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公开(公告)号：US07022690B2
公开(公告)日：2006-04-04
申请号：US11020751
申请日：2004-12-23
申请人： Kevin Koch , Andreas Termin , John A. Josey
发明人： Kevin Koch , Andreas Termin , John A. Josey
IPC分类号： C07D225/02 , A61K31/395
CPC分类号： C07D223/12
摘要： Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of inflamation, tissue degradation and related diseases. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号：US08779197B2
公开(公告)日：2014-07-15
申请号：US12249270
申请日：2008-10-10
IPC分类号： C07C233/65 , A61K31/165 , A61K31/44 , C07D213/02
CPC分类号： C07D213/65 , C07C237/42 , C07C311/08 , C07C317/40 , C07D213/643
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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73.发明授权公开(公告)号：US08519137B2
公开(公告)日：2013-08-27
申请号：US12249230
申请日：2008-10-10
申请人： Pramod Joshi , Paul Krenitsky , Andreas Termin , Dean Wilson
发明人： Pramod Joshi , Paul Krenitsky , Andreas Termin , Dean Wilson
IPC分类号： C07D211/70 , C07D249/08 , C07D263/34 , C07D285/12 , C07D405/02 , A61K31/4525 , A61K31/4196 , A61K31/421 , A61K31/433 , A61K31/44 , A61P25/06 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00
CPC分类号： C07D277/56 , C07D213/82 , C07D249/10 , C07D261/18 , C07D263/34 , C07D285/12 , C07D307/68 , C07D333/38
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07858786B2
公开(公告)日：2010-12-28
申请号：US11418163
申请日：2006-05-04
申请人： Dean Wilson , Andreas Termin , Dewey Fanning , Paul Krenitsky , Pramod Joshi , Urvi Sheth
发明人： Dean Wilson , Andreas Termin , Dewey Fanning , Paul Krenitsky , Pramod Joshi , Urvi Sheth
IPC分类号： C07D403/04 , C07D401/04 , A61K31/506 , A61K31/496 , A61P19/02 , A61P25/02 , A61P25/06
CPC分类号： C07D239/42 , C07D241/20 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14 , C07F9/65583
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07683065B2
公开(公告)日：2010-03-23
申请号：US11418278
申请日：2006-05-04
申请人： Dean Wilson , Andreas Termin , Dewey Fanning , Paul Krenitsky , Pramod Joshi
发明人： Dean Wilson , Andreas Termin , Dewey Fanning , Paul Krenitsky , Pramod Joshi
IPC分类号： A61K31/497 , C07D401/02
CPC分类号： C07D401/04 , C07D213/74
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20090118333A1
公开(公告)日：2009-05-07
申请号：US12249251
申请日：2008-10-10
IPC分类号： A61K31/444 , C07D213/62 , A61P25/18 , A61P25/08 , A61P29/00
CPC分类号： C07D213/76 , C07D213/72
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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77.发明申请公开(公告)号：US20090099233A1
公开(公告)日：2009-04-16
申请号：US12249230
申请日：2008-10-10
申请人： Pramod Joshi , Paul Krenitsky , Andreas Termin , Dean Wilson
发明人： Pramod Joshi , Paul Krenitsky , Andreas Termin , Dean Wilson
IPC分类号： A61K31/4525 , C07D211/70 , A61K31/44 , A61K31/433 , C07D285/12 , C07D405/02 , A61P29/00 , A61P25/28 , A61P25/22 , A61P25/24 , A61P25/06 , C07D263/34 , A61K31/421 , A61K31/4196 , C07D249/08
CPC分类号： C07D277/56 , C07D213/82 , C07D249/10 , C07D261/18 , C07D263/34 , C07D285/12 , C07D307/68 , C07D333/38
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20080221137A1
公开(公告)日：2008-09-11
申请号：US11598576
申请日：2006-11-13
申请人： Dean Wilson , Lev T.D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
发明人： Dean Wilson , Lev T.D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
IPC分类号： A61K31/517 , C07D403/04 , A61P25/00
CPC分类号： C07D403/04
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20070238733A1
公开(公告)日：2007-10-11
申请号：US11786166
申请日：2007-04-11
申请人： Pramod Joshi , Paul Krenitsky , Jesus Gonzalez , Jian Wang , Dean Wilson , Andreas Termin
发明人： Pramod Joshi , Paul Krenitsky , Jesus Gonzalez , Jian Wang , Dean Wilson , Andreas Termin
IPC分类号： A61K31/53 , A61K31/4965 , A61K31/505 , A61K31/501 , A61K31/44 , A61K31/433 , A61K31/4245 , A61K31/426 , A61K31/421
CPC分类号： C07C311/46 , C07C323/62 , C07D207/327 , C07D213/56 , C07D213/65 , C07D213/68 , C07D213/74 , C07D213/82 , C07D231/12 , C07D233/36 , C07D233/64 , C07D233/70 , C07D239/34 , C07D257/04 , C07D285/08 , C07D295/096 , C07D295/155 , C07D295/205 , C07D317/68
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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80.发明授权Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands 有权取代的噻唑和恶唑作为促肾上腺皮质激素释放激素配体公开(公告)号：US07276526B2
公开(公告)日：2007-10-02
申请号：US10192055
申请日：2002-07-10
申请人： Andreas Termin , Peter Grootenhuis , Dean Wilson , Valentina Molteni , Long Mao
发明人： Andreas Termin , Peter Grootenhuis , Dean Wilson , Valentina Molteni , Long Mao
IPC分类号： C07D417/08 , A61K31/427
CPC分类号： C07D277/22 , C07D263/32 , C07D277/24 , C07D277/26 , C07D277/28 , C07D277/30 , C07D417/04 , C07D417/08 , C07D417/10
摘要： Provided herein are novel substituted thiazoles and oxazoles of the Formula (I): as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof in the treatment of various neurological and psychological disorders, e.g., affective disorder, anxiety and depression, treatable by antagonizing CRF receptors.
摘要翻译： 本文提供式（I）的新型取代的噻唑和恶唑：以及包含其的药物组合物的组合物及其在治疗各种神经和心理障碍（例如情感障碍，焦虑和抑郁症）中的用途 可通过拮抗CRF受体治疗。
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