利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

723 条记录 (耗时 0.028 秒)

    Phosphonic acid derivatives and use thereof
    71.
    发明授权
    Phosphonic acid derivatives and use thereof 失效
    膦酸衍生物及其用途

    公开(公告)号：US5330978A

    公开(公告)日：1994-07-19

    申请号：US892768

    申请日：1992-06-03

    申请人： Mitsuhiro Wakimasu ,  Masaaki Mori ,  Akira Kawada

    发明人： Mitsuhiro Wakimasu ,  Masaaki Mori ,  Akira Kawada

    IPC分类号： A61K38/00 ,  A61K38/55 ,  A61P9/00 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07F9/22 ,  A61K33/42

    CPC分类号： C07K5/06191 ,  A61K38/00 ,  Y02P20/55

    摘要： A phosphonic acid derivative compound represented by formula [I ] or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent hydrocarbon groups which may be substituted, except cases in which (1) R.sub.2 is unsubstituted methyl, ( 2 ) R.sub.3 is an unsubstituted hydrocarbon group having 1 to 3 carbon atoms, and (3) R.sub.1 is benzyloxycarbonylaminomethyl, R.sub.2 is isobutyl and R.sub.3 is isobutyl or phenylmethyl, which has endothelin-converting enzyme inhibiting activity and is useful as pharmaceutical drugs such as therapeutic agents for hypertension, cardiac or cerebral circulatory diseases and renal diseases.

    摘要翻译： 由式[I]表示的膦酸衍生物或其药学上可接受的盐：其中R 1，R 2和R 3各自表示可以被取代的烃基，除了（1）R 2是未取代的甲基 ，（2）R3为未取代的碳原子数1〜3的烷基，（3）R1为苄氧羰基氨基甲基，R2为异丁基，R3为异丁基或苯甲基，具有内皮素转化酶抑制活性，可用作药物 作为高血压，心脏或脑循环系统疾病和肾脏疾病的治疗剂。

    Method for purifying aminomethylenephosphonic acids for pharmaceutical use
    74.
    发明授权
    Method for purifying aminomethylenephosphonic acids for pharmaceutical use 失效
    纯化用于药物用途的氨基亚甲基膦酸的方法

    公开(公告)号：US4937333A

    公开(公告)日：1990-06-26

    申请号：US389441

    申请日：1989-08-04

    申请人： Joseph R. Garlich ,  Jaime Simon ,  Tipton T. Masterson

    发明人： Joseph R. Garlich ,  Jaime Simon ,  Tipton T. Masterson

    IPC分类号： C07F9/22 ,  C07F9/02 ,  C07F9/38 ,  C07F9/44 ,  C07F9/6524

    CPC分类号： C07F9/6524 ,  C07F9/025 ,  C07F9/3817

    摘要： High purity ethylenediaminetetra(methylenephosphonic acid) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylenephosphonic acid) are prepared by dissolving the aminomethylenephosphonic acid in an aqueous base, acidifying with a mineral acid at an elevated temperature to precipitate the crystals, maintaining the solution at an elevated temperature for a period of time sufficient to assure crystallization, cooling to a lower temperature and maintaining at that temperature for a time sufficient to precipitate the crystals and filtering the resulting crystals at that temperature, washing the crystals with water and recovering the desired high purity aminophosphonic acid. The ethylenediaminetetra(methylenephosphonic acid) is obtained in a purer state during its synthesis if the crystals are filtered hot without prior cooling.

    Ethylenically unsaturated phosphinic acid and thiophosphinic acid isocyanates and isothiocyanates, and a process for their preparation
    76.
    发明授权
    Ethylenically unsaturated phosphinic acid and thiophosphinic acid isocyanates and isothiocyanates, and a process for their preparation 失效
    烯键式不饱和次膦酸和硫代次膦酸异氰酸酯和异硫氰酸酯及其制备方法

    公开(公告)号：US4859795A

    公开(公告)日：1989-08-22

    申请号：US047102

    申请日：1987-05-08

    申请人： Thomas Gerdau ,  Hans-Jerg Kleiner ,  Georg Pawlowski

    发明人： Thomas Gerdau ,  Hans-Jerg Kleiner ,  Georg Pawlowski

    IPC分类号： C07F9/02 ,  C07F9/22 ,  C07F9/36 ,  C08F30/02

    CPC分类号： C07F9/36

    摘要： Compounds of the general formula ##STR1## wherein X and Y are the same or different and denote oxygen or sulfur,R.sub.1 is an ethylenically unsaturated aliphatic radical containing from 2 to 6 carbon atoms, andR.sub.2 is a saturated aliphatic radical containing from 1 to 6 carbon atoms or an aryl radical containing from 6 to 10 carbon atoms,are intermediate products used for the preparation of photocrosslinkable polymers with lateral (thio)phosphinyl(thio)urethane groups or (thio)phosphinyl(thio)urea groups, which polymers are useful in photosensitive mixtures and recording material.

    摘要翻译： 通式（I）的化合物，其中X和Y相同或不同，表示氧或硫，R 1是含有2-6个碳原子的烯属不饱和脂族基团，R 2是含有 1至6个碳原子或含有6至10个碳原子的芳基是用于制备具有侧面（硫代）氧膦基（硫代）氨基甲酸酯基或（硫代）氧膦基（硫））脲基的光可交联聚合物的中间产物，其中 聚合物可用于光敏混合物和记录材料。

    Cyclotriphosphazatriene-derivatives
    79.
    发明授权
    Cyclotriphosphazatriene-derivatives 失效
    环三磷杂三烯衍生物

    公开(公告)号：US4618691A

    公开(公告)日：1986-10-21

    申请号：US688101

    申请日：1984-12-31

    申请人： Ramiro Medina ,  Jack M. Sullivan

    发明人： Ramiro Medina ,  Jack M. Sullivan

    IPC分类号： C01B21/097 ,  C05G3/08 ,  C07F9/6593 ,  C07F9/22 ,  C12P3/00

    CPC分类号： C05G3/08 ,  C01B21/097 ,  C07F9/65815

    摘要： Tests show that 2,2,4,4,6,6-hexaaminocyclotriphosphazatriene, 2-phenoxy-2,4,4,6,6-pentaaminocyclotriphosphazatriene, 2,4-diphenoxy-2,4,6,6-tetraaminocyclotriphosphazatriene and 2,4,6-triphenoxy-2,4,6-triaminocyclotriphosphazatriene (also frequently called phosphonitrilic derivatives) of the formula ##STR1## are highly effective inhibitors of urease activity in agricultural soil systems wherein(1) R.sub.1 . . . R.sub.3 '=NH.sub.2 or(2) R.sub.1 '=R.sub.2 '=R.sub.3 '=R.sub.2 =R.sub.3 =NH.sub.2 and R.sub.1 =OC.sub.6 H.sub.5 or(3) R.sub.1 '=R.sub.2 '=R.sub.3 '=R.sub.3 =NH.sub.2 and R.sub.1 =R.sub.2 =OC.sub.6 H.sub.5 or(4) R.sub.1 '=R.sub.2 '=R.sub.3 '=NH.sub.2 and R.sub.1 =R.sub.2 =R.sub.3 =OC.sub.6 H.sub.5.

    摘要翻译： 试验表明，2,2,4,4,6,6-六氨基环三磷杂三烯，2-苯氧基-2,4,4,6,6-五氨基环三磷杂三烯，2,4-二苯氧基-2,4,6,6-四氨基环三磷杂三烯和2 式（IMAGE）的4,6-三苯氧基-2,4,6-三氨基环三磷杂三烯（也称为次膦酸衍生物）是农业土壤系统中尿素酶活性的高效抑制剂，其中（1）R1。 。 。 R3'= NH2或（2）R1'= R2'= R3'= R2 = R3 = NH2且R1 = OC6H5或（3）R1'= R2'= R3'= R3 = NH2，R1 = R2 = OC6H5或（ 4）R1'= R2'= R3'= NH2，R1 = R2 = R3 = OC6H5。