利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

182 条记录 (耗时 0.036 秒)

    Block copolymer elastomer catheter balloons
    71.
    发明授权
    Block copolymer elastomer catheter balloons 失效
    嵌段共聚物弹性体导管气球

    公开(公告)号：US06171278B2

    公开(公告)日：2001-01-09

    申请号：US08811761

    申请日：1997-03-06

    申请人： Lixiao Wang ,  Jianhua Chen

    发明人： Lixiao Wang ,  Jianhua Chen

    IPC分类号： A61M2900

    CPC分类号： A61L29/06 ,  A61L29/14 ,  A61M25/1027 ,  A61M25/1029 ,  B29C2049/0089 ,  B29K2105/258 ,  B29L2022/022 ,  B29L2031/7542 ,  Y10T428/1352 ,  C08L77/12 ,  C08L67/02

    摘要： Balloons for medical devices, particularly balloon angioplasty catheters, which have hybrid compliance curves are made from particular block copolymer thermoplastic elastomers. Melt blends of an engineering resin having by a flexural modulus of about 240,000 psi or greater and a block copolymer elastomer having a flexural modulus of about 150,000 psi or less, the block copolymer including at least one block which is structurally similar to the engineering resin are also used to produce medical device balloons.

    摘要翻译： 具有混合顺应性曲线的用于医疗装置，特别是球囊血管成形术导管的气球由特定的嵌段共聚物热塑性弹性体制成。 具有约240,000psi或更大的挠曲模量的工程树脂和具有约150,000psi或更小的挠曲模量的嵌段共聚物弹性体的熔融共混物，所述嵌段共聚物包括至少一个在工程树脂上结构相似的嵌段， 也用于生产医疗器械气球。

    Block copolymer elastomer catheter balloons
    75.
    发明授权
    Block copolymer elastomer catheter balloons 失效

    公开(公告)号：US5556383A

    公开(公告)日：1996-09-17

    申请号：US397837

    申请日：1995-03-02

    申请人： Lixiao Wang ,  Jianhua Chen

    发明人： Lixiao Wang ,  Jianhua Chen

    IPC分类号： A61M25/00 ,  A61L29/00 ,  A61L29/06 ,  A61L29/14 ,  A61M29/00

    CPC分类号： A61M25/1027 ,  A61L29/06 ,  A61L29/14 ,  A61M25/1029 ,  B29L2031/7542

    摘要： Balloons for medical devices, particularly balloon angioplasty catheters, are made from particular block copolymer thermoplastic elastomers in which the block copolymer is made up of hard segments of a polyester or polyamide and soft segments of polyether; the polyester hard segments are polyesters of an aromatic dicarboxylic acid and a C.sub.2 -C.sub.4 diol; the polyamide hard segments are polyamides of C.sub.6 or higher carboxylic acids and C.sub.6 or higher organic diamines or of C.sub.6 or higher aliphatic .omega.-amino-.alpha.-acids, and the polyether soft segments are polyethers of C.sub.2 -C.sub.10, diols; the block copolymer has a low flexural modulus, namely less than 150,000 psi; the block copolymer has a hardness, Shore D scale, of greater than 60; and the percentage by weight of the block polymer attributable to the hard segments is between about 50% and about 95%. The polymers provide high strength, thin wall, compliant and semi-compliant balloons, which leads to a low profile catheter. The low profile catheters have very good initial crossing, good trackability, good recrossing after first inflation.

    Drug releasing coatings for medical devices
    79.
    发明授权
    Drug releasing coatings for medical devices 有权
    用于医疗器械的药物释放涂层

    公开(公告)号：US08414525B2

    公开(公告)日：2013-04-09

    申请号：US12121986

    申请日：2008-05-16

    申请人： Lixiao Wang

    发明人： Lixiao Wang

    IPC分类号： A61M25/10 ,  A61K31/337 ,  A61K31/436

    CPC分类号： A61L31/16 ,  A61K31/337 ,  A61K31/436 ,  A61L29/16 ,  A61L31/08 ,  A61L2300/416 ,  A61L2300/80 ,  A61L2300/802 ,  A61K2300/00

    摘要： The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.

    摘要翻译： 本发明涉及一种用于将治疗剂递送至组织的医疗装置。 医疗装置具有覆盖医疗装置的外表面的层。 该层含有治疗剂和添加剂。 在某些实施方案中，添加剂具有亲水部分和药物亲和部分，其中药物亲和部分是疏水部分，通过氢键与治疗剂具有亲和性的部分中的至少一个，以及具有 通过范德华相互作用对治疗剂的亲和力。 在实施方案中，添加剂是水溶性的。 在另外的实施方案中，添加剂是表面活性剂和化合物中的至少一种，化合物的分子量为80至750或具有多于4个羟基。

    Drug releasing coatings for medical devices
    80.
    发明授权
    Drug releasing coatings for medical devices 有权

    公开(公告)号：US08366662B2

    公开(公告)日：2013-02-05

    申请号：US13042221

    申请日：2011-03-07

    申请人： Lixiao Wang

    发明人： Lixiao Wang

    IPC分类号： A61L29/16 ,  A61M25/10

    CPC分类号： A61L31/16 ,  A61K31/337 ,  A61K31/436 ,  A61L29/16 ,  A61L31/08 ,  A61L2300/416 ,  A61L2300/80 ,  A61L2300/802 ,  A61K2300/00

    摘要： The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.