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公开(公告)号：US06914047B2
公开(公告)日：2005-07-05
申请号：US10004860
申请日：2001-12-07
申请人： Steven M. Ruben , Craig A. Rosen , Paul A. Moore
发明人： Steven M. Ruben , Craig A. Rosen , Paul A. Moore
CPC分类号： G01N33/68 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N15/11 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US06605441B1
公开(公告)日：2003-08-12
申请号：US09572406
申请日：2000-05-16
IPC分类号： G01N3353
CPC分类号： C07K16/22 , A61K38/00 , C07K14/50 , C07K2317/24 , C07K2317/622
摘要： The present invention relates to a novel human protein called Fibroblast Growth Factor 11, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
摘要翻译： 本发明涉及称为成纤维细胞生长因子11的新型人类蛋白质和编码该蛋白质的分离的多核苷酸。 还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。
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公开(公告)号：US06410701B1
公开(公告)日：2002-06-25
申请号：US08462509
申请日：1995-06-05
申请人： Daniel R. Soppet , Yi Li , Craig A. Rosen
发明人： Daniel R. Soppet , Yi Li , Craig A. Rosen
IPC分类号： C07H2102
CPC分类号： C07K14/70571 , A61K38/00 , C07K16/286 , C12N2799/026 , C12N2799/027 , G01N2333/70571 , G01N2333/726 , G01N2500/10
摘要： Human neuropeptide receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the neuropeptide receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the neuropeptide receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
摘要翻译： 公开了人类神经肽受体多肽和编码这些多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与神经肽受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测神经肽受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。
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公开(公告)号：US20080261252A1
公开(公告)日：2008-10-23
申请号：US12136927
申请日：2008-06-11
CPC分类号： C07H21/04 , C07K14/7155
摘要： The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein. IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are further provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
摘要翻译： 本发明涉及作为Ig超家族成员的新型可溶性IL-1受体辅助分子（IL-1RACM）蛋白质。 特别地，提供编码人IL-1R AcM蛋白的分离的核酸分子。 还提供IL-1R AcM多肽，载体，宿主细胞和用于制备它们的重组方法。 还提供筛选方法用于鉴定IL-1信号转导的激动剂和拮抗剂。 本发明还涉及用IL-1R AcM拮抗剂治疗生理和病理疾病状况的方法。
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公开(公告)号：US06346246B1
公开(公告)日：2002-02-12
申请号：US09333033
申请日：1999-06-15
IPC分类号： A61K39395
CPC分类号： C07K14/475 , A61K38/00
摘要： Disclosed is human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and the use of such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations is also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.
摘要翻译： 公开了人类造血成熟因子多肽和编码这种造血成熟因子多肽的DNA（RNA）。 还提供了通过重组技术产生此类多肽的方法以及使用这些多肽来治疗白血病，自身免疫疾病和血液相关病症。 还公开了抗这些多肽的拮抗剂及其作为预防T细胞群扩增的治疗剂的用途。 还公开了诊断测定法，其检测造血成熟因子核酸序列中突变的存在和蛋白质的改变水平。
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公开(公告)号：US07482326B2
公开(公告)日：2009-01-27
申请号：US11272757
申请日：2005-11-15
IPC分类号： C07K14/435 , C07K14/475 , C07K14/52 , C07K14/00 , A61K38/16 , A61K38/17 , A61K38/18 , A61K38/19
CPC分类号： C07K14/52
摘要： A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译： 公开了编码这种多肽的人类EMAP III多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽预防和/或治疗瘤形成的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。
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公开(公告)号：US07390880B2
公开(公告)日：2008-06-24
申请号：US11066006
申请日：2005-02-25
CPC分类号： C07H21/04 , C07K14/7155
摘要： The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein. IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are futher provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
摘要翻译： 本发明涉及作为Ig超家族成员的新型可溶性IL-1受体辅助分子（IL-1RACM）蛋白质。 特别地，提供编码人IL-1R AcM蛋白的分离的核酸分子。 还提供IL-1R AcM多肽，载体，宿主细胞和用于制备它们的重组方法。 提供筛选方法用于鉴定IL-1信号转导的激动剂和拮抗剂。 本发明还涉及用IL-1R AcM拮抗剂治疗生理和病理疾病状况的方法。
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公开(公告)号：US06974682B1
公开(公告)日：2005-12-13
申请号：US08917710
申请日：1997-08-26
CPC分类号： C07H21/04 , C07K14/7155
摘要： The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are further provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
摘要翻译： 本发明涉及作为Ig超家族成员的新型可溶性IL-1受体辅助分子（IL-1RACM）蛋白质。 特别地，提供编码人IL-1R AcM蛋白的分离的核酸分子IL-1R也提供了如用于制备它们的载体，宿主细胞和重组方法的AcM多肽。 还提供筛选方法用于鉴定IL-1信号转导的激动剂和拮抗剂。 本发明还涉及用IL-1R AcM拮抗剂治疗生理和病理疾病状况的方法。
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公开(公告)号：US20090029914A1
公开(公告)日：2009-01-29
申请号：US11759843
申请日：2007-06-07
申请人： Craig A. Rosen , Adam Bell , David W. LaFleur , Douglas B. Woods , Ping Feng , Rodger G. Smith , Baiqin Teng
发明人： Craig A. Rosen , Adam Bell , David W. LaFleur , Douglas B. Woods , Ping Feng , Rodger G. Smith , Baiqin Teng
CPC分类号： C12N9/96 , A61K38/00 , C07K14/765 , C07K2319/00 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译： 本发明包括白蛋白融合蛋白。 编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法 酸，载体和/或宿主细胞。 另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。
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公开(公告)号：US08334365B2
公开(公告)日：2012-12-18
申请号：US11759843
申请日：2007-06-07
申请人： Craig A. Rosen , David W. LaFleur
发明人： Craig A. Rosen , David W. LaFleur
CPC分类号： C12N9/96 , A61K38/00 , C07K14/765 , C07K2319/00 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
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