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    METHODS AND APPARATUS FOR CELL TRACKING AND MOLECULAR IMAGING
    71.
    发明申请
    METHODS AND APPARATUS FOR CELL TRACKING AND MOLECULAR IMAGING 审中-公开

    公开(公告)号：US20180099059A1

    公开(公告)日：2018-04-12

    申请号：US15729164

    申请日：2017-10-10

    申请人： John A. Hossack ,  Adam Joseph Dixon ,  Edwin Lu

    发明人： John A. Hossack ,  Adam Joseph Dixon ,  Edwin Lu

    IPC分类号： A61K49/22

    CPC分类号： A61K49/223 ,  A61K49/225 ,  A61K49/227

    摘要： A composition for cell tracking and molecular imaging containing perfluorocarbon (“PFC”) droplets having a liquid PFC core enclosed within a stabilizing shell and embedded with solid nanoparticles. The solid nanoparticles act as nucleating agents for reducing the activation pressure of the liquid PFC core required to transition the liquid PFC core to a gaseous microbubble thereby permitting the use of more body-temperature stable longer chain PFCs in the liquid PFC core. The improved stability of the PFC droplets with a reduced or limited increase in the activation pressure required due to the nucleating nanoparticles improves the efficacy of using the PFC droplets as phase-change contrast agents.

    SYSTEM AND METHOD FOR BINDING DYNAMICS OF TARGETED MICROBUBBLES
    73.
    发明申请
    SYSTEM AND METHOD FOR BINDING DYNAMICS OF TARGETED MICROBUBBLES 有权
    用于绑定微量元素动力学的系统和方法

    公开(公告)号：US20150150534A1

    公开(公告)日：2015-06-04

    申请号：US14559422

    申请日：2014-12-03

    申请人： F. William Mauldin, JR. ,  Shiying Wang ,  John A. Hossack ,  Alexander L. Klibanov

    发明人： F. William Mauldin, JR. ,  Shiying Wang ,  John A. Hossack ,  Alexander L. Klibanov

    IPC分类号： A61B8/08 ,  A61B8/00

    CPC分类号： A61B8/481 ,  A61B8/0891 ,  A61B8/587 ,  G06T7/0016 ,  G06T2207/10132 ,  G06T2207/30104

    摘要： An ultrasound system and method that can include: a receive beamformer configured to receive signals from a transducer; a processor coupled to the receive beamformer, the processor configured to: analyze echo data reflected from a region of interest, the echo data elicited by a transmitted pulse sequence; using the echo data, determine a central tendency of a signal magnitude from regions of adherent microbubbles over time within the region of interest; determine a time series of the signal magnitude; using the time series, determine an initial signal magnitude parameter; obtain a saturated signal parameter and a residual signal parameter using the time series; and determine a relative indication of information indicative of the residual signal magnitude versus the saturated signal magnitude.

    摘要翻译： 一种超声系统和方法，其可以包括：接收波束形成器，被配置为从换能器接收信号; 耦合到所述接收波束形成器的处理器，所述处理器被配置为：分析从感兴趣区域反射的回波数据，所述回波数据由所发射的脉冲序列引起; 使用回波数据，确定在感兴趣区域内随时间的粘附微泡区域的信号幅度的集中趋势; 确定信号幅度的时间序列; 使用时间序列，确定初始信号幅度参数; 使用时间序列获得饱和信号参数和残差信号参数; 并确定指示残留信号幅度与饱和信号幅度相关的信息的相对指示。

    Specialized, high performance, ultrasound transducer substrates and related method thereof
    74.
    发明授权
    Specialized, high performance, ultrasound transducer substrates and related method thereof 有权
    专用，高性能，超声换能器基板及其相关方法

    公开(公告)号：US08093782B1

    公开(公告)日：2012-01-10

    申请号：US12191839

    申请日：2008-08-14

    申请人： John A. Hossack

    发明人： John A. Hossack

    IPC分类号： A61B18/00

    CPC分类号： G10K11/002

    摘要： Backing substrates for reducing parasitic echoes produced within a ultrasonic transducer are provided comprising a polymeric material, for example, an epoxy having a glass transition temperature (Tg) ranging from about 10 to 50° C.; or an epoxy having an acoustical attenuation that increases by at least about 2 dB/mm at 5 MHz in a temperature range of about 5° C. to 40° C. Transducer assemblies comprising the backing substrates and methods for producing the assemblies are also provided.

    摘要翻译： 提供用于减少在超声波换能器内产生的寄生回波的背衬基底，其包括聚合物材料，例如玻璃化转变温度（Tg）为约10至50℃的环氧树脂; 或在约5℃至40℃的温度范围内具有在5MHz下增加至少约2dB / mm的声学衰减的环氧树脂。还提供了包括背衬基板的传感器组件以及用于制造组件的方法 。

    Efficient architecture for 3D and planar ultrasonic imaging—synthetic axial acquisition and method thereof
    75.
    发明授权
    Efficient architecture for 3D and planar ultrasonic imaging—synthetic axial acquisition and method thereof 有权
    用于3D和平面超声成像 - 合成轴向采集的高效架构及其方法

    公开(公告)号：US08057392B2

    公开(公告)日：2011-11-15

    申请号：US11245266

    申请日：2005-10-05

    申请人： John A. Hossack ,  Travis N. Blalock ,  William F. Walker

    发明人： John A. Hossack ,  Travis N. Blalock ,  William F. Walker

    IPC分类号： A61B8/00

    CPC分类号： A61B8/4483 ,  A61B8/00 ,  A61B8/483 ,  G01S7/52025 ,  G01S7/52088

    摘要： An improved device and method for collecting data used for ultrasonic imaging. The data is gathered over numerous transmit and echo receive cycles, or iterations and combined into a synthetic acquisition representing a complete echo characteristic acquisition. At each iteration, only a portion, or subset, of the echo characteristic is sampled and stored. During the iterations, the portion of the echo characteristic that is measured and sampled is varied by changing the relative sampling instants. That is, the time offset from the transmission to the respective sampling instant is varied. The sample sets representative of the entire echo characteristic are then compiled from the multiple subsets of the ultrasonic transmissions.

    摘要翻译： 一种用于收集用于超声成像的数据的改进的装置和方法。 数据在多个发送和回波接收周期或迭代中被收集，并被组合成代表完整回波特征采集的合成采集。 在每次迭代中，仅对回波特性的一部分或子集进行采样和存储。 在迭代期间，通过改变相对采样时刻来改变测量和采样的部分回波特性。 也就是说，从发送到相应采样时刻的时间偏移是变化的。 然后，从超声波传输的多个子集编译表示整个回波特性的样本集合。

    Electric circuit for tuning a capacitive electrostatic transducer
    78.
    发明授权
    Electric circuit for tuning a capacitive electrostatic transducer 有权
    用于调谐电容式静电传感器的电路

    公开(公告)号：US07670290B2

    公开(公告)日：2010-03-02

    申请号：US10803808

    申请日：2004-03-17

    申请人： John A. Hossack ,  Brett Bymaster ,  Igal Ladabaum ,  Paul A. Wagner ,  Christopher M. W. Daft

    发明人： John A. Hossack ,  Brett Bymaster ,  Igal Ladabaum ,  Paul A. Wagner ,  Christopher M. W. Daft

    IPC分类号： A61B8/00

    CPC分类号： B06B1/0292 ,  A61B8/4483 ,  G01S7/52079

    摘要： An electrostatic transducer circuit and method of tuning the same, in which a balancing circuit is inserted into the electrostatic transducer circuit, is described. The electrostatic transducer circuit generally includes transmit circuitry, receive circuitry, a capacitive electrostatic transducer and the balancing circuit. The balancing circuit can include, either singly or in combination, an inductance and a negative capacitance. The balancing inductance is tuned to counteract the negative reactance of the capacitive electrostatic transducer at a desired operating frequency and can be inserted into the transmit circuitry and/or the receive circuitry. The balancing negative capacitance is tuned to counteract the capacitance of the capacitive electrostatic transducer and can be inserted into the receive circuitry and/or the transmit circuitry. The transmit circuitry can be isolated from the receive circuitry, and vice versa, once the balancing circuit has been inserted. Isolation can be achieved by switching the electrostatic transducer circuit between transmit and receive modes of operation, or by providing separate transmit and receive electrode subsets.

    摘要翻译： 描述了一种静电换能器电路及其调谐方法，其中平衡电路插入到静电换能器电路中。 静电换能器电路通常包括发射电路，接收电路，电容式静电变换器和平衡电路。 平衡电路可以单独地或组合地包括电感和负电容。 调整平衡电感以抵消在期望的工作频率下的电容式静电换能器的负电抗并且可以插入到发射电路和/或接收电路中。 调整平衡负电容以抵消电容式静电变换器的电容，并可将其插入接收电路和/或发射电路。 一旦平衡电路被插入，发射电路可以与接收电路隔离，反之亦然。 可以通过在发射和接收工作模式之间切换静电转换器电路，或通过提供单独的发射和接收电极子集来实现隔离。

    Efficient ultrasound system for two-dimensional C-scan imaging and related method thereof
    79.
    发明授权
    Efficient ultrasound system for two-dimensional C-scan imaging and related method thereof 有权
    用于二维C扫描成像的高效超声系统及其相关方法

    公开(公告)号：US07402136B2

    公开(公告)日：2008-07-22

    申请号：US10542242

    申请日：2004-01-15

    申请人： John A. Hossack ,  William F. Walker ,  Travis N. Blalock

    发明人： John A. Hossack ,  William F. Walker ,  Travis N. Blalock

    IPC分类号： A61B8/00

    CPC分类号： G01S15/8925 ,  A61B8/13 ,  A61B8/483 ,  G01S7/52085 ,  G01S7/52095 ,  G01S15/8993

    摘要： An ultrasound system and related method for forming 2D C-scan images and/or collecting 3D image data from 2D transducer arrays. The system including in part a 2D transducer array of elements, transmit voltage generation means for each element, a memory buffer with or part of channels for each element, and a receive beamformer. On a time serial or sequential basis, several times for each line of firing, the contents of the per element memory buffer are read into the beamformer with different focusing values for each buffer reading cycle. In this way, the beamformer can calculate beamformed image values for multiple points per line firing cycle—or per each line of signals between the transducer array and receive beamformer.

    摘要翻译： 用于形成2D C扫描图像和/或从2D换能器阵列收集3D图像数据的超声系统和相关方法。 该系统部分地包括2D换能器元件阵列，为每个元件传输电压产生装置，具有用于每个元件的通道的一部分的存储器缓冲器和接收波束形成器。 在时间序列或顺序的基础上，对于每一次触发行，几次，每个缓冲区读取周期将每个元素存储器缓冲器的内容读入波束形成器，具有不同的聚焦值。 以这种方式，波束形成器可以计算每行发射周期的多个点的波束形成图像值，或者计算换能器阵列和接收波束形成器之间的每一行信号。

    Electric circuit for tuning a capactive electrostatic transducer
    80.
    发明授权
    Electric circuit for tuning a capactive electrostatic transducer 有权
    用于调节主动静电传感器的电路

    公开(公告)号：US06726626B1

    公开(公告)日：2004-04-27

    申请号：US10222002

    申请日：2002-08-14

    申请人： John A. Hossack

    发明人： John A. Hossack

    IPC分类号： A61B800

    CPC分类号： B06B1/0292

    摘要： An electrostatic transducer circuit and method of tuning the same, in which a balancing inductance is inserted into the electrostatic transducer circuit is described. The electrostatic transducer circuit generally includes transmit circuitry, receive circuitry and a capacitive electrostatic transducer. The balancing inductance is tuned to counteract the negative reactance of the capacitive electrostatic transducer at a desired operating frequency during the transmit mode. The balancing inductance is inserted into the transmit circuitry and is then isolated from the remaining parts of the electrostatic transducer circuit. Isolation is achieved by switching the electrostatic transducer circuit between transmit and receive modes of operation. Further, a receive circuit balancing reactance can also be included. The method provides a balancing inductance that is used to counteract negative reactance of the capacitive electrostatic transducer at a desired operating frequency during transmit mode.

    摘要翻译： 描述了静电换能器电路及其调谐方法，其中平衡电感被插入到静电换能器电路中。 静电换能器电路通常包括发射电路，接收电路和电容式静电换能器。 在发射模式期间，调节​​平衡电感以抵消电容性静电换能器在期望工作频率下的负电抗。 平衡电感插入到发射电路中，然后与静电转换器电路的其余部分隔离。 通过在发射和接收操作模式之间切换静电换能器电路实现隔离。 此外，还可以包括接收电路平衡电抗。 该方法提供平衡电感，其用于在发射模式期间以期望的工作频率抵消电容式静电换能器的负电抗。