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公开(公告)号:US20120296160A1
公开(公告)日:2012-11-22
申请号:US13241961
申请日:2011-09-23
申请人: Jason Hill , Scott R. Smith
发明人: Jason Hill , Scott R. Smith
IPC分类号: A61B1/00
CPC分类号: A61F2/2442 , A61B2017/00243 , A61B2017/3488 , A61B2090/3966 , A61F2/2466
摘要: A positioning device and method of using are provided herein. The positioning device includes an expandable cage through which blood can flow. The expandable cage is insertable into a bodily organ, for example a heart, and expanded to temporarily secure the positioning device within the organ. Then, the cage can be used to steady the implantation of an annuloplasty device, for example. Alternatively, the expanded cage can be used to locate a desired area or feature of the body organ in which it is inserted by way of fluoroscopy.
摘要翻译: 本文提供了定位装置和使用方法。 定位装置包括血液可以流过的可膨胀笼。 可膨胀的保持架可插入身体器官,例如心脏,并膨胀以将定位装置临时固定在器官内。 然后,例如,可以使用保持架来稳定瓣膜成形术装置的植入。 或者,扩展的笼可以用于通过荧光透视来定位其中插入的身体器官的期望的区域或特征。
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公开(公告)号:US08263610B2
公开(公告)日:2012-09-11
申请号:US12649762
申请日:2009-12-30
申请人: Syed M. Ali , Mark A. Ashwell , Chris Brassard , Audra Dalton , Anton Filikov , Jason Hill , Nivedita Namdev , Rocio Palma , Manish Tandon , David Vensel , Jianqiang Wang , Neil Westlund
发明人: Syed M. Ali , Mark A. Ashwell , Chris Brassard , Audra Dalton , Anton Filikov , Jason Hill , Nivedita Namdev , Rocio Palma , Manish Tandon , David Vensel , Jianqiang Wang , Neil Westlund
IPC分类号: A01N43/42 , A61K31/44 , C07D471/00 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00
CPC分类号: C07D471/04 , C07D471/14 , C07D491/14 , C07D495/14
摘要: The present invention relates to substituted imidazolyl-5,6-dihydrobenzo[n]isoquinoline compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazolyl-5,6-dihydrobenzo[n]isoquinoline compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译: 本发明涉及取代的咪唑基-5,6-二氢苯并[n]异喹啉化合物和合成这些化合物的方法。 本发明还涉及含有取代的咪唑基-5,6-二氢苯并[n]异喹啉化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗细胞增殖性疾病如癌症的方法。
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公开(公告)号:US08173808B2
公开(公告)日:2012-05-08
申请号:US12981113
申请日:2010-12-29
申请人: Mark A. Ashwell , Chris Brassard , Audra Dalton , Jason Hill , Robert Nicewonger , David Vensel
发明人: Mark A. Ashwell , Chris Brassard , Audra Dalton , Jason Hill , Robert Nicewonger , David Vensel
IPC分类号: C07D401/00
CPC分类号: C07D239/42 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/10 , C07D473/16 , C07D473/34 , C07D487/04 , C07D495/04 , Y02A50/401 , Y02A50/409 , Y02A50/411 , A61K2300/00
摘要: The present invention relates to substituted naphthalenyl-pyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted naphthalenyl-pyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译: 本发明涉及取代的萘基 - 嘧啶化合物和合成这些化合物的方法。 本发明还涉及含有取代的萘基 - 嘧啶化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗细胞增殖性疾病如癌症的方法。
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公开(公告)号:US20110190870A1
公开(公告)日:2011-08-04
申请号:US12982080
申请日:2010-12-30
申请人: Roger Hastings , Jason Hill
发明人: Roger Hastings , Jason Hill
IPC分类号: A61F2/82
摘要: A stent assembly includes a stent, a covering on at least a portion of the stent, and a string encircling at least a portion of the covering. The string is releasably engaged to the covering or stent or both the covering and the stent. The string can be adhered to the stent, or the stent assembly, to the covering of the stent assembly, or both the covering and the stent. The string can be wrapped around the stent or covering in an interwoven loop or knit pattern. The covering can be made to overlap a perforation in a body lumen such as an artery or blood vessel and prevent bleeding.
摘要翻译: 支架组件包括支架,支架的至少一部分上的覆盖物和围绕至少一部分覆盖物的绳索。 绳子可释放地接合到覆盖物或支架或覆盖物和支架两者。 绳可以粘附到支架或支架组件到支架组件的覆盖物或覆盖物和支架两者上。 绳子可以缠绕在支架上或以交织的环圈或编织图案覆盖。 可以使覆盖物与诸如动脉或血管的体腔中的穿孔重叠,并防止出血。
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公开(公告)号:USD635487S1
公开(公告)日:2011-04-05
申请号:US29349245
申请日:2010-03-19
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76.
公开(公告)号:US20100311754A1
公开(公告)日:2010-12-09
申请号:US12854687
申请日:2010-08-11
申请人: Mark A. Ashwell , Yanbin Liu , Syed Ali , Jason Hill , Woj Wrona
发明人: Mark A. Ashwell , Yanbin Liu , Syed Ali , Jason Hill , Woj Wrona
IPC分类号: A61K31/54 , C07D295/088 , C07D417/12 , C07D413/12 , C07D403/12 , A61P19/02 , A61P1/04 , A61P1/00 , A61P37/00 , A61P29/00 , A61P17/06 , C12N5/071
CPC分类号: C07D295/185 , C07D207/27 , C07D207/327 , C07D207/404 , C07D209/12 , C07D209/42 , C07D209/44 , C07D209/48 , C07D211/22 , C07D211/46 , C07D211/58 , C07D211/60 , C07D213/30 , C07D213/56 , C07D213/61 , C07D213/81 , C07D213/82 , C07D215/38 , C07D217/04 , C07D217/26 , C07D231/12 , C07D231/14 , C07D239/38 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/56 , C07D241/08 , C07D249/12 , C07D257/04 , C07D261/08 , C07D263/14 , C07D277/24 , C07D285/14 , C07D295/088 , C07D295/155 , C07D307/42 , C07D317/60 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D491/10
摘要: Naphthalene-based compounds having linked heterocyclic and aromatic rings capable of inhibiting P38, methods for inhibiting P38 in vivo or in vitro, diagnostics for determining activity in the treatment of P38 and/or cytokine-associated conditions and methods for treating conditions associated with P38 activity or cytokine activity; more particularly naphthalene-based compounds of Formula (I) having a morpholine heterocyclic ring, and methods of use thereof.
摘要翻译: 具有能够抑制P38的连接的杂环和芳环的萘基化合物,体内或体外抑制P38的方法,用于确定治疗P38和/或细胞因子相关病症的活性的诊断和用于治疗与P38活性相关的病症的方法 或细胞因子活性; 更具体地,具有吗啉杂环的式(I)的萘系化合物及其使用方法。
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公开(公告)号:US20100249120A1
公开(公告)日:2010-09-30
申请号:US12751396
申请日:2010-03-31
申请人: Jason Hill , Manish Tandon , Nivedita Namdev , Rocio Palma , Neil Westlund , Anton Filikov
发明人: Jason Hill , Manish Tandon , Nivedita Namdev , Rocio Palma , Neil Westlund , Anton Filikov
IPC分类号: A61K31/541 , C07D471/14 , A61K31/437 , A61P35/00
CPC分类号: C07D471/14
摘要: The present invention relates to substituted pyrazolo-pyrrolo-pyridine-dione compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrazolo-pyrrolo-pyridine-dione compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.
摘要翻译: 本发明涉及取代的吡唑并吡啶 - 二酮化合物和合成这些化合物的方法。 本发明还涉及含有取代的吡唑并吡啶 - 二酮化合物的药物组合物和通过将这些化合物或药物组合物给予有需要的受试者来治疗细胞增殖性疾病如癌症的方法。
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公开(公告)号:US07713969B2
公开(公告)日:2010-05-11
申请号:US11350335
申请日:2006-02-09
申请人: Chiang J. Li , Mark A. Ashwell , Jason Hill , Magdi M. Moussa , Neru Munshi
发明人: Chiang J. Li , Mark A. Ashwell , Jason Hill , Magdi M. Moussa , Neru Munshi
IPC分类号: A61P35/00 , A61K31/473 , A61K31/551 , A61K31/661 , C07D471/06 , C07D487/06 , C07F9/12
CPC分类号: C07D471/06 , A61K31/138 , A61K31/337 , A61K31/4535 , A61K31/4745 , A61K31/513 , A61K31/5377 , A61K31/5517 , A61K31/664 , A61K31/675 , A61K31/683 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K38/08 , A61K38/12 , C07D455/00 , C07D487/06 , C07F9/65583 , C07F9/6561 , C07K2/00
摘要: The present invention relates to pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or pyrroloquinolinyl-pyrrolidine-2,5-dione compound of the present invention.
摘要翻译: 本发明涉及吡咯并喹啉基 - 吡咯-2,5-二酮化合物和吡咯并喹啉基 - 吡咯烷-2,5-二酮化合物,以及这些化合物的制备方法。 本发明还涉及包含吡咯并喹啉基 - 吡咯-2,5-二酮化合物和吡咯并喹啉基 - 吡咯烷-2,5-二酮化合物的药物组合物。 本发明提供了治疗细胞增殖性疾病如癌症的方法,通过向有需要的受试者施用治疗有效量的吡咯并喹啉基 - 吡咯-2,5-二酮化合物或吡咯并喹啉基 - 吡咯烷-2,5-二酮, 二酮化合物。
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公开(公告)号:US07550003B2
公开(公告)日:2009-06-23
申请号:US10200997
申请日:2002-07-23
申请人: David Sogard , Susan Shoemaker , Jason Hill , Bruce A. Parsons
发明人: David Sogard , Susan Shoemaker , Jason Hill , Bruce A. Parsons
IPC分类号: A61F2/06
CPC分类号: A61F2/07 , A61F2/90 , A61F2002/072 , A61F2002/075 , Y10S623/901 , Y10T29/49927
摘要: A method and apparatus for forming a covered endoprosthesis employs a conformed polymeric coating about an expandable stent. The expandable stent has an open tubular construction. A first polymeric liner is positioned about an inner surface of the tubular stent and a second polymeric liner is positioned about an outer surface of the tubular stent. The first and second polymeric liners are conformed to the tubular stent and laminated together through the open construction of the stent at a location coextensive with the inner surface of the tubular stent.
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公开(公告)号:US20090139139A1
公开(公告)日:2009-06-04
申请号:US12328360
申请日:2008-12-04
申请人: G. David Tilman , Dario Fornara , Jason Hill , Clarence Lehman
发明人: G. David Tilman , Dario Fornara , Jason Hill , Clarence Lehman
IPC分类号: A01G1/00
CPC分类号: A01G2/00
摘要: Provided herein are mixtures of C4 grasses and legumes, and methods of using such mixtures to sequester carbon. Methods of using the sequestered carbon in the form of, for example, carbon credits, to offset or mitigate carbon usage also are provided.
摘要翻译: 本文提供了C4草和豆类的混合物,以及使用这种混合物螯合碳的方法。 还提供了使用碳信用形式的隔离碳抵消或减少碳利用的方法。
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