公开(公告)号：US20140303542A1

公开(公告)日：2014-10-09

申请号：US13830276

申请日：2013-03-14

申请人： Brian J. LeBerthon

发明人： Brian J. LeBerthon

IPC分类号： A61M1/36

CPC分类号： A61M1/3486 ,  A61M1/3489 ,  A61M1/3493 ,  A61M1/3616 ,  A61M1/362 ,  A61M1/3687

摘要： A method and device treats cancer where blood from a cancer patient passes through an array of passageways within an interior of a chamber. The passageways include wells having porous membrane wall portions that enable a molecular-sized activating agent in a carrier fluid that enhances an immune response to pass through these porous wall portions. Pore size is such to allow the molecular-sized activating agent in the interior of the chamber to enter the wells yet prevents immune cells and cancer cells in the wells to pass through the porous wall portions into the interior of the chamber. Blood is retained in the wells so that it remains in contact with the immune cells and cancer cells for a predetermined period sufficient to enhance an immune response. Then the cells with an enhanced immune response are return to the patient.

摘要翻译： 一种方法和装置治疗来自癌症患者的血液通过腔室内的通道阵列的癌症。 通道包括具有多孔膜壁部分的孔，其能够使载体流体中的分子尺寸的活化剂增强免疫应答以通过这些多孔壁部分。 孔径使得室内部的分子尺寸的活化剂进入孔中，但是防止孔中的免疫细胞和癌细胞通过多孔壁部分进入腔室的内部。 血液保留在孔中，使其保持与免疫细胞和癌细胞接触足够增强免疫应答的预定时间。 然后具有增强的免疫应答的细胞返回患者。

公开(公告)号：US20140209542A1

公开(公告)日：2014-07-31

申请号：US14168822

申请日：2014-01-30

申请人： The Charles Stark Draper Laboratory, Inc.

发明人： Tammy Spain ,  Jason O. Fiering ,  Leila Albers

IPC分类号： A61M1/36

CPC分类号： A61M1/362 ,  A61M1/3678 ,  A61M1/3693 ,  B01D21/283

摘要： Systems, methods, and compositions for removing organophosphate toxins from blood are disclosed herein. The compositions include a lipid-based capture particle that displays BChE that binds to the toxin. The methods include acoustically separating toxins bound to lipid-based capture particles from blood factors of whole blood.

摘要翻译： 本文公开了从血液中除去有机磷酸盐毒素的系统，方法和组合物。 组合物包括显示结合毒素的BChE的基于脂质的捕获颗粒。 这些方法包括将与脂质捕获颗粒结合的毒素与全血的血液因子进行声学分离。

公开(公告)号：US20140166578A1

公开(公告)日：2014-06-19

申请号：US14185033

申请日：2014-02-20

申请人： AETHLON MEDICAL, INC.

发明人： Thomas Ichim ,  Richard H. Tullis

IPC分类号： A61M1/36 ,  A61M1/16

CPC分类号： A61M1/362 ,  A61M1/16 ,  A61M1/3496 ,  A61M1/3679 ,  B01D15/00 ,  B01J20/28014 ,  B01J20/3242

摘要： The invention described herein teaches methods of removing microvesicular particles, which include but are not limited to exosomes, from the systemic circulation of a subject in need thereof with the goal of reversing antigen-specific and antigen-nonspecific immune suppression. Said microvesicular particles could be generated by host cells that have been reprogrammed by neoplastic tissue, or the neoplastic tissue itself. Compositions of matter, medical devices, and novel utilities of existing medical devices are disclosed.

公开(公告)号：US20130131627A1

公开(公告)日：2013-05-23

申请号：US13657027

申请日：2012-10-22

申请人： Searete LLC

发明人： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR.

IPC分类号： A61M1/00

CPC分类号： A61B5/14503 ,  A61B18/18 ,  A61F2/82 ,  A61M1/00 ,  A61M1/362 ,  A61M1/3679 ,  A61M1/3681 ,  A61M1/3683 ,  A61M5/00 ,  A61M5/007 ,  A61M5/14276 ,  A61M2202/0405 ,  A61M2205/04 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/062 ,  A61N7/00

摘要： Devices, systems, and methods are described herein for controlling or modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject. Devices and systems are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to fluid flow into the at least one lumen; at least one first reservoir disposed within the body and configured to include one or more bifunctional tags, wherein the one or more bifunctional tags are configured to selectively bind to one or more target components in one or more of blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; and at least one second reservoir disposed in the at least one treatment region and configured to include one or more reactive components, wherein the one or more reactive components are configured to sequester the one or more bifunctional tags when bound to the one or more target components.

公开(公告)号：US20130109934A1

公开(公告)日：2013-05-02

申请号：US13656964

申请日：2012-10-22

申请人： Searete LLC

发明人： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood

IPC分类号： A61M5/00 ,  A61B5/145

CPC分类号： A61B5/14503 ,  A61B18/18 ,  A61F2/82 ,  A61M1/00 ,  A61M1/362 ,  A61M1/3679 ,  A61M1/3681 ,  A61M1/3683 ,  A61M5/00 ,  A61M5/007 ,  A61M5/14276 ,  A61M2202/0405 ,  A61M2205/04 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/062 ,  A61N7/00

摘要： Devices, systems, and methods are described herein for controlling or modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject. Devices and systems are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to fluid flow into the at least one lumen; at least one first reservoir disposed within the body and configured to include one or more bifunctional tags, wherein the one or more bifunctional tags are configured to selectively bind to one or more target components in one or more of blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; and at least one second reservoir disposed in the at least one treatment region and configured to include one or more reactive components, wherein the one or more reactive components are configured to sequester the one or more bifunctional tags when bound to the one or more target components.

摘要翻译： 本文描述了用于控制或调节脊椎动物受试者的血液和/或淋巴中的一种或多种靶组分的水平的装置，系统和方法。 提供了设备和系统，其包括限定被配置用于流体流动的至少一个内腔的主体; 流体流入所述至少一个内腔中的至少一个可控流动屏障; 设置在体内并被配置为包括一个或多个双功能标签的至少一个第一储存器，其中所述一个或多个双功能标签被配置为选择性地结合脊椎动物的一种或多种血液流体或淋巴液中的一种或多种靶组分 学科; 设置在所述至少一个内腔内的至少一个治疗区域; 以及设置在所述至少一个处理区域中并且被配置为包括一个或多个反应性组分的至少一个第二储存器，其中所述一个或多个反应性组分被配置为当结合到所述一种或多种靶组分时螯合所述一种或多种双功能标签 。

公开(公告)号：US08246565B2

公开(公告)日：2012-08-21

申请号：US12660926

申请日：2010-03-05

申请人： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, Jr.

发明人： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, Jr.

IPC分类号： A61M37/00 ,  C02F1/44 ,  A61K9/22

CPC分类号： A61B5/14503 ,  A61B18/18 ,  A61F2/82 ,  A61M1/00 ,  A61M1/362 ,  A61M1/3679 ,  A61M1/3681 ,  A61M1/3683 ,  A61M5/00 ,  A61M5/007 ,  A61M5/14276 ,  A61M2202/0405 ,  A61M2205/04 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/062 ,  A61N7/00

摘要： Devices, systems, and methods are described herein for controlling or modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject. Devices and systems are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to fluid flow into the at least one lumen; at least one first reservoir disposed within the body and configured to include one or more bifunctional tags, wherein the one or more bifunctional tags are configured to selectively bind to one or more target components in one or more of blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; and at least one second reservoir disposed in the at least one treatment region and configured to include one or more reactive components, wherein the one or more reactive components are configured to sequester the one or more bifunctional tags when bound to the one or more target components.

公开(公告)号：US08167871B2

公开(公告)日：2012-05-01

申请号：US12660928

申请日：2010-03-05

申请人： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, Jr.

发明人： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, Jr.

IPC分类号： A61K9/22

CPC分类号： A61B5/14503 ,  A61B18/18 ,  A61F2/82 ,  A61M1/00 ,  A61M1/362 ,  A61M1/3679 ,  A61M1/3681 ,  A61M1/3683 ,  A61M5/00 ,  A61M5/007 ,  A61M5/14276 ,  A61M2202/0405 ,  A61M2205/04 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/062 ,  A61N7/00

摘要： Devices, systems, and methods are described herein for controlling the level of one or more target cell types in the blood fluid and/or lymph fluid of a vertebrate subject. Devices and systems are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to the at least one lumen; one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; at least one reactive component disposed in the at least one treatment region, the at least one reactive component configured to modulate a physiological effect of the one or more target cell types in the vertebrate subject; and at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen; wherein the at least one controller is configured to open or close the at least one controllable flow barrier in response to the one or more sensor.

摘要翻译： 本文描述了用于控制脊椎动物受试者的血液流体和/或淋巴液中的一种或多种靶细胞类型的水平的装置，系统和方法。 提供了设备和系统，其包括限定被配置用于流体流动的至少一个内腔的主体; 至少一个可控流阻挡至所述至少一个内腔; 一个或多个传感器被配置为检测脊椎动物对象的血液流体或淋巴液中的一种或多种靶细胞类型; 设置在所述至少一个内腔内的至少一个治疗区域; 设置在所述至少一个处理区域中的至少一个反应性组分，所述至少一个反应性组分配置成调节脊椎动物对象中所述一种或多种靶细胞类型的生理作用; 以及与所述一个或多个传感器通信并与所述至少一个可控流动屏障连通至少一个内腔的至少一个控制器; 其中所述至少一个控制器被配置为响应于所述一个或多个传感器来打开或关闭所述至少一个可控流动屏障。

公开(公告)号：US20110184377A1

公开(公告)日：2011-07-28

申请号：US12958355

申请日：2010-12-01

申请人： Robert S. WARD ,  Keith R. MCCREA ,  Olle Larm ,  Lars Adolfsson

发明人： Robert S. WARD ,  Keith R. MCCREA ,  Olle Larm ,  Lars Adolfsson

IPC分类号： A61M5/00 ,  B01D61/00

CPC分类号： A61M1/362 ,  A61K31/60 ,  A61K31/722 ,  A61K31/727 ,  A61K31/728 ,  A61M1/3472 ,  A61M1/3496 ,  A61M1/36 ,  A61M1/3621 ,  A61M1/3673 ,  A61M1/3679 ,  A61M1/3687 ,  A61M1/38 ,  A61M2202/0057

摘要： The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.

摘要翻译： 本发明涉及通过使血液与已经用肝素，硫酸乙酰肝素和/或表面处理的固体，基本上非微孔的底物接触，从血液或血清（血液）中除去细胞因子和/或病原体的方法 对待除去的细胞因子或病原体（吸附物）具有结合亲和力的其它分子或化学基团（吸附介质或介质），并且其中所述介质中的间质通道的大小与介质的量平衡 表面积和培养基上结合位点的表面浓度，以提供足够的吸附能力，同时还允许血液通过吸附介质的相对较高的流速。

公开(公告)号：US20100268199A1

公开(公告)日：2010-10-21

申请号：US12660926

申请日：2010-03-05

申请人： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR.

发明人： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR.

IPC分类号： A61M37/00

CPC分类号： A61B5/14503 ,  A61B18/18 ,  A61F2/82 ,  A61M1/00 ,  A61M1/362 ,  A61M1/3679 ,  A61M1/3681 ,  A61M1/3683 ,  A61M5/00 ,  A61M5/007 ,  A61M5/14276 ,  A61M2202/0405 ,  A61M2205/04 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/062 ,  A61N7/00

摘要： Devices, systems, and methods are described herein for controlling or modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject. Devices and systems are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to fluid flow into the at least one lumen; at least one first reservoir disposed within the body and configured to include one or more bifunctional tags, wherein the one or more bifunctional tags are configured to selectively bind to one or more target components in one or more of blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; and at least one second reservoir disposed in the at least one treatment region and configured to include one or more reactive components, wherein the one or more reactive components are configured to sequester the one or more bifunctional tags when bound to the one or more target components.

公开(公告)号：US20100210989A1

公开(公告)日：2010-08-19

申请号：US12628303

申请日：2009-12-01

申请人： Janet Lesley Macpherson ,  David Perritt ,  Kevin Henrichsen ,  Geoffrey Phillip Symonds ,  Susan Pond ,  Philip Wong

发明人： Janet Lesley Macpherson ,  David Perritt ,  Kevin Henrichsen ,  Geoffrey Phillip Symonds ,  Susan Pond ,  Philip Wong

IPC分类号： A61M1/38

CPC分类号： A61M1/3496 ,  A61M1/362 ,  A61M1/3626 ,  A61M1/3672 ,  A61M1/3689 ,  A61M1/3696 ,  A61M1/38 ,  A61M2202/0064 ,  A61M2202/0439 ,  B03C1/015 ,  B04B5/10 ,  B04B11/02

摘要： Methods (300), devices, and systems of processing blood are described. The method (300) comprises the steps of: obtaining (312) blood from a patient coupled to a single blood processing device to form a closed loop between the patient and the blood processing device; collecting (314) bulk mononuclear blood cells from the blood by leukapheresis implemented using the blood processing device in the closed loop; and enriching (316) concurrently target cells separated from non-target cells in the bulk mononuclear blood cells using the blood processing device in the closed loop.

摘要翻译： 描述了处理血液的方法（300），装置和系统。 方法（300）包括以下步骤：从连接到单个血液处理装置的患者获得（312）血液，以在患者和血液处理装置之间形成闭合环路; 通过在闭环中使用血液处理装置实现白细胞分选从血液中收集（314）大量单核血细胞; 并且使用闭环中的血液处理装置，将大量单核细胞中的非靶细胞分离并富集（316）。