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189 条记录 (耗时 0.052 秒)

    Heterocyclecarboxamide derivative
    71.
    发明授权
    Heterocyclecarboxamide derivative 有权
    杂环酰胺衍生物

    公开(公告)号：US06797706B1

    公开(公告)日：2004-09-28

    申请号：US10009276

    申请日：2001-12-10

    申请人： Hiroyuki Hisamichi ,  Souichirou Kawazoe ,  Kazuhito Tanabe ,  Atsushi Ichikawa ,  Akiko Orita ,  Takayuki Suzuki ,  Kenichi Onda ,  Makoto Takeuchi

    发明人： Hiroyuki Hisamichi ,  Souichirou Kawazoe ,  Kazuhito Tanabe ,  Atsushi Ichikawa ,  Akiko Orita ,  Takayuki Suzuki ,  Kenichi Onda ,  Makoto Takeuchi

    IPC分类号： A61K3133

    CPC分类号： C07D213/82 ,  C07D239/48 ,  C07D241/26 ,  C07D253/07

    摘要： A nitrogen-containing six-membered heterocyclic compound having substituents —X—A—R3, —N(R1)-(Ph substituted by R2), and —CONH2, a salt thereof, a prodrug thereof, and a Syk inhibitor containing the same as an active ingredient. (In the formula, A: a (substituted) lower alkylene, a (substituted) arylene, or the like; X: NR4, CONR4, NR4CO, O, or S; R1, R4: H, a lower alkyl, —CO-lower alkyl, or —SO2-lower alkyl; R2: H, a (substituted) lower alkyl, —O-lower alkyl, —S-lower alkyl, —O-aryl, nitro, cyano, or the like; R3: —CO2H, —CO2-lower alkyl, -lower alkylene-CO2H, —NH2, -alkylene-NH2 or the like.

    摘要翻译： 具有取代基-XAR 3，-N（R 1） - （Ph被R 2取代的）的含氮六元杂环化合物和-CONH 2，其盐，其前药和 含有与活性成分相同的Syk抑制剂。 （式中，A：（取代的）低级亚烷基，（取代的）亚芳基等; X：NR 4，CONR 4，NR 4 CO，O或S; R 1 R 4：H，低级烷基，-CO-低级烷基或-SO 2 - 低级烷基; R 2：H，（取代的）低级烷基，-O-低级烷基，-S-低级 烷基，-O-芳基，硝基，氰基等; R 3：-CO 2 H，-CO 2 - 低级烷基， - 低级亚烷基-CO 2 H，-NH 2， - 亚烷基-NH 2等。

    Benzimidazolinone derivatives
    74.
    发明授权
    Benzimidazolinone derivatives 失效
    苯并咪唑啉酮衍生物

    公开(公告)号：US5162318A

    公开(公告)日：1992-11-10

    申请号：US684866

    申请日：1991-04-15

    申请人： Hiromu Hara ,  Tatsuya Maruyama ,  Munetoshi Saito ,  Makoto Takeuchi ,  Toshiyasu Mase

    发明人： Hiromu Hara ,  Tatsuya Maruyama ,  Munetoshi Saito ,  Makoto Takeuchi ,  Toshiyasu Mase

    IPC分类号： C07D235/26 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D235/26 ,  C07D249/08

    摘要： Benzimidazolinone derivatives of the general formula (I): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each is a hydrogen or halogen atom or a lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, hydroxyl, lower alkoxy, aryloxy, acyl, cyano, carboxyl, a lower alkoxycarbonyl, carbamoyl, nitro or nitrogen-containing 5- or 6-membered heterocyclic group; A is an ethylene group which may optionally have at least one branch; R.sup.4 and R.sup.5, which may be the same or different, each is a lower alkyl group or R.sup.4 and R.sup.5, together with the adjacent nitrogen atom, represent a pyrrolidinyl, piperidino or a morpholino group provided that when ##STR2## is a piperidino or diethylamino group, at least one of R.sup.1, R.sup.2 and R.sup.3 is other than a hydrogen atom, or pharmaceutically acceptable salts thereof, methods of producing the same and pharmaceutical compositions containing the same are disclosed. Pharmacologically, the above compounds (I) have pulmonary surfactant secretion promoting activity.

    Longitudinal-effect type laminar piezoelectric/electrostrictive driver, and printing actuator using the driver
    75.
    发明授权
    Longitudinal-effect type laminar piezoelectric/electrostrictive driver, and printing actuator using the driver 失效
    纵向效应型层压压电/电致动力驱动器和使用驱动器的打印执行器

    公开(公告)号：US5126618A

    公开(公告)日：1992-06-30

    申请号：US663662

    申请日：1991-03-04

    申请人： Yoshikazu Takahashi ,  Masahiko Suzuki ,  Makoto Takeuchi ,  Masaaki Deguchi

    发明人： Yoshikazu Takahashi ,  Masahiko Suzuki ,  Makoto Takeuchi ,  Masaaki Deguchi

    IPC分类号： H01L41/083 ,  H01L41/09 ,  H04R17/08

    CPC分类号： H01L41/083 ,  H02N2/043 ,  H04R17/08

    摘要： A laminar longitudinal-effect type piezoelectric or electrostrictive driver which is displaced upon application of an electric field thereto. The driver includes laminar electro-mechanical converting elements each undergoes a displacement in a direction of the electric field due to the longitudinal mode of the reverse piezoelectric effect or the electrostrictive effect, and the temperature compensating elements each of which is interposed between the appropriate adjacent two laminar electro-mechanical converting elements. The temperature compensating elements have a higher coefficient of linear thermal expansion in the direction of the electric field or direction of displacement of the driver. The driver is suitably usable for an actuator for operating a print element of a printer, for example.

    摘要翻译： 一种层状纵向效应型压电或电致伸缩驱动器，其在施加电场时移位。 驱动器包括由于反向压电效应或电致伸缩效应的纵向模式而在电场方向上发生位移的层流机电转换元件，并且每个温度补偿元件插入在适当的相邻两个 层流机电转换元件。 温度补偿元件在电场方向或驱动器的位移方向上具有较高的线性热膨胀系数。 例如，驱动器适用于用于操作打印机的打印元件的致动器。

    Laminate type piezoelectric actuator element
    76.
    发明授权
    Laminate type piezoelectric actuator element 失效
    层压型压电致动器元件

    公开(公告)号：US5089739A

    公开(公告)日：1992-02-18

    申请号：US669982

    申请日：1991-03-15

    申请人： Yoshikazu Takahashi ,  Masahiko Suzuki ,  Makoto Takeuchi

    发明人： Yoshikazu Takahashi ,  Masahiko Suzuki ,  Makoto Takeuchi

    IPC分类号： B41J2/295 ,  H01L41/083

    CPC分类号： B41J2/295 ,  H01L41/083

    摘要： A laminate piezoelectric actuator element comprising plural laminated piezoelectric subunits each of which comprises piezoelectric ceramic layers for generating longitudinal electrostrictive strain with a voltage, internal electrodes for applying the voltage to said piezoelectric ceramic layers, and piezoelectrically-inactive portions which correspond to parts of the piezoelectric ceramic layers having no internal electrodes laminated thereon. The piezoelectric ceramic layers and the internal electrodes are alternatively laminated on each other to form a piezoelectric subunit. An adhesive member having an attaching area equal to or smaller than an area of each internal electrode is provided between the neighboring piezoelectric subunits to thereby attach and assemble the plural piezoelectric subunits to form the piezoelectric actuator element and form slit portions between the laminated piezoelectric subunits in such a manner as to surround the adhesive member. The piezoelectric actuator element further includes external electrodes provided at both sides thereof in such a manner as to be connected to the internal electrodes to apply the voltage to the internal electrodes.

    Heterocyclic bisphosphonic acid derivatives
    77.
    发明授权
    Heterocyclic bisphosphonic acid derivatives 失效
    杂环二膦酸衍生物

    公开(公告)号：US5039669A

    公开(公告)日：1991-08-13

    申请号：US566145

    申请日：1990-08-10

    申请人： Yasuo Isomura ,  Makoto Takeuchi ,  Tetshshi Abe

    发明人： Yasuo Isomura ,  Makoto Takeuchi ,  Tetshshi Abe

    IPC分类号： C07F9/6561

    CPC分类号： C07F9/6561

    摘要： A novel heterocyclic bisphosphonic acid derivatives represented by the following general formula (I): ##STR1## in which .circle.Het means one of the following (A) and (B): ##STR2## wherein a dotted line in (A) means that two adjacent atoms are bonded by a single bond or a double bond, ##STR3## wherein R.sup.6 and R.sup.7 may be the same or different, each represents a hydrogen atom, a lower alkyl group, a halogen atom or a hydroxyl group,R.sup.1 represents a hydrogen atom or a hydroxyl group,R.sup.2, R.sup.3, R.sup.4 and R.sup.5 may be the same or different, each represents a hydrogen atom or a lower alkyl group,"n" is 0 or 1,provided that "n" is 1 when the ring .circle.Het means (A), and "R.sup.1 " is a hydroxyl group when the ring .dotthalfcircle.Het means (B), or pharmaceutically acceptable salts thereof and bone resorption inhibitors containing the compound as an active ingredient.

    Heterocyclic bisphosphonic acid derivatives
    78.
    发明授权
    Heterocyclic bisphosphonic acid derivatives 失效

    公开(公告)号：US4990503A

    公开(公告)日：1991-02-05

    申请号：US390090

    申请日：1989-08-07

    申请人： Yasuo Isomura ,  Makoto Takeuchi ,  Tetsushi Abe

    发明人： Yasuo Isomura ,  Makoto Takeuchi ,  Tetsushi Abe

    IPC分类号： C07F9/6561

    CPC分类号： C07F9/6561

    摘要： A novel heterocyclic bisphosphonic acid derivatives represented by the following general formula (I): ##STR1## in which, .circle.Het means one of following (A) and (B): ##STR2## wherein a dotted line in (A) means that two adjacent atoms are bonded by a single bond or a double bond, ##STR3## wherein R.sup.6 and R.sup.7 may be the same or different, each represents a hydrogen atom, a lower alkyl group, a halogen atom or a hydroxyl group,R.sup.1 represents a hydrogen atom or a hydroxyl group,R.sup.2, R.sup.3, R.sup.4 and R.sup.5 may be the same or different, each represents a hydrogen atom or a lower alkyl group,"n" is 0 or 1,provided that "n" is 1 when the ring .circle.Het means (A), and "R.sup.1 " is a hydroxyl group when the ring .circle.Het means (B),or pharmaceutically acceptable salts thereof and bone resorption inhibitors containing the compound as an active ingredient.