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公开(公告)号：US07629477B2
公开(公告)日：2009-12-08
申请号：US12142621
申请日：2008-06-19
申请人： Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
发明人： Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC分类号： C07D311/22
CPC分类号： C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号：US07582668B2
公开(公告)日：2009-09-01
申请号：US11598250
申请日：2006-11-08
申请人： Xiangping Qian , Luke W. Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley P. Morgan , David J. Morgans, Jr. , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin J. Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Luke W. Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley P. Morgan , David J. Morgans, Jr. , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin J. Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/4178 , C07D403/10
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
摘要翻译： 提供了可用于治疗癌症或其它增殖性疾病的式I化合物及其药学上可接受的盐。
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公开(公告)号：US07557115B2
公开(公告)日：2009-07-07
申请号：US10529745
申请日：2003-09-30
IPC分类号： A61K31/517 , C07D239/88
CPC分类号： C07D471/04 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D475/00 , C07D475/02 , C07D491/04 , C07D495/04
摘要： Compounds, compositions and methods useful for treating cellular proliferative diseases and disorders, for example, by modulating the activity of KSP, are disclosed.
摘要翻译： 公开了用于治疗细胞增殖性疾病和病症的化合物，组合物和方法，例如通过调节KSP的活性。
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公开(公告)号：US07439254B2
公开(公告)日：2008-10-21
申请号：US11005629
申请日：2004-12-07
申请人： Gustave Bergnes
发明人： Gustave Bergnes
IPC分类号： C07D471/02 , A61K31/4375
CPC分类号： C07D217/24 , A61K31/4709 , A61K31/496 , C07D471/04
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译： 公开了通过调节KSP的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20080255182A1
公开(公告)日：2008-10-16
申请号：US12007143
申请日：2008-01-07
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/437 , A61P35/00
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20080242695A1
公开(公告)日：2008-10-02
申请号：US12058127
申请日：2008-03-28
申请人： Bradley P. Morgan , David J. Morgans , Gustave Bergnes , Alex Muci , Scott Collibee , Pu-Ping Lu , Luke W. Ashcraft , William F. Browne , Marc Andrew Garard
发明人： Bradley P. Morgan , David J. Morgans , Gustave Bergnes , Alex Muci , Scott Collibee , Pu-Ping Lu , Luke W. Ashcraft , William F. Browne , Marc Andrew Garard
IPC分类号： A61K31/444 , C07D471/02 , A61P21/00
CPC分类号： C07D471/04
摘要： Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of muscle weakness and/or cachexia, as part of a rehabilitation or conditioning exercise regimen, or in the treatment of fraility, post-polio syndrome, obesity, sarcopenia, wasting syndrome, muscle spasm, and other indications.
摘要翻译： 提供某些化学实体以及用于调节骨骼肌球蛋白，骨骼肌动蛋白，骨骼原肌球蛋白，骨骼肌钙蛋白C，骨骼肌钙蛋白I，骨骼肌钙蛋白T和骨骼肌（包括其片段和同种型）以及骨骼肌节的使用方法， 以及用于治疗肌肉无力和/或恶病质的方法，作为康复或调理运动方案的一部分，或用于治疗虚弱，脊髓灰质炎综合征，肥胖症，肌肉减少症，消瘦综合征，肌肉痉挛和其他适应症 。
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公开(公告)号：US20070232597A1
公开(公告)日：2007-10-04
申请号：US10552611
申请日：2004-04-09
IPC分类号： A61K31/5395 , A61P9/00 , C07D273/02
CPC分类号： C07D273/04
摘要： Compounds useful for treating cellular proliferative diseases and disorders by inhibiting the activity of KSP are disclosed.
摘要翻译： 公开了通过抑制KSP的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20070149516A1
公开(公告)日：2007-06-28
申请号：US11598250
申请日：2006-11-08
申请人： Xiangping Qian , Luke Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley Morgan , David Morgans , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Luke Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley Morgan , David Morgans , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/5383 , A61K31/4745 , A61K31/424 , A61K31/4196 , A61K31/4172
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
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公开(公告)号：US20070135432A1
公开(公告)日：2007-06-14
申请号：US11600683
申请日：2006-11-15
申请人： Han-Jie Zhou , David Morgans , Gustave Bergnes , Steven Knight , Kenneth Newlander , Dashyant Dhanak , Nicholas Adams
发明人： Han-Jie Zhou , David Morgans , Gustave Bergnes , Steven Knight , Kenneth Newlander , Dashyant Dhanak , Nicholas Adams
IPC分类号： C07D413/02 , C07D403/02 , A61K31/5377 , A61K31/513
CPC分类号： C07D239/36 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/91 , C07D249/08 , C07D403/06
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译： 公开了通过调节KSP的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20070066591A1
公开(公告)日：2007-03-22
申请号：US10553987
申请日：2004-05-12
申请人： Xiangping Qian , Xianping Qian , Gustave Bergnes
发明人： Xiangping Qian , Xianping Qian , Gustave Bergnes
IPC分类号： A61K31/554 , A61K31/553 , A61K31/551 , A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4245 , C07D413/02 , C07D417/02
CPC分类号： C07D271/07
摘要： Compounds useful for treating cellular proliferative diseases and disorders by inhibiting the activity of KSP are disclosed.
摘要翻译： 公开了通过抑制KSP的活性来治疗细胞增殖性疾病和病症的化合物。
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