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1.Insulin Derivatives Conjugated with Structurally Well Defined Branched Polymers 审中-公开
标题翻译: 与结构定义良好的支化聚合物共轭的胰岛素衍生物公开(公告)号:US20090036353A1
公开(公告)日:2009-02-05
申请号:US11814184
申请日:2006-01-26
申请人: Carsten Behrens , Jesper Lau , Janos Tibor Kodra , Mikael Kofod-Hansen , Thomas Hoeg-Jensen , Peter Madsen , Svend Havelund
发明人: Carsten Behrens , Jesper Lau , Janos Tibor Kodra , Mikael Kofod-Hansen , Thomas Hoeg-Jensen , Peter Madsen , Svend Havelund
CPC分类号: B82Y5/00 , A61K47/59 , A61K47/595 , A61K47/60 , A61K47/641 , A61K47/6949
摘要: Insulin conjugated with structurally well defined, bifurcated and trifurcated polymers can be use by pulmonary delivery for systemic absorption through the lungs to reduce or eliminate the need for administering other insulins by injection.
摘要翻译: 与结构良好定义的分叉和三化聚合物结合的胰岛素可以通过肺部递送用于通过肺的全身吸收,以减少或消除通过注射施用其它胰岛素的需要。
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公开(公告)号:US20050203108A1
公开(公告)日:2005-09-15
申请号:US10980199
申请日:2004-11-03
申请人: Jesper Lau , Peter Madsen , Christian Sams , Carsten Behrens , Josef Vagner , Inge Christensen , Behrend Lundt , Ulla Sidelmann , Henning Thogersen , Anthony Ling , Michael Plewe , Larry Truesdale , Anker Jogensen , Janos Kodra , Shenghua Shi
发明人: Jesper Lau , Peter Madsen , Christian Sams , Carsten Behrens , Josef Vagner , Inge Christensen , Behrend Lundt , Ulla Sidelmann , Henning Thogersen , Anthony Ling , Michael Plewe , Larry Truesdale , Anker Jogensen , Janos Kodra , Shenghua Shi
IPC分类号: C07C237/36 , C07C237/42 , C07C243/38 , C07C271/56 , C07C271/58 , C07C275/24 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/38 , C07C275/42 , C07C275/60 , C07C275/62 , C07C311/47 , C07C317/22 , C07C317/32 , C07C317/42 , C07C323/21 , C07C323/44 , C07D209/08 , C07D209/48 , C07D211/58 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/30 , C07D257/06 , C07D277/72 , C07D295/13 , C07D295/135 , C07D307/68 , C07D317/66 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/60 , C07D333/68 , C07D333/70 , C07D409/12 , C07D417/12 , C07D487/04 , A61K31/519 , A61K31/415 , A61K31/445
CPC分类号: C07D209/48 , C07B2200/07 , C07C237/36 , C07C237/42 , C07C243/38 , C07C271/56 , C07C271/58 , C07C275/24 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/38 , C07C275/42 , C07C275/60 , C07C275/62 , C07C311/47 , C07C317/22 , C07C317/32 , C07C317/42 , C07C323/21 , C07C323/44 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/18 , C07C2603/68 , C07C2603/94 , C07D209/08 , C07D211/58 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/30 , C07D257/06 , C07D277/72 , C07D295/13 , C07D295/135 , C07D307/68 , C07D317/66 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/60 , C07D333/68 , C07D333/70 , C07D409/12 , C07D417/12 , C07D487/04
摘要: A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.
摘要翻译: 一类新颖的化合物,其作用是拮抗胰高血糖素激素对胰高血糖素受体的作用。 由于它们对胰高血糖素受体的拮抗作用,所述化合物可适用于治疗和/或预防任何胰高血糖素介导的病症和疾病如高血糖症,1型糖尿病,2型糖尿病和肥胖症。
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公开(公告)号:US06503949B1
公开(公告)日:2003-01-07
申请号:US09572553
申请日:2000-05-16
申请人: Jesper Lau , Peter Madsen , Christian Sams , Carsten Behrens , Josef Vagner , Inge Thøger Christensen , Behrend Frederik Lundt , Ulla Grove Sidelmann , Henning Thøgersen , Anthony L. Ling , Michael Bruno Plewe , Larry Kenneth Truesdale , Shenghua Shi
发明人: Jesper Lau , Peter Madsen , Christian Sams , Carsten Behrens , Josef Vagner , Inge Thøger Christensen , Behrend Frederik Lundt , Ulla Grove Sidelmann , Henning Thøgersen , Anthony L. Ling , Michael Bruno Plewe , Larry Kenneth Truesdale , Shenghua Shi
IPC分类号: A01N3718
CPC分类号: C07D209/48 , C07B2200/07 , C07C237/36 , C07C237/42 , C07C243/38 , C07C271/56 , C07C271/58 , C07C275/24 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/38 , C07C275/42 , C07C275/60 , C07C275/62 , C07C311/47 , C07C317/22 , C07C317/32 , C07C317/42 , C07C323/21 , C07C323/44 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/18 , C07C2603/68 , C07C2603/94 , C07D209/08 , C07D211/58 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/30 , C07D257/06 , C07D277/72 , C07D295/13 , C07D295/135 , C07D307/68 , C07D317/66 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/60 , C07D333/68 , C07D333/70 , C07D409/12 , C07D417/12 , C07D487/04
摘要: Disclosed is a novel class of compounds of formula (I) wherein V, A, Y, Z, R1, E, X and D are as defined in the specification. These compounds act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor, the compounds are suitable for treating or preventing glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.
摘要翻译: 公开了一类新的式(I)化合物,其中V,A,Y,Z,R 1,E,X和D如说明书中所定义。 这些化合物用于拮抗胰高血糖素激素对胰高血糖素受体的作用。 由于其拮抗胰高血糖素受体的作用,该化合物适用于治疗或预防胰高血糖素介导的病症和疾病如高血糖症,1型糖尿病,2型糖尿病和肥胖症。
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公开(公告)号:US06649641B2
公开(公告)日:2003-11-18
申请号:US09996025
申请日:2001-11-16
申请人: Carsten Behrens , Jesper Lau , Peter Madsen
发明人: Carsten Behrens , Jesper Lau , Peter Madsen
IPC分类号: A61K3141
CPC分类号: C07D209/48 , C07C275/42 , C07C2601/14 , C07C2601/16 , C07D209/08 , C07D257/04 , C07D263/57 , C07D271/06 , C07D271/07 , C07D277/82 , C07D319/08 , C07D319/20 , C07D333/36 , C07D413/12 , C07D417/12
摘要: A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism and obesity.
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公开(公告)号:US20090143592A1
公开(公告)日:2009-06-04
申请号:US11949075
申请日:2007-12-03
申请人: Jesper Lau , Peter Madsen , Christian Sams , Carsten Behrens , Josef Vagner , Inge Thoger Christensen , Behrend Frederik Lundt , Ulla Grove Sidelmann , Henning Thogersen , Anthony L. Ling , Michael Bruno Plewe , Larry Kenneth Truesdale , Anker Steen Jogensen , Janos Tibor Kodra , Shenghua Shi
发明人: Jesper Lau , Peter Madsen , Christian Sams , Carsten Behrens , Josef Vagner , Inge Thoger Christensen , Behrend Frederik Lundt , Ulla Grove Sidelmann , Henning Thogersen , Anthony L. Ling , Michael Bruno Plewe , Larry Kenneth Truesdale , Anker Steen Jogensen , Janos Tibor Kodra , Shenghua Shi
IPC分类号: C07D211/88 , C07D257/06 , C07D333/24 , C07C57/62
CPC分类号: C07D209/48 , C07B2200/07 , C07C237/36 , C07C237/42 , C07C243/38 , C07C271/56 , C07C271/58 , C07C275/24 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/38 , C07C275/42 , C07C275/60 , C07C275/62 , C07C311/47 , C07C317/22 , C07C317/32 , C07C317/42 , C07C323/21 , C07C323/44 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/18 , C07C2603/68 , C07C2603/94 , C07D209/08 , C07D211/58 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/30 , C07D257/06 , C07D277/72 , C07D295/13 , C07D295/135 , C07D307/68 , C07D317/66 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/60 , C07D333/68 , C07D333/70 , C07D409/12 , C07D417/12 , C07D487/04
摘要: A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.
摘要翻译: 一类新颖的化合物,其作用是拮抗胰高血糖素激素对胰高血糖素受体的作用。 由于它们对胰高血糖素受体的拮抗作用,所述化合物可适用于治疗和/或预防任何胰高血糖素介导的病症和疾病如高血糖症,1型糖尿病,2型糖尿病和肥胖症。
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公开(公告)号:US06927214B1
公开(公告)日:2005-08-09
申请号:US09483504
申请日:2000-01-14
申请人: Min Teng , Larry Kenneth Truesdale , Dilip Bhumralkar , Dan Kiel , Michael D. Johnson , Christine Thomas , Anker Steen Jorgensen , Peter Madsen , Preben Houlberg Olesen , Liselotte Bjerre Knudsen , Ingrid Vivika Petterson , Johannes Cornelis de Jong , Carsten Behrens , Janos Tibor Kodra , Jesper Lau
发明人: Min Teng , Larry Kenneth Truesdale , Dilip Bhumralkar , Dan Kiel , Michael D. Johnson , Christine Thomas , Anker Steen Jorgensen , Peter Madsen , Preben Houlberg Olesen , Liselotte Bjerre Knudsen , Ingrid Vivika Petterson , Johannes Cornelis de Jong , Carsten Behrens , Janos Tibor Kodra , Jesper Lau
IPC分类号: C07D215/20 , C07D215/36 , C07D241/44 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D417/12 , C07D491/10 , C07D495/04 , A61K31/33 , A61K31/495 , C07D239/00 , C07D241/36
CPC分类号: C07D491/10 , C07D215/20 , C07D215/36 , C07D241/44 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D417/12 , C07D495/04
摘要: Novel non-peptide GLP-1 agonists, pharmaceutical compositions comprising them, use of the non-peptide GLP-1 agonists for the preparation of pharmaceutical compositions and methods for the treatment and/or prevention of disorders and diseases wherein an activation of the human GLP-1 receptor is beneficial, especially metabolic disorders such as IGT, Type 1 diabetes, Type 2 diabetes and obesity.
摘要翻译: 新型非肽GLP-1激动剂,包含它们的药物组合物,使用非肽GLP-1激动剂来制备用于治疗和/或预防疾病和疾病的药物组合物和方法,其中人GLP -1受体是有益的,特别是代谢疾病如IGT,1型糖尿病,2型糖尿病和肥胖。
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公开(公告)号:US06881746B2
公开(公告)日:2005-04-19
申请号:US10448529
申请日:2003-05-30
申请人: Jesper Lau , Inge Thoger Christensen , Peter Madsen , Paw Bloch , Carsten Behrens , Janos Tibor Kodra , Poul Enrico Nielsen
发明人: Jesper Lau , Inge Thoger Christensen , Peter Madsen , Paw Bloch , Carsten Behrens , Janos Tibor Kodra , Poul Enrico Nielsen
IPC分类号: A61K31/195 , A61K31/198 , A61K31/41 , A61K31/4439 , A61K45/06 , A61K31/425 , A61P3/00 , C07D277/04
CPC分类号: A61K45/06 , A61K31/195 , A61K31/198 , A61K31/41 , A61K31/4439 , A61K2300/00
摘要: Novel compounds that act to antagonize the action of the glucagon peptide hormone on the glucagon receptor. More particularly, it relates to glucagon antagonists or inverse agonists.
摘要翻译: 用于拮抗胰高血糖素肽激素对胰高血糖素受体的作用的新型化合物。 更具体地,涉及胰高血糖素拮抗剂或反向激动剂。
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公开(公告)号:US06875760B2
公开(公告)日:2005-04-05
申请号:US10233851
申请日:2002-08-30
申请人: Jesper Lau , Peter Madsen , Christian Sams , Carsten Behrens , Inge Thøger Christensen , Behrend Frederik Lundt , Ulla Grove Sidelmann , Henning Thøgersen , Anthony L. Ling , Michael Bruno Plewe , Larry Kenneth Truesdale , Anker Steen Jøgensen , Janos Tibor Kodra , Shenghua Shi
发明人: Jesper Lau , Peter Madsen , Christian Sams , Carsten Behrens , Inge Thøger Christensen , Behrend Frederik Lundt , Ulla Grove Sidelmann , Henning Thøgersen , Anthony L. Ling , Michael Bruno Plewe , Larry Kenneth Truesdale , Anker Steen Jøgensen , Janos Tibor Kodra , Shenghua Shi
IPC分类号: C07C237/36 , C07C237/42 , C07C243/38 , C07C271/56 , C07C271/58 , C07C275/24 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/38 , C07C275/42 , C07C275/60 , C07C275/62 , C07C311/47 , C07C317/22 , C07C317/32 , C07C317/42 , C07C323/21 , C07C323/44 , C07D209/08 , C07D209/48 , C07D211/58 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/30 , C07D257/06 , C07D277/72 , C07D295/13 , C07D295/135 , C07D307/68 , C07D317/66 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/60 , C07D333/68 , C07D333/70 , C07D409/12 , C07D417/12 , C07D487/04 , A61K31/33 , A61K31/695 , C07D257/00
CPC分类号: C07D209/48 , C07B2200/07 , C07C237/36 , C07C237/42 , C07C243/38 , C07C271/56 , C07C271/58 , C07C275/24 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/38 , C07C275/42 , C07C275/60 , C07C275/62 , C07C311/47 , C07C317/22 , C07C317/32 , C07C317/42 , C07C323/21 , C07C323/44 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/18 , C07C2603/68 , C07C2603/94 , C07D209/08 , C07D211/58 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/30 , C07D257/06 , C07D277/72 , C07D295/13 , C07D295/135 , C07D307/68 , C07D317/66 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/60 , C07D333/68 , C07D333/70 , C07D409/12 , C07D417/12 , C07D487/04
摘要: A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.
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公开(公告)号:US20050256175A1
公开(公告)日:2005-11-17
申请号:US11063117
申请日:2005-02-22
申请人: Jesper Lau , Inger Christensen , Peter Madsen , Paw Bloch , Carsten Behrens , Janos Kodra , Poul Nielsen
发明人: Jesper Lau , Inger Christensen , Peter Madsen , Paw Bloch , Carsten Behrens , Janos Kodra , Poul Nielsen
IPC分类号: A61K31/195 , A61K31/198 , A61K31/41 , A61K31/4439 , A61K45/06 , A61K31/428 , A61K31/426
CPC分类号: A61K45/06 , A61K31/195 , A61K31/198 , A61K31/41 , A61K31/4439 , A61K2300/00
摘要: Novel compounds that act to antagonize the action of the glucagon peptide hormone on the glucagon receptor. More particularly, it relates to glucagon antagonists or inverse agonists.
摘要翻译: 用于拮抗胰高血糖素肽激素对胰高血糖素受体的作用的新型化合物。 更具体地,涉及胰高血糖素拮抗剂或反向激动剂。
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公开(公告)号:US06953812B2
公开(公告)日:2005-10-11
申请号:US10372536
申请日:2003-02-24
申请人: Anker Steen Jorgensen , Inge Thoger Christensen , Janos Tibor Kodra , Christian Sams , Carsten Behrens , Peter Madsen , Jesper Lau
发明人: Anker Steen Jorgensen , Inge Thoger Christensen , Janos Tibor Kodra , Christian Sams , Carsten Behrens , Peter Madsen , Jesper Lau
IPC分类号: C07C237/42 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/42 , C07C317/42 , C07C323/44 , C07D209/08 , C07D209/42 , C07D209/48 , C07D213/40 , C07D213/75 , C07D213/82 , C07D257/04 , C07D263/56 , C07D263/57 , C07D271/06 , C07D277/28 , C07D277/66 , C07D277/82 , C07D307/68 , C07D319/08 , C07D333/20 , C07D333/36 , C07D333/68 , C07D513/04 , A01N43/06
CPC分类号: C07D209/48 , C07C237/42 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/42 , C07C317/42 , C07C323/44 , C07C2601/14 , C07C2601/16 , C07D209/08 , C07D209/42 , C07D213/40 , C07D213/75 , C07D213/82 , C07D257/04 , C07D263/57 , C07D271/06 , C07D277/28 , C07D277/66 , C07D277/82 , C07D307/68 , C07D319/08 , C07D333/20 , C07D333/36 , C07D333/68 , C07D513/04
摘要: A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism, such as dyslipidemia, and obesity.
摘要翻译: 一类新颖的化合物,其作用是拮抗胰高血糖素激素对胰高血糖素受体的作用。 由于它们对胰高血糖素受体的拮抗作用,这些化合物可能适用于治疗和/或预防任何疾病和病症,其中胰高血糖素拮抗作用是有益的,例如高血糖症,1型糖尿病,2型糖尿病, 脂质代谢,如血脂异常和肥胖。
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