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    4,5,6,7-tetrahydro-thieno(2,3-C)pyridine derivatives
    74.
    发明授权
    4,5,6,7-tetrahydro-thieno(2,3-C)pyridine derivatives 失效
    4,5,6,7-四氢 - 噻吩并（2,3-C）吡啶衍生物

    公开(公告)号：US6090797A

    公开(公告)日：2000-07-18

    申请号：US387290

    申请日：1999-08-31

    申请人： Peter Madsen ,  Jane Marie Lundbeck ,  Niels Westergaard ,  Palle Jakobsen

    发明人： Peter Madsen ,  Jane Marie Lundbeck ,  Niels Westergaard ,  Palle Jakobsen

    IPC分类号： C07D495/04 ,  A61K31/435 ,  C07D471/04

    CPC分类号： C07D495/04

    摘要： Disclosed are compounds of formula (I) ##STR1## wherein R1 is C.sub.1-8 -alkyl, C.sub.2-8 -alkenyl, C.sub.3-8 -cycloalkyl, C.sub.5-8 -cycloalkenyl, Q or aryl;R2 is C.sub.1-8 -alkyl, C.sub.2-8 -alkenyl, C.sub.3-8 -cycloalkyl, C.sub.5-8 -cycloalkenyl, aralkyl or COR3;R3 is C.sub.1-8 -alkyl, C.sub.2-8 -alkenyl, C.sub.3-8 -cycloalkyl, C.sub.5-8 -cycloalkenyl, w or aryl;R5, R6 and R7 are independently selected from amino-C.sub.1-6 -alkyl, hydroxy-C.sub.1-6 -alkyl, hydrogen, C.sub.1-6 -alkyl, aryl, aralkyl, aryloxy, aryloxy-C.sub.1-6 -alkyl, benzyl, halogen, hydroxy, mercapto, cyano, nitro, carboxy, carbamoyl, CONHC.sub.1-4 -alkyl, CON(C.sub.1-4 alkyl).sub.2, C.sub.1-4 -acyl, C.sub.1-4 -alkoxy, C.sub.1-4 -alkylthio, --SOC.sub.1-6 -alkyl, --SO.sub.2 C.sub.1-6 -alkyl, C.sub.1-4 -alkoxycarbonyl, C.sub.1-4 -alkanoyloxy, amino, optionally substituted mono- or di-C.sub.1-6 -alkylamino, acylamino, --NC.sub.1-4 -alkylCOC.sub.1-4 -alkyl, --SO3H, --SO2NH--C.sub.1-6 -alkyl, tetrazolyl, perhalomethyl, perhalomethoxy;wherein R1, R2 and R3 are all optionally substituted with one or more substituents;or salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer; a pharmaceutical composition containing them, and the use of these compounds for preparing medicaments for the treatment of diseases of the endocrinologic system, preferably hyperglycemia or diabetes.

    摘要翻译： 公开了式（I）的化合物，其中R 1是C 1-8烷基，C 2-8 - 烯基，C 3-8 - 环烷基，C 5-8 - 环烯基，Q或芳基; R 2是C 1-8 - 烷基，C 2-8 - 烯基，C 3-8 - 环烷基，C 5-8 - 环烯基，芳烷基或COR 3; R 3是C 1-8烷基，C 2-8 - 烯基，C 3-8 - 环烷基，C 5-8 - 环烯基，w或芳基; R 5，R 6和R 7独立地选自氨基-C 1-6 - 烷基，羟基-C 1-6 - 烷基，氢，C 1-6 - 烷基，芳基，芳烷基，芳氧基，芳氧基-C 1-6 - 烷基，苄基，卤素 ，羟基，巯基，氰基，硝基，羧基，氨基甲酰基，CONHC1-4-烷基，CON（C 1-4烷基）2，C 1-4 - 酰基，C 1-4 - 烷氧基，C 1-4 - 烷硫基，-SOC 1-6 - 烷基，-SO 2 C 1-6 - 烷基，C 1-4 - 烷氧基羰基，C 1-4 - 烷酰氧基，氨基，任选取代的一或二-C 1-6 - 烷基氨基，酰基氨基，-NC 1-4 - 烷基C 1 -C 1-4烷基 - SO 3 H，-SO 2 NH-C 1-6 - 烷基，四唑基，全卤代甲基，全卤代甲氧基; 其中R1，R2和R3全部被一个或多个取代基取代; 或其盐与药学上可接受的酸或碱，或任何旋光异构体; 含有它们的药物组合物，以及这些化合物用于制备用于治疗内分泌系统疾病，优选高血糖或糖尿病的药物的用途。