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    Microfluidic device and microfluidic analysis equipment
    71.
    发明授权
    Microfluidic device and microfluidic analysis equipment 有权
    微流控装置和微流体分析设备

    公开(公告)号：US08440148B2

    公开(公告)日：2013-05-14

    申请号：US12562058

    申请日：2009-09-17

    申请人： Dong-Ho Shin ,  Minsuk Jeong ,  Kyu Ho Song ,  HyeYoon Kim ,  JuHyun Jeon ,  Moon Youn Jung ,  Seon Hee Park

    发明人： Dong-Ho Shin ,  Minsuk Jeong ,  Kyu Ho Song ,  HyeYoon Kim ,  JuHyun Jeon ,  Moon Youn Jung ,  Seon Hee Park

    IPC分类号： B01L99/00 ,  G01N21/01

    CPC分类号： G01N21/645 ,  B01L3/50273 ,  B01L3/502792 ,  B01L2200/0673 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/043 ,  B01L2400/0475 ,  B01L2400/0688

    摘要： Provided are a microfluidic device and a microfluidic analysis equipment. The microfluidic device includes guides disposed along both edges, a lower plate including a flow path defined between the guides, and a movable upper plate moved along the guides on the lower plate and having a length less than that the flow path. A fluid flow can be simply accurately controlled by adjusting a position of the movable upper plate. As a result, the fluid can sufficiently react in the detection part and the reaction part. Therefore, effective reaction and detection can be realized using only a small amount of fluid, thereby improving sensitivity. In addition, due to the improved sensitivity, a washing process for removing materials that are not consumed in the reaction can be omitted. Also, the movable upper plate can be manually moved using a user's finger.

    摘要翻译： 提供了微流体装置和微流体分析设备。 微流体装置包括沿着两个边缘布置的引导件，下板包括限定在引导件之间的流路，以及沿着下板上的引导件移动并且具有小于流动路径的长度的可移动上板。 可以通过调节可动上板的位置来简单地精确地控制流体流动。 结果，流体可以在检测部分和反应部分中充分反应。 因此，仅使用少量流体即可实现有效的反应和检测，从而提高灵敏度。 此外，由于提高的灵敏度，可以省略用于除去反应中不消耗的材料的洗涤方法。 此外，可以使用用户的手指来手动移动可动上板。

    Method of manufacturing hollow microneedle structures
    72.
    发明授权
    Method of manufacturing hollow microneedle structures 有权
    制造中空微针结构的方法

    公开(公告)号：US08402629B2

    公开(公告)日：2013-03-26

    申请号：US12635480

    申请日：2009-12-10

    申请人： Dae Sik Lee ,  Yong Sun Yoon ,  Moon Youn Jung ,  Seon Hee Park

    发明人： Dae Sik Lee ,  Yong Sun Yoon ,  Moon Youn Jung ,  Seon Hee Park

    IPC分类号： B23P25/00 ,  B22D11/126 ,  A61M5/32 ,  B05D3/12

    CPC分类号： A61M37/0015 ,  A61B5/14514 ,  A61B5/685 ,  A61M2037/0053 ,  Y10T29/49885 ,  Y10T29/4998 ,  Y10T156/1062

    摘要： Provided is a method of manufacturing a hollow microneedle structure. The method includes coating a hollow core having a predetermined section and being long in a lengthwise direction with a coating solution, and solidifying the coating solution to form a coating layer, depositing a metal seed layer on the coating layer, plating the seed metal layer with a metal to form a plated layer, cutting the hollow core having the plated layer at an inclination angle with respect to the lengthwise direction for form a surface inclination, and removing the hollow core and the coating layer to form a hollow microneedle structure. Thus, the hollow microneedle structure can be manufactured to have such diameter, length, hardness, and inclination angle as to minimize pain. By use of the hollow core, the microneedle structure can have vertical microneedles with a uniform inner diameter.

    摘要翻译： 提供一种制造中空微针结构的方法。 该方法包括用涂布溶液涂布具有预定部分并在长度方向上长的中空芯，并固化涂布溶液以形成涂层，在涂层上沉积金属籽晶层，将种子金属层与 金属以形成镀层，切割具有相对于长度方向的倾斜角度的镀层的中空芯以形成表面倾斜，并且移除中空芯和涂层以形成中空微针结构。 因此，可以制造中空微针结构以具有使疼痛最小化的直径，长度，硬度和倾斜角度。 通过使用中空芯，微针结构可以具有均匀内径的垂直微针。

    FILTERING DEVICE
    77.
    发明申请
    FILTERING DEVICE 失效
    过滤装置

    公开(公告)号：US20110068053A1

    公开(公告)日：2011-03-24

    申请号：US12835230

    申请日：2010-07-13

    申请人： Bong Kyu KIM ,  Wan Joong Kim ,  Gun Yong Sung ,  Seon Hee Park

    发明人： Bong Kyu KIM ,  Wan Joong Kim ,  Gun Yong Sung ,  Seon Hee Park

    IPC分类号： B01D35/14

    CPC分类号： B01D46/0086

    摘要： Provided is a filtering device including a filter part having a plurality of filters stacked to filter contaminants in fluid, and a sample part disposed on an outer plane of the filter part and having a plurality of samples corresponding to the filters, respectively. Therefore, a filter exchange period can be accurately determined by measuring properties of the filter varied during filtering of contaminants, and indiscriminate exchange of the filters can be prevented to reduce maintenance cost.

    摘要翻译： 提供了一种过滤装置，其包括具有多个过滤器的过滤器部件，所述过滤器被堆叠以过滤流体中的污染物，以及样品部分，其分别设置在过滤器部分的外平面上并且具有与过滤器对应的多个样品。 因此，可以通过测量在过滤污染物期间变化的过滤器的性质来精确地确定过滤器更换周期，并且可以防止过滤器的不加选择的更换以降低维护成本。

    METHOD OF MANUFACTURING HOLLOW MICRONEEDLE STRUCTURES
    78.
    发明申请
    METHOD OF MANUFACTURING HOLLOW MICRONEEDLE STRUCTURES 有权
    制造中空微结构的方法

    公开(公告)号：US20110005669A1

    公开(公告)日：2011-01-13

    申请号：US12635480

    申请日：2009-12-10

    申请人： Dae Sik LEE ,  Yong Sun Yoon ,  Moon Youn Jung ,  Seon Hee Park

    发明人： Dae Sik LEE ,  Yong Sun Yoon ,  Moon Youn Jung ,  Seon Hee Park

    IPC分类号： B05D7/00 ,  B05D3/12 ,  B32B38/00

    CPC分类号： A61M37/0015 ,  A61B5/14514 ,  A61B5/685 ,  A61M2037/0053 ,  Y10T29/49885 ,  Y10T29/4998 ,  Y10T156/1062

    摘要： Provided is a method of manufacturing a hollow microneedle structure. The method includes coating a hollow core having a predetermined section and being long in a lengthwise direction with a coating solution, and solidifying the coating solution to form a coating layer, depositing a metal seed layer on the coating layer, plating the seed metal layer with a metal to form a plated layer, cutting the hollow core having the plated layer at an inclination angle with respect to the lengthwise direction to form a surface inclination, and removing the hollow core and the coating layer to form a hollow. Thus, the hollow microneedle structure can be manufactured to have such diameter, length, hardness, and inclination angle as to minimize pain. By use of the hollow core, the microneedle structure can have vertical microneedles with a uniform inner diameter.

    摘要翻译： 提供一种制造中空微针结构的方法。 该方法包括用涂布溶液涂布具有预定部分并在长度方向上长的中空芯，并固化涂布溶液以形成涂层，在涂层上沉积金属籽晶层，将种子金属层与 金属以形成镀层，切割具有相对于长度方向的倾斜角度的镀层的中空芯，以形成表面倾斜，并且移除中空芯和涂层以形成中空部。 因此，可以制造中空微针结构以具有使疼痛最小化的直径，长度，硬度和倾斜角度。 通过使用中空芯，微针结构可以具有均匀内径的垂直微针。

    Method and apparatus for detecting bio-complexes using rule-based templates
    79.
    发明授权
    Method and apparatus for detecting bio-complexes using rule-based templates 有权
    使用基于规则的模板检测生物复合物的方法和装置

    公开(公告)号：US07869960B2

    公开(公告)日：2011-01-11

    申请号：US11635553

    申请日：2006-12-08

    申请人： Jae Hun Choi ,  Jong Min Park ,  Seon Hee Park

    发明人： Jae Hun Choi ,  Jong Min Park ,  Seon Hee Park

    IPC分类号： G01N33/48

    CPC分类号： G06F19/12 ,  G06F19/24

    摘要： Provided are a method and apparatus for detecting bio-complexes that are important sub protein interaction networks using a rule-based template in large interaction networks present in a single species. The method includes (a) defining a rule-based template corresponding to a bio-complex to be detected by defining a node that consists of at least one protein, a triplet that consists of two defined nodes and a protein interaction relationship therebetween, and single and composite rules using the triplet and an operator; (b) analyzing the rules of the defined rule-based template by analyzing whether the protein corresponding to the node included in the defined rule-based template and the protein interaction relationship corresponding to the triplet are present in a protein interaction network; and (c) detecting a bio-complex in the protein interaction network by assessing the triplet included in the rules analyzed and the node included in the triplet using a protein interaction relationship and protein of the protein interaction networks.

    摘要翻译： 提供了一种用于检测生物复合物的方法和装置，其是在单个物种中存在的大型相互作用网络中使用基于规则的模板的重要的亚蛋白质相互作用网络。 该方法包括（a）通过定义由至少一个蛋白质组成的节点，由两个定义的节点组成的三联体以及它们之间的蛋白质相互作用关系来定义与要检测的生物复合物相对应的基于规则的模板，以及单个 和使用三元组和运算符的复合规则; （b）通过分析蛋白质相互作用网络中是否存在与定义的基于规则的模板中包含的节点相对应的蛋白质和对应于三联体的蛋白质相互作用关系来分析所定义的基于规则的模板的规则; 和（c）通过使用蛋白质相互作用网络的蛋白质相互作用关系和蛋白质评估包含在所分析的规则中的三联体和包含在三联体中的节点来检测蛋白质相互作用网络中的生物复合物。

    Micro gas sensor and manufacturing method thereof
    80.
    发明授权
    Micro gas sensor and manufacturing method thereof 有权
    微气体传感器及其制造方法

    公开(公告)号：US07861575B2

    公开(公告)日：2011-01-04

    申请号：US12142695

    申请日：2008-06-19

    申请人： Chi Hoon Jun ,  Sang Choon Ko ,  Moon Youn Jung ,  Seon Hee Park

    发明人： Chi Hoon Jun ,  Sang Choon Ko ,  Moon Youn Jung ,  Seon Hee Park

    IPC分类号： G01N7/00 ,  G01N27/12

    CPC分类号： G01N33/0027 ,  G01N27/128

    摘要： A micro gas sensor is disclosed including a substrate; an open cavity formed in the substrate; an electrode pad separation groove formed on the substrate; a first and a second electrode pads formed over the substrate and electrically insulated from each other by the electrode pad separation groove; a micro heater connected to the first electrode pad and configured of a bridge structure suspended over the open cavity; a first sensing electrode extending from the first electrode pad and suspended over the open cavity; a second sensing electrode extending from the first electrode pad and suspended over the open cavity; and a gas sensing film electrically coupled to the micro heater and filling a gap between the first and the second sensing electrodes.

    摘要翻译： 公开了一种包括基板的微气体传感器; 在所述基板中形成的开放空腔; 形成在所述基板上的电极焊盘分离槽; 第一和第二电极焊盘，形成在所述衬底上并且由所述电极焊盘分离槽彼此电绝缘; 连接到第一电极焊盘并由悬挂在开放空腔上的桥结构构成的微加热器; 第一感测电极，其从所述第一电极焊盘延伸并悬挂在所述开放腔上; 第二感测电极，其从所述第一电极焊盘延伸并悬挂在所述开口腔上; 以及电气耦合到微加热器并填充第一和第二感测电极之间的间隙的气体感测膜。