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71.发明授权Antibodies that recognize the 85P1B3 protein useful in treatment and detection of cancer 有权识别85P1B3蛋白的抗体可用于治疗和检测癌症公开(公告)号：US07217799B2
公开(公告)日：2007-05-15
申请号：US09942052
申请日：2001-08-28
申请人： Arthur B. Raitano , Mary Faris , Rene S. Hubert , Daniel E. Afar , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Mary Faris , Rene S. Hubert , Daniel E. Afar , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
CPC分类号： C07K14/47
摘要： A novel gene (designated 85P1B3) and its encoded protein are described. While 85P1B3 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 85P1B3 provides a diagnostic and/or therapeutic target for cancers. The 85P1B3 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
摘要翻译： 描述了一种新型基因（命名为85P1B3）及其编码的蛋白质。 虽然85P1B3在正常成人组织中表现出组织特异性表达，但是在多种癌症中异常表达，如表1所示。因此，85P1B3为癌症提供了诊断和/或治疗靶点。 85P1B3基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。
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72.发明授权公开(公告)号：US07172898B2
公开(公告)日：2007-02-06
申请号：US10283722
申请日：2002-10-29
申请人： Arthur B. Raitano , Daniel E. H. Afar , Gazelle S. Rastegar , Steve Chappell Mitchell , Rene S. Hubert , Pia M. Challita-Eid , Mary Faris , Aya Jakobovits
发明人： Arthur B. Raitano , Daniel E. H. Afar , Gazelle S. Rastegar , Steve Chappell Mitchell , Rene S. Hubert , Pia M. Challita-Eid , Mary Faris , Aya Jakobovits
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/3069 , C07K2317/622 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： A novel gene (designated 103P2D6) and its encoded protein are described. 103P2D6 is not expressed in normal adult tissue, but is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in prostate cancer. 103P2D6 is also expressed in some fetal tissues, and in breast, bladder, lung, bone, colon, pancreatic, testicular, cervical and ovarian cancers. Consequently, 103P2D6 provides a diagnostic and/or therapeutic target for cancers, and the 103P2D6 gene or fragment thereof, or its encoded protein or a fragment thereof can be used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为103P2D6）及其编码的蛋白质。 103P2D6在正常成人组织中不表达，但在前列腺组织异种移植物中高度表达，提供了在前列腺癌中开启的证据。 103P2D6也在一些胎儿组织，乳腺，膀胱，肺，骨，结肠，胰腺，睾丸，宫颈和卵巢癌中表达。 因此，103P2D6为癌症提供诊断和/或治疗靶标，103P2D6基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。
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73.发明授权121P1F1: a tissue specific protein highly expressed in various cancers 失效121P1F1：在各种癌症中高度表达的组织特异性蛋白公开(公告)号：US06924358B2
公开(公告)日：2005-08-02
申请号：US09799250
申请日：2001-03-05
申请人： Pia M. Challita-Eid , Rene S. Hubert , Steve Chappell Mitchell , Arthur B. Raitano , Mary Faris , Daniel E. H. Afar , Aya Jakobovits
发明人： Pia M. Challita-Eid , Rene S. Hubert , Steve Chappell Mitchell , Arthur B. Raitano , Mary Faris , Daniel E. H. Afar , Aya Jakobovits
CPC分类号： G01N33/574 , A61K38/00 , C07K14/47 , Y02A50/465 , Y02A50/473
摘要： A novel gene (designated 121P1F1) and its encoded protein are described. While 121P1F1 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including prostate, bladder, kidney, brain, bone, cervical, uterine, ovarian, breast, pancreatic, stomach, colon, rectal, leukocytic, liver and lung cancers. Consequently, 121P1F1 provides a diagnostic and/or therapeutic target for cancers, and the 121P1F1 gene or fragment thereof, or its encoded protein or a fragment thereof used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为121P1F1）及其编码的蛋白质。 121P1F1在正常成人组织中表现出组织特异性表达，但其在前列腺，膀胱，肾，脑，骨，子宫颈，子宫，卵巢，乳腺，胰腺，胃，结肠，直肠，白细胞，肝，肺等多种癌症中异常表达 癌症 因此，121P1F1提供癌症的诊断和/或治疗靶标，以及用于引发免疫应答的121P1F1基因或其片段，或其编码的蛋白质或其片段。
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74.发明授权Nucleic acids and corresponding proteins entitled 202P5A5 useful in treatment and detection of cancer 失效核酸和相应的蛋白质，名称为202P5A5，可用于治疗和检测癌症公开(公告)号：US08426571B2
公开(公告)日：2013-04-23
申请号：US13021202
申请日：2011-02-04
CPC分类号： C12N5/0693 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K47/6851 , A61K2039/505 , C07K14/435 , C07K14/47 , C07K2319/00 , G01N33/57484 , Y02A50/466
摘要： A novel gene 202P5A5 and its encoded protein, and variants thereof, are described wherein 202P5A5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 202P5A5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 202P5A5 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 202P5A5 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因202P5A5及其编码的蛋白质及其变体，其中202P5A5在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，202P5A5提供诊断，预后，预防和/ 或癌症的治疗靶标。 202P5A5基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与202P5A5反应的抗体或T细胞可用于主动或被动免疫。
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75.发明授权Reduction of cell-cell communication in prostate cancer using STEAP-1 siRNA 有权使用STEAP-1 siRNA减少前列腺癌细胞间通讯公开(公告)号：US07939503B2
公开(公告)日：2011-05-10
申请号：US10861662
申请日：2004-06-04
申请人： Aya Jakobovits , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
发明人： Aya Jakobovits , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
IPC分类号： A61K31/70
CPC分类号： C07K14/4748 , A01K67/0271 , A61K38/00 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/705 , C07K14/723 , C07K16/30 , C07K2317/34 , C07K2317/77 , C07K2319/00 , C12N9/0091 , G01N33/57484
摘要： Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
摘要翻译： 描述了结合于新型STEAP-1蛋白质的抗体和衍生自其的变体及其变体，其中STEAP-1在正常成人组织中显示组织特异性表达，并且在表I中列出的癌症中异常表达。因此，STEAP-1 提供癌症的诊断，预后，预防和/或治疗靶标。 STEAP-1基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与STEAP-1反应的抗体或T细胞可用于主动或被动免疫。
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76.发明授权Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer 有权核酸和相应的蛋白质98P4B6可用于治疗和检测癌症公开(公告)号：US07622569B2
公开(公告)日：2009-11-24
申请号：US11588203
申请日：2006-10-25
IPC分类号： C07H21/04
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/4748 , C07K16/30 , C07K16/3069 , C07K2319/00 , C07K2319/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , C12Q2600/16 , G01N33/574
摘要： A novel gene 098P4B6 (also designated STEAP-2) and its encoded protein, and variants thereof, are described wherein 98P4B6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 98P4B6 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 98P4B6 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 98P4B6 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因098P4B6（也称为STEAP-2）及其编码的蛋白及其变体，其中98P4B6在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，98P4B6提供了 诊断，预后，预防和/或治疗靶标。 98P4B6基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与98P4B6反应的抗体或T细胞可用于主动或被动免疫。
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77.发明申请NUCLEIC ACID AND CORRESPONDING PROTEIN NAMED 158P1D7 USEFUL IN THE TREATMENT AND DETECTION OF BLADDER AND OTHER CANCERS 审中-公开核酸和相关蛋白158P1D7有用于治疗和检测刀片和其他癌症公开(公告)号：US20090252728A1
公开(公告)日：2009-10-08
申请号：US12050895
申请日：2008-03-18
申请人： Aya JAKOBOVITS , Robert Kendall Morrison , Arthur B. Raitano , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen Jane Meyrick Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven B. Kanner
发明人： Aya JAKOBOVITS , Robert Kendall Morrison , Arthur B. Raitano , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen Jane Meyrick Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven B. Kanner
摘要： The invention described herein relates to novel nucleic acid sequences and their encoded proteins, referred to as 158P1D7 and variants thereof, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express 158P1D7 and variants thereof.
摘要翻译： 本文描述的本发明涉及新颖的核酸序列及其编码的蛋白质，被称为158P1D7及其变体，以及可用于治疗表达158P1D7及其变体的各种癌症的诊断和治疗方法和组合物。
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78.发明申请Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer 有权核酸和相应的标题为STEAP-1的蛋白质可用于治疗和检测癌症公开(公告)号：US20090169476A1
公开(公告)日：2009-07-02
申请号：US11581227
申请日：2006-10-12
IPC分类号： A61K39/395 , C07K16/18 , A01K67/00 , C12N5/08 , A61K31/7088 , A61K38/00 , C07K7/06 , C07H21/00 , A61K35/00 , A61P35/00 , C12Q1/68 , G01N33/53 , A61K49/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/705 , C07K14/723 , C07K16/30 , C07K2319/00 , G01N33/57484
摘要： A novel gene 08P1D4 (also designated STEAP-1) and its encoded protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
摘要翻译： 描述了新型基因08P1D4（也称为STEAP-1）及其编码的蛋白及其变体，其中STEAP-1在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，STEAP -1提供了癌症的诊断，预后，预防和/或治疗靶标。 STEAP-1基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与STEAP-1反应的抗体或T细胞可用于主动或被动免疫。
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79.发明授权公开(公告)号：US07494646B2
公开(公告)日：2009-02-24
申请号：US10830899
申请日：2004-04-23
申请人： Aya Jakobovits , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
发明人： Aya Jakobovits , Soudabeh Etessami , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen J. Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur B. Raitano
IPC分类号： A61K48/00
CPC分类号： C07K14/4748 , A01K67/0271 , A61K38/00 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/705 , C07K14/723 , C07K16/30 , C07K2317/34 , C07K2317/77 , C07K2319/00 , C12N9/0091 , G01N33/57484
摘要： Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
摘要翻译： 描述了结合于新型STEAP-1蛋白质的抗体和衍生自其的变体及其变体，其中STEAP-1在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，STEAP-1 提供癌症的诊断，预后，预防和/或治疗靶标。 STEAP-1基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与STEAP-1反应的抗体或T细胞可用于主动或被动免疫。
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80.发明授权Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers 有权核酸和相应的名为158P1D7的蛋白质可用于膀胱癌和其他癌症的治疗和检测公开(公告)号：US07358353B2
公开(公告)日：2008-04-15
申请号：US10776773
申请日：2004-02-10
申请人： Aya Jakobovits , Robert Kendall Morrison , Arthur B. Raitano , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen Jane Meyrick Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven B. Kanner
发明人： Aya Jakobovits , Robert Kendall Morrison , Arthur B. Raitano , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen Jane Meyrick Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven B. Kanner
CPC分类号： C07K16/18 , A61K38/00 , A61K47/646 , A61K47/6813 , A61K51/1093 , C07K14/47 , C07K16/30 , C07K16/3038 , C07K2317/54 , C07K2317/55 , C07K2317/622 , G01N33/57484 , Y10T436/25
摘要： A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 158P1D7 provides a diagnostic and/or therapeutic target for cancers. The 158P1D7 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为158P1D7）及其编码的蛋白质。 虽然158P1D7在正常成人组织中表现出组织特异性表达，但在多种癌症中异常表达，包括表1所示。因此，158P1D7为癌症提供诊断和/或治疗靶标。 158P1D7基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。
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