公开(公告)号：US4436492A

公开(公告)日：1984-03-13

申请号：US298121

申请日：1981-08-31

申请人： Daniel G. Peterson ,  John W. Erickson

发明人： Daniel G. Peterson ,  John W. Erickson

IPC分类号： F04B47/08 ,  F04B35/02

CPC分类号： F04B47/08

摘要： A surface power unit for use on a subterranean well generates a series of pulses of pressurized fluid to a downhole pump. A pump means generates a flow of fluid from a reservoir through a charging line to a charging side of a cylinder. A piston is slidably disposed within the cylinder, dividing the cylinder into the charging side and a power side. Position or pressure transducer means responsive to the movement of the piston generates control signals representing the position of the piston in the cylinder. The charging line can include a first valve means responsive to one of the control signals for regulating the flow of fluid through the charging line. A return line is provided for returning fluid from the charging side of the cylinder to the pump means. The return line includes a second valve means responsive to another one of the control signals for regulating the flow of fluid through the return line. Whenever the first valve means is closed to permit fluid to flow through the charging line into the charging side of the cylinder, the second valve means is opened to prevent fluid from escaping from the charging side of the cylinder and the piston is moved through a power stroke to generate a pressurized fluid pulse, then the first valve means is opened, and the second valve means is closed. A return pipe supplies fluid from the well to the power side of the cylinder to move the piston through a return stroke. A power line supplies the pulses of fluid generated by the movement of the piston in the cylinder to the downhole pump. In alternate embodiments, an energy storage tank is connected between the well and the return pipe; the first and second valve means can be a four-way valve; or the first valve means can be eliminated.

摘要翻译： 用于地下井的表面动力单元产生一系列加压流体脉冲到井下泵。 泵装置产生流体从储存器通过充电管线流到汽缸的充电侧。 活塞可滑动地设置在气缸内，将气缸分为充气侧和动力侧。 响应于活塞运动的位置或压力传感器装置产生表示活塞在气缸中的位置的控制信号。 充电管线可以包括响应于控制信号中的一个的第一阀装置，用于调节通过充电管线的流体的流动。 提供了一个返回线，用于将流体从气缸的充电侧返回到泵装置。 返回管线包括响应另一个控制信号的第二阀装置，用于调节通过返回管线的流体流动。 每当第一阀装置关闭以允许流体通过充气管路流入气缸的充气侧时，第二阀装置打开以防止流体从气缸的充气侧逸出并且活塞通过动力 行程以产生加压流体脉冲，然后打开第一阀装置，并且第二阀装置关闭。 回流管将液体从油井提供到气缸的动力侧，以通过返回行程移动活塞。 电力线将由气缸中的活塞的运动产生的流体的脉冲提供给井下泵。 在替代实施例中，能量储存罐连接在井和返回管之间; 第一和第二阀装置可以是四通阀; 或者可以消除第一阀装置。

公开(公告)号：US4449582A

公开(公告)日：1984-05-22

申请号：US410300

申请日：1982-08-23

申请人： Daniel G. Peterson ,  John W. Erickson ,  Horace M. Robinson

发明人： Daniel G. Peterson ,  John W. Erickson ,  Horace M. Robinson

IPC分类号： E21B43/00 ,  E21B43/12

CPC分类号： E21B43/12 ,  E21B43/00

摘要： A surface power unit for use on a subterranean well generates a series of pulses of pressurized fluid to a downhole pump. A sequencing mechanism connects and disconnects the surface power unit to each of a plurality of downhole pumps in a predetermined order such that a pulse of pressurized fluid is being applied to one or more of the plurality of downhole pumps during a power cycle while each of the other ones of the plurality of downhole pumps is completing its pumping cycle. The number of downhole pumps which can be operated from a single surface power unit is limited by the ratio of the length of the power cycle to the length of the pumping cycle of the downhole pumps. The sequencing means can include a clocking device such as a shift register which generates a sequence of enabling signals to corresponding signal amplifiers for each well. Each amplifier generates an output signal to a solenoid actuated valve having an input connected to a common surface power unit and a fluid output connected to a downhole pump in an associated well. Each of the output lines from the shift register is connected to an input of an AND gate having another input connected to a pressure transducer which senses the end of the return stroke of the surface power unit cylinder.

摘要翻译： 用于地下井的表面动力单元产生一系列加压流体脉冲到井下泵。 排序机构以预定顺序将表面动力单元连接和断开多个井下泵中的每一个，使得加压流体的脉冲在功率循环期间被施加到多个井下泵中的一个或多个， 多个井下泵中的其他一个正在完成其泵送循环。 可以从单个表面动力单元操作的井下泵的数量受到功率循环的长度与井下泵的泵送循环的长度的比率的限制。 排序装置可以包括时钟设备，例如移位寄存器，其产生用于每个阱的相应信号放大器的使能信号序列。 每个放大器产生到电磁致动阀的输出信号，其具有连接到公共表面动力单元的输入和连接到相关井中的井下泵的流体输出。 来自移位寄存器的每条输出线连接到与门相连的输入端，其另一输入端连接到感测表面动力单元气缸的返回行程结束的压力传感器。

公开(公告)号：US4425086A

公开(公告)日：1984-01-10

申请号：US298122

申请日：1981-08-31

申请人： Daniel G. Peterson ,  John W. Erickson

发明人： Daniel G. Peterson ,  John W. Erickson

IPC分类号： F04B47/08 ,  F04B53/12 ,  F04B53/14 ,  F04B35/02

CPC分类号： F04B53/142 ,  F04B47/08 ,  F04B53/126

摘要： A combined surface power unit and velocity actuated valve for a downhole pump is disclosed. The surface power unit generates a series of pulses of pressurized fluid. A power line supplies the fluid pulses to a downhole pump. Within the downhole pump, a piston means is slidably disposed for pumping fluid therefrom. The piston means includes an orifice for permitting fluid flow therethrough. The velocity of the fluid passing through the orifice causes a pressure differential across the orifice and valve means closes for the duration of each pulse. When the valve means is closed, pressure builds up in the downhole pump causing the piston means to move in a power stroke, pumping the production fluid. Between pulses, the pressure of the fluid in the downhole pump drops and a velocity valve opens. When the velocity valve is opened, fluid can flow freely therethrough, and the piston means retracts under the influence of gravity in a re-charging stroke.

摘要翻译： 公开了用于井下泵的组合表面动力单元和速度致动阀。 表面动力单元产生一系列加压流体的脉冲。 电力线将流体脉冲提供给井下泵。 在井下泵内，活塞装置可滑动地设置成用于从其中泵送流体。 活塞装置包括用于允许流体流过其中的孔口。 通过孔口的流体的速度导致孔口两端的压差，阀门装置在每个脉冲的持续时间内关闭。 当阀装置关闭时，在井下泵中产生压力，导致活塞装置在动力冲程中移动，泵送生产流体。 在脉冲之间，井下泵中的流体压力下降并且速度阀打开。 当速度阀打开时，流体可以自由地流过，活塞装置在重力作用下在重力作用下缩回。

公开(公告)号：US4425083A

公开(公告)日：1984-01-10

申请号：US298060

申请日：1981-08-31

申请人： Daniel G. Peterson ,  John W. Erickson

发明人： Daniel G. Peterson ,  John W. Erickson

IPC分类号： F04B47/08 ,  F04B53/12 ,  F04B53/14 ,  F04B47/12

CPC分类号： F04B47/08 ,  F04B53/126 ,  F04B53/142

摘要： A downhole pump for a well is disclosed which includes a piston slidably disposed within a housing for pumping fluid from the well. The longitudinal axes of the piston and the housing extend in a generally vertical direction with respect to the surface of the well. A surface unit supplies a pulsating flow of fluid to the piston. A velocity actuated valve is formed in the piston and includes a ball which is spaced from an orifice by a bias. The bias holds the ball away from the orifice such that the valve is normally open. The flow of fluid through the velocity actuated valve during each fluid pulse creates a pressure differential which is resisted by the bias. When the pressure differential exceeds the force generated by the bias, the ball will seat in the orifice and close the valve to further fluid flow. The balance of the fluid pulse will be applied to the lower side of the piston and the piston moves upwardly within the housing, thereby pumping fluid from the well. At the end of each fluid pulse, the pressure will drop such that the bias forces the ball away from the orifice. Thus, the velocity actuated valve is opened and fluid can flow freely therethrough, to permit gravity to move the piston downwardly for the next power stroke and permits production fluid to enter the housing through a traveling valve and bottom discharge valve and flow through the velocity actuated valve to the upper side of the piston.

摘要翻译： 公开了一种用于井的井下泵，其包括可滑动地设置在壳体内用于从井抽出流体的活塞。 活塞和壳体的纵向轴线相对于井的表面在大致垂直的方向上延伸。 表面单元向活塞提供脉动的流体流。 速度致动阀形成在活塞中并且包括通过偏压与孔隔开的球。 偏压使球远离孔口，使得阀门通常打开。 在每个流体脉冲期间通过速度致动阀的流体流产生由偏压抵抗的压力差。 当压力差超过偏压产生的力时，球将位于孔中并关闭阀以进一步流体流动。 流体脉冲的平衡将被施加到活塞的下侧，并且活塞在壳体内向上移动，从而从井中泵送流体。 在每个流体脉冲结束时，压力将下降，使得偏压迫使球远离孔口。 因此，速度致动阀打开并且流体可以自由地流过其中，以允许重力将活塞向下移动用于下一次动力冲程，并允许生产流体通过行进阀和底部排出阀进入壳体并流过速度致动 阀门到活塞的上侧。

公开(公告)号：US20110166061A1

公开(公告)日：2011-07-07

申请号：US12767646

申请日：2010-04-26

申请人： John W. Erickson ,  Dominique P. Bridon ,  Martin Robitaille ,  Grant A. Krafft ,  Dong Xie ,  Elena Afonina ,  Jun Liang ,  Sandra De Meyer

发明人： John W. Erickson ,  Dominique P. Bridon ,  Martin Robitaille ,  Grant A. Krafft ,  Dong Xie ,  Elena Afonina ,  Jun Liang ,  Sandra De Meyer

IPC分类号： A61K38/16 ,  C07K14/00 ,  A61P31/18

CPC分类号： C07K14/005 ,  A61K38/00 ,  C07K2319/00 ,  C12N2740/16122

摘要： The present invention is concerned with This invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.

摘要翻译： 本发明涉及作为病毒感染抑制剂和/或表现出抗融合性质的C34肽衍生物。 特别地，本发明涉及具有长期持续时间的针对人免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））具有抑制活性的C34衍生物 的治疗各自病毒感染的作用。

公开(公告)号：US07157495B2

公开(公告)日：2007-01-02

申请号：US10606342

申请日：2003-06-25

申请人： Guangyang Wang ,  Michael Eissenstat ,  John W. Erickson ,  Piet T. B. P. Wigerinck

发明人： Guangyang Wang ,  Michael Eissenstat ,  John W. Erickson ,  Piet T. B. P. Wigerinck

IPC分类号： A61K31/35

CPC分类号： C07D493/04

摘要： Compositions comprising bis-tetrahydrofuran benzodioxyolyl sulfonamide compounds that are surprisingly effective protease inhibitors and a second antiretroviral compound are disclosed. Methods of inhibiting retrovirus proteases, in particular multi-drug resistant retrovirus proteases, methods of treating or preventing infection or disease associated with retrovirus infection in a mammal, and methods of inhibiting viral replication are also disclosed.

摘要翻译： 公开了包含令人惊讶的有效蛋白酶抑制剂和第二抗逆转录病毒化合物的双 - 四氢呋喃苯并二氧基甲硅烷基磺酰胺化合物的组合物。 还公开了抑制逆转录病毒蛋白酶，特别是多药耐药逆转录病毒蛋白酶的方法，治疗或预防哺乳动物中与逆转录病毒感染相关的感染或疾病的方法，以及抑制病毒复制的方法。

公开(公告)号：US07151163B2

公开(公告)日：2006-12-19

申请号：US10833304

申请日：2004-04-28

申请人： John W. Erickson ,  Abelardo Silva

发明人： John W. Erickson ,  Abelardo Silva

IPC分类号： C07K14/165 ,  C07K17/00 ,  A61K39/215 ,  A61K39/385

CPC分类号： C07K14/005 ,  A61K38/162 ,  C12N2770/20022

摘要： The invention provides compositions and methods that are useful for preventing and treating a coronavirus infection in a subject. More specifically, the invention provides peptides and conjugates and pharmaceutical compositions containing those peptides and conjugates that block fusion of a coronavirus, such as the SARS virus, to a target cell. This blocking mechanism prevents or treats a coronavirus infection, such as a SARS infection, in a subject, such as a human subject.

摘要翻译： 本发明提供可用于预防和治疗受试者冠状病毒感染的组合物和方法。 更具体地，本发明提供了含有阻断冠状病毒例如SARS病毒融合的那些肽和缀合物的肽和缀合物和药物组合物与靶细胞。 这种阻断机制防止或治疗诸如人受试者的受试者中的冠状病毒感染，例如SARS感染。

公开(公告)号：US07132420B2

公开(公告)日：2006-11-07

申请号：US10458873

申请日：2003-06-11

申请人： Ramnarayan S. Randad ,  John W. Erickson ,  Michael A. Eissenstat ,  Lucyna Lubkowska

发明人： Ramnarayan S. Randad ,  John W. Erickson ,  Michael A. Eissenstat ,  Lucyna Lubkowska

IPC分类号： A61K31/5375 ,  A61K31/505 ,  C07D413/12 ,  C07D239/04

CPC分类号： C07D207/27 ,  C07C235/20 ,  C07C235/50 ,  C07C237/34 ,  C07C271/20 ,  C07C271/22 ,  C07C311/29 ,  C07D211/60 ,  C07D213/30 ,  C07D215/48 ,  C07D239/10 ,  C07D277/24 ,  C07D295/215 ,  C07D307/20 ,  C07D405/12 ,  C07D417/12

摘要： The present invention provides an aspartic proteinase-inhibiting compound of the formula: wherein a, b, c, d, and e, can be the same or different and each are R7, OR7, SR7, NR7R8, NHCOR7, CO2R7, CN, NO2, NH2, N3, or a halogen, wherein R7 and R8 are independently H or an alkyl. Substituents R1 or R2 are each H or an alkyl. Substituent R3 is a straight chain or branched alkyl, alkenyl, or alkynyl substituent, or is a cycloalkyl. Substituent A is OH, NH2, or SH. Further provided are pharmaceutical compositions, which include a therapeutically effective amount of at least one of the foregoing compounds, and therapeutic methods of using the foregoing compounds.

摘要翻译： 本发明提供了下式的天冬氨酸蛋白酶抑制化合物：其中a，b，c，d和e可以相同或不同，分别为R 7，或7 7，7号，7号，8号，7号，7号，7号， CN，NO 2，NH 2，N 3，或卤素，其中R 1，R 2， R 7和R 8独立地是H或烷基。 取代基R 1或R 2各自为H或烷基。 取代基R 3是直链或支链烷基，烯基或炔基取代基，或是环烷基。 取代基A是OH，NH 2或SH。 还提供药物组合物，其包括治疗有效量的至少一种前述化合物，以及使用前述化合物的治疗方法。

公开(公告)号：US06613764B1

公开(公告)日：2003-09-02

申请号：US09868775

申请日：2001-09-28

申请人： Ramnarayan S. Randad ,  John W. Erickson ,  Michael A. Eissenstat ,  Lucyna Lubkowska

发明人： Ramnarayan S. Randad ,  John W. Erickson ,  Michael A. Eissenstat ,  Lucyna Lubkowska

IPC分类号： A61K315377

CPC分类号： C07D207/27 ,  C07C235/20 ,  C07C235/50 ,  C07C237/34 ,  C07C271/20 ,  C07C271/22 ,  C07C311/29 ,  C07D211/60 ,  C07D213/30 ,  C07D215/48 ,  C07D239/10 ,  C07D277/24 ,  C07D295/215 ,  C07D307/20 ,  C07D405/12 ,  C07D417/12

摘要： The present invention provides a compound of formula (I) wherein a, b, c, d, and e, are R7, OR7, SR7, NR7R8, NHCOR7, CO2R7, CN, NO2, NH2, N3, or a halogen. R7 and R8 are H or alkyl, R1 and R2 are H or alkyl, and R3 is a non-aromatic substituent. Substituent A is OH, NH2, or SH. Substituents B and B1 include amide and sulfonamide groups, which can be cyclic, acyclic, or amino acid derivatives. Alternatively, B and R′ together with the nitrogen to which they are bonded, and/or B′ and R2 together with the nitrogen to which they are bonded, define a heterocycle. The present invention further provides a pharmaceutical composition that includes a carrier and a therapeutically effective amount of at least one compound of the present invention. The present invention further provides therapeutic methods that include administering a therapeutically effective amount of at least one compound of the present invention

摘要翻译： 本发明提供式（I）化合物，其中a，b，c，d和e分别是R 7，OR 7，SR 7，NR 7 R 8，NHCOR 7，CO 2 R 7，CN，NO 2，NH 2，N 3或卤素。 R 7和R 8是H或烷基，R 1和R 2是H或烷基，R 3是非芳族取代基。 取代基A是OH，NH 2或SH。 取代基B和B1包括酰胺和磺酰胺基团，其可以是环状，非环状或氨基酸衍生物。 或者，B和R'与它们所键合的氮一起，和/或B'和R 2与它们所键合的氮一起定义杂环。 本发明还提供了包含载体和治疗有效量的至少一种本发明化合物的药物组合物。 本发明进一步提供治疗方法，其包括施用治疗有效量的至少一种本发明化合物

公开(公告)号：US5763464A

公开(公告)日：1998-06-09

申请号：US562013

申请日：1995-11-22

申请人： Ramnarayan S. Randad ,  John W. Erickson ,  Talapadi N. Bhat

发明人： Ramnarayan S. Randad ,  John W. Erickson ,  Talapadi N. Bhat

IPC分类号： C07C235/50 ,  C07C235/60 ,  C07C237/34 ,  C07C271/20 ,  C07C271/22 ,  C07D213/30 ,  C07D213/70 ,  A61K31/44

CPC分类号： C07D213/30 ,  C07C235/50 ,  C07C235/60 ,  C07C237/34 ,  C07C271/20 ,  C07C271/22

摘要： The present invention provides novel retroviral agents containing anthranilamide, substituted benzamide, amino acid, and other subunits, a pharmaceutical composition comprising such compound, and a method of using such compounds to treat retroviral infections in mammals, specifically HIV and more specifically HIV-1 and HIV-2, in humans.

摘要翻译： 本发明提供了含有邻氨基苯甲酰胺，取代苯甲酰胺，氨基酸和其他亚基的新型逆转录病毒剂，包含这种化合物的药物组合物，以及使用这些化合物治疗哺乳动物，特别是HIV和更具体地HIV-1的逆转录病毒感染的方法， HIV-2，在人类。