公开(公告)号：US4044943A

公开(公告)日：1977-08-30

申请号：US697987

申请日：1976-06-21

申请人： Francis Barton Brown ,  John W. Erickson

发明人： Francis Barton Brown ,  John W. Erickson

IPC分类号： B04B1/12 ,  B04B11/02 ,  F04D1/12

CPC分类号： B04B11/02 ,  B04B1/12 ,  F04D1/12 ,  Y10S494/90 ,  Y10S494/901

摘要： A constant flow rate input fluid of mixed gas, oil, water and suspended solids separates into its phases by centrifuging in a chamber of a multiple phase separator. Clean oil draws off through a mouth of a pitot tube tap which extends into the chamber. Solids leave the chamber through radially perimetric orifices. Water leaves the chamber through a radial passage opening into the chamber radially inward of the orifices and outward of the mouth of the pitot tube. Gas leaves the chamber through an annular tap radially inside the mouth of the pitot tube. An overflow oil stream leaves through this annulus and keeps separate from the gas by gravity. The quantity of water in the chamber determines the radial positions of the lighter constituents of oil and gas so that each tap for these phases draws only the proper phase. Insufficient water in the chamber reduces the water flow rate from the separator, which generates a signal that recirculates water from a reservoir into the separator to increase the quantity of water there. Too much water increases the water flow rate from the separator. Too little oil results in stoppage of the overflow oil stream. When the latter flow stops, oil flow from the pitot tube stops to allow the input fluid to increase the percentage of oil in the chamber. The overflow annulus is sufficiently capacious to drain excess oil without further phase adjustment.

摘要翻译： 混合气体，油，水和悬浮固体的恒定流速输入流体通过在多相分离器的室中离心分离成其相。 清洁油通过延伸到室中的皮托管龙头的嘴部抽出。 固体通过径向周边孔离开室。 水通过径向向内通入孔的径向通道并离开皮托管口的外部离开室。 气体通过径向位于皮托管口内的环形抽头离开室。 溢流油流通过这个环带离开，并通过重力与气体保持分开。 室内的水量决定了油和气的较轻组分的径向位置，因此这些阶段的每个抽头只能取消适当的相位。 室内水分不足会降低来自分离器的水流量，从而产生将水从储存器再循环到分离器中以增加水量的信号。 太多的水增加了来自分离器的水流量。 过少的油会导致溢流油流停止。 当后一个流程停止时，来自皮托管的油流停止，以允许输入流体增加腔室中的油的百分比。 溢流环足够大以排出多余的油而无需进一步的相位调整。

公开(公告)号：US07470506B1

公开(公告)日：2008-12-30

申请号：US09720276

申请日：1999-06-23

申请人： John W. Erickson ,  Sergei V. Gulnik ,  Hiroaki Mitsuya ,  Arun K. Ghosh

发明人： John W. Erickson ,  Sergei V. Gulnik ,  Hiroaki Mitsuya ,  Arun K. Ghosh

IPC分类号： C12Q1/70

CPC分类号： A61K31/341 ,  A61K31/34 ,  A61K31/343 ,  A61K31/35 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4523 ,  A61K31/4525 ,  A61K31/47 ,  A61K31/4725 ,  A61K31/496 ,  C12Q1/025 ,  C12Q1/37 ,  G01N2333/16 ,  G01N2333/8142 ,  Y02A50/411

摘要： The present invention provides an assay for determining the biochemical fitness of a biochemical species in a mutant replicating biological entity relative to its predecessor. The present invention further provides a continuous fluorogenic assay for measuring the anti-HIV protease activity of protease inhibitor. The present invention also provides a method of administering a therapeutic compound that reduces the chances of the emergence of drug resistance in therapy. The present invention also provides a compound of formula (I) or a pharmaceutically acceptable salt, a prodrug, a composition, or an ester thereof, wherein A is a group of formulas (A), (B), (C) or (D); R1, R2, R3, R5 or R6 is H, or an optionally substituted and/or heteroatom-bearing alkyl, alkenyl, alkynyl, or cyclic group; Y and/or Z are CH2, O, S, SO, SO2, amino, amides, carbamates, ureas, or thiocarbonyl derivatives thereof, optionally substituted with an alkyl, alkenyl, or alkynyl group; n is from 1 to 5; X is a bond, an optionally substituted methylene or ethylene, an amino, O or S; Q is C(O), C(S), or SO2; m is from 0 to 6; R4 is OH, ═O (keto), NH2, or alkylamino, including esters, amides, and salts thereof; and W is C(O), C(S), S(O), or SO2. Optionally, R5 and R6, together with the N—W bond of formula (I), comprises a macrocyclic ring.

摘要翻译： 本发明提供了一种用于确定突变体复制生物实体中生物化学物质相对于其前身的生物化学适应性的测定法。 本发明还提供了用于测量蛋白酶抑制剂的抗HIV蛋白酶活性的连续荧光测定法。 本发明还提供了一种给药治疗化合物的方法，所述治疗化合物降低了治疗中耐药性出现的机会。 本发明还提供式（I）化合物或其药学上可接受的盐，前药，组合物或酯，其中A为式（A），（B），（C）或（D ）; R 1，R 2，R 3，R 5或R 6为H，或任选取代的和/或含杂原子的烷基，烯基，炔基或环状基团; Y和/或Z是任选被烷基，烯基或炔基取代的CH 2，O，S，SO，SO 2，氨基，酰胺，氨基甲酸酯，脲或硫代羰基衍生物; n为1〜5; X是一个键，任选取代的亚甲基或亚乙基，氨基，O或S; Q是C（O），C（S）或SO 2; m为0〜6; R4是OH，-O（酮基），NH2或烷基氨基，包括酯，酰胺和其盐; W是C（O），C（S），S（O）或SO 2。 任选地，R 5和R 6与式（I）的N-W键一起包含大环。

公开(公告)号：US5695127A

公开(公告)日：1997-12-09

申请号：US542691

申请日：1995-10-13

申请人： William A. Delmer ,  Daniel W. C. Delmer ,  Robert J. Delmer ,  John W. Erickson ,  Ray Charles Emmons

发明人： William A. Delmer ,  Daniel W. C. Delmer ,  Robert J. Delmer ,  John W. Erickson ,  Ray Charles Emmons

IPC分类号： A01G25/02 ,  B05B15/00

CPC分类号： A01G25/02

摘要： A constant-flow drip irrigation tape hose includes a primary flow path communicating water along the length of the hose. A secondary drip-flow path leads from the primary flow path to an emitter site outwardly of the hose. The hose is formed with a pair of variably spaced apart walls at least one of which is formed with a continuously-open channel defining part of the secondary flow path. A second variable-area part of the secondary flow path is defined by radial spacing of the pair of walls from one another. At least one of the pair of walls is responsive to internal water pressure in the primary flow path to open and close the variable-area part of the secondary flow path in response, respectively, to decreasing and increasing water pressure in the hose. A plurality of emitter sites are spaced regularly along a length of the hose. Consequently, the hose has at least one pressure range within which it provides a nearly constant drip-flow irrigation rate to plants of a row crop as the water pressure within the hose decreases over the length of an elongate run of hose.

公开(公告)号：US4785211A

公开(公告)日：1988-11-15

申请号：US18353

申请日：1987-02-24

申请人： John W. Erickson ,  Samuel D. Fegan

发明人： John W. Erickson ,  Samuel D. Fegan

IPC分类号： H02K5/128 ,  H02K9/197 ,  H02K9/08

CPC分类号： H02K9/197 ,  H02K5/128

摘要： A pressure variable sealed container such as a length of rubber tubing is filled with a compressible, thermally conductive fluid such as helium or hydrogen and is placed in a sealed motor stator chamber otherwise filled with a heat conductive liquid, such as oil, before final assembly. As the oil in the stator chamber expands with temperature, the thermally conductive fluid in the container is compressed thereby absorbing the expansion of the oil in the stator chamber.

摘要翻译： 诸如一段橡胶管的压力可变密封容器填充有可压缩的导热流体，例如氦气或氢气，并且在最终组装之前放置在密封的电动机定子室中，否则填充有诸如油的导热液体 。 当定子室中的油随着温度膨胀时，容器中的导热流体被压缩，从而吸收定子室中的油的膨胀。

公开(公告)号：US4767233A

公开(公告)日：1988-08-30

申请号：US28358

申请日：1987-03-20

申请人： John W. Erickson

发明人： John W. Erickson

IPC分类号： F04D29/20 ,  F16B41/00 ,  F16D1/072 ,  F16D1/08 ,  B25G3/00

CPC分类号： F16B41/002 ,  F04D29/20 ,  F16D1/072 ,  F16D1/0894 ,  Y10T403/585 ,  Y10T403/7018 ,  Y10T403/7079

摘要： The impeller mounting apparatus includes one or more pins extending through the hub into the shaft with the pins being retained in the holes by means of a resilient metallic band of continuous construction which is forced onto the hub into grooves or recesses which prevent the dislodgement of the band and the inadvertent loosening of the impeller on the shaft.

摘要翻译： 叶轮安装装置包括一个或多个销，其延伸穿过轮毂进入轴，其中销通过连续结构的弹性金属带保持在孔中，该弹性金属带被迫在轮毂上形成凹槽或凹槽，从而防止 带和叶轮在轴上的无意松动。

公开(公告)号：US4425086A

公开(公告)日：1984-01-10

申请号：US298122

申请日：1981-08-31

申请人： Daniel G. Peterson ,  John W. Erickson

发明人： Daniel G. Peterson ,  John W. Erickson

IPC分类号： F04B47/08 ,  F04B53/12 ,  F04B53/14 ,  F04B35/02

CPC分类号： F04B53/142 ,  F04B47/08 ,  F04B53/126

摘要： A combined surface power unit and velocity actuated valve for a downhole pump is disclosed. The surface power unit generates a series of pulses of pressurized fluid. A power line supplies the fluid pulses to a downhole pump. Within the downhole pump, a piston means is slidably disposed for pumping fluid therefrom. The piston means includes an orifice for permitting fluid flow therethrough. The velocity of the fluid passing through the orifice causes a pressure differential across the orifice and valve means closes for the duration of each pulse. When the valve means is closed, pressure builds up in the downhole pump causing the piston means to move in a power stroke, pumping the production fluid. Between pulses, the pressure of the fluid in the downhole pump drops and a velocity valve opens. When the velocity valve is opened, fluid can flow freely therethrough, and the piston means retracts under the influence of gravity in a re-charging stroke.

摘要翻译： 公开了用于井下泵的组合表面动力单元和速度致动阀。 表面动力单元产生一系列加压流体的脉冲。 电力线将流体脉冲提供给井下泵。 在井下泵内，活塞装置可滑动地设置成用于从其中泵送流体。 活塞装置包括用于允许流体流过其中的孔口。 通过孔口的流体的速度导致孔口两端的压差，阀门装置在每个脉冲的持续时间内关闭。 当阀装置关闭时，在井下泵中产生压力，导致活塞装置在动力冲程中移动，泵送生产流体。 在脉冲之间，井下泵中的流体压力下降并且速度阀打开。 当速度阀打开时，流体可以自由地流过，活塞装置在重力作用下在重力作用下缩回。

公开(公告)号：US4425083A

公开(公告)日：1984-01-10

申请号：US298060

申请日：1981-08-31

申请人： Daniel G. Peterson ,  John W. Erickson

发明人： Daniel G. Peterson ,  John W. Erickson

IPC分类号： F04B47/08 ,  F04B53/12 ,  F04B53/14 ,  F04B47/12

CPC分类号： F04B47/08 ,  F04B53/126 ,  F04B53/142

摘要： A downhole pump for a well is disclosed which includes a piston slidably disposed within a housing for pumping fluid from the well. The longitudinal axes of the piston and the housing extend in a generally vertical direction with respect to the surface of the well. A surface unit supplies a pulsating flow of fluid to the piston. A velocity actuated valve is formed in the piston and includes a ball which is spaced from an orifice by a bias. The bias holds the ball away from the orifice such that the valve is normally open. The flow of fluid through the velocity actuated valve during each fluid pulse creates a pressure differential which is resisted by the bias. When the pressure differential exceeds the force generated by the bias, the ball will seat in the orifice and close the valve to further fluid flow. The balance of the fluid pulse will be applied to the lower side of the piston and the piston moves upwardly within the housing, thereby pumping fluid from the well. At the end of each fluid pulse, the pressure will drop such that the bias forces the ball away from the orifice. Thus, the velocity actuated valve is opened and fluid can flow freely therethrough, to permit gravity to move the piston downwardly for the next power stroke and permits production fluid to enter the housing through a traveling valve and bottom discharge valve and flow through the velocity actuated valve to the upper side of the piston.

摘要翻译： 公开了一种用于井的井下泵，其包括可滑动地设置在壳体内用于从井抽出流体的活塞。 活塞和壳体的纵向轴线相对于井的表面在大致垂直的方向上延伸。 表面单元向活塞提供脉动的流体流。 速度致动阀形成在活塞中并且包括通过偏压与孔隔开的球。 偏压使球远离孔口，使得阀门通常打开。 在每个流体脉冲期间通过速度致动阀的流体流产生由偏压抵抗的压力差。 当压力差超过偏压产生的力时，球将位于孔中并关闭阀以进一步流体流动。 流体脉冲的平衡将被施加到活塞的下侧，并且活塞在壳体内向上移动，从而从井中泵送流体。 在每个流体脉冲结束时，压力将下降，使得偏压迫使球远离孔口。 因此，速度致动阀打开并且流体可以自由地流过其中，以允许重力将活塞向下移动用于下一次动力冲程，并允许生产流体通过行进阀和底部排出阀进入壳体并流过速度致动 阀门到活塞的上侧。

公开(公告)号：US4363063A

公开(公告)日：1982-12-07

申请号：US290370

申请日：1981-08-05

申请人： John W. Erickson

发明人： John W. Erickson

IPC分类号： H01H83/14 ,  H01H83/20 ,  H02H3/33 ,  H02H3/28

CPC分类号： H01H83/20 ,  H01H83/144 ,  H01H2083/203 ,  H02H3/33

摘要： A plural phase high current low voltage load break switch with built-in ground fault sensing comprises an insulator base and a plurality of individual phase circuits mounted on and extending across the base in parallel spaced relation to each other, each phase circuit including, in series, an input connector, a fixed switch contact, a movable switch contact, a fuse, and an output conductor; a neutral conductor is mounted on and extends across the base in parallel spaced relation to the phase circuits. A switch operator mechanism mounted on the base is connected to all of the movable switch contacts for opening and closing these contacts simultaneously; that mechanism includes an electrically operated trip actuator for actuating the operator mechanism to open the switch contacts. A zero sequence ground fault sensor coil is disposed in encompassing relation to all of the phase circuits and the neutal conductor; the sensor coil is aligned with the movable switch contacts. A control relay is electrically connected to the ground fault sensor coil and to the trip actuator for energizing the trip actuator in response to the sensing of a ground fault condition by the sensor coil.

摘要翻译： 具有内置接地故障检测的多相高电流低电压负载断路开关包括绝缘体基座和安装在彼此平行间隔开的​​基底上并延伸穿过基座的多个单相相位电路，每个相电路包括串联 ，输入连接器，固定开关触点，可动开关触点，保险丝和输出导体; 中性导体安装在基极上且与相位电路平行间隔地延伸。 安装在基座上的开关操作机构连接到所有可移动开关触点，以同时打开和关闭这些触点; 该机构包括电动跳闸致动器，用于致动操作机构以打开开关触点。 零序接地故障传感器线圈与所有的相电路和中性导体包含在一起; 传感器线圈与可移动开关触点对准。 控制继电器电连接到接地故障传感器线圈和跳闸致动器，以响应于传感器线圈对接地故障状况的感测而激励跳闸致动器。

公开(公告)号：US4332521A

公开(公告)日：1982-06-01

申请号：US120188

申请日：1980-02-11

申请人： John W. Erickson

发明人： John W. Erickson

IPC分类号： F04D1/12

CPC分类号： F04D1/12

摘要： A fluid compressor of the pitot type includes a high speed, high stress rotary casing. The casing is formed from a pair of tapered discs spaced apart and mounted for rotation about an axis. The discs form the end walls of the casing. A side wall is connected between the opposed peripheral portions of the discs to enclose the casing and a stationary pitot tube. The side wall is formed from a pair of concentric rings connected by a plurality of beams. In one embodiment, the beams are C-shaped with an upper leg attached to the outer ring and a lower leg attached to the inner ring, the longitudinal axis of the beams being parallel to the axis of rotation. In an alternate embodiment, the rings are formed from the upper and lower legs of a plurality of I-shaped beams, the longitudinal axis of the beams being parallel to the axis of rotation.

摘要翻译： 皮托托式流体压缩机包括高速，高应力旋转壳体。 壳体由一对间隔开并安装成围绕轴线旋转的锥形盘形成。 圆盘形成套管的端壁。 侧壁连接在盘的相对的周边部分之间以包围壳体和固定皮托管。 侧壁由一对由多个梁连接的同心环形成。 在一个实施例中，梁是C形的，上腿连接到外环，并且小腿附接到内环，梁的纵向轴线平行于旋转轴线。 在替代实施例中，环由多个I形梁的上腿和下腿形成，梁的纵向轴线平行于旋转轴线。

公开(公告)号：US4294573A

公开(公告)日：1981-10-13

申请号：US039775

申请日：1979-05-17

申请人： John W. Erickson ,  Harold L. Petrie

发明人： John W. Erickson ,  Harold L. Petrie

IPC分类号： E21B43/12 ,  F04B23/14 ,  F04D13/10 ,  F04D13/12

CPC分类号： F04D13/12 ,  E21B43/124 ,  E21B43/128 ,  F04B23/14 ,  F04D13/10

摘要： A petroleum well has a plurality of centrifugal pump stages, a jet pump stage, and an electrical drive motor. A recirculated portion of the output from high pressure stages of the centrifugal pump provides power fluid for the jet pump, and the jet pump aspirates fluid from lower pressure centrifugal pump stages. The balance of the output of the high pressure stages goes to the surface as production. The output of the jet pump supplies the high pressure stages. A centrifugal cleaner upstream of the power fluid inlet for the jet pump cleans that stream of particulates. The overall flow rate through the centrifugal stages exceeds the production rate of the pump by the amount of power fluid for the jet pump. The jet pump caps the assembly and can be separately removed for servicing and adapting the pump to the flow requirements of the well.

摘要翻译： 石油井具有多个离心泵级，喷射泵级和电驱动马达。 来自离心泵的高压级的输出的再循环部分为喷射泵提供动力流体，并且喷射泵从低压离心泵级吸出流体。 高压级的输出的平衡作为生产进入表面。 喷射泵的输出提供高压级。 用于喷射泵的动力流体入口上游的离心式清洁器清除该颗粒物流。 通过离心级的总流量超过泵的生产速率，用于喷射泵的动力流体的量。 喷射泵将组件盖住，可以单独拆卸，以便维修和使泵适应井的流量要求。