公开(公告)号：US20130030963A1

公开(公告)日：2013-01-31

申请号：US13192590

申请日：2011-07-28

Applicant: Christiane Cramer ,  Astrid R. Graeber ,  Ingmar Hericks ,  Michael Hoffmann ,  Jan Piechalski ,  Elena Renkewitsch ,  Andreas Schaefers ,  Dominic Schmoigl ,  Jerrold Tarbet ,  Andreas Reccius ,  Sandra Zech ,  Joachim Welte ,  Heiko Einsiedel ,  Till Oppert ,  Juergen A. Seyfried ,  Martin Osterloh ,  Jelena Wevelsiep-Djokic ,  Dietmar Kaiser ,  Alexander Fuerbach ,  Edoardo Leva ,  Peter Illg ,  Martin Walew ,  Mathias Sonnek ,  Deepak K. S. ,  Nagarathna V. ,  Sunil S. Parvatikar ,  Shree Sheshadri ,  Martin Von Der Emde ,  Martin Schorr ,  Kai-Michael Roesner

Inventor： Christiane Cramer ,  Astrid R. Graeber ,  Ingmar Hericks ,  Michael Hoffmann ,  Jan Piechalski ,  Elena Renkewitsch ,  Andreas Schaefers ,  Dominic Schmoigl ,  Jerrold Tarbet ,  Andreas Reccius ,  Sandra Zech ,  Joachim Welte ,  Heiko Einsiedel ,  Till Oppert ,  Juergen A. Seyfried ,  Martin Osterloh ,  Jelena Wevelsiep-Djokic ,  Dietmar Kaiser ,  Alexander Fuerbach ,  Edoardo Leva ,  Peter Illg ,  Martin Walew ,  Mathias Sonnek ,  Deepak K. S. ,  Nagarathna V. ,  Sunil S. Parvatikar ,  Shree Sheshadri ,  Martin Von Der Emde ,  Martin Schorr ,  Kai-Michael Roesner

IPC: G06Q40/02 ,  G06Q20/40

CPC classification number: G06Q40/02 ,  G06Q10/10

Abstract: A business object model, which reflects data that is used during a given business transaction, is utilized to generate interfaces. This business object model facilitates commercial transactions by providing consistent interfaces that are suitable for use across industries, across businesses, and across different departments within a business during a business transaction. In some operations, software creates, updates, or otherwise processes information related to a financial plan, a financials notification, a bank directory entry file and/or a direct debit mandate business object.

Abstract translation: 用于反映在给定业务事务期间使用的数据的业务对象模型被用于生成接口。 该业务对象模型通过提供一致的接口来促进商业交易，该接口适合于在业务交易期间跨业务，跨企业以及业务中的不同部门使用。 在一些操作中，软件创建，更新或以其他方式处理与财务计划，财务通知，银行目录录入文件和/或直接付款授权业务对象相关的信息。

公开(公告)号：US20130005758A1

公开(公告)日：2013-01-03

申请号：US13529857

申请日：2012-06-21

Applicant: Erika Hoffmann ,  Michael Hoffmann ,  Roland Horres ,  Sabine Küsters

Inventor： Erika Hoffmann ,  Michael Hoffmann ,  Roland Horres ,  Sabine Küsters

IPC: A61K31/439 ,  B05D5/00 ,  A61P31/10 ,  A61P37/08 ,  A61P29/00

CPC classification number: A61L29/16 ,  A61F2/95 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/426 ,  A61L2300/80 ,  A61M25/1029 ,  A61M2025/1031 ,  A61M2025/1075

Abstract: The invention relates to stents and catheter balloons having optimized coatings for eluting rapamycin as well as methods for manufacturing these coatings.

Abstract translation: 本发明涉及具有用于洗脱雷帕霉素的优化涂层的支架和导管球囊以及制造这些涂层的方法。

公开(公告)号：US20120316496A1

公开(公告)日：2012-12-13

申请号：US13500875

申请日：2010-10-16

Applicant: Michael Hoffmann ,  Erika Hoffmann ,  Roland Horres

Inventor： Michael Hoffmann ,  Erika Hoffmann ,  Roland Horres

IPC: A61M25/10

CPC classification number: A61L29/085 ,  A61L29/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/606 ,  A61L2300/802

Abstract: The present invention is related to dilatable medical products having short-term contact with the organism, as e.g. balloon catheters coated with at least one layer of at least one antiproliferative, immunosuppressive, anti-angiogenic, anti-inflammatory, fungicidal and/or anti-thrombotic agent and a transport mediator or a mixture of transport mediators, methods for coating of these coated dilatable medical products and the use of compositions for this coating.

Abstract translation: 本发明涉及与生物短期接触的可扩张医疗产品，例如， 涂覆有至少一层至少一种抗增殖，免疫抑制，抗血管生成，抗炎，杀真菌和/或抗血栓形成剂的运送介质或运输介质的混合物的球囊导管，这些涂覆的可扩张的 医疗产品和用于该涂层的组合物。

公开(公告)号：US07915042B2

公开(公告)日：2011-03-29

申请号：US12392221

申请日：2009-02-25

Applicant: Allen R. Comer ,  Michael Hoffmann ,  B. Lynn Allen-Hoffmann

Inventor： Allen R. Comer ,  Michael Hoffmann ,  B. Lynn Allen-Hoffmann

IPC: C12N5/08 ,  A01N43/04 ,  C12N5/00 ,  A01N63/00 ,  C07H21/02

CPC classification number: C07K14/52 ,  A61K35/12 ,  C07K14/515 ,  C12N5/0698 ,  C12N2501/165 ,  C12N2501/17 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2502/99

Abstract: The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1 or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.

Abstract translation: 本发明涉及体外培养的皮肤组织，特别涉及包含编码血管生成生长因子的外源基因的培养的皮肤组织。 在一些实施方案中，角质形成细胞表达外源血管生成素-1或VEGF家族的成员，优选VEGF-A。 在特别优选的实施方案中，将角质细胞掺入培养的皮肤组织中。

公开(公告)号：US07897120B2

公开(公告)日：2011-03-01

申请号：US11909494

申请日：2006-03-23

Applicant: Michael Hoffmann ,  Renzo Nardini

Inventor： Michael Hoffmann ,  Renzo Nardini

IPC: B01J8/06 ,  B01J8/00

CPC classification number: B01J8/0035 ,  B01J8/002 ,  B01J8/003 ,  B01J8/06 ,  B01J2208/00752

Abstract: A charging device for a tube reactor has a plurality of metering chambers which can be filled with filling material, for example a catalytically coated carrier material. Each metering chamber is adjoined by a drop tube or some other filling device via which a tube of the filling device can be filled in each case. The metering chambers can each be filled via antechambers which are combined into one replaceable antechamber unit.

Abstract translation: 用于管式反应器的充电装置具有多个计量室，其可填充填充材料，例如催化涂覆的载体材料。 每个计量室通过下落管或一些其它填充装置邻接，通过该装置可以在每种情况下填充装置的管。 每个计量室可以通过组合成一个可替换的前室单元的前厅来填充。

公开(公告)号：US20100153295A1

公开(公告)日：2010-06-17

申请号：US12711417

申请日：2010-02-24

Applicant: J. Craig Cleaveland ,  Michael Hoffmann

Inventor： J. Craig Cleaveland ,  Michael Hoffmann

IPC: G06F17/00 ,  G06Q40/00 ,  G06Q10/00

CPC classification number: G06Q10/04 ,  G06Q10/067

Abstract: Software is disclosed that creates a way of controlling alterations to cell contents of a data flow network so they can easily be turned on and off as separate layers. These layers can then be grouped as scenarios. Scenarios allow different layers of formula changes to be easily added and removed from the model.

Abstract translation: 公开了一种软件，其创建了控制数据流网络的小区内容的改变的方式，使得它们可以容易地作为单独的层被打开和关闭。 然后可以将这些层分组为场景。 方案允许不同层次的公式更改从模型中轻松添加和删除。

公开(公告)号：US20090302729A1

公开(公告)日：2009-12-10

申请号：US12482301

申请日：2009-06-10

Applicant: Joerg Amelung ,  Christian Kirchhof ,  Jan Hesse ,  Michael Hoffmann

Inventor： Joerg Amelung ,  Christian Kirchhof ,  Jan Hesse ,  Michael Hoffmann

IPC: H01L51/52 ,  H01L21/02

CPC classification number: H01L51/5203 ,  F21S2/005 ,  F21Y2105/00 ,  F21Y2115/15 ,  H01L27/3202 ,  H01L27/3204 ,  H01L27/3293 ,  H01L51/5209 ,  H01L51/5212 ,  H01L51/5228 ,  H01L2251/5361

Abstract: A flat lighting device includes a layer arrangement, anode and cathode contact regions. The layer arrangement includes an anode layer, a cathode layer, and an organic light-emitting layer arranged between the anode and cathode layers, the layer arrangement having a flat shape which is laterally bounded by an edge region. The anode contact regions contact the anode layer and are implemented along the edge region. The cathode contact regions contact the cathode layer and are implemented along the edge region. The flat shape has a rotational invariance toward rotation by discrete angles. The anode and cathode contact regions may be contacted from one side of the flat shape of the layer arrangement and are arranged to be laterally distributed over the edge region such that the lateral distribution of the anode and cathode contact regions is maintained upon rotation of the layer arrangement by the discrete angles.

Abstract translation: 平面照明装置包括层布置，阳极和阴极接触区域。 层布置包括阳极层，阴极层和布置在阳极和阴极层之间的有机发光层，该层布置具有由边缘区域侧向限定的平坦形状。 阳极接触区域接触阳极层并沿着边缘区域实现。 阴极接触区域与阴极层接触并沿边缘区域实现。 扁平形状具有以离散角度旋转的旋转不变性。 阳极和阴极接触区域可以从层布置的平面形状的一侧接触并且布置成横向分布在边缘区域上，使得阳极和阴极接触区域的横向分布在层的旋转时保持 以离散角度排列。

公开(公告)号：US20090285736A1

公开(公告)日：2009-11-19

申请号：US12465141

申请日：2009-05-13

Applicant: Adolf SCHAFER-SINDLINGER ,  Marcus Pfeifer ,  Ulrich Hackbarth ,  Wilfried Muller ,  Egbert Lox ,  Thomas Kreuzer ,  Roger Staab ,  Michael Hoffmann ,  Jurgen Gieshoff

Inventor： Adolf SCHAFER-SINDLINGER ,  Marcus Pfeifer ,  Ulrich Hackbarth ,  Wilfried Muller ,  Egbert Lox ,  Thomas Kreuzer ,  Roger Staab ,  Michael Hoffmann ,  Jurgen Gieshoff

IPC: B01D53/94 ,  B01D50/00

CPC classification number: B01J23/6562 ,  B01D53/944 ,  B01D2255/102 ,  B01D2255/202 ,  B01D2255/204 ,  B01D2255/206 ,  B01D2255/50 ,  B01D2255/908 ,  B01D2257/502 ,  B01D2257/702 ,  B01J23/56 ,  F01N3/0222 ,  F01N3/0253 ,  F01N3/035 ,  F01N2430/085 ,  F01N2510/065 ,  F01N2570/12 ,  F01N2570/16 ,  F02B3/06 ,  F02D41/024 ,  F02D41/025 ,  F02D41/029 ,  F02D41/405 ,  Y02A50/2341 ,  Y02T10/26 ,  Y02T10/44

Abstract: The invention provides a process for reducing the amounts of carbon monoxide, hydrocarbons and soot particles in the lean exhaust gas from an internal combustion engine using a particle filter, wherein the soot particles have a soot ignition temperature TZ and the particle filter is regenerated from time to time by raising the temperature of the particle filter to above the soot ignition temperature and burning the soot particles, wherein the temperature of the filter is increased to the temperature required to initiate soot ignition by burning additional fuel on the catalytic coating when the exhaust gas back pressure reaches a predetermined value. The process is characterised in that the particle filter is provided with a catalytic coating comprising a first group of components for reducing the ignition temperature of soot, said first group of components contains at least one oxygen storage component and at least one platinum group metal selected from the group consisting of platinum, palladium and rhodium. In a preferred embodiment of the process the catalytic coating further comprises a second group of components for oxidising carbon monoxide and hydrocarbons, said second group of components comprises at least a support material selected from the group consisting of aluminium oxide, silicon oxide, titanium oxide, zirconium oxide and zeolite and at least one platinum group metal selected from the group consisting of platinum, palladium and rhodium deposited on said support materials.

Abstract translation: 本发明提供了一种减少来自使用颗粒过滤器的内燃机的贫废气中的一氧化碳，碳氢化合物和烟灰颗粒的量的方法，其中烟灰颗粒具有烟灰着火温度TZ，并且颗粒过滤器从时间再生 通过将颗粒过滤器的温度升高到烟炱点燃温度以上并燃烧烟灰颗粒，其中过滤器的温度通过在催化涂层上燃烧附加燃料而增加到启动烟灰点火所需的温度 背压达到预定值。 该方法的特征在于，颗粒过滤器设置有包含用于降低烟灰的点燃温度的第一组成分的催化涂层，所述第一组组分含有至少一种储氧组分和至少一种选自以下的铂族金属： 由铂，钯和铑组成的组。 在该方法的优选实施方案中，催化涂层还包含用于氧化一氧化碳和烃的第二组组分，所述第二组组分至少包含选自氧化铝，氧化硅，氧化钛， 氧化锆和沸石以及选自沉积在所述载体材料上的铂，钯和铑中的至少一种铂族金属。

公开(公告)号：US07516737B2

公开(公告)日：2009-04-14

申请号：US12006712

申请日：2008-01-05

Applicant: Victor Cerabone ,  Harald Gieb ,  Michael Hoffmann ,  Walter Kerschbaum ,  Eberhard Schneider ,  Gotz von Esebeck

Inventor： Victor Cerabone ,  Harald Gieb ,  Michael Hoffmann ,  Walter Kerschbaum ,  Eberhard Schneider ,  Gotz von Esebeck

IPC: F02B47/08 ,  F02M25/07

CPC classification number: F01P3/12 ,  F02M26/25 ,  F02M26/28 ,  F02M26/30 ,  F02M26/32

Abstract: In an internal combustion engine with a cooling system and an exhaust gas recirculation (EGR) system including an EGR heat exchanger with a coolant inlet opening connected to a coolant outlet opening of the engine for receiving coolant therefrom and the engine including a coolant collecting rail mounted directly to the engine and having a coolant inlet opening connected to the EGR heat exchanger and at least one other coolant inlet opening in communication directly with at least one other coolant outlet opening of the engine.

Abstract translation: 在具有冷却系统和废气再循环（EGR）系统的内燃机中，该内燃机系统包括具有连接到发动机的冷却剂出口开口的冷却剂入口的EGR热交换器，用于从其中接收冷却剂，并且该发动机包括安装 直接连接到发动机并且具有连接到EGR热交换器的冷却剂入口和与发动机的至少一个其它冷却剂出口开口直接连通的至少一个其它冷却剂入口。

公开(公告)号：US07407805B2

公开(公告)日：2008-08-05

申请号：US11235814

申请日：2005-09-27

Applicant: Allen Comer ,  Lynn Allen-Hoffmann ,  Michael Hoffmann

Inventor： Allen Comer ,  Lynn Allen-Hoffmann ,  Michael Hoffmann

IPC: A61K35/36 ,  C12N5/08 ,  C12N5/02 ,  C12N5/00

CPC classification number: C12N5/0698 ,  C12N2500/36 ,  C12N2500/38 ,  C12N2500/90 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/13 ,  C12N2501/385 ,  C12N2501/39 ,  C12N2501/60 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2510/00 ,  C12N2533/54

Abstract: The present invention relates to in vitro cultured skin substitutes, and in particular to in vitro cultured skin substitutes that have improved barrier function. In some embodiments, improved barrier function is a result of improved culture conditions, while in other embodiments, improved barrier function results from genetic modification of keratinocytes. Improved culture conditions to improve barrier function include organotypic culture in the presence of linoleic acid and/or linoleic acid at about 75% humidity. Suitable genetic modifications for improving barrier function includes transfection with a DNA construct capable of expressing GKLF.

Abstract translation: 本发明涉及体外培养的皮肤替代物，特别涉及具有改善的屏障功能的体外培养的皮肤代用品。 在一些实施方案中，改进的屏障功能是改善的培养条件的结果，而在其它实施方案中，角质形成细胞的遗传修饰改善的屏障功能结果。 提高屏障功能的改善的培养条件包括在约75％湿度下亚油酸和/或亚油酸存在下的器官培养。 用于改善屏障功能的合适的遗传修饰包括用能够表达GKLF的DNA构建体的转染。