charge and to discharge the charge, during a first discharge phase, the charge of the charge is intermediately stored in a storage capacity and during a first charging phase, which is used to charge the charge, the charge from the charge capacity is charged in the charge.

摘要翻译： 用于类似地控制电容性电荷的电路具有用于提供用于对电容性电荷充电的操作电压或操作流的驱动源，用于对电荷充电和放电的电路装置，以及用于中断存储 在充电期间充电的充电，并在充电期间向充电发出中间存储的电荷。 在用于通过施加驱动源的操作电压或操作流来类似地控制电容性电荷以便将电容电荷充电到电荷和放电电荷的方法中，在第一放电阶段期间，电荷的充电是 中间存储在存储容量中，并且在用于对电荷充电的第一充电阶段期间，来自充电容量的充电在充电中被充电。

公开(公告)号：US20070087350A1

公开(公告)日：2007-04-19

申请号：US10581936

申请日：2004-11-26

申请人： Andreas Kappel

发明人： Andreas Kappel

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/156

摘要： The invention relates to the use of oligonucleotide probes comprising exon 15 of the BRAF gene or a part thereof comprising codon 599 for the detection of the malignancy of melanoma cells.

摘要翻译： 本发明涉及包含BRAF基因的外显子15或包含密码子599的部分的寡核苷酸探针用于检测黑素瘤细胞恶性肿瘤的用途。

公开(公告)号：US20050235367A1

公开(公告)日：2005-10-20

申请号：US11015329

申请日：2004-12-17

申请人： Georg Breier ,  Werner Risau ,  Volker Ronicke ,  Andreas Kappel ,  Barbara Risau

发明人： Georg Breier ,  Werner Risau ,  Volker Ronicke ,  Andreas Kappel ,  Barbara Risau

IPC分类号： A01K67/027 ,  A61K31/7105 ,  A61K38/00 ,  A61K38/21 ,  A61K38/22 ,  A61K38/43 ,  A61K38/48 ,  A61K45/00 ,  A61K48/00 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P35/00 ,  C07K14/47 ,  C07K14/52 ,  C07K14/57 ,  C07K14/58 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/02 ,  C12N9/72 ,  C12N15/09 ,  C12N15/12 ,  C12N15/16 ,  C12N15/19 ,  C12N15/23 ,  C12N15/53 ,  C12N15/58 ,  C12N15/85 ,  C12Q1/00 ,  A01K67/00 ,  C07H21/04 ,  C07K14/71

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2267/0375 ,  A01K2267/0393 ,  A61K48/00 ,  C07K14/4702 ,  C12N15/85 ,  C12N2830/008 ,  C12N2830/42 ,  C12N2830/85

摘要： Described are recombinant DNA molecules comprising the regulatory sequence(s) of an intron of the Endothelial Growth Factor (VEGF) receptor-2 gene (Flk-1) or of a gene homologous to the Flk-1 gene, being capable of conferring expression of a heterologous DNA sequence in endothelial cells, preferably in vivo. Vectors comprising said DNA molecules as well as host cells containing the same are provided. Also provided are pharmaceutical and diagnostic compositions comprising such recombinant DNA molecules and vectors. Furthermore, cells and transgenic non-human animals, comprising the aforementioned recombinant DNA molecules or vectors stably integrated into their genome and their use for the identification of substances capable of suppressing or activating transcription of a gene in endothelial cells are described. Described is further the use of the before described recombinant DNA molecules and vectors for the preparation of pharmaceutical compositions for treating, preventing, and/or delaying a vascular or tumorous disease in a subject. Furthermore, uses of the recombinant DNA molecules and vectors of the invention for the preparation of pharmaceutical compositions for inducing a vascular or tumorous disease in a non-human animal are provided.

摘要翻译： 描述了包含内皮生长因子（VEGF）受体-2基因（Flk-1）的内含子的调节序列或与Flk-1基因同源的基因的重组DNA分子，其能够赋予 内皮细胞中的异源DNA序列，优选在体内。 提供了包含所述DNA分子的载体以及含有该DNA分子的宿主细胞。 还提供包含这样的重组DNA分子和载体的药物和诊断组合物。 此外，描述了包含上述重组DNA分子或稳定整合到其基因组中的载体的细胞和转基因非人动物及其用于鉴定能够抑制或激活内皮细胞中基因转录的物质的用途。 还描述了前述重组DNA分子和载体用于制备用于治疗，预防和/或延缓受试者的血管或肿瘤疾病的药物组合物的用途。 此外，提供了本发明的重组DNA分子和载体用于制备用于在非人动物中诱导血管或肿瘤疾病的药物组合物的用途。

公开(公告)号：US20050092854A1

公开(公告)日：2005-05-05

申请号：US11010587

申请日：2004-12-13

申请人： Bernhard Fischer ,  Bernhard Gottlieb ,  Andreas Kappel ,  Tim Schwebel

发明人： Bernhard Fischer ,  Bernhard Gottlieb ,  Andreas Kappel ,  Tim Schwebel

IPC分类号： F02M61/18 ,  F02M59/00 ,  F02M61/08

CPC分类号： F02M61/18 ,  F02M61/08

摘要： The injector tip of an injection valve which injects directly into the combustion chamber protrudes therein, thereby incurring the risk that combustion residues can become deposited on the injector tip. When the injection valve is in a closed state, the possible attachments of combustion residues along a separation line (10) are eliminated by means of a special configuration of the surface at the separation line (10) between the valve body and a valve plate. The surface is represented in a smooth, step-less, edge-less and curved manner.

摘要翻译： 直接喷射到燃烧室中的喷射阀的喷射器尖端在其中突出，从而引起燃烧残余物可能沉积在喷射器尖端上的风险。 当注射阀处于关闭状态时，通过在阀体和阀板之间的分离管线（10）处的表面的特殊构造来消除沿着分离管线（10）的燃烧残余物的可能附着。 表面以平滑，无级，无边缘和弯曲的方式表示。

公开(公告)号：US20050017096A1

公开(公告)日：2005-01-27

申请号：US10924007

申请日：2004-08-23

申请人： Georg Bachmaier ,  Bernhard Fischer ,  Bernhard Gottlieb ,  Andreas Kappel ,  Hans Meixner ,  Enrico Ulivieri

发明人： Georg Bachmaier ,  Bernhard Fischer ,  Bernhard Gottlieb ,  Andreas Kappel ,  Hans Meixner ,  Enrico Ulivieri

IPC分类号： F02M51/06 ,  F02M61/08 ,  F02M61/16 ,  F02M61/20 ,  B05B1/08 ,  B05B3/04

CPC分类号： F02M61/167 ,  F02M51/0603 ,  F02M61/08

摘要： An injection valve for injecting fuel comprises a valve housing (1) inside of which a drive unit (15) controls the movement of a valve needle (5) that is pretensioned by a spring (11). The injection valve also comprises a main chamber (27), which is provided inside the valve housing, is filled with fuel and accommodates the valve needle (5), and comprises a hydraulic bearing for the drive unit (15). The hydraulic bearing has a hydraulic chamber (29) that is connected to the main chamber (27), whereby fuel serves as the operating substance of the hydraulic bearing.

摘要翻译： 用于喷射燃料的喷射阀包括阀壳体（1），驱动单元（15）在其内部控制由弹簧（11）预张紧的阀针（5）的运动。 注射阀还包括设置在阀壳体内部的主室（27），其被填充燃料并容纳阀针（5），并且包括用于驱动单元（15）的液压轴承。 液压轴承具有连接到主室（27）的液压室（29），由此燃料用作液压轴承的操作物质。

公开(公告)号：US06441536B2

公开(公告)日：2002-08-27

申请号：US09827715

申请日：2001-04-06

申请人： Bernhard Fischer ,  Andreas Kappel ,  Enrico Ulivieri ,  Bernhard Gottlieb ,  Randolf Mock

发明人： Bernhard Fischer ,  Andreas Kappel ,  Enrico Ulivieri ,  Bernhard Gottlieb ,  Randolf Mock

IPC分类号： H02N200

CPC分类号： H02N2/105 ,  H02N2/0095 ,  H02N2/02

摘要： A wobble motor has at least one shaft guided in a rotatably and axially displaceable fashion, and at least one drive ring which surrounds the shaft and can be tilted with respect to a longitudinal axis of the shaft. The at least one guide ring can be displaced in a frictionally locked fashion and free from rotation.

摘要翻译： 摆动马达具有以可旋转和轴向移动的方式引导的至少一个轴，以及围绕轴并可相对于轴的纵向轴线倾斜的至少一个驱动环。 至少一个导向环可以以摩擦锁定的方式移动并且不受旋转。

公开(公告)号：US6062533A

公开(公告)日：2000-05-16

申请号：US312692

申请日：1999-05-14

申请人： Andreas Kappel ,  Randolf Mock ,  Hans Meixner

发明人： Andreas Kappel ,  Randolf Mock ,  Hans Meixner

IPC分类号： F02M47/02 ,  F02M51/06 ,  F02M59/46 ,  F02M63/00 ,  F16K31/00 ,  F16K31/12

CPC分类号： F02M63/0026 ,  F02M47/027 ,  F02M51/0603 ,  F16K31/004 ,  F01L2009/0413 ,  F02M2200/704 ,  F02M2200/706

摘要： A wall-controllable primary drive, for example a piezo actuator, guided in a first bore transfers its stroke motion-commutated onto a secondary-side lifter element guided in a second bore, transmitting said stroke by a piston-hydraulic stroke transmission on the basis of a hydraulic chamber. The pressure in a valve chamber is controlled via secondary-side lifter element.

摘要翻译： 在第一孔中引导的壁可控主驱动器，例如压电致动器将其行程运动换向到在第二孔中引导的次级侧升降器元件，基于基础的活塞 - 液压冲程变速器传递所述行程 的液压室。 通过次级侧升降器元件控制阀室中的压力。

公开(公告)号：US5685485A

公开(公告)日：1997-11-11

申请号：US408158

申请日：1995-03-21

申请人： Randolf Mock ,  Andreas Kappel ,  Hans Meixner

发明人： Randolf Mock ,  Andreas Kappel ,  Hans Meixner

IPC分类号： B05B1/30 ,  B05B17/06 ,  F02M61/18 ,  F02M69/04 ,  F23D11/34 ,  G05D7/06 ,  B05B1/08

CPC分类号： B05B17/0646 ,  F02M61/1853 ,  F02M69/041 ,  F23D11/345

摘要： A device is provided which allows exact apportioning and controllable atomization of fuel as necessary for various operating conditions of an internal combustion engine. The apportioning ensues with an apportioning aperture that can be closed via a valve needle. Separately therefrom, the atomization ensues with a piezoelectrically driven nozzle having an atomizer orifice placed into vibration. The shape of the atomizer aperture can be round, triangular, quadrangular or cross-like.

摘要翻译： 提供一种装置，其允许对内燃机的各种操作条件所必需的精确的分配和燃料的可控雾化。 通过分配孔径分配可以通过阀针闭合。 与此分开，雾化随着压电驱动喷嘴而起，喷嘴具有放置在振动中的雾化孔。 雾化器孔的形状可以是圆形，三角形，四边形或十字形。

公开(公告)号：US5400063A

公开(公告)日：1995-03-21

申请号：US992754

申请日：1992-12-18

申请人： Andreas Kappel

发明人： Andreas Kappel

IPC分类号： B41J2/14 ,  H05K1/02 ,  B41J2/05

CPC分类号： H05K1/0265 ,  B41J2/14072 ,  B41J2202/11 ,  H05K2201/0784 ,  H05K2201/09727

摘要： A substantially uniform and nevertheless low feed line resistance of the conductor paths (L.sub.i) can be realized for all heating elements in an ink jet printer by a suitable dimensioning of a transition structure (UV) of a conductor path layout disposed on a thin-film substrate. This transition structure connects the conductor paths of close spacing (LA) in the region of the heating elements (RH) to the conductor paths of wide spacing (LB) in the region of the bonding contacts to each other. For this purpose a dimensioning requirement is required, which in case of predetermined input values, i.e. the conductor path widths (d.sub.a, d.sub.b) and the separation distance widths (s.sub.a, s.sub.b) furnishes in the two regions and in the separation distance width (s.sub.v) of the transition structure (UV) as starting value the conductor width (d.sub.v) in the transition structure (UV).

摘要翻译： 通过适当尺寸设置在薄膜上的导体路径布局的过渡结构（UV），可以实现对喷墨打印机中所有加热元件的导体路径（Li）的基本上均匀且仍然低的馈电线电阻 基质。 该过渡结构将在加热元件（RH）的区域中的紧密间隔（LA）的导体路径与接合触点的区域中的宽间距（LB）的导体路径彼此连接。 为此，需要尺寸要求，在预定的输入值的情况下，即导体路径宽度（da，db）和间隔距离宽度（sa，sb）在两个区域中提供并且在间隔距离宽度（sv ）作为过渡结构（UV）中的导体宽度（dv）作为起始值的过渡结构（UV）。