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公开(公告)号：US6143018A
公开(公告)日：2000-11-07
申请号：US545864
申请日：1996-03-28
申请人： Jurgen Beuthan , Andre Roggan , Gerhard Muller
发明人： Jurgen Beuthan , Andre Roggan , Gerhard Muller
CPC分类号： A61B18/24 , A61N5/0601 , A61B18/28 , A61B2018/206 , A61B2018/2261 , A61N2005/067
摘要： A process is disclosed for thermally obliterating biological tissues by laser radiation introduced into the tissue by means of an optical waveguide. The laser radiation is scattered by means associated with the radiation output surface of the optical waveguide. A biocompatible, medium to highly visquous liquid which does not substantially absorb the laser radiation but scatters it, is injected into the tissue, forming a scattering fluid deposit around the radiation output surface which is not separated from the tissue and which allows the tissue to be heated in a controlled manner.
摘要翻译： PCT No.PCT / DE94 / 00554 Sec。 371日期：1996年3月28日 102（e）1996年3月28日PCT PCT 1994年5月11日PCT公布。 出版物WO94 / 26184 日期1994年11月24日公开了通过光波导将激光辐射引入组织中的热消除生物组织的方法。 通过与光波导的辐射输出表面相关联的装置来散射激光辐射。 将基本上不吸收激光辐射但将其散射的生物相容的中等到高度粘稠的液体注射到组织中，在辐射输出表面周围形成散射流体沉积物，辐射输出表面不与组织分离，并且允许组织为 以受控的方式加热。
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公开(公告)号：US6096030A
公开(公告)日：2000-08-01
申请号：US935412
申请日：1997-09-23
申请人： Mark V. Ortiz
发明人： Mark V. Ortiz
CPC分类号： A61N5/062 , A61N5/0601 , A61B2018/2261
摘要： A light delivery catheter (2), for use in PDT treatments, includes a hollow sheath (4) with a balloon (24) at its distal end. Target tissue (33) at a target site on a hollow body organ, such as a blood vessel, is inoculated with an appropriate photosensitizing agent. A light guide (14) extends along the sheath and has a light-radiating portion or light source (20) at its end within the balloon. The balloon is positioned at the target site and target tissue is irradiated causing destruction of the target tissue. The balloon defines perfusion channels (30) when the balloon is inflated so that during use fluid can continue passing through the blood vessel. The light irradiating the vessel wall is preferably of generally equal intensity. This can be achieved in whole or in part in several different ways.
摘要翻译： 用于PDT处理的光输送导管（2）包括在其远端具有气囊（24）的中空护套（4）。 在适当的光敏剂上接种空心体器官如血管上的目标部位的靶组织（33）。 导光体（14）沿着护套延伸并且在其气球内部具有光辐射部分或光源（20）。 气球位于目标位置，靶组织被照射，从而破坏目标组织。 当气囊膨胀时，气囊限定灌注通道（30），使得在使用期间，流体可以继续通过血管。 照射血管壁的光优选地具有大致相等的强度。 这可以以几种不同的方式全部或部分地实现。
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公开(公告)号：US6039728A
公开(公告)日：2000-03-21
申请号：US313256
申请日：1994-12-05
CPC分类号： A61N5/0601 , A61B2018/00023 , A61B2018/2261
摘要： An optical working shaft system. The system includes a working shaft for insertion into a working tube of at least one of an endoscope and a catheter. The working shaft has a distal end defining a distal area in a vicinity thereof, and further includes: a device for radiating optical beams through the distal end; and a fluid for scattering the beams at least in the distal area. The fluid is operatively associated with the device for radiating such that, at least in the distal area, a path of the beams extends inside the fluid, the fluid further being effective as a coolant for removing waste heat generated by a scattering of the beams in the distal area.
摘要翻译： PCT No.PCT / DE93 / 00321 Sec。 371日期1994年12月5日第 102（e）日期1994年12月5日PCT提交1993年4月2日PCT公布。 公开号WO93 / 19680 日期1993年10月14日光学工作轴系统。 该系统包括用于插入到内窥镜和导管中的至少一个的工作管中的工作轴。 工作轴具有限定其附近的远侧区域的远端，并且还包括：用于通过远端辐射光束的装置; 以及用于至少在远侧区域中散射梁的流体。 流体与装置可操作地相关联，用于辐射，使得至少在远侧区域中，梁的路径在流体内部延伸，流体作为冷却剂进一步有效，用于消除由梁中的散射产生的废热 远端区域。
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公开(公告)号：US6013053A
公开(公告)日：2000-01-11
申请号：US649439
申请日：1996-05-17
申请人： Bob Bower , Mike Stonefield , Joseph Yan
发明人： Bob Bower , Mike Stonefield , Joseph Yan
IPC分类号： A61M25/00 , A61B17/00 , A61B17/22 , A61B18/00 , A61B18/22 , A61B18/24 , A61N5/06 , A61M29/00
CPC分类号： A61N5/062 , A61B18/24 , A61N5/0601 , A61B2017/00057 , A61B2017/22058 , A61B2017/22059 , A61B2018/2261
摘要： The present invention provides improved balloon catheter apparatuses for use in therapies requiring delivery of uniform light to a treatment area. The improved apparatus comprises a balloon having a defined treatment window where the window is delineated using a reflective material. The apparatus may further include a fiber optic cable that terminates in a diffusion tip where the diffusion tip is longer than the treatment window. The present invention further provides improved therapeutic methods that use the improved balloon catheters of the present invention.
摘要翻译： 本发明提供了改进的球囊导管装置，其用于需要向治疗区域递送均匀光的疗法。 改进的装置包括具有限定的处理窗口的气球，其中使用反射材料描绘窗口。 该装置还可以包括光纤电缆，其终止于扩散尖端，其中扩散尖端比治疗窗口长。 本发明还提供了使用本发明的改进的气囊导管的改进的治疗方法。
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公开(公告)号：US5964751A
公开(公告)日：1999-10-12
申请号：US140116
申请日：1998-08-25
申请人： Curtis A. Amplatz , Mark A. Rydell , Robert J. Ziebol , Christopher H. Porter , Michael Kasinkas
发明人： Curtis A. Amplatz , Mark A. Rydell , Robert J. Ziebol , Christopher H. Porter , Michael Kasinkas
CPC分类号： A61B17/22 , A61B18/22 , A61B2017/22051 , A61B2018/2261 , A61M1/00 , A61M25/104 , A61M29/02
摘要： A light delivery system for use in irradiating vascular tissue includes a balloon catheter with a working lumen for receiving an optical fiber therein and an inflation/flushing lumen adapted to receive a liquid at a proximal end and leading to a space defined within the balloon member attached to a distal end of the catheter. The balloon member has a pattern of holes or pores in the wall thereof through which the saline may flow when the balloon is inflated, causing any blood or other absorbing substances that may interfere with good radiant energy transmission to be flushed away from the treatment site.
摘要翻译： 用于照射血管组织的光输送系统包括球囊导管，其具有用于在其中接收光纤的工作腔，以及适于在近端接收液体并且导致限定在所述球囊构件附近的空间的充气/冲洗腔 到导管的远端。 气球构件在其壁中具有孔或孔的图案，当气囊膨胀时，盐可以通过该孔或孔流动，导致可能干扰良好的辐射能量传递的任何血液或其它吸收物质从治疗部位冲洗掉。
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公开(公告)号：US5947959A
公开(公告)日：1999-09-07
申请号：US991130
申请日：1997-12-16
申请人： Edward L. Sinofsky
发明人： Edward L. Sinofsky
CPC分类号： A61L2/10 , A61L29/085 , A61N5/0601 , A61B2018/2261
摘要： Methods and devices are disclosed in which a dielectric structure is operatively coupled to phototherapeutic instrument to reflect light without substantial heating. The invention is particularly useful in light diffusive tip assemblies for phototherapy that have components which increase in temperature after prolonged exposure to light, such as metallic plugs or coatings typically located at the end cap of the diffusive tip assembly to terminate light propagation, and also metallic structures incorporated into phototherapeutic instruments to facilitate radiographic or fluoroscopic imaging during a therapeutic procedure.
摘要翻译： 公开了一种方法和装置，其中介电结构可操作地耦合到光电仪器以反射光而不需要大量加热。 本发明特别适用于具有长时间暴露在光照之后温度升高的成分的光扩散尖端组件，例如通常位于扩散尖端组件的端盖处以终止光传播的金属塞或涂层，以及金属 结合到光治疗仪器中的结构以便于在治疗过程中促进放射照相或荧光透视成像。
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77.发明授权Reduction of an arteriosclerotic lesion by selective absorption of electromagnetic energy in a component thereof 失效通过在其组件中选择性吸收电磁能来减少动脉硬化病变
公开(公告)号：US5876397A
公开(公告)日：1999-03-02
申请号：US953329
申请日：1992-09-29
CPC分类号： A61B18/28 , A61B18/245 , A61B2018/2261
摘要： A novel method for reducing an arteriosclerotic lesion is disclosed in which the electromagnetic energy directed at the lesion is selectively absorbed by a lesion component, e.g. cholesterol. The resulting decomposition of said lesion component leads to reduction of the lesion with minimal risk of damage to blood constituents and adjacent healthy blood vessel tissue. Preferably, monochromatic electromagnetic energy is generated by a laser and is conducted to the vicinity of the lesion by at least one optical fiber.
摘要翻译： 公开了一种用于减少动脉硬化病变的新方法，其中指向病变的电磁能量被病变部件选择性地吸收，例如， 胆固醇。 由此导致的所述损伤组分的分解导致损伤的减少，同时对血液成分和相邻的健康血管组织的损伤风险最小。 优选地，单色电磁能量由激光产生，并通过至少一根光纤传导到病变附近。
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公开(公告)号：US5861020A
公开(公告)日：1999-01-19
申请号：US849370
申请日：1997-06-06
CPC分类号： A61N5/0601 , A61B2018/2261 , A61N2005/061
摘要： In an apparatus used to irradiate body tissue with high-intensity laser light, a probe with at least one waveguide is used which can be coupled with a laser light source and which at its light-exiting section, which can be inserted in the body tissue, is equipped with a diffuser element which consists of a base material that is highly transparent to the laser light and, dispersed therein, scattering particles that deflect the light rays, and with a first cover tube that surrounds the waveguide at a distance, that connects to a coolant source, that is open at its distal end and that, at least in the region of the diffuser element, is made of a transparent and good heat-conducting material, a device for modifying beam intensity is situated in the path of the laser beam before the input coupling point, with the waveguide in the region of the light-exiting section being surrounded by a reflector and/or absorber that has at least one light outlet in the region of the target radiation surface.
摘要翻译： PCT No.PCT / EP95 / 04629 Sec。 371日期：1997年6月6日 102（e）日期1997年6月6日PCT提交1995年11月23日PCT公布。 公开号WO96 / 17655 日期1996年6月13日在用于以高强度激光照射身体组织的装置中，使用具有至少一个波导的探针，其可以与激光光源耦合，并且在其光出射部分处可以是 插入身体组织中，配备有扩散器元件，该扩散器元件由对激光高度透明并且分散在其中的散射粒子偏转光线的基底材料以及围绕波导的第一覆盖管组成 连接到冷却剂源的距离，其在其远端处是开放的，并且至少在扩散器元件的区域中由透明和良好的导热材料制成，用于修改束强度的装置位于 在输入耦合点之前的激光束的路径中，光出射部分的区域中的波导被反射器和/或吸收器所包围，所述反射器和/或吸收器具有至少一个光源出口， t辐射面。
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公开(公告)号：US5797868A
公开(公告)日：1998-08-25
申请号：US690329
申请日：1996-07-25
申请人： James E. Leone
发明人： James E. Leone
CPC分类号： A61N5/062 , A61N5/0601 , A61B2018/2261 , A61M25/10
摘要： A photodynamic therapy balloon catheter is provided which has an elongated light-emanating optical fiber, an inner tubular member, a balloon member surrounding the inner tubular member, and fluid material provided between the inner tubular member and the balloon member. Light-reflective material is included in any one or a plurality of the inner member, fluid material, and balloon member in any combination to provide a uniform illumination for activating treatment fluids located on an elongated treatment site within a living body.
摘要翻译： 提供一种光动力治疗球囊导管，其具有细长的发光光纤，内部管状构件，围绕内部管状构件的气囊构件以及设置在内部管状构件和气囊构件之间的流体材料。 光反射材料以任何组合包括在任何一个或多个内部构件，流体材料和气囊构件中，以提供用于激活位于活体内的细长治疗部位上的处理流体的均匀照明。
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公开(公告)号：US5754717A
公开(公告)日：1998-05-19
申请号：US813255
申请日：1997-03-07
申请人： Victor C. Esch
发明人： Victor C. Esch
CPC分类号： G02B6/241 , G02B6/0008 , A61B2018/2261 , Y10S385/902
摘要： A diffusing tip is provided for diffusing light from a light-emitting end of an optical fiber in a radial distribution pattern relative to the axis of the tip and along a length of the tip. The tip has an inner core and an outer covering which define a light guide. The outer covering is modified on its interior surface adjacent to the core such that light transmitted down the light guide is removed from the core upon encountering a surface modification on the interior surface. The light so removed is transmitted to the outer surface along the length of the tip, where it can be used to irradiate a selected object or material. The diffusing tip preferably provides light in a substantially uniform intensity distribution for the substantially uniform irradiation of a selected object or material.
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