Substituted acetylpridine derivatives and process for the preparation of intermediates for optically active beta-3 agonist by the use of the same
    75.
    发明授权
    Substituted acetylpridine derivatives and process for the preparation of intermediates for optically active beta-3 agonist by the use of the same 失效
    取代的乙酰嘌呤衍生物和通过使用它们制备光学活性β-3激动剂的中间体的方法

    公开(公告)号:US06515134B1

    公开(公告)日:2003-02-04

    申请号:US09926021

    申请日:2001-11-07

    IPC分类号: C07D21326

    摘要: It is an objective to produce intermediates of optically active beta-3 adrenaline receptor agonists from readily available raw materials in a safe, efficient and industrially advantageous manner. A substituted acetylpyridine derivative represented by the general formula (9) is reduced by enantioselective reduction to produce an optically active hydroxyethyl derivative represented by the general formula (10) (wherein * represents an asymmetric carbon atom), and it is further derivatized to an intermediate of an optically active beta-3 adrenaline receptor agonist, such as an optically active dihydroxyethylpyridine derivative represented by the general formula (14) or an optically active oxirane derivative represented by the general formula (16).

    摘要翻译: 目的是以安全,有效和工业上有利的方式从容易获得的原料生产光学活性β-3肾上腺素受体激动剂的中间体。 由通式(9)表示的取代的乙酰基吡啶衍生物通过对映选择性还原而被还原,以制备由通式(10)表示的光学活性羟乙基衍生物(其中*表示不对称碳原子),并进一步衍生为中间体 的光学活性β-3肾上腺素受体激动剂,例如由通式(14)表示的光学活性二羟基乙基吡啶衍生物或由通式(16)表示的光学活性环氧乙烷衍生物。

    Processes for producing &bgr;-halogeno-&agr;-amino-carboxylic acids and phenylcysteine derivatives and intermediates thereof
    76.
    发明授权
    Processes for producing &bgr;-halogeno-&agr;-amino-carboxylic acids and phenylcysteine derivatives and intermediates thereof 失效
    制备β-卤代-α-氨基 - 羧酸和苯基半胱氨酸衍生物的方法及其中间体

    公开(公告)号:US06372941B1

    公开(公告)日:2002-04-16

    申请号:US09582461

    申请日:1999-08-16

    IPC分类号: C07C22900

    摘要: An industrially advantageous method of producing &bgr;-halogeno-&agr;-aminocarboxylic acids is provided. Methods are also provided of producing optically active N-protected-S-phenylcysteines having high optical purity and of intermediates thereof, respectively, in which the above production method is utilized. A method of producing &bgr;-halogeno-&agr;-aminocarboxylic acids or salts thereof is disclosed which comprises halogenating the hydroxyl group of a &bgr;-hydroxy-&agr;-aminocarboxylic acid (in which the basicity of the amino group in &agr;-position is not masked by the presence of a substituent on said amino group) or a salt thereof with an acid with a halogenating agent. A method of producing optically active N-protected-S-phenylcysteines represented by the general formula (3) or salts thereof is further disclosed which comprises applying the above production method to optically active serine or a salt thereof and then carrying out treatment with an amino-protecting agent and reaction with thiophenol under a basic condition.

    摘要翻译: 提供了产生β-卤代-α-氨基羧酸的工业上有利的方法。 还提供了分别制备具有高光学纯度的光学活性N-保护的S-苯基半胱氨酸及其中间体的方法,其中使用上述制备方法.1。制备β-卤代-α-氨基羧酸或其盐的方法 其中包括将β-羟基-α-氨基羧酸的羟基(其中在所述氨基上不存在取代基的α-位置上的氨基的碱性)或其盐与卤素化反应 具有卤化剂的酸。 进一步公开了制备由通式(3)表示的光学活性N-保护的S-苯基半胱氨酸或其盐的方法,其包括将上述制备方法应用于光学活性丝氨酸或其盐,然后用氨基 保护剂和与苯硫酚在基本条件下的反应。

    Push-button switch, and operation device and teaching pendant comprising the same
    77.
    发明授权
    Push-button switch, and operation device and teaching pendant comprising the same 有权
    按钮开关,以及包括该按钮开关的操作装置和示教器

    公开(公告)号:US06288352B1

    公开(公告)日:2001-09-11

    申请号:US09415497

    申请日:1999-10-12

    IPC分类号: H01H1300

    摘要: A push-button switch provided with a hollow push button, a case supporting it, and a switching mechanism having a first contact disposed within the case and a second contact disposed opposite to the first contact, with one of its ends being inserted into a hole of the push button. Within a hole formed in an inserted section of the switching mechanism, a slide block is provided slidably in a direction crossing the direction in which the push button is pushed. A slope capable of engaging with a slope of the hole of the push button is formed on the slide block. A coil spring (return spring) for energizing a shaft of the switching mechanism so as to abut the push button is provided on the bottom of the case. This configuration enables the push button to take up a first OFF state, an ON state and a second OFF state in order of depression.

    摘要翻译: 具有中空按钮的按钮开关,支撑它的壳体,以及具有设置在壳体内的第一触点和与第一触点相对设置的第二触点的开关机构,其一端插入孔 的按钮。 在形成在切换机构的插入部分中的孔内,滑动块沿与推动按钮的方向交叉的方向可滑动地设置。 在滑块上形成能够与按钮的孔的斜面接合的斜面。 用于对切换机构的轴进行激励以抵靠按钮的螺旋弹簧(复位弹簧)设置在壳体的底部。 该配置使得按钮能够按照按钮的顺序占据第一OFF状态,ON状态和第二OFF状态。

    Method of processing desulfurization absorption liquid and apparatus therefor
    78.
    发明授权
    Method of processing desulfurization absorption liquid and apparatus therefor 有权
    脱硫吸收液处理方法及其设备

    公开(公告)号:US06254771B1

    公开(公告)日:2001-07-03

    申请号:US09355799

    申请日:1999-08-04

    IPC分类号: C02F124

    摘要: This invention relates to a method for the treatment of a desulfurization absorbing fluid after gas-liquid contact with combustion exhaust gas in which fine particles of unburned carbon and other materials are efficiently removed from the desulfurization absorbing fluid to improve the quality of a by-product (e.g., gypsum) obtained therefrom. The method of this invention comprises the steps of feeding a gas into a desulfurization absorbing fluid (A) containing fine particles of unburned carbon and other materials and thereby producing gas bubbles so as to cause the fine particles to adhere to the surfaces of the gas bubbles and create a foam phase (D) consisting of the gas bubbles; and breaking the foam phase (D) to obtain a liquid (E) containing the fine particles.

    摘要翻译: 本发明涉及一种在与燃烧废气接触气液之后处理脱硫吸收液的方法,其中将未燃碳和其它材料的细颗粒从脱硫吸收液中有效地除去以提高副产物的质量 (例如,石膏)。 本发明的方法包括以下步骤:将气体供给到含有未燃烧碳和其他材料的微粒的脱硫吸收液(A)中,由此产生气泡,以使细颗粒附着在气泡的表面 并产生由气泡组成的泡沫相(D); 并破坏泡沫相(D)以获得含有微粒的液体(E)。

    Process for producing L-allysine acetals
    79.
    发明授权
    Process for producing L-allysine acetals 失效
    生产L-赖氨酸乙缩醛的方法

    公开(公告)号:US06174707B1

    公开(公告)日:2001-01-16

    申请号:US09202901

    申请日:1999-03-04

    IPC分类号: G01N3853

    CPC分类号: C12P7/40 C12P13/04 C12P41/006

    摘要: The present invention has for its object to provide a method for producing an L-allysine acetal which involves a fewer steps and is efficient. This invention relates to method for producing an L-allysine acetal which comprises; converting a D,L-allysine acetal of the following general formula (1) (wherein R1 and R2 are the same or different, and each of them represents an alkyl group having 1 to 8 carbon atoms, or they combinedly form a ring and represent an alkylene group having 2 to 8 carbon atoms) to a mixture of a 2-oxo-6,6-dialkoxyhexanoic acid of the following general formula (2) (wherein R1 and R2 are as defined above) and an L-allysine acetal of the following general formula (3) (wherein R1 and R2 are as defined above) by reacting in the presence of an enzyme capable of stereoselective oxidative deamination of D-amino acids and; isolating said L-allysine acetal after said converting.

    摘要翻译: 本发明的目的是提供一种生产L-赖氨酸缩醛的方法,该方法涉及较少的步骤并且是有效的。本发明涉及L-赖氨酸缩醛的制备方法,其包括:将D,L-烯丙基乙缩醛 的下述通式(1)(其中,R 1和R 2相同或不同,它们各自表示碳原子数1〜8的烷基,或者它们组合形成环,表示碳原子数2〜8的亚烷基 原子)与下述通式(2)的2-氧代-6,6-二烷氧基己酸(其中R 1和R 2如上定义)和下列通式(3)的L-烯丙基缩醛的混合物 其中R1和R2如上所定义)通过在能够进行D-氨基酸的立体选择性氧化脱氨作用的酶存在下反应;和在所述转化后分离所述L-赖氨酸缩醛。

    Shoe press belt and manufacturing method therefor
    80.
    发明授权
    Shoe press belt and manufacturing method therefor 失效
    鞋带及其制造方法

    公开(公告)号:US5968318A

    公开(公告)日:1999-10-19

    申请号:US94829

    申请日:1998-06-15

    摘要: A shoe press belt for the shoe press of a paper making machine includes first and second resin layers and a base layer. Resin is coated and cured on the polished surface of a cylindrical mandrel to form the first resin layer endlessly. An inner layer of the base layer is formed by spirally winding a relatively narrower belt shaped mesh with warp threads running in the major direction of the belt and weft threads running perpendicular thereto, with the weft threads against the outer surface of the first resin layer, and without overlapping the end edges of the belt-shaped mesh. An outer layer of the base layer is formed by inserting the mandrel, with the first resin layer and the belt-shaped mesh layer applied, into a tubular mesh, and pulling the ends of the tubular mesh apart, so as to reduce its diameter and press it radially against the belt-shaped mesh layer. A second resin layer is then applied over the base layer and impregnates the base layer down to the outer surface of the first resin layer, so that the base layer is included within the second resin layer when the second resin layer is cured.

    摘要翻译: 用于造纸机的靴式压榨机的靴形压榨带包括第一和第二树脂层和基底层。 树脂在圆柱形心轴的抛光表面上被涂覆和固化,从而形成第一树脂层。 基层的内层通过螺旋卷绕相对较窄的带状网,通过沿着主带方向延伸的经线和垂直于其的纬纱螺旋卷绕,纬纱相对于第一树脂层的外表面, 并且不重叠带状网的端边缘。 基层的外层通过将第一树脂层和带状网层施加到管状网中并将管状网的端部分开来将芯棒插入,从而减小其直径和 将其径向按压在带状网格层上。 然后将第二树脂层施加在基层上,并将基底层浸渍到第一树脂层的外表面,使得当第二树脂层固化时,基层包含在第二树脂层内。