公开(公告)号：US11998616B2

公开(公告)日：2024-06-04

申请号：US17215443

申请日：2021-03-29

Applicant: California Institute of Technology

Inventor： Mark E. Davis ,  Emily A. Wyent

IPC: A61K47/69 ,  A61K9/16 ,  A61K31/137 ,  A61K31/4045 ,  A61K31/4745 ,  B82Y5/00 ,  C07K16/32

CPC classification number: A61K47/6935 ,  A61K9/1641 ,  A61K31/137 ,  A61K31/4045 ,  A61K31/4745 ,  C07K16/32 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/906

Abstract: The present application discloses nanoparticles carrying therapeutic agents, including chemotherapeutic agents, and targeting ligands suitable for delivering these therapeutic agents through the blood brain barrier and methods of using these patients on those patients in need of such treatment.

公开(公告)号：US20230234038A1

公开(公告)日：2023-07-27

申请号：US18149942

申请日：2023-01-04

Applicant: California Institute of Technology

Inventor： Donglong Fu ,  Mark E. Davis

IPC: B01J29/18 ,  B01J29/85 ,  B01J29/00 ,  B01J38/02 ,  B01J29/90 ,  B01D53/04 ,  B01D53/26

CPC classification number: B01J29/18 ,  B01J29/85 ,  B01J29/005 ,  B01J38/02 ,  B01J29/90 ,  B01D53/04 ,  B01D53/261 ,  B01D2253/1085 ,  B01D2253/1122 ,  B01D2257/504 ,  B01D2257/80 ,  B01D2259/40083

Abstract: The present disclosure is directed to metal ion-containing zeolitic compositions having MOR topology that are useful for scavenging CO2 from low-CO2-content feed streams, including air, and method of making and using the same.

公开(公告)号：US11691131B2

公开(公告)日：2023-07-04

申请号：US16952486

申请日：2020-11-19

Applicant: California Institute Of Technology

Inventor： Michiel J. Dusselier ,  Mark E. Davis

IPC: B01J29/70 ,  B01J29/04 ,  C01B39/48 ,  B01D53/86 ,  C07C67/37 ,  C07C29/48 ,  C07C209/14 ,  C01B39/06 ,  C07C29/50 ,  C07C1/20 ,  C10G45/68 ,  C10G3/00 ,  C10G45/64 ,  C10G50/00 ,  C10G49/08 ,  C10G47/20 ,  C01B21/04 ,  C07C7/13 ,  B01D53/94

CPC classification number: B01J29/048 ,  B01D53/8628 ,  C01B21/0411 ,  C01B39/06 ,  C01B39/48 ,  C07C1/20 ,  C07C7/13 ,  C07C29/48 ,  C07C29/50 ,  C07C67/37 ,  C07C209/14 ,  C10G3/49 ,  C10G45/64 ,  C10G45/68 ,  C10G47/20 ,  C10G49/08 ,  C10G50/00 ,  B01D53/9418 ,  B01D2251/2062 ,  B01D2255/20792 ,  B01D2255/50 ,  B01J2229/186 ,  C07C2521/12 ,  C07C2523/06 ,  C07C2529/70 ,  C10G2300/1088 ,  C10G2300/1096 ,  C10G2400/22 ,  C10G2400/30 ,  Y02C20/10 ,  Y02C20/30 ,  Y02P20/52 ,  Y02P30/20 ,  Y02P30/40 ,  C07C67/37 ,  C07C69/14 ,  C07C29/48 ,  C07C31/04 ,  C07C29/50 ,  C07C31/04 ,  C07C1/20 ,  C07C11/02

Abstract: The present disclosure is directed to microporous crystalline aluminosilicate structures with GME topologies having pores containing organic structure directing agents (OSDAs) comprising at least one piperidinium cation, the compositions useful for making these structures, and methods of using these structures. In some embodiments, the crystalline zeolite structures have a molar ratio of Si:Al that is greater than 3.5.

公开(公告)号：US11285212B2

公开(公告)日：2022-03-29

申请号：US16200095

申请日：2018-11-26

Applicant: California Institute Of Technology

Inventor： Mark E. Davis ,  Han Han

IPC: A61K45/06 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/727 ,  A61K9/51 ,  A61K47/60 ,  A61K47/69

Abstract: Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a nitroboronic boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing the nitroboronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.

公开(公告)号：US20210220483A1

公开(公告)日：2021-07-22

申请号：US17215443

申请日：2021-03-29

Applicant: California Institute of Technology

Inventor： Mark E. Davis ,  Emily A. Wyatt

IPC: A61K47/69 ,  A61K9/16 ,  A61K31/4045 ,  A61K31/4745 ,  C07K16/32 ,  A61K31/137

Abstract: The present application discloses nanoparticles carrying therapeutic agents, including chemotherapeutic agents, and targeting ligands suitable for delivering these therapeutic agents through the blood brain barrier and methods of using these patients on those patients in need of such treatment.

公开(公告)号：US11041050B2

公开(公告)日：2021-06-22

申请号：US16880065

申请日：2020-05-21

Applicant: California Institute Of Technology

Inventor： Mark E. Davis ,  Dorothy Pan

IPC: C08G81/00 ,  A61K47/34 ,  C08G69/40 ,  C08G79/08 ,  C08G73/02 ,  C08J3/12 ,  A61K9/50

Abstract: The present disclosure is directed to nanoparticle delivery systems for delivering biological agents, pharmaceutical compositions of comprising these nanoparticles, and methods of using these compositions. Certain embodiments of the present disclosure provide nanoparticles comprising polymers comprising alternating charged and uncharged segments comprising one or more of the following structural units of Formula (I) Formula (III): wherein A is an uncharged segment comprising polyalkylene glycol; and B is a cationically charged segment comprising at least one polyhydroxy linkage.

公开(公告)号：US20210154649A1

公开(公告)日：2021-05-27

申请号：US17147911

申请日：2021-01-13

Applicant: California Institute Of Technology

Inventor： Joel E. Schmidt ,  Mark E. Davis ,  Ben W. Boal ,  Jong Hun Kang

IPC: B01J29/04 ,  B01J29/70 ,  C01B39/06 ,  C01B39/08 ,  C01B39/48 ,  B01J35/00 ,  B01J37/08 ,  B01J37/10 ,  B01J37/30 ,  C01B39/02 ,  C01B39/46

Abstract: The present disclosure is directed to novel phyllosilicate compositions designated CIT-13P and methods of producing and using the same.

公开(公告)号：US20210154648A1

公开(公告)日：2021-05-27

申请号：US17147866

申请日：2021-01-13

Applicant: California Institute Of Technology

Inventor： Joel E. Schmidt ,  Mark E. Davis ,  Ben W. Boal ,  Jong Hun Kang

IPC: B01J29/04 ,  B01J29/70 ,  C01B39/06 ,  C01B39/08 ,  C01B39/48 ,  B01J35/00 ,  B01J37/08 ,  B01J37/10 ,  B01J37/30 ,  C01B39/02 ,  C01B39/46

Abstract: The present disclosure is directed to novel germanosilicate compositions and methods of producing the same. In particular, this disclosure describes new silica-rich compositions of the germanosilicate designated CIT-13, with and without added metal oxides. The disclosure also describes methods of preparing and using these new germanosilicate compositions as well as the compositions themselves.

公开(公告)号：US20210069682A1

公开(公告)日：2021-03-11

申请号：US16952486

申请日：2020-11-19

Applicant: California Institute Of Technology

Inventor： Michiel J. Dusselier ,  Mark E. Davis

IPC: B01J29/04 ,  C01B39/48 ,  B01D53/86 ,  C07C67/37 ,  C07C29/48 ,  C07C209/14 ,  C01B39/06 ,  C07C29/50 ,  C07C1/20 ,  C10G45/68 ,  C10G3/00 ,  C10G45/64 ,  C10G50/00 ,  C10G49/08 ,  C10G47/20 ,  C01B21/04 ,  C07C7/13

Abstract: The present disclosure is directed to microporous crystalline aluminosilicate structures with GME topologies having pores containing organic structure directing agents (OSDAs) comprising at least one piperidinium cation, the compositions useful for making these structures, and methods of using these structures. In some embodiments, the crystalline zeolite structures have a molar ratio of Si:Al that is greater than 3.5.

公开(公告)号：US10913053B2

公开(公告)日：2021-02-09

申请号：US15449317

申请日：2017-03-03

Applicant: California Institute of Technology ,  Chevron U.S.A., Inc.

Inventor： Joel E. Schmidt ,  Mark E. Davis ,  Ben W. Boal ,  Jong Hun Kang ,  Dan Xie

IPC: C01B39/02 ,  C01B39/48 ,  B01J29/70 ,  B01J29/04 ,  C01B39/06 ,  C01B39/08 ,  B01J35/00 ,  B01J37/08 ,  B01J37/10 ,  B01J37/30 ,  C01B39/46

Abstract: The present disclosure is directed to novel germanosilicate compositions and methods of producing the same. In particular, this disclosure describes an array of transformations originating from the extra-large-pore crystalline germanosilicate compositions, designated CIT-13, possessing 10- and 14-membered rings. Included among the new materials are the new phyllosilicate compositions, designated CIT-13P, new crystalline microporous germanosilicates including high silica versions of CIT-5 and CIT-13, with and without added metal oxides, and new germanosilicate compounds designated CIT-14 and CIT-15. The disclosure also describes methods of preparing these new germanosilicate compositions as well as the compositions themselves.