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    Device for actively removing a target component from blood or lymph of a vertebrate subject
    3.
    发明授权
    Device for actively removing a target component from blood or lymph of a vertebrate subject 有权
    用于从脊椎动物受试者的血液或淋巴中主动去除靶组分的装置

    公开(公告)号：US08317737B2

    公开(公告)日：2012-11-27

    申请号：US12803449

    申请日：2010-06-25

    申请人： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, Jr.

    发明人： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, Jr.

    IPC分类号： A61M37/00 ,  C02F1/44 ,  A61K9/22

    CPC分类号： A61M5/14276 ,  A61M5/1723

    摘要： Devices, systems, and methods are disclosed herein for modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject for treatment of a disease or condition in the vertebrate subject. An implantable device is provided which includes a body defining at least one lumen configured for fluid flow; at least one first reservoir in communication with at least one lumen; one or more energy sources configured to provide energy to elicit one or more signal responses associated with one or more labels that bind to one or more target components in one or more of blood fluid or lymph fluid of the vertebrate subject; one or more sensors configured to detect the one or more signal responses associated with one or more labeled target components; and one or more reactive components in communication with the at least one lumen for release responsive to the one or more sensors.

    摘要翻译： 本文公开的装置，系统和方法用于调节脊椎动物受试者的血液和/或淋巴中的一种或多种靶组分的水平以治疗脊椎动物受试者中的疾病或病症。 提供了一种可植入装置，其包括限定为流体流动配置的至少一个内腔的主体; 与至少一个内腔连通的至少一个第一储存器; 一个或多个能量源被配置为提供能量以引发与一个或多个与所述脊椎动物对象的一个​​或多个血液流体或淋巴液中的一个或多个目标成分结合的一个或多个标签相关联的一个或多个信号响应; 一个或多个传感器被配置为检测与一个或多个标记的目标分量相关联的一个或多个信号响应; 以及响应于所述一个或多个传感器而与所述至少一个内腔连通的一个或多个反应性部件用于释放。

    Device for actively removing a target cell from blood or lymph of a vertebrate subject
    6.
    发明授权
    Device for actively removing a target cell from blood or lymph of a vertebrate subject 有权
    用于主动地从脊椎动物受试者的血液或淋巴中去除靶细胞的装置

    公开(公告)号：US08167871B2

    公开(公告)日：2012-05-01

    申请号：US12660928

    申请日：2010-03-05

    申请人： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, Jr.

    发明人： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, Jr.

    IPC分类号： A61K9/22

    CPC分类号： A61B5/14503 ,  A61B18/18 ,  A61F2/82 ,  A61M1/00 ,  A61M1/362 ,  A61M1/3679 ,  A61M1/3681 ,  A61M1/3683 ,  A61M5/00 ,  A61M5/007 ,  A61M5/14276 ,  A61M2202/0405 ,  A61M2205/04 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/062 ,  A61N7/00

    摘要： Devices, systems, and methods are described herein for controlling the level of one or more target cell types in the blood fluid and/or lymph fluid of a vertebrate subject. Devices and systems are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to the at least one lumen; one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; at least one reactive component disposed in the at least one treatment region, the at least one reactive component configured to modulate a physiological effect of the one or more target cell types in the vertebrate subject; and at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen; wherein the at least one controller is configured to open or close the at least one controllable flow barrier in response to the one or more sensor.

    摘要翻译： 本文描述了用于控制脊椎动物受试者的血液流体和/或淋巴液中的一种或多种靶细胞类型的水平的装置，系统和方法。 提供了设备和系统，其包括限定被配置用于流体流动的至少一个内腔的主体; 至少一个可控流阻挡至所述至少一个内腔; 一个或多个传感器被配置为检测脊椎动物对象的血液流体或淋巴液中的一种或多种靶细胞类型; 设置在所述至少一个内腔内的至少一个治疗区域; 设置在所述至少一个处理区域中的至少一个反应性组分，所述至少一个反应性组分配置成调节脊椎动物对象中所述一种或多种靶细胞类型的生理作用; 以及与所述一个或多个传感器通信并与所述至少一个可控流动屏障连通至少一个内腔的至少一个控制器; 其中所述至少一个控制器被配置为响应于所述一个或多个传感器来打开或关闭所述至少一个可控流动屏障。