公开(公告)号：US06335364B1

公开(公告)日：2002-01-01

申请号：US09352648

申请日：1999-06-29

申请人： Faith M. Uckun ,  Chen Mao ,  He Huang

发明人： Faith M. Uckun ,  Chen Mao ,  He Huang

IPC分类号： A61K3135

CPC分类号： C07D493/10 ,  C07C323/41 ,  C07D307/12 ,  C07D307/42 ,  C07K14/47

摘要： Novel tubulin binding compounds (SPIKETS) having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The compounds are adapted to interact favorably with a novel SP binding pocket on tubulin, which pocket is useful for screening of anti-tubulin, anti-proliferation, and anti-cancer drugs.

摘要翻译： 新型微管蛋白结合化合物（SPIKETS）具有强大的微管蛋白解聚活性和对微管蛋白聚合的抑制活性。 这些化合物是抑制细胞增殖的有效剂，例如在癌细胞中。 该化合物适于与微管蛋白上的新型SP结合袋有利地相互作用，该口袋可用于筛选抗微管蛋白，抗增殖和抗癌药物。

公开(公告)号：US5856895A

公开(公告)日：1999-01-05

申请号：US887499

申请日：1997-07-02

申请人： Mark J. Schaenzer ,  Zine-Eddine Boutaghou ,  He Huang

发明人： Mark J. Schaenzer ,  Zine-Eddine Boutaghou ,  He Huang

IPC分类号： G11B5/10 ,  G11B5/48 ,  G11B5/55 ,  G11B5/596 ,  G11B5/60 ,  G11B21/21 ,  G11B33/10

CPC分类号： G11B21/21 ,  G11B5/10 ,  G11B5/4806 ,  G11B5/5582 ,  G11B5/6005 ,  G11B33/10 ,  G11B5/5547 ,  G11B5/5565 ,  G11B5/596 ,  Y10T29/42 ,  Y10T29/49041 ,  Y10T29/49812

摘要： A data storage system head slider and a method of making the same are disclosed. The head slider includes a slider body and an accelerometer formed integrally with the slider body. In preferred embodiments, the accelerometer includes a cavity formed in the slider body. A structural beam extends over the cavity such that the structural beam deflects in response to acceleration of the head slider. A piezo transducer formed on the structural beam provides a transducer output signal indicative of a magnitude of the acceleration of the head slider.

摘要翻译： 公开了一种数据存储系统磁头滑动器及其制造方法。 磁头滑块包括与滑块体一体形成的滑块体和加速度计。 在优选实施例中，加速度计包括形成在滑块体中的空腔。 结构梁在空腔上方延伸，使得结构梁响应于磁头滑块的加速度而偏转。 形成在结构梁上的压电换能器提供指示磁头滑动器的加速度大小的换能器输出信号。

公开(公告)号：US5431889A

公开(公告)日：1995-07-11

申请号：US251341

申请日：1994-05-31

申请人： He Huang ,  William H. Calkins

发明人： He Huang ,  William H. Calkins

IPC分类号： B01J3/04 ,  B01J19/00 ,  B01L7/00 ,  F28D21/00

CPC分类号： B01L7/52 ,  B01J19/0013 ,  B01J3/04 ,  B01J2219/00105

摘要： A process and apparatus for carrying out reactions at elevated temperatures and pressures which minimizes the heat-up and cool-down times by rapid transport of the reactants using pressurized gas through a preheater to a preheated reactor, agitating the reaction mixture and discharging the reactants with high pressure gas through a precooler.

摘要翻译： 一种用于在升高的温度和压力下进行反应的方法和装置，其通过使用加压气体通过预热器快速转运反应物到预热的反应器，使反应混合物快速运输并使反应物排出，从而使加热和冷却时间最小化， 高压气体通过预冷器。

公开(公告)号：US20150165308A1

公开(公告)日：2015-06-18

申请号：US14404603

申请日：2012-06-01

申请人： He Huang

发明人： He Huang

IPC分类号： A63F7/00

CPC分类号： A63F7/0005 ,  A63B47/025 ,  A63B69/3661 ,  A63B71/022 ,  A63B2071/025 ,  A63F2007/0011

摘要： The present invention relates to a ball game instrument comprising a ball table, a ball stop device and a lane. The ball table is provided with a panel enclosure higher than a panel of the ball table. The ball stop device is provided on a ball stop face of the ball table, corresponds to and is independent of the ball table or is mounted on the ball table, and is higher than the panel enclosure. The lane corresponds to and is independent of the ball table, and has a width less than the width or diameter of the ball table.

摘要翻译： 本发明涉及一种包括球台，球停止装置和车道的球类游戏仪器。 球台设置有比球台的面板高的面板外壳。 球形止挡装置设置在球台的球形止挡面上，对应于并且独立于球台，或者安装在球台上，并且高于面板外壳。 车道对应于并且独立于球台，并且具有小于球台的宽度或直径的宽度。

公开(公告)号：US08828093B1

公开(公告)日：2014-09-09

申请号：US12419521

申请日：2009-04-07

申请人： Todd Kuiken ,  He Huang

发明人： Todd Kuiken ,  He Huang

IPC分类号： A61F2/70

CPC分类号： A61F2/72 ,  A61F2/60 ,  A61F2/68 ,  A61F2/80 ,  A61F2002/607 ,  A61F2002/701 ,  A61F2002/704 ,  A61F2002/7615 ,  A61F2002/762 ,  A61F2002/7625 ,  A61F2002/7635 ,  A61F2002/764 ,  A61F2002/7645

摘要： Apparatus and methods are provided for determining a locomotion mode that can be provided to a controller of a lower prosthesis limb in order to accurately control the prosthesis. One or more prosthesis sensors are provided that break a gait cycle down into a plurality of gait phases. EMG sensors provide signals to a processor that directs them to a gait phase specific classifier that is used to determine a particular locomotion mode for the wearer. With the locomotion mode accurately known, the prosthetic device can be accurately controlled.

摘要翻译： 提供了用于确定可以提供给下假肢肢体的控制器以便精确地控制假体的运动模式的装置和方法。 提供了一个或多个假体传感器，其将步态循环分解成多个步态相。 EMG传感器向处理器提供信号，该处理器将它们引导到用于确定佩戴者的特定运动模式的步态相位分类器。 通过精确地知道运动模式，可以准确地控制假体装置。

公开(公告)号：US08663972B2

公开(公告)日：2014-03-04

申请号：US13992233

申请日：2011-04-16

申请人： He Huang ,  Shuang Li ,  Qing Xu ,  Zhen Gao

发明人： He Huang ,  Shuang Li ,  Qing Xu ,  Zhen Gao

IPC分类号： C12N1/14 ,  C12N15/01 ,  C12P7/46 ,  C12P19/20

CPC分类号： C12P7/46 ,  C12N1/14 ,  C12N15/01 ,  C12R1/845

摘要： A rhizopus oryzae strain, mutagenesis and screening methods thereof, and methods of producing fumaric acid by fermentation. The strain is named as Rhizopus oryzae ME-F13, and deposited in China Center for Type Culture Collection with depository number CCTCC M 2010351. The strain is obtained by physically mutagenizing the original strain ME-F12 through ion injection, culturing the processed bacteria on the solid selective plate containing 2-D-deoxylucose (2-DG) and picking up 2-DG-resistant single colony. The strain is capable of simultaneously saccharifying starchy material and fermenting it to produce fumaric acid. With an improved enzymatic activity, the strain can be directly used to ferment raw starchy materials without needing pre-saccharifying.

摘要翻译： 根霉菌株，其诱变和筛选方法，以及通过发酵产生富马酸的方法。 该菌株被命名为米曲霉ME-F13，并存放于中国型号培养基中心，存放号码为CCTCC M 2010351.该菌株是通过离子注射物理诱变原始菌株ME-F12获得的， 含有2-D脱氧葡萄糖（2-DG）的固体选择性板和拾取2-DG抗性单个菌落。 该菌株能够同时糖化淀粉物质并发酵以产生富马酸。 具有改善的酶活性，该菌株可以直接用于发酵生淀粉材料，而不需要预糖化。

公开(公告)号：US20130217085A1

公开(公告)日：2013-08-22

申请号：US13812496

申请日：2011-01-13

申请人： He Huang ,  Qianqian Tong ,  Lujing Ren ,  Xiaojun Ji ,  Aihua Xiao ,  Ping Wei ,  Jiangying You ,  Liang Qu ,  Dongping Gong ,  Jiangyao Zhu

发明人： He Huang ,  Qianqian Tong ,  Lujing Ren ,  Xiaojun Ji ,  Aihua Xiao ,  Ping Wei ,  Jiangying You ,  Liang Qu ,  Dongping Gong ,  Jiangyao Zhu

IPC分类号： C12P7/64

CPC分类号： C12P7/6427

摘要： The present invention discloses a method of improving the fermentation yield of polyunsaturated fatty acids, in which Schizochytrium limacinum is used as production strain to produce polyunsaturated fatty acids (PUFA), and glycine betaine or trehalose is added to the fermentation medium. In the present invention, after Schizochytrium limacinum fermentation system is treated with exogenous glycine betaine, the yield of PUFA produced by fermentation with Schizochytrium limacinum can be greatly improved. The present invention significantly improves the yield of PUFA produced by microorganism, reduces the cost without harming the environment, and saves manpower and material resources by simple and effective regulation of fermentation, and thus the method is simple, convenient and cost-effective.

摘要翻译： 本发明公开了一种提高多不饱和脂肪酸的发酵产量的方法，其中使用裂殖壶菌作为生产菌株生产多不饱和脂肪酸（PUFA），将甘氨酸甜菜碱或海藻糖加入到发酵培养基中。 在本发明中，利用外源甘氨酸甜菜碱处理裂殖壶菌发酵系统后，可以大大提高利用裂殖壶菌发酵产生的PUFA产率。 本发明显着提高了微生物生产的PUFA的产量，降低了成本而不损害环境，通过简单有效的发酵调节节省了人力物力资源，方法简便，成本效益好。

公开(公告)号：US20120310370A1

公开(公告)日：2012-12-06

申请号：US13556527

申请日：2012-07-24

申请人： He Huang ,  Qing K. Yang ,  Yan Sun

发明人： He Huang ,  Qing K. Yang ,  Yan Sun

IPC分类号： A61F2/72

CPC分类号： A61F2/60 ,  A61B5/04888 ,  A61B5/7207 ,  A61B5/7267 ,  A61F2/72 ,  G06K9/00348

摘要： A neural-machine interface system is disclosed for providing control of a leg prosthesis. The system includes a plurality of input channels for receiving electromyographic signals from a subject, a feature vector formation unit for processing the electromyographic signals, and a pattern classification unit for identifying the intended movement of the subject's leg prosthesis.

摘要翻译： 公开了一种用于提供腿假体的控制的神​​经机器接口系统。 该系统包括用于接收来自对象的肌电信号的多个输入通道，用于处理肌电图信号的特征矢量形成单元，以及用于识别对象的腿假体的预期运动的模式分类单元。

公开(公告)号：US08244966B2

公开(公告)日：2012-08-14

申请号：US12648197

申请日：2009-12-28

申请人： He Huang

发明人： He Huang

IPC分类号： G06F12/00

CPC分类号： G11C16/10 ,  G06F12/0246 ,  G06F2212/7202 ,  G06F2212/7208

摘要： A self-adaptive control method for logical strips based on a multi-channel solid-state non-volatile storage device is provided. The method includes the following steps. Storage space of every channel is divided into a plurality of storage units of equal size. At least one logical strip is set by which the storage units with discrete physical addresses across the channels are organized into a continuous logical space, and a logical strip variable is set for determining the storage units organized by the logical strip. Historical operation information of the storage device is obtained statistically, and the logical strip variable is dynamically adjusted according to the obtained operation information. During data interaction, the data is divided according to the logical strip variable, the divided data is mapped to the storage units of every channel, and parallel reading and writing operations are performed among the channels.

摘要翻译： 提供了一种基于多通道固态非易失性存储设备的逻辑条带自适应控制方法。 该方法包括以下步骤。 每个通道的存储空间被分成多个相同大小的存储单元。 设置至少一个逻辑条，通过该逻辑条将具有跨信道的离散物理地址的存储单元组织成连续逻辑空间，并且设置逻辑条变量以确定由逻辑条组织的存储单元。 统计获得存储装置的历史操作信息，并根据获得的操作信息动态地调整逻辑条带变量。 在数据交互过程中，根据逻辑条带变量分割数据，将分割后的数据映射到每个通道的存储单元，并在通道之间执行并行读写操作。

公开(公告)号：US08242633B2

公开(公告)日：2012-08-14

申请号：US12690176

申请日：2010-01-20

申请人： He Huang

发明人： He Huang

IPC分类号： H02J9/00 ,  H02M3/06

CPC分类号： G11C16/22 ,  Y10T307/625

摘要： A power failure protection circuit (10) for a non-volatile semiconductor storage device includes at least an energy storage unit (C1) that serves as a backup power supply for providing backup electrical energy when a power failure occurs. During normal operation of the device, a main control unit (12) is responsible for controlling an external power input to charge the energy storage unit, for dynamically detecting the status of the energy storage unit and for using information about the status to ensure sufficient backup electrical energy for the energy storage unit. During an abnormal operation of the power supply, the main control unit (12) is responsible for discharging the energy storage unit.

摘要翻译： 用于非易失性半导体存储装置的停电保护电路（10）至少包括作为备用电源的能量存储单元（C1），用于在发生电源故障时提供备用电能。 在设备的正常操作期间，主控制单元（12）负责控制外部电力输入以对能量存储单元充电，用于动态地检测能量存储单元的状态并使用关于状态的信息来确保足够的备份 储能单元的电能。 在电源异常操作期间，主控制单元（12）负责排出能量存储单元。