摘要:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
摘要:
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
摘要:
By mounting the shower-head device on the ceiling, the spray from the shower-heads is in a downward direction from above the bather(s) taking the shower, as opposed to spraying at the bather(s) in a sideways or angular direction from the wall. The center shower-head is positioned near the middle of the shower ceiling so it can imitate natural rainfall directly above the bather(s). The other two (2) shower-heads are positioned approximately one (1) foot to one and a half (1.5) feet on either side of the center shower-head and angled toward the center so that the spray is hitting the bather(s) from two (2) sides, either front/rear or left/right depending on how the device is installed or how the bather is standing. All three shower-heads may be replaced and/or interchanged with any commercially available shower-head(s) therefore NO CLAIM is made with respect to the three shower-heads (5a, 5b, 5c) attached to the SuperShower device. No Claims are made with respect to the elbow fitting (1) shown in the drawing as this is just one of many ways the device may be connected to the existing water supply. No claims are made with respect to the flexible hose (2) shown in the drawing as there are many types of such hose available commercially. Chrome or stainless steel hoses are preferred, but vinyl, plastic or even rubber flexible hoses can be used. Lastly, no claims are made with respect to the clips (4) shown in the drawing as there are a wide variety of clips available commercially that will permit attachment of the device to the ceiling.
摘要:
A system and method for providing access and/or roaming features on a network system. The network system includes a plurality of wireless and/or wired access points coupled to a network. Access points (APs) for the network may be widely distributed in various facilities, such as airports, mass-transit stations, and various businesses. The network may couple to a wide area network, such as the Internet. In one embodiment, a portable computing device (PCD) of a user may store identification information which uniquely indicates a network provider of a plurality of possible network providers. The identification information may also or instead indicate an access or privilege level of the user. Each of the access points are operable to “listen for” or detect identification information associated with numerous different providers. When the access point receives the identification information from a PCD of a user, the access point may determine the appropriate network provider for the portable computing device using the identification information. Network access may then be provided to the portable computing device through the determined network provider. Thus the network system is useable by subscribers of each of the plurality of possible network providers, thereby enabling subscribers to “roam” on various wireless networks, including networks maintained by other providers. The access information may also include an access level which indicates the user's access or privilege level. Thus, the local network may provide various local resources which are available to users having a first access level, and users with a second access level may not be entitled to view or utilize these network resources on the network, but may be simply provided external Internet access.
摘要:
This invention relates to compounds, compositions, and methods useful for modulating Stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of Stearoyl-CoA desaturase (SCD) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of Stearoyl-CoA desaturase (SCD) genes.
摘要:
The U.S. Food and Drug Administration defines the four separate components of Female Sexual Dysfunction (FSD) to be decreased sexual desire, decreased sexual arousal, dyspareunia (pain with intercourse), and persistent difficulty in achieving or inability to achieve orgasm (anorgasmia). To establish a diagnosis of FSD, these components must be associated with personal distress, as determined by the affected woman. A topical combination of menthol/L-arginine and the specific 5-PDE inhibitor vardenafil can be used to treat any of the defined components, or a combination of two or more of the defined components of FSD, as a safe, first-line therapy for FSD.
摘要:
The present invention provides a system for controlling speed of the fuel pump. The system includes a fuel pump, a controller, and a field modification module. The fuel pump is configured to receive a driving signal causing the fuel pump to pump fuel. The controller is configured to determine a desired fuel pump speed and generate a control signal based on the desired fuel pump speed. The field modification module is located proximate the fuel pump and is in communication with the controller to receive the control signal. The field modification module generates a flux in response the control signal thereby controlling speed and torque of the fuel pump.
摘要:
A transcribed non-naturally occurring RNA molecule comprising a desired 10 RNA molecule, wherein the 3+ region of the RNA is able to base-pair with at least 8 bases at the 5′ terminus of the same RNA molecule.
摘要:
This invention relates to novel chemically-modified nucleic acid molecules having specified formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using the novel chemically modified nucleic acid molecules, and compositions and cells comprising said molecules.
摘要:
This invention relates to compounds, compositions, and methods useful for modulating cyclin (e.g., cyclin D1) and/or cyclin dependent kinase (CDK) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of cyclin (e.g., cyclin D1) and/or cyclin dependent kinase (CDK) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of cyclin (e.g., cyclin D1) and/or cyclin dependent kinase (CDK) genes.