公开(公告)号：US07289690B2

公开(公告)日：2007-10-30

申请号：US11107098

申请日：2005-04-15

申请人： Zhiyong Li ,  Raymond G. Beausoleil ,  Philip J. Kuekes ,  Shih-Yuan Wang ,  M. Saif Islam

发明人： Zhiyong Li ,  Raymond G. Beausoleil ,  Philip J. Kuekes ,  Shih-Yuan Wang ,  M. Saif Islam

IPC分类号： G02B6/00

CPC分类号： G02B6/1225 ,  B82Y20/00 ,  G02B2006/1215

摘要： An apparatus for sensing at least one property of a fluid is described. A first photonic crystal structure and a second photonic crystal structure are defined in a dielectric slab. The first and second photonic crystal structures comprise differently patterned arrays of channels extending through the dielectric slab. The apparatus further comprises a fluid introduction device configured to introduce a common volume of the fluid into the channels of the first and second photonic crystal structures. The at least one property of the fluid can be sensed by measuring the propagation of radiation through the first and second photonic crystal structures.

摘要翻译： 描述了用于感测流体的至少一个性质的装置。 在介质板中限定第一光子晶体结构和第二光子晶体结构。 第一和第二光子晶体结构包括延伸穿过电介质板的不同图案的通道阵列。 该装置还包括流体引入装置，其构造成将共同体积的流体引入第一和第二光子晶体结构的通道中。 可以通过测量通过第一和第二光子晶体结构的辐射的传播来感测流体的至少一个性质。

公开(公告)号：US20070165214A1

公开(公告)日：2007-07-19

申请号：US11257073

申请日：2006-01-17

申请人： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang

发明人： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wang

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01J3/44 ,  G01J3/02 ,  G01J3/0227 ,  G01J3/0256 ,  G01J3/18 ,  G01N21/65 ,  G01N21/658 ,  G02B5/1809

摘要： A Raman spectroscopy system is disclosed which includes a sub-wavelength resonant grating filter and a photodiode with integrated sub-wavelength resonant grating filter are disclosed. The resonant grating filter comprises an array of diffraction elements having a periodic spacing that is less than the wavelength of radiation to be filtered and which are formed over a waveguide layer. The filter, which can reject a specific wavelength of radiation, can be placed between a Raman sample and a Raman detector in order to filter radiation that is elastically scattered from the sample while transmitting other wavelengths. The wavelength rejected by the filter can be selected by tilting the filter with respect to the radiation incident upon the filter.

摘要翻译： 公开了一种拉曼光谱系统，其包括亚波长谐振光栅滤波器和具有集成子波长谐振光栅滤波器的光电二极管。 谐振光栅滤波器包括衍射元件的阵列，其具有小于待滤波的辐射的波长并且在波导层上形成的周期间隔。 可以将能够抑制特定波长的辐射的滤光器放置在拉曼样品和拉曼检测器之间，以便过滤从样品弹性散射的辐射，同时传输其他波长。 可以通过使过滤器相对于入射到过滤器上的辐射倾斜来选择由过滤器拒绝的波长。

公开(公告)号：US20070086001A1

公开(公告)日：2007-04-19

申请号：US11252134

申请日：2005-10-17

申请人： M. Islam ,  Shih-Yuan Wang ,  R. Williams ,  Philip Kuekes ,  Wei Wu ,  Zhiyong Li

发明人： M. Islam ,  Shih-Yuan Wang ,  R. Williams ,  Philip Kuekes ,  Wei Wu ,  Zhiyong Li

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01N21/658

摘要： A NERS-active structure includes a deformable, active nanoparticle support structure for supporting a first nanoparticle and a second nanoparticle that is disposed proximate the first nanoparticle. The nanoparticles each comprise a NERS-active material. The deformable, active nanoparticle support structure is configured to vary the distance between the first nanoparticle and the second nanoparticle while performing NERS. Various active nanoparticle support structures are disclosed. A NERS system includes such a NERS-active structure, a radiation source for generating radiation scatterable by an analyte located proximate the NERS-active structure, and a radiation detector for detecting Raman scattered radiation scattered by the analyte. A method for performing NERS includes providing such a NERS-active structure, providing an analyte at a location proximate the NERS-active structure, irradiating the NERS-active structure and the analyte with radiation, varying the distance between the nanoparticles, and detecting Raman scattered radiation scattered by the analyte.

摘要翻译： NERS活性结构包括用于支撑第一纳米颗粒的可变形的活性纳米颗粒支撑结构和邻近第一纳米颗粒设置的第二纳米颗粒。 纳米颗粒各自包含NERS-活性材料。 可变形的活性纳米颗粒支撑结构被配置为在执行NERS的同时改变第一纳米颗粒和第二纳米颗粒之间的距离。 公开了各种活性纳米颗粒载体结构。 NERS系统包括这样的NERS-活性结构，用于产生由位于NERS-活性结构附近的分析物可散射的辐射的辐射源，以及用于检测被分析物散射的拉曼散射辐射的辐射检测器。 执行NERS的方法包括提供这样的NERS活性结构，在靠近NERS-活性结构的位置提供分析物，用辐射照射NERS-活性结构和分析物，改变纳米颗粒之间的距离并检测拉曼散射 被分析物散射的辐射。

公开(公告)号：US07151599B2

公开(公告)日：2006-12-19

申请号：US11044421

申请日：2005-01-27

申请人： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

发明人： M. Saif Islam ,  Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li ,  R. Stanley Williams

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01N21/658 ,  G01N2201/0873

摘要： Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed in a waveguide. The molecular analysis device also includes a wavelength demultiplexer and radiation sensors disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.

摘要翻译： 公开了用于增强拉曼光谱和超拉曼的装置，系统和方法。 用于执行拉曼光谱的分子分析装置包括设置在基板上的基板和激光源。 激光源可以被配置为发射激光辐射，其可照射设置在拉曼增强结构上的分析物。 拉曼增强结构可以设置在波导中。 该分子分析装置还包括布置在基板上的波长解复用器和辐射传感器，并且被配置为用于接收可以通过分析物的照射和拉曼增强结构产生的拉曼散射辐射。

公开(公告)号：US20060275911A1

公开(公告)日：2006-12-07

申请号：US11145038

申请日：2005-06-03

申请人： Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li

发明人： Shih-Yuan Wang ,  Wei Wu ,  Zhiyong Li

IPC分类号： G01N33/00

CPC分类号： G01N21/658 ,  B01L3/5027 ,  B01L2200/0663 ,  B82Y15/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N33/48707 ,  Y10T436/17 ,  C12Q2565/632 ,  C12Q2565/631

摘要： Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device includes a molecule sensor and a molecule guide. The molecule sensor comprises a nanostructure, which is configured for producing a nanostructure-enhanced Raman scattered radiation when an excitation radiation irradiates at least a portion of a molecule disposed near the NERS structure.

摘要翻译： 公开了用于检测生物聚合物的组成部分的装置和方法。 分子分析装置包括分子传感器和分子指导。 分子传感器包括纳米结构，其被配置为当激发辐射照射设置在NERS结构附近的分子的至少一部分时产生纳米结构增强的拉曼散射辐射。

公开(公告)号：US20060056463A1

公开(公告)日：2006-03-16

申请号：US10942004

申请日：2004-09-14

申请人： Shih-Yuan Wang ,  M. Islam ,  Zhiyong Li

发明人： Shih-Yuan Wang ,  M. Islam ,  Zhiyong Li

IPC分类号： H01S3/30

CPC分类号： G01N21/658 ,  G01J3/10 ,  G01N21/774 ,  H01S3/1086 ,  H01S3/169 ,  H01S5/026 ,  H01S5/1021 ,  H01S5/183 ,  H01S5/423

摘要： Integrated radiation source/amplifying structures for use in surface enhanced Raman spectroscopy (SERS) and hyper-SERS are disclosed. The structures include a radiation source integrated with a SERS-active structure that is provided within a resonant cavity. SERS and hyper-SERS systems employing the integrated radiation source/amplifying structures are disclosed. Methods of performing SERS and hyper-SERS are also disclosed.

摘要翻译： 公开了用于表面增强拉曼光谱（SERS）和超SERS的集成放射源/放大结构。 该结构包括与设置在谐振腔内的SERS-活性结构集成的辐射源。 公开了采用集成放射源/放大结构的SERS和超SERS系统。 还公开了执行SERS和超SERS的方法。

公开(公告)号：US20060054881A1

公开(公告)日：2006-03-16

申请号：US10942693

申请日：2004-09-16

申请人： Zhiyong Li ,  Shih-Yuan Wang

发明人： Zhiyong Li ,  Shih-Yuan Wang

IPC分类号： H01L29/06 ,  H01L31/0328

CPC分类号： G01N21/658 ,  B82Y30/00

摘要： A SERS-active structure is disclosed that includes a substrate and at least one nanowire disposed on the substrate. The at least one nanowire includes a core including a first material and a coating including a SERS-active material. A SERS system is also disclosed that includes a SERS-active structure. Also disclosed are methods for forming a SERS-active structure and methods for performing SERS with SERS-active structures.

摘要翻译： 公开了一种SERS-活性结构，其包括衬底和设置在衬底上的至少一个纳米线。 所述至少一个纳米线包括包含第一材料和包含SERS-活性材料的涂层的芯。 还公开了包括SERS活性结构的SERS系统。 还公开了形成SERS活性结构的方法和用SERS活性结构进行SERS的方法。

公开(公告)号：US09212997B2

公开(公告)日：2015-12-15

申请号：US14405334

申请日：2012-07-29

申请人： Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven Barcelo ,  Zhang-Lin Zhou

发明人： Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven Barcelo ,  Zhang-Lin Zhou

IPC分类号： G01J3/44 ,  G01N21/65 ,  B82Y15/00

CPC分类号： G01N21/658 ,  B82Y15/00 ,  G01J3/4412 ,  G01N2021/651 ,  G01N2201/06113 ,  Y10S977/902

摘要： A scattering spectroscopy nanosensor includes a nanoscale-patterned sensing substrate to produce an optical scattering response signal indicative of a presence of an analyte when interrogated by an optical stimulus. The scattering spectroscopy nanosensor further includes a protective covering to cover and protect the nanoscale-patterned sensing substrate. The protective covering is to be selectably removed by exposure to an optical beam incident on the protective covering. The protective covering is to prevent the analyte from interacting with the nanoscale-patterned sensing substrate prior to being removed.

摘要翻译： 散射光谱纳米传感器包括纳米级图案化的感测衬底，以产生指示当通过光学刺激询问的分析物存在时的光学散射响应信号。 散射光谱纳米传感器还包括覆盖并保护纳米级图案化感测基板的保护覆盖层。 通过暴露在入射到保护罩上的光束可选地去除保护罩。 保护性覆盖物是在去除之前防止分析物与纳米级图案化的感测基板相互作用。

公开(公告)号：US08547549B2

公开(公告)日：2013-10-01

申请号：US13129571

申请日：2008-11-17

申请人： Huei Pei Kuo ,  Jing Tang ,  Fung Suong Ou ,  Zhiyong Li ,  Shih-Yuan Wang

发明人： Huei Pei Kuo ,  Jing Tang ,  Fung Suong Ou ,  Zhiyong Li ,  Shih-Yuan Wang

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： B82Y20/00 ,  G01N21/658

摘要： A substrate for Surface Enhanced Raman Scattering (SERS). The substrate comprises at least one nanostructure protruding from a surface of the substrate and a SERS active metal over the at least one nanostructure, wherein the SERS active metal substantially covers the at least one nanostructure and the SERS active metal creates a textured layer on the at least one nanostructure.

摘要翻译： 用于表面增强拉曼散射的衬底（SERS）。 衬底包括从衬底的表面突出的至少一个纳米结构和在至少一个纳米结构上的SERS活性金属，其中SERS活性金属基本上覆盖至少一个纳米结构，并且SERS活性金属在其上形成纹理化层 至少一个纳米结构。

公开(公告)号：US20120300202A1

公开(公告)日：2012-11-29

申请号：US13383385

申请日：2009-07-22

申请人： David A. Fattal ,  Jingjing Li ,  Zhiyong Li ,  Shih-Yuan Wang

发明人： David A. Fattal ,  Jingjing Li ,  Zhiyong Li ,  Shih-Yuan Wang

IPC分类号： G01J3/44 ,  B82Y15/00

CPC分类号： G01N21/658

摘要： An autonomous light amplifying device for surface enhanced Raman spectroscopy includes a dielectric layer, at least one laser cavity defined by at least one light confining mechanism formed in the dielectric layer, at least one nano-antenna established on the dielectric layer in proximity to the at least one laser cavity, and a gain region positioned in the dielectric layer or adjacent to the dielectric layer.

摘要翻译： 用于表面增强拉曼光谱的自主光放大装置包括电介质层，至少一个激光腔，其由形成在电介质层中的至少一个限光机构限定，至少一个在电介质层上建立的纳米天线邻近于 至少一个激光腔，以及位于所述介电层中或与所述电介质层相邻的增益区。