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121 条记录 (耗时 0.033 秒)

    Artificial intervertebral disc nucleus
    71.
    发明申请
    Artificial intervertebral disc nucleus 审中-公开
    人造椎间盘核

    公开(公告)号：US20090105823A1

    公开(公告)日：2009-04-23

    申请号：US11659437

    申请日：2005-09-30

    申请人： Michael S. Williams ,  Jeffrey A. Smith

    发明人： Michael S. Williams ,  Jeffrey A. Smith

    IPC分类号： A61F2/44

    CPC分类号： A61F2/441 ,  A61B2017/00871 ,  A61F2002/30016 ,  A61F2002/30092 ,  A61F2002/30579 ,  A61F2002/30583 ,  A61F2002/30586 ,  A61F2002/444 ,  A61F2210/0014 ,  A61F2210/0085 ,  A61F2250/0019

    摘要： Devices and methods for manufacturing devices for treating degenerated and/or traumatized intervertebral discs are disclosed. Artificial discs and components of discs may include an artificial nucleus and/or an artificial annulus and may be comprised of shape memory materials synthesized to achieve desired mechanical and physical properties. An artificial nucleus and/or annulus according to the invention may comprise a filler retention membrane that may be filled with a curable material for deployment. A filler retention membrane according to the invention may comprise one or more partitions to define one or more chambers and may comprise one or more valves for selectively permitting the flow of material within the nuclear region and annular region of the filler retention membrane.

    摘要翻译： 公开了用于制造用于治疗退化和/或创伤性椎间盘的装置的装置和方法。 人造盘和盘的组件可以包括人造核和/或人造环，并且可以由合成以实现期望的机械和物理性质的形状记忆材料组成。 根据本发明的人造核和/或环可以包括可填充有用于展开的可固化材料的填料保持膜。 根据本发明的填料保持膜可以包括一个或多个隔板以限定一个或多个室，并且可以包括一个或多个阀，用于选择性地允许填料保持膜的核区域和环形区域内的材料流动。

    Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same
    72.
    发明授权
    Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same 失效
    具有选择性改性结晶度的聚合材料的管腔内假体及其制备方法

    公开(公告)号：US06932930B2

    公开(公告)日：2005-08-23

    申请号：US10701101

    申请日：2003-11-04

    申请人： Joseph M. DeSimone ,  Michael S. Williams

    发明人： Joseph M. DeSimone ,  Michael S. Williams

    IPC分类号： A61F20060101 ,  A61F2/06 ,  A61L31/04 ,  A61L31/14 ,  B29C71/02 ,  B32B1/08

    CPC分类号： A61F2/07 ,  A61L27/44 ,  A61L27/54 ,  A61L27/58 ,  A61L31/04 ,  A61L31/14 ,  A61L2300/20 ,  Y10T428/1352 ,  Y10T428/139

    摘要： Methods of manufacturing polymeric intraluminal prostheses include annealing the polymeric material to selectively modify the crystallinity thereof. Annealing may be utilized to selectively modify various properties of the polymeric material of an intraluminal prosthesis, including: selectively increasing the modulus of the polymeric material; selectively increasing the hoop strength of the intraluminal prosthesis; selectively modifying the elution rate (increase or decrease) of a pharmacological agent subsequently disposed on or within the annealed polymeric material; selectively increasing/decreasing stress in the intraluminal prosthesis; and selectively modifying the polymeric material such that it erodes at a different rate.

    摘要翻译： 制造聚合物腔内假体的方法包括退火聚合物材料以选择性地改变其结晶度。 可以使用退火来选择性地修改管腔内假体的聚合材料的各种性质，包括：选择性地增加聚合材料的模量; 选择性地增加腔内假体的环箍强度; 选择性地改变随后设置在退火的聚合材料上或其内的药剂的洗脱速率（增加或减少）; 在腔内假体中选择性增加/减少应力; 并且选择性地改性聚合材料，使得其以不同的速率腐蚀。

    Drug loaded elastic membrane and method for delivery
    73.
    发明授权
    Drug loaded elastic membrane and method for delivery 失效
    药物负载弹性膜和输送方法

    公开(公告)号：US5707385A

    公开(公告)日：1998-01-13

    申请号：US340717

    申请日：1994-11-16

    申请人： Michael S. Williams

    发明人： Michael S. Williams

    IPC分类号： A61F2/92 ,  A61M29/00

    CPC分类号： A61F2/92 ,  A61M31/00 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0013 ,  A61M2025/0183

    摘要： An expandable sheath is provided for delivering a therapeutic drug in a body lumen which comprises an expandable membrane with a therapeutic drug incorporated therein. The expandable membrane is in a cylindrical configuration and mounted on the balloon portion of a catheter for intraluminal drug delivery into a patient's vascular system. The expandable membrane may also be mounted on an intravascular stent, both of which are implanted within the patient's vascular system. The therapeutic drug then diffuses into the vascular system at a controlled rate to match a specific clinical need.

    摘要翻译： 提供可扩张护套用于将治疗药物输送到体腔中，其包含结合有治疗药物的可膨胀膜。 可膨胀膜是圆柱形构造并且安装在导管的球囊部分上，用于腔内药物递送到患者的血管系统中。 可膨胀膜也可以安装在血管内支架上，两者均植入患者的血管系统内。 然后治疗药物以受控的速率扩散到血管系统中以匹配特定的临床需要。

    Device and method for retaining a medical device within a vessel
    76.
    发明授权
    Device and method for retaining a medical device within a vessel 有权
    用于将医疗装置保持在容器内的装置和方法

    公开(公告)号：US08239045B2

    公开(公告)日：2012-08-07

    申请号：US10453971

    申请日：2003-06-04

    申请人： Terrance Ransbury ,  Michael S. Williams

    发明人： Terrance Ransbury ,  Michael S. Williams

    IPC分类号： A61N1/05

    CPC分类号： A61N1/05 ,  A61N1/056 ,  A61N1/057 ,  A61N1/37205

    摘要： A method and apparatus for retaining a medical device within a blood vessel are described. A medical device (e.g. a pulse generator or a lead) is positioned within a blood vessel. An expandable the retention sleeve is passed into the vessel adjacent to the medical device and expanded to an expanded position to engage the medical device between an exterior surface of the retention sleeve and a surface of the vessel.

    摘要翻译： 描述了用于将医疗装置保持在血管内的方法和装置。 医疗装置（例如脉冲发生器或引线）位于血管内。 将可扩张的保持套筒传送到与医疗装置相邻的容器中并且膨胀到扩张位置，以在保持套筒的外表面和容器的表面之间接合医疗装置。

    Highly convertible endolumenal prostheses and methods of manufacture
    79.
    发明授权
    Highly convertible endolumenal prostheses and methods of manufacture 失效
    高度可转换的腔内假体和制造方法

    公开(公告)号：US07377939B2

    公开(公告)日：2008-05-27

    申请号：US10988814

    申请日：2004-11-15

    申请人： Michael S. Williams ,  Robert S. Langer ,  Yadong Wang

    发明人： Michael S. Williams ,  Robert S. Langer ,  Yadong Wang

    IPC分类号： A61F2/06

    CPC分类号： A61F2/06 ,  A61L31/04 ,  A61L31/041 ,  A61L31/14 ,  A61L2400/16

    摘要： Endolumenal prostheses that readily and extensively convert from a delivery configuration to a deployed configuration are disclosed. Endolumenal prostheses may be fabricated from one or more shape memory polymers, a high modulus elastomer, a polymer that is both elastomeric and exhibits shape memory behavior, a hydrogel, or some combination thereof. Polymers used to fabricate the prostheses are selectively synthesized to exhibit desired characteristics such as crystallinity, strain fixity rate, strain recovery rate, elasticity, tensile strength, mechanical strength, cross-linking density, extent physical cross-linking, extent of covalent cross-linking, extent of interpenetrating networks, rate of erosion, heat of fusion, crystallization temperature, and acidity during erosion. The endolumenal prostheses convert to the deployed configuration following delivery to a treatment site, upon exposure to an initiator either present within the body naturally or introduced into the body.

    摘要翻译： 公开了容易且广泛地从输送配置转换成展开构型的腔内假体。 腔内假体可以由一种或多种形状记忆聚合物，高模量弹性体，弹性体和表现出形状记忆行为的聚合物，水凝胶或其某些组合制成。 用于制造假体的聚合物被选择性地合成以显示所需的特性，例如结晶度，应变固定率，应变恢复速率，弹性，拉伸强度，机械强度，交联密度，物理交联程度，共价交联程度 互穿网络的程度，侵蚀速率，熔化热，结晶温度和侵蚀过程中的酸度。 在暴露于身体内自然存在或引入体内的引发剂之后，腔内假体转化为部署构型。