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公开(公告)号：US20200345699A1
公开(公告)日：2020-11-05
申请号：US16849747
申请日：2020-04-15
Applicant: Gilead Sciences, Inc.
Inventor： Aesop Cho , John O. Link , Jie Xu
IPC: A61K31/4196 , A61K45/06 , C07D403/10 , C07D403/14 , A61P31/18 , A61K31/7076 , A61K31/537 , A61K31/52 , A61K31/675
Abstract: The present disclosure provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject using these compounds. The present disclosure also provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of a coronavirus, treating coronavirus symptoms or delaying the onset of coronavirus symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of a coronavirus, treating coronavirus symptoms or delaying the onset of coronavirus symptoms in a subject using these compounds.
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公开(公告)号：US10654827B2
公开(公告)日：2020-05-19
申请号：US16016718
申请日：2018-06-25
Applicant: Gilead Sciences, Inc.
Inventor： Michael Graupe , Steven J. Henry , John O. Link , Roland D. Saito , Scott D. Schroeder , Dimitrios Stefanidis , Winston C. Tse , Jennifer R. Zhang
IPC: A61K31/44 , C07D401/14 , A61K31/4439 , A61K31/537 , A61K31/675 , A61K31/7076 , A61K45/06 , C07C317/08 , C07D231/54 , C07F5/02
Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.
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公开(公告)号：US10577352B2
公开(公告)日：2020-03-03
申请号：US16045518
申请日：2018-07-25
Applicant: Gilead Sciences, Inc.
Inventor： Gayatri Balan , Chienhung Chou , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary Phillips , Roland D. Saito , Neil H. Squires , James G. Taylor , William J. Watkins , Nathan E. Wright
IPC: C07D401/14 , C07D403/12 , C07D405/14 , C07D417/14
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US10442804B2
公开(公告)日：2019-10-15
申请号：US15885390
申请日：2018-01-31
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Eda Canales , Kevin S. Currie , Darryl Kato , Jiayao Li , John O. Link , Samuel E. Metobo , Roland D. Saito , Scott D. Schroeder , Nathan Shapiro , Winston C. Tse , Qiaoyin Wu , Yunfeng Eric Hu
IPC: C07D471/14 , C07D491/22 , C07D498/14 , C07D519/00 , A61P31/20 , C07B59/00
Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.
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公开(公告)号：US20190248807A1
公开(公告)日：2019-08-15
申请号：US16391673
申请日：2019-04-23
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Gayatri Balan , Chienhung Chou , Christopher T. Clark , Jeromy J. Cottell , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary B. Phillips , Scott D. Schroeder , Neil H. Squires , Kirk L. Stevens , James G. Taylor , William J. Watkins , Nathan E. Wright , Sheila M. Zipfel
IPC: C07D498/04 , C07D495/04 , C07D471/04 , C07D417/14 , C07D409/14 , C07B59/00 , C07D413/14 , C07D405/14 , C07D401/14 , C07D401/12
CPC classification number: C07D498/04 , C07B59/002 , C07B2200/05 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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Patent Agency Ranking
公开(公告)号：US20190016705A1
公开(公告)日：2019-01-17
申请号：US16045518
申请日：2018-07-25
Applicant: Gilead Sciences, Inc.
Inventor： Gayatri Balan , Chienhung Chou , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary Phillips , Roland D. Saito , Neil H. Squires , James G. Taylor , William J. Watkins , Nathan E. Wright
IPC: C07D403/12 , C07D417/14 , C07D401/14 , C07D405/14
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US10100052B2
公开(公告)日：2018-10-16
申请号：US15596844
申请日：2017-05-16
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Eda Canales , Elbert Chin , Kevin S. Currie , Ashley Anne Katana , Darryl Kato , John O. Link , Samuel E. Metobo , Roland D. Saito , Zheng-Yu Yang
IPC: C07D471/04
Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.
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公开(公告)号：US20180273508A1
公开(公告)日：2018-09-27
申请号：US15910083
申请日：2018-03-02
Applicant: Gilead Sciences, Inc.
Inventor： Gediminas Brizgys , Eda Canales , Chien-Hung Chou , Michael Graupe , Randall L. Halcomb , Yunfeng Eric Hu , Scott E. Lazerwith , John O. Link , Qi Liu , Yafan Lu , Roland D. Saito , Scott D. Schroeder , John R. Somoza , Winston C. Tse , Jennifer R. Zhang
IPC: C07D401/12 , C07D487/04 , A61K31/517 , A61K31/496 , A61K31/4725 , C07D491/052 , A61K31/4439 , A61K31/437 , A61K45/06 , A61K31/444 , A61K31/5377 , C07D401/14 , C07D403/14 , C07D471/04 , C07D401/04 , C07D417/14 , C07D413/14 , A61K31/506
CPC classification number: C07D401/12 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/052
Abstract: Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
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公开(公告)号：US20180258097A1
公开(公告)日：2018-09-13
申请号：US15888749
申请日：2018-02-05
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Elbert Chin , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , John O. Link , Nathan Shapiro , Teresa Alejandra Trejo Martin , Zheng-Yu Yang
IPC: C07D487/08 , A61K45/06 , A61K31/55 , A61K31/685 , A61K31/688 , A61P31/18 , A61K31/52 , A61K31/553
CPC classification number: C07D487/08 , A61K31/52 , A61K31/55 , A61K31/553 , A61K31/685 , A61K31/688 , A61K45/06 , A61P31/18 , C07C243/28 , C07C275/16 , C07D401/12 , C07D403/12 , C07D405/14 , C07D471/08 , C07D487/10 , C07D491/04
Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
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公开(公告)号：US20180251460A1
公开(公告)日：2018-09-06
申请号：US15885390
申请日：2018-01-31
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Eda Canales , Kevin S. Currie , Darryl Kato , Jiayao Li , John O. Link , Samuel E. Metobo , Roland D. Saito , Scott D. Schroeder , Nathan Shapiro , Winston C. Tse , Qiaoyin Wu
IPC: C07D471/14 , C07D498/14 , C07D519/00 , C07D491/22 , C07B59/00 , A61P31/20
CPC classification number: C07D471/14 , A61P31/20 , C07B59/002 , C07B2200/05 , C07D491/22 , C07D498/14 , C07D519/00
Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.
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