公开(公告)号：US4769148A

公开(公告)日：1988-09-06

申请号：US122307

申请日：1987-11-18

申请人： Richard F. Fibiger ,  Ja-young Koo ,  David J. Forgach ,  Robert J. Petersen ,  Donald L. Schmidt ,  Ritchie A. Wessling ,  Thomas F. Stocker

发明人： Richard F. Fibiger ,  Ja-young Koo ,  David J. Forgach ,  Robert J. Petersen ,  Donald L. Schmidt ,  Ritchie A. Wessling ,  Thomas F. Stocker

IPC分类号： C08G69/00 ,  B01D69/12 ,  B01D71/56 ,  B01D13/00

CPC分类号： B01D69/125 ,  B01D71/56

摘要： An improved composite polyamide membrane and methods of making the membrane are described. This improved membrane is prepared using a cationic polymeric wetting agent in an aqueous solution containing a polyfunctional amine reactant which is interfacially polymerized with an acyl halide to form a thin film polyamide discriminating layer on a microporous support. Alternatively, the wetting agent can be applied directly to the substrate and the interfacial polymerization can occur on said treated substrate. The resulting membrane exhibits an unexpected combination of high water flux, high rejection of divalent anion salts, variable sodium chloride rejection and good caustic resistance at low operating pressures. In one embodiment of this invention, a porous substrate is first treated with an aqueous piperazine solution containing a copolymer of vinylbenzyl dimethyl sulfonium chloride and methacrylic acid and then the coated microporous support is contacted with trimesoyl chloride in an organic solvent.

公开(公告)号：US4161502A

公开(公告)日：1979-07-17

申请号：US789385

申请日：1977-04-02

申请人： Ritchie A. Wessling ,  Edward F. Gurnee

发明人： Ritchie A. Wessling ,  Edward F. Gurnee

IPC分类号： B29C43/14 ,  B29C43/16 ,  B29C3/00

CPC分类号： B29C43/16 ,  B29C43/14 ,  B29C2791/001 ,  B29K2105/251 ,  B29K2105/255

摘要： An improvement in the process of forming plastic articles wherein such articles are forged from a compression formed briquette of resinous powder, such improvement comprising (1) compressing a resinous powder having lamellar crystalline nonspherulitic morphology into a substantially unoriented briquette having green strength, (2) removing the briquette from the compressing device and placing the briquette in a forging press wherein lubrication is provided between the contacting surfaces of the briquette and the forging press to permit plug flow, and (3) forging the briquette into a shaped article while maintaining the briquette at a temperature between the alpha-transition temperature and the melt temperature of the resinous powder.

摘要翻译： 制造塑料制品的方法的改进，其中这种制品是由压制成型的树脂粉末形成的，这样的改进包括：（1）将具有层状结晶非熔点形态的树脂粉末压成具有绿色强度的基本上无取向的块状物;（2） 从压缩装置中取出团块并将该团块放置在锻压机中，其中在煤饼和锻压机的接触表面之间提供润滑以允许活塞流动，和（3）将团块锻压成成型制品，同时保持压块 在α转变温度和树脂粉末的熔融温度之间的温度下。

公开(公告)号：US4017442A

公开(公告)日：1977-04-12

申请号：US569724

申请日：1975-04-21

申请人： Dale S. Gibbs ,  Earl H. Wagener ,  Ritchie A. Wessling

发明人： Dale S. Gibbs ,  Earl H. Wagener ,  Ritchie A. Wessling

IPC分类号： C08C1/06 ,  C08F291/00 ,  C08L33/08

CPC分类号： C08C1/06 ,  C08F291/00

摘要： Structured-particle latexes are prepared from nonionic or slightly cationic latexes, either preformed or polymerized in situ, by emulsion polymerizing monomeric materials which include an ethylenically unsaturated, activated-halogen monomer such as vinylbenzyl chloride in the absence of a sufficient amount of a surfactant to initiate new particles whereby the activated-halogen monomer is copolymerized on the surface of the existing particles which are dispersed in aqueous media. To the resulting structured particle latex may then be added conventional cationic surfactants to provide greater stability. The cationic latexes are suitable for coatings.

摘要翻译： 通过在不存在足够量的表面活性剂的情况下通过乳液聚合包括烯属不饱和的活性卤素单体如乙烯基苄基氯的单体材料，由非离子或微阳离子胶乳制备结构粒子胶乳， 引发新的颗粒，由此活性卤素单体在分散在水性介质中的现有颗粒的表面上共聚。 然后可以向得到的结构化颗粒胶乳中加入常规阳离子表面活性剂以提供更大的稳定性。 阳离子胶乳适用于涂料。

公开(公告)号：US20120282412A1

公开(公告)日：2012-11-08

申请号：US13343584

申请日：2012-01-04

申请人： David R. Markle ,  Huashi Zhang ,  Matthew A. Romey ,  Ritchie A. Wessling

发明人： David R. Markle ,  Huashi Zhang ,  Matthew A. Romey ,  Ritchie A. Wessling

IPC分类号： C08F2/46 ,  B06B1/00 ,  B65B33/00

CPC分类号： G01N21/7703 ,  G01N2021/6434 ,  G01N2021/773 ,  G01N2021/7786

摘要： In preferred embodiments, the present invention relates to methods for polymerizing a monomer solution within a cavity covered by a porous membrane to generate a smooth polymer surface. More specifically, the method can be used to provide a medical device or sensor with a smooth polymer surface.

摘要翻译： 在优选的实施方案中，本发明涉及在由多孔膜覆盖的空腔内聚合单体溶液以产生光滑聚合物表面的方法。 更具体地，该方法可用于提供具有光滑聚合物表面的医疗装置或传感器。

公开(公告)号：US07968714B2

公开(公告)日：2011-06-28

申请号：US12189089

申请日：2008-08-08

申请人： Bakthan Singaram ,  Ritchie A. Wessling

发明人： Bakthan Singaram ,  Ritchie A. Wessling

IPC分类号： C07F5/02 ,  C07D401/04

CPC分类号： A61K49/0019 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y15/00 ,  B82Y30/00 ,  C07D213/82 ,  C07F5/025 ,  C09K9/02 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1029 ,  G01N33/542 ,  G01N33/543 ,  G01N33/582 ,  G01N33/66 ,  Y10T436/144444

摘要： The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

摘要翻译： 本发明涉及一种改进的光学方法和光学感测装置，用于确定水性介质中体外和/或体内多羟基取代的有机分子的水平。 检测范围在约400和800nm之间。 特别地，在哺乳动物中实施感官设计以确定糖水平。 具体地说，在糖如果糖或葡萄糖的存在下，将染料与共轭含氮杂环芳族硼酸取代的双鎓化合物组合。 紫罗兰是优选的芳族共轭含氮硼酸取代的化合物。 该方法对于测定人的糖含量是有用的。

公开(公告)号：US07829341B2

公开(公告)日：2010-11-09

申请号：US12172059

申请日：2008-07-11

申请人： Soya Gamsey ,  Ritchie A. Wessling

发明人： Soya Gamsey ,  Ritchie A. Wessling

IPC分类号： G01N33/52 ,  G01N33/66 ,  G01N21/64 ,  C07D213/22 ,  C07F5/02

CPC分类号： C07F5/025 ,  C08G73/0627 ,  C09K9/02 ,  C09K2211/1029 ,  Y10T436/143333 ,  Y10T436/144444

摘要： The invention relates to a class of glucose-responsive, polyviologen boronic acid quenchers that may be used in combination with fluophores to achieve real-time measurement of glucose levels in vivo.

摘要翻译： 本发明涉及可与荧光团组合使用的一类葡萄糖反应型聚io烯硼酸猝灭剂，以实现体内葡萄糖水平的实时测量。

公开(公告)号：US07751863B2

公开(公告)日：2010-07-06

申请号：US11671880

申请日：2007-02-06

申请人： David R. Markle ,  Jeff T. Suri ,  Ritchie A. Wessling ,  Matthew A. Romey

发明人： David R. Markle ,  Jeff T. Suri ,  Ritchie A. Wessling ,  Matthew A. Romey

IPC分类号： A61B5/145

CPC分类号： A61B5/14532 ,  A61B5/1451 ,  A61B5/14539 ,  A61B5/1459 ,  G01N33/66 ,  G01N33/84 ,  G01N2400/00

摘要： Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.

摘要翻译： 本发明的实施例涉及一种能够与单个指示器系统同时测量两种分析物的光学传感器。 在优选的实施方案中，传感器包括具有促进比例pH感测的酸和碱形式的荧光染料，其中染料进一步与葡萄糖结合部分相关联并且被配置为产生随葡萄糖浓度而变化的信号。

公开(公告)号：US20090081803A1

公开(公告)日：2009-03-26

申请号：US12172059

申请日：2008-07-11

申请人： Soya Gamsey ,  Ritchie A. Wessling

发明人： Soya Gamsey ,  Ritchie A. Wessling

IPC分类号： G01N21/64 ,  C07F5/02

CPC分类号： C07F5/025 ,  C08G73/0627 ,  C09K9/02 ,  C09K2211/1029 ,  Y10T436/143333 ,  Y10T436/144444

摘要： The invention relates to a class of glucose-responsive, polyviologen boronic acid quenchers that may be used in combination with fluophores to achieve real-time measurement of glucose levels in vivo.

摘要翻译： 本发明涉及可与荧光团组合使用的一类葡萄糖反应型聚io烯硼酸猝灭剂，以实现体内葡萄糖水平的实时测量。

公开(公告)号：US20080305009A1

公开(公告)日：2008-12-11

申请号：US12113876

申请日：2008-05-01

申请人： Soya Gamsey ,  Ritchie A. Wessling

发明人： Soya Gamsey ,  Ritchie A. Wessling

IPC分类号： G01N21/64 ,  C07F5/02 ,  C08F126/08 ,  C08F128/02 ,  C08F120/06

CPC分类号： G01N33/523 ,  C07F5/025 ,  G01N2400/00

摘要： Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.

摘要翻译： 公开了用硼酸官能化的新型吡啶鎓盐及其制备方法。 当与荧光染料组合时，该化合物可用于检测多羟基取代的有机分子。

公开(公告)号：US5736748A

公开(公告)日：1998-04-07

申请号：US677749

申请日：1996-07-10

申请人： Zenon Lysenko ,  Ritchie A. Wessling

发明人： Zenon Lysenko ,  Ritchie A. Wessling

IPC分类号： C08G65/32 ,  C08G18/48 ,  C08G18/50 ,  C08G63/668 ,  C08G63/685 ,  C08G65/333 ,  C09K3/08

CPC分类号： C08G18/5057 ,  C08G18/4866 ,  C08G63/668 ,  C08G63/6854 ,  C08G65/33365 ,  C08G65/33396

摘要： The unsaturation of a hydroxyl-containing compound can be reduced by reaction with a nitrile oxide compound such as tetramethyl terephthalonitrile, N,N'-dioxide. The reaction of a nitrile oxide with terminal unsaturation associated with the preparation of a polyol from propylene oxide reduces the monol content of the polyol composition.

摘要翻译： 含羟基化合物的不饱和度可以通过与腈化合物如四甲基对苯二腈，N，N'-二氧化物的反应来还原。 与由环氧丙烷制备多元醇相关的腈氧化物与末端不饱和键的反应降低了多元醇组合物的单醇含量。