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    HETEROARYL AMIDES AS INHIBITORS OF PROTEIN AGGREGATION
    73.
    发明申请
    HETEROARYL AMIDES AS INHIBITORS OF PROTEIN AGGREGATION 审中-公开

    公开(公告)号：US20190308965A1

    公开(公告)日：2019-10-10

    申请号：US16438348

    申请日：2019-06-11

    Applicant: UCB Biopharma SPRL

    Inventor： Wolfgang WRASIDLO ,  Emily M. Stocking

    IPC: C07D417/12 ,  C07D413/12 ,  C07D417/14 ,  C07D403/12

    Abstract: The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.

    Multivalent antibodies
    74.
    发明授权
    Multivalent antibodies 有权

    公开(公告)号：US10421816B2

    公开(公告)日：2019-09-24

    申请号：US15165131

    申请日：2016-05-26

    Applicant: UCB PHARMA S.A.

    Inventor： Ralph Adams ,  Emma Dave ,  David Paul Humphreys

    IPC: C07K16/46 ,  C07K16/28 ,  C07K7/06 ,  C07K7/08 ,  C07K16/18

    Abstract: The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.

    Antibodies
    75.
    发明授权
    Antibodies 有权

    公开(公告)号：US10421814B2

    公开(公告)日：2019-09-24

    申请号：US15883130

    申请日：2018-01-30

    Applicant: UCB BIOPHARMA SPRL

    Inventor： Graham Craggs ,  Karine Jeannine Madeleine Herve ,  Diane Marshall

    IPC: C07K16/28 ,  C07K16/00 ,  A61K38/18 ,  A61K39/00

    Abstract: The present invention relates to an anti-CSF-1R antibody and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The present invention also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment.

    HOUSING FOR A USB CONNECTOR PLUG
    79.
    发明申请
    HOUSING FOR A USB CONNECTOR PLUG 审中-公开

    公开(公告)号：US20180337485A1

    公开(公告)日：2018-11-22

    申请号：US15777483

    申请日：2016-11-17

    Applicant: UCB Biopharma SPRL

    Inventor： Barry Alan KNIGHT ,  Oliver Frederik STUMPP

    IPC: H01R13/516 ,  H01R13/62

    CPC classification number: H01R13/516 ,  H01R13/62

    Abstract: Provided is a housing for a USB connector plug comprising a body for partly surrounding the USB connector plug, the body defining a forward aperture from which a plug head of the USB connector plug extends and a rearward aperture from which a cable of the USB connector plug extends. The body has an outer form, which defines on a first surface thereof, a thumb pad and on a second opposing surface, a finger pad. The outer form of the body is provided with a thumb push element that stands proud from a forward part of the thumb pad. The housing may also be configured as an over-housing for a conventional USB connector plug.

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