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公开(公告)号：US5943458A
公开(公告)日：1999-08-24
申请号：US870522
申请日：1997-06-06
申请人： William J. Miller
发明人： William J. Miller
CPC分类号： G02B6/29352 , G02B6/2835 , G02F1/3136 , G02F1/3517 , G02B2006/12145 , G02B6/243 , G02F1/3131
摘要： A Mach-Zehnder wavelength selective device is made using one or more composite optical fibers each incorporating a phase shift region having one effective refractive index spliced between coupling regions having a different effective refractive index. The optical path length difference or phase delay induced by each such composite fiber is a linear function of the length of the phase shift region.
摘要翻译： 使用一个或多个复合光纤制造马赫 - 策德尔波长选择装置，每个复合光纤包括具有在具有不同有效折射率的耦合区域之间接合的一个有效折射率的相移区域。 由每个这样的复合光纤引起的光程长度差或相位延迟是相移区域的长度的线性函数。
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公开(公告)号：US5916415A
公开(公告)日：1999-06-29
申请号：US825975
申请日：1997-04-04
申请人： William J. Miller
发明人： William J. Miller
CPC分类号： D21C9/147 , D21C9/1057 , D21C9/163
摘要： The invention described a method of oxygen delignification of medium consistency pulp slurry, which includes the steps of providing a pulp slurry of from approximately ten percent to sixteen percent consistency, at a temperature of from approximately 170-240.degree. F., preferably from 190 to 220.degree. F., thoroughly impregnating the slurry with oxygen gas, and with alkali to bring the slurry to a pH of at least 11, more preferably 12, introducing the slurry to oxygen gas in a high shear mixer, for agitating mixing therein, reacting the slurry in a first pressurized reactor for between 5 to 10 minutes, returning the pH of the slurry to at least 11, more preferably 12, with a residual alkali concentration of at least 1.25 gpl, thoroughly impregnating the slurry with H.sub.2 O.sub.2 and oxygen gas, and reacting the slurry in a second reactor for between 30 to 180 minutes. By only employing the hydrogen peroxide during the slower bleaching reaction, a lower Kappa number with higher %ISO is obtained in the product, these beneficial characteristics being retained in subsequent processing steps.
摘要翻译： 本发明描述了中等浓度浆浆的氧脱木质素的方法，其包括以下步骤：在大约170-240°F的温度下提供约10％至16％的稠度的纸浆，优选为190至 220°F，用氧气充分浸渍浆料，并用碱使浆料达到至少11℃，更优选12的pH，在高剪切混合器中将浆料引入氧气中，搅拌混合，使 在第一加压反应器中的淤浆5至10分钟，将浆料的pH值返回到至少11，更优选12，残余碱浓度至少为1.25gp1，用H 2 O 2和氧气彻底浸渍浆料， 并使该浆料在第二反应器中反应30至180分钟。 通过在较慢漂白反应中仅使用过氧化氢，在产品中获得具有较高％ISO的较低卡伯值，这些有益特征在随后的加工步骤中保留。
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公开(公告)号：US5916286A
公开(公告)日：1999-06-29
申请号：US528933
申请日：1995-09-15
申请人： Jay E. Seashore , William J. Miller
发明人： Jay E. Seashore , William J. Miller
CPC分类号： H04L41/0856 , H04L41/082 , B60W2050/041
摘要： A portable automotive diagnostic tool (30) for receiving information from an automotive computer of a vehicle. The portable automotive diagnostic tool (30) is battery powered. The portable automotive diagnostic tool (30) comprises a microcontroller (31), a display (32), a keypad (33), a flash memory (34), a SRAM (35), a battery backup circuit (36), a ROM (37), a UART (38), and a port (39). Automotive codes for configuring the portable automotive diagnostic tool (30) are stored in flash memory (34). The automotive codes are compressed to increase storage to the flash memory (34). The flash memory (34) is non-volatile and retains the automotive codes when power is removed. The automotive codes are updated by writing new automotive codes to the flash memory (34). Information or data received from an automotive computer is stored in SRAM (35). The battery backup circuit (36) powers the SRAM (35) to maintain the information to be taken to a different location when the power is turned off.
摘要翻译： 一种用于从车辆的汽车计算机接收信息的便携式汽车诊断工具（30）。 便携式汽车诊断工具（30）由电池供电。 便携式汽车诊断工具（30）包括微控制器（31），显示器（32），键盘（33），闪存（34），SRAM（35），电池备用电路（36），ROM （37），UART（38）和端口（39）。 用于配置便携式汽车诊断工具（30）的汽车代码被存储在闪存（34）中。 汽车代码被压缩以将存储器增加到闪速存储器（34）。 闪存（34）是非易失性的，并且在去电时保留汽车代码。 通过将新的汽车代码写入闪存（34）来更新汽车代码。 从汽车计算机接收的信息或数据存储在SRAM（35）中。 当电源关闭时，电池备用电路（36）为SRAM（35）供电，以将信息保持在不同的位置。
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公开(公告)号：US5915966A
公开(公告)日：1999-06-29
申请号：US150606
申请日：1998-09-10
申请人： William J. Miller
发明人： William J. Miller
摘要： A tooth crown preparation system is provided including a handle and a tooth cover fixed to the handle and defining an interior space and an open bottom. A grinding assembly is rotatably mounted to the handle and situated within the tooth cover for rotating upon its actuation to grind a tooth situated within the interior space of the tooth cover. A plurality of tooth covers and grinding assemblies are included for affording a system which may accommodate various sized teeth. Also provided is a suction assembly for removing particles from within the grinding assembly.
摘要翻译： 提供了一种牙冠制备系统，其包括固定到手柄上的手柄和齿盖，并且限定内部空间和敞开的底部。 磨削组件可旋转地安装到手柄并且位于齿盖内，用于在其致动时旋转以研磨位于齿盖的内部空间内的齿。 包括多个齿盖和研磨组件，以提供可容纳各种尺寸的齿的系统。 还提供了一种用于从研磨组件内除去颗粒的抽吸组件。
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75.发明授权
公开(公告)号：US5847112A
公开(公告)日：1998-12-08
申请号：US970460
申请日：1997-11-14
申请人： Peter J. Kniskern , William J. Miller , Arpi Hagopian , Charlotte C. Ip , John P. Hennessey, Jr. , Dennis J. Kubek , Pamela D. Burke
发明人： Peter J. Kniskern , William J. Miller , Arpi Hagopian , Charlotte C. Ip , John P. Hennessey, Jr. , Dennis J. Kubek , Pamela D. Burke
IPC分类号： A61K39/00 , A61K39/09 , A61P31/04 , C07H1/08 , C08B37/00 , C12N1/20 , C12P19/00 , C12P19/04 , C12R1/46
CPC分类号： A61K39/092 , C12P19/04
摘要： Type-specific capsular polysaccharide preparations from Streptococcus pneumoniae, having on average less than about 1000 oligosaccharide repeat units per molecule, polydispersities between 1.0 and 1.4, intrinsic viscosities between 0.6 and 3.0 dL/g, and less than 3% contamination of type-specific polysaccharide by group-specific C-polysaccharide, are produced by a novel process. The novel type specific polysaccharide products are useful in the preparation of vaccines, especially covalent conjugates comprising the novel polysaccharide linked to a T-cell stimulatory carrier protein. Vaccines comprising the novel polysaccharides are useful in the prevention of infection and of diseases associated with infection by Streptococcus pneumoniae.
摘要翻译： 来自肺炎链球菌的特异性荚膜多糖制剂，其平均每分子平均小于约1000个寡糖重复单位，多分散性在1.0至1.4之间，特性粘度在0.6至3.0dL / g之间，小于3％的特异性多糖污染 通过组特异性C-多糖通过新方法产生。 新型特异性多糖产物可用于制备疫苗，特别是包含与T细胞刺激性载体蛋白连接的新型多糖的共价缀合物。 包含新型多糖的疫苗可用于预防感染和与肺炎链球菌感染相关的疾病。
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公开(公告)号：US5623057A
公开(公告)日：1997-04-22
申请号：US246394
申请日：1994-05-20
申请人： Stephen Marburg , Richard L. Tolman , Peter J. Kniskern , William J. Miller , Arpi Hagopian , Charlotte C. Ip , John P. Hennessey, Jr. , Dennis J. Kubek , Pamela D. Burke
发明人： Stephen Marburg , Richard L. Tolman , Peter J. Kniskern , William J. Miller , Arpi Hagopian , Charlotte C. Ip , John P. Hennessey, Jr. , Dennis J. Kubek , Pamela D. Burke
IPC分类号： A61K39/00 , A61K38/16 , A61K39/02 , A61K39/09 , A61K39/095 , A61K39/295 , A61K39/395 , A61K47/36 , A61P29/00 , C07K20060101 , C07K1/113 , C07K1/14 , C07K14/00 , C07K14/195 , C07K14/22 , C07K14/315 , C07K14/41 , C07K17/02 , C07K17/10 , C08B37/00 , C12P19/04 , C12P21/00 , C12R1/36 , C12R1/46 , A61K39/385
CPC分类号： A61K39/095 , A61K39/092 , A61K2039/6068 , A61K2039/627
摘要： A novel conjugate vaccine comprising partially hydrolyzed, highly purified, capsular polysaccharide (Ps) from Streptococcus pneumoniae bacteria (pneumococci, Pn) linked to an immunogenic carrier protein, is produced by a new process. The conjugate is useful in the prevention of pneumococcal infections. Vaccines comprising a mixture of from one to ten different pneumococcal polysaccharide-immunogenic protein (Pn-Ps-PRO) conjugates induce broadly protective recipient immune responses against the cognate pathogens from which the polysaccharide components are derived. Young children and infants younger than 2 years old, normally unable to mount a protective immune response to the Pn-Ps alone, exhibit protective immune responses upon vaccination with these Pn-Ps-PRO conjugates.
摘要翻译： 通过新方法生产包含与免疫原性载体蛋白连接的来自肺炎链球菌（Streptococcus pneumoniae）（肺炎球菌，Pn））的部分水解，高度纯化的荚膜多糖（Ps）的新型缀合疫苗。 该缀合物可用于预防肺炎球菌感染。 包含1至10种不同的肺炎球菌多糖 - 免疫原性蛋白（Pn-Ps-PRO）缀合物的混合物的疫苗诱导针对多糖成分衍生的同源病原体的广泛保护性受体免疫应答。 年龄小于2岁的幼儿和婴儿通常无法对Pn-Ps单独施加保护性免疫应答，在用这些Pn-Ps-PRO缀合物接种疫苗后，会显示出保护性的免疫应答。
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公开(公告)号：US5351326A
公开(公告)日：1994-09-27
申请号：US959610
申请日：1992-10-13
申请人： William J. Miller
发明人： William J. Miller
CPC分类号： G02B6/2856
摘要： A 1.times.N fiber optic coupler is formed by assembling a coupler preform including spacer tube means surrounded by an outer glass tube that is concentric with the spacer tube means. A first optical fiber is disposed in an axial bore in the spacer tube means, and N optical fibers are disposed within a gap between the spacer tube means and the outer tube, the first fiber and the N fibers extending through the midregion of the coupler preform. The midregion of the outer tube is heated to collapse it about the fibers, and the central portion of the midregion is stretched to reduce the diameter thereof over a predetermined length. In accordance with the invention, the spacer tube means is glued to the first optical fiber and to the outer tube.
摘要翻译： 1xN光纤耦合器通过组装耦合器预制件形成，该耦合器预制件包括由与间隔管装置同心的外部玻璃管包围的间隔管装置。 第一光纤设置在间隔管装置中的轴向孔中，并且N个光纤设置在间隔管装置和外管之间的间隙内，第一纤维和N个纤维延伸穿过联接器预成型件的中间区 。 外管的中间区被加热以将其围绕纤维折叠，并且中间区域的中心部分被拉伸以将其直径减小预定长度。 根据本发明，间隔管装置粘合到第一光纤和外管上。
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公开(公告)号：US5339372A
公开(公告)日：1994-08-16
申请号：US75129
申请日：1993-06-09
CPC分类号： G02B6/2856
摘要： A low loss fiber optic coupler of the type wherein a plurality of single-mode optical fibers are fused together along a portion of the lengths thereof to form a coupling region. Each fiber includes a core and a cladding, the lowest refractive index of the fiber claddings being n.sub.2. Each of the output fibers of the coupler further includes a surface region of refractive index n.sub.4 that inhibits the coupling of light to lossy composite modes, n.sub.4 being lower than n.sub.2.
摘要翻译： 一种低损耗光纤耦合器，其中多个单模光纤沿其长度的一部分熔合在一起以形成耦合区域。 每个光纤包括芯和包层，光纤包层的最低折射率为n2。 耦合器的每个输出光纤还包括折射率为n4的表面区域，其阻止光耦合到有损复合模式，n4低于n2。
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公开(公告)号：US5295205A
公开(公告)日：1994-03-15
申请号：US38244
申请日：1993-03-29
申请人： William J. Miller , Daniel A. Nolan
发明人： William J. Miller , Daniel A. Nolan
CPC分类号： G02B6/29332 , G02B6/2835 , G02B6/29352
摘要： A monolithic, environmentally stable Mach-Zehnder device is formed by threading first and second dissimilar optical fibers through the bore of a glass tube. The tube is evacuated and heated to collapse it onto the fibers. The tube is further heated and stretched at two spaced locations to form two couplers that are joined by the two optical fibers. The fibers have different propagation constants in the region between the two couplers, whereby there is a relative delay in the optical signal propagating in one of the fibers with respect to the optical signal propagating in the other fiber.
摘要翻译： 通过将第一和第二不同光纤穿过玻璃管的孔而形成整体式，环境稳定的马赫 - 策德尔装置。 将管抽真空并加热以使其折叠到纤维上。 将管进一步加热并在两个间隔位置拉伸以形成由两根光纤连接的两个耦合器。 纤维在两个耦合器之间的区域中具有不同的传播常数，由此相对于在另一个光纤中传播的光信号，光信号在一个光纤中传播的相对延迟。
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公开(公告)号：US5268014A
公开(公告)日：1993-12-07
申请号：US972417
申请日：1992-11-05
CPC分类号： G02B6/2835 , G02B6/2856
摘要： After a plurality of optical fibers are fused to make a fiber optic coupler, the ends thereof are glued to a substrate to provide the outwardly extending fibers with adequate pull strength. The glue can flow from the point of application toward the fused region where it can adversely affect the the device. To prevent the glue from flowing too far toward the fused region and yet permit sufficient flow to strengthen the fibers, a beam of UV light is directed onto the fibers at that predetermined point where glue flow should stop. When the glue is cured by the beam, it stops flowing. Thereafter, the remainder of the glue is cured.
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