公开(公告)号：US12083499B2

公开(公告)日：2024-09-10

申请号：US17311437

申请日：2019-11-11

申请人： SHOWA DENKO K.K.

发明人： Hirotsugu Nakanishi ,  Ritsuko Wakayama

IPC分类号： B01J20/283 ,  B01J20/10 ,  B01J20/28 ,  B01J20/30 ,  B01J20/32 ,  G01N30/08 ,  G01N30/56 ,  G01N30/74

CPC分类号： B01J20/283 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28061 ,  B01J20/3092 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3248 ,  G01N30/08 ,  G01N30/56 ,  G01N30/74 ,  G01N2030/565

摘要： Provided is a guard column including a filling part having a length of 2.0 cm to 3.5 cm formed of a filler, in which the filler is made of porous silica gel having a hydrophilized surface and an average particle size of 1.5 μm to 2.5 μm, and a pressure difference when an aqueous solution is fed at a linear flow rate of 2.1 cm/min is 4.0 MPa or more.

公开(公告)号：US11927573B2

公开(公告)日：2024-03-12

申请号：US17156939

申请日：2021-01-25

申请人： CYTIVA BIOPROCESS R&D AB

发明人： Klaus Gebauer

IPC分类号： B01D15/18 ,  B01D15/20 ,  B01D15/22 ,  G01N30/56 ,  G01N30/60 ,  G01N30/86

CPC分类号： G01N30/6004 ,  B01D15/18 ,  B01D15/206 ,  B01D15/22 ,  G01N30/56 ,  G01N30/606 ,  G01N30/8658 ,  G01N2030/565 ,  G01N30/6017 ,  G01N30/6021 ,  G01N30/6052

摘要： The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.

公开(公告)号：US20160206972A1

公开(公告)日：2016-07-21

申请号：US15067694

申请日：2016-03-11

申请人： Bio-Rad Laboratories, Inc.

发明人： Sébastien Lefebvre ,  Lilian Portier ,  Maurice Agée

IPC分类号： B01D15/22 ,  B01D15/20

CPC分类号： B01D15/22 ,  B01D15/206 ,  B65B1/24 ,  F16L11/00 ,  F16L33/00 ,  G01N30/56 ,  G01N30/6021 ,  G01N30/603 ,  G01N30/6082 ,  G01N2030/565 ,  Y10T29/49865

摘要： A chromatography column design and a packing device, as well as a method for obtaining a column with a very compact and uniform bed are provided. The bed remains compact and uniform during operation of the column and during sanitization, storage and transportation of the column. The amount of hardware, particularly the hardware parts in contact with product, is minimized, especially with the implementation of an internal liner. With this internal liner, the packed bed can be separated from the column in intact form, or even prepared separately from, and outside of, the column.

公开(公告)号：US09110060B2

公开(公告)日：2015-08-18

申请号：US12251491

申请日：2008-10-15

申请人： Kristian Windahl

发明人： Kristian Windahl

IPC分类号： G01N30/56 ,  B01D15/20 ,  G01N30/60

CPC分类号： G01N30/56 ,  B01D15/206 ,  G01N30/6021 ,  G01N2030/565

摘要： A column packing system comprises a control unit provided with software for monitoring the column interior pressure and/or flow through the column for use in calculating the breakpoint where a movable adapter comes into contact with a consolidated bed of bed media. The calculated breakpoint is used by the control unit to determine how much further the movable adapter has to move into the column in order to achieve a desired amount of bed compression.

摘要翻译： 柱填充系统包括控制单元，该控制单元具有用于监测柱内部压力和/或流过柱的软件，用于计算可移动适配器与固定的床介质床接触的断点。 所计算的断点由控制单元用于确定可移动适配器进一步移动到柱中以进一步达到期望的床压缩量。

公开(公告)号：US20150129501A1

公开(公告)日：2015-05-14

申请号：US14077286

申请日：2013-11-12

申请人： Orochem Technologies, Inc.

发明人： Anil R. Oroskar ,  Asha A. Oroskar ,  Ved Bhushan Gulati ,  Rakesh Vikraman Nair Rema

IPC分类号： B01D15/16

CPC分类号： B01D15/165 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N2030/562 ,  G01N2030/565

摘要： A flash chromatography apparatus which provides an improved apparatus for large and medium commercial scale flash chromatography columns. More particularly, the invention relates to a flash chromatography column and cartridge system for positioning and ease of loading and unloading of stationary phase agent in the flash chromatography column. The flash chromatography column further provides flow distributors to support the stationary phase and permit plug flow through the column. The apparatus of the present is modular and can be disposed in any configuration to reduce maintenance cost and downtime in a commercial installation. Flash chromatography is widely used for purification of low molecular weight organic compounds and products of organic synthetic reactions.

摘要翻译： 一种快速色谱装置，其提供用于大中型商业规模的快速色谱柱的改进装置。 更具体地说，本发明涉及一种用于定位和易于在快速色谱柱中装载和卸载固定相试剂的快速色谱柱和色谱柱系统。 快速色谱柱进一步提供流动分配器以支持固定相并允许活塞流通过柱。 本发明的设备是模块化的，并且可以以任何配置来布置，以降低商业安装中的维护成本和停机时间。 快速色谱法广泛用于低分子量有机化合物和有机合成反应产物的纯化。

公开(公告)号：US20130228501A1

公开(公告)日：2013-09-05

申请号：US13771371

申请日：2013-02-20

申请人： Sébastien Lefebvre ,  Lilian Portier ,  Maurice Agée

发明人： Sébastien Lefebvre ,  Lilian Portier ,  Maurice Agée

IPC分类号： B01D15/22 ,  F16L11/00 ,  F16L33/00 ,  B65B1/24

CPC分类号： B01D15/22 ,  B01D15/206 ,  B65B1/24 ,  F16L11/00 ,  F16L33/00 ,  G01N30/56 ,  G01N30/6021 ,  G01N30/603 ,  G01N30/6082 ,  G01N2030/565 ,  Y10T29/49865

摘要： A chromatography column design and a packing device, as well as a method for obtaining a column with a very compact and uniform bed are provided. The bed remains compact and uniform during operation of the column and during sanitization, storage and transportation of the column. The amount of hardware, particularly the hardware parts in contact with product, is minimized, especially with the implementation of an internal liner. With this internal liner, the packed bed can be separated from the column in intact form, or even prepared separately from, and outside of, the column.

摘要翻译： 提供色谱柱设计和包装装置，以及用于获得具有非常紧凑和均匀的床的柱的方法。 在塔的运行期间和在柱的消毒，储存和运输期间，该床保持紧凑和均匀。 硬件的数量，特别是与产品接触的硬件部件的数量被最小化，特别是通过实施内衬。 使用这种内衬，填充床可以以完整的形式与柱分离，或者甚至与柱分离制备，也可以与柱分离。

公开(公告)号：US20130193051A1

公开(公告)日：2013-08-01

申请号：US13639165

申请日：2011-04-05

申请人： Mary Jean Wirth ,  Sampath Ranasinghe Kodithuwakkuge ,  Charu Yerneni ,  Robert Birdsall ,  Tharanga Ranasinghe Kodituwakkuge

发明人： Mary Jean Wirth ,  Sampath Ranasinghe Kodithuwakkuge ,  Charu Yerneni ,  Robert Birdsall ,  Tharanga Ranasinghe Kodituwakkuge

IPC分类号： B01D15/20

CPC分类号： B01D15/206 ,  B01D15/168 ,  B01D15/305 ,  B01D15/325 ,  B01J20/283 ,  G01N30/56 ,  G01N2030/562 ,  G01N2030/565 ,  G01N2030/8831

摘要： Improved methods for packing a chromatographic column and columns packed by these methods are provided. The methods include introducing a packing material into a chromatographic column, while simultaneously ultrasonicating and applying pressure to the packing material to form a packed column with radial homogeneity.

摘要翻译： 提供了通过这些方法包装色谱柱和色谱柱的改进方法。 所述方法包括将包装材料引入色谱柱，同时对包装材料进行超声波和施加压力以形成具有径向均匀性的填充柱。

公开(公告)号：US20120124810A1

公开(公告)日：2012-05-24

申请号：US13362184

申请日：2012-01-31

申请人： Mark A. SNYDER

发明人： Mark A. SNYDER

IPC分类号： B23P11/00 ,  F16B35/00

CPC分类号： B01D15/22 ,  B01D15/206 ,  G01F23/04 ,  G01N30/56 ,  G01N30/6021 ,  G01N2030/565 ,  Y10T29/49826

摘要： In an axial-flow preparative chromatography column that contains a piston, commonly termed an adaptor, that is lowered over the top of the resin, the ability to lower the piston in a controlled manner to minimize the chances of damage to the resin is achieved by use of an aperture either in the piston head itself or in a compound bolt that secures the upper column frit to the piston head. The aperture is closed with a removable plug during storage and use of the piston head and column. During packing of the bed, however, the plug is replaced by a graduated rod operating as a dipstick to allow the operator to determine the distance between the bottom face of the piston head and the upper surface of the column packing.

摘要翻译： 在轴流式制备色谱柱中，其包含通常称为适配器的活塞，其在树脂的顶部被降低，以受控的方式降低活塞以使树脂损坏机会最小化的能力通过 在活塞头本身或复合螺栓中使用孔，其将上柱玻璃料固定到活塞头。 在活塞头和柱的储存和使用期间，孔用可移除的塞子封闭。 然而，在包装床的过程中，插头被作为量油尺操作的刻度杆代替，以使操作者确定活塞头的底面与柱填料的上表面之间的距离。

公开(公告)号：US08128816B2

公开(公告)日：2012-03-06

申请号：US12813844

申请日：2010-06-11

申请人： Mark A. Snyder

发明人： Mark A. Snyder

IPC分类号： B01D15/08

CPC分类号： B01D15/22 ,  B01D15/206 ,  G01F23/04 ,  G01N30/56 ,  G01N30/6021 ,  G01N2030/565 ,  Y10T29/49826

摘要： In an axial-flow preparative chromatography column that contains a piston, commonly termed an adaptor, that is lowered over the top of the resin, the ability to lower the piston in a controlled manner to minimize the chances of damage to the resin is achieved by use of an aperture either in the piston head itself or in a compound bolt that secures the upper column frit to the piston head. The aperture is closed with a removable plug during storage and use of the piston head and column. During packing of the bed, however, the plug is replaced by a graduated rod operating as a dipstick to allow the operator to determine the distance between the bottom face of the piston head and the upper surface of the column packing.

摘要翻译： 在轴流式制备色谱柱中，其包含通常称为适配器的活塞，其在树脂的顶部被降低，以受控的方式降低活塞以使树脂损坏机会最小化的能力通过 在活塞头本身或复合螺栓中使用孔，其将上柱玻璃料固定到活塞头。 在活塞头和柱的储存和使用期间，孔用可移除的塞子封闭。 然而，在包装床的过程中，插头被作为量油尺操作的刻度杆代替，以使操作者确定活塞头的底面与柱填料的上表面之间的距离。

公开(公告)号：US20110139689A1

公开(公告)日：2011-06-16

申请号：US12797986

申请日：2010-06-10

申请人： Mark A. Snyder

发明人： Mark A. Snyder

IPC分类号： B01D35/14 ,  B30B9/00 ,  F17D1/00

CPC分类号： B01D15/206 ,  B01D15/22 ,  G01N30/56 ,  G01N30/6021 ,  G01N30/6082 ,  G01N2030/565 ,  Y10T137/0318

摘要： In an axial-flow cylindrical preparative chromatography column that utilizes a piston to close off the top of the resin space inside the column and thereby eliminate void spaces at the top of the resin, a sight glass is incorporated in the column wall to allow monitoring of the packing height and density as the packing material is being placed inside the column, as well as the position of the piston head relative to the packing while the piston is being lowered to consolidated and/or compress the packing. By observing the column interior through the sight glass, the operator can assure that the column receives a more uniform packing density and can minimize the risk of damage to the packing material by excessive force from the piston head.

摘要翻译： 在轴流式圆柱形制备色谱柱中，利用活塞封闭柱内的树脂空间的顶部，从而消除树脂顶部的空隙，在柱壁中加入观察玻璃以监测 作为包装材料的包装高度和密度被放置在柱内，以及活塞头相对于填料的位置，同时活塞被降低以固结和/或压缩包装。 通过观察玻璃观察柱内部，操作人员可以确保色谱柱接收到更均匀的填充密度，并可以通过活塞头过大的力使包装材料损坏的风险最小化。