公开(公告)号：US20180306807A1

公开(公告)日：2018-10-25

申请号：US15769237

申请日：2016-10-19

申请人： Dyax Corp.

发明人： Daniel J. Sexton ,  Ryan Faucette ,  Janja Cosic

IPC分类号： G01N33/68 ,  G01N33/86 ,  G01N33/543 ,  C07K16/36

CPC分类号： G01N33/6893 ,  C07K16/36 ,  G01N33/54306 ,  G01N33/86 ,  G01N2333/745 ,  G01N2800/50

摘要： The present disclosure provides immunoassay methods of detecting a cleaved high molecular weight kininogen (HMWK) with high sensitivity and specificity and isolated antibodies that specifically bind cleaved HMWK

公开(公告)号：US20180289803A1

公开(公告)日：2018-10-11

申请号：US15945011

申请日：2018-04-04

申请人： Eli Lilly and Company ,  Zymeworks Inc.

发明人： Yiwen LI ,  Dale Lincoln LUDWIG ,  Yang SHEN ,  Yi ZHANG ,  Igor Edmondo Paolo D'ANGELO

IPC分类号： A61K39/395 ,  A61K39/40 ,  A61K45/06 ,  C07K16/12 ,  C07K16/26 ,  C07K16/28 ,  C07K16/36 ,  C07K16/46 ,  A61P35/00 ,  C12P21/00 ,  A61K9/00

CPC分类号： A61K39/3955 ,  A61K9/0019 ,  A61K31/351 ,  A61K31/4164 ,  A61K33/24 ,  A61K39/40 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  A61P35/00 ,  C07K16/1278 ,  C07K16/1282 ,  C07K16/26 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2827 ,  C07K16/283 ,  C07K16/2866 ,  C07K16/2896 ,  C07K16/36 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94 ,  C12P21/005

摘要： The present invention relates to antibodies that are heterodimeric and bind human PD-L1 and human TIM-3, and may be useful for treating cancer alone and in combination with chemotherapy and other cancer therapeutics.

公开(公告)号：US20180251570A1

公开(公告)日：2018-09-06

申请号：US15981744

申请日：2018-05-16

申请人： BAYER HEALTHCARE LLC

发明人： Zhuozhi WANG ,  Ruth WINTER ,  John MURPHY

IPC分类号： C07K16/38 ,  C07K16/36 ,  C07K14/745

CPC分类号： C07K16/38 ,  A61K39/3955 ,  C07K14/745 ,  C07K16/36 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92

摘要： This disclosure provides protease-regulated antibodies which specifically bind to tissue factor pathway inhibitor (TFPI). The antibodies are useful for treating bleeding disorders such as hemophilia.

公开(公告)号：US20180244799A1

公开(公告)日：2018-08-30

申请号：US15908705

申请日：2018-02-28

申请人： BAYER HEALTHCARE LLC

发明人： Ye JIN ,  John E. MURPHY ,  Terry HERMISTON ,  Timothy MYLES ,  Frank DITTMER ,  Michael STRERATH ,  Uwe GRITZAN

IPC分类号： C07K16/36 ,  A61K38/48 ,  A61K45/06 ,  C07K16/18 ,  C07K16/38

CPC分类号： C07K16/36 ,  A61K38/4846 ,  A61K45/06 ,  C07K16/18 ,  C07K16/38 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565

摘要： This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (ATβH). These ATβH binding proteins can block the anti-coagulant activity of ATβ to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.

公开(公告)号：US10040866B2

公开(公告)日：2018-08-07

申请号：US15691736

申请日：2017-08-30

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Andreas Wilmen ,  Julia Straßburger ,  Frank Dittmer ,  Michael Strerath ,  Anja Buchmüller ,  Joanna Grudzinska-Goebel ,  Ricarda Finnern ,  Martina Schäfer ,  Christoph Gerdes ,  Hannah Jörißen ,  Asako Itakura ,  Philberta Y. Leung ,  Erik Tucker

IPC分类号： C07K16/36 ,  A61K39/00

摘要： The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.

公开(公告)号：US10035862B2

公开(公告)日：2018-07-31

申请号：US14891441

申请日：2014-05-16

申请人： Ablynx N.V.

发明人： Yves Meyvis ,  Veronique De Brabandere ,  Hans Ulrichts ,  Ann Brige ,  Filip Callewaert

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K9/08 ,  A61K9/00 ,  C07K16/36 ,  A61K9/19

摘要： The present invention relates to stable formulations of polypeptides, e.g. immunoglobulin single variable domains, in particular immunoglobulin single variable domains directed against von Willebrand Factor (vWF). The invention provides formulations which are stable upon storage for prolonged periods of time and over a broad range of temperatures. The formulations of the invention ensure a high stability of the polypeptide, allowing multiple freeze-thaw cycles without chemical or physical deterioration, and provide stability in relation to mechanical stress, such as shake, shear or stir stress. They are suitable for pharmaceutical and diagnostic preparations and compatible with pharmaceutically acceptable diluents.

公开(公告)号：US20180186832A1

公开(公告)日：2018-07-05

申请号：US15900461

申请日：2018-02-20

申请人： Genentech, Inc. ,  Hoffmann-La Roche Inc.

发明人： Paul MCDONALD ,  Richard ST. JOHN ,  Marc WONG ,  Roberto FALKENSTEIN ,  Wolfgang KOEHNLEIN ,  Klaus SCHWENDNER ,  Bernhard SPENSBERGER ,  Michael WIEDMANN ,  Frank ZETTL ,  Annika KLEINJANS ,  Carina KOPP ,  Benjamin TRAN ,  Ryan ERICKSON

IPC分类号： C07K1/22 ,  C07K16/28 ,  C07K16/18 ,  C07K16/32 ,  C07K16/22 ,  C07K16/36

CPC分类号： C07K1/22 ,  C07K16/18 ,  C07K16/22 ,  C07K16/2854 ,  C07K16/32 ,  C07K16/36 ,  C07K2317/14 ,  C07K2317/31

摘要： The current invention reports a method for purifying an antibody by reducing the content of a host cell protein. The method employs a wash step with a low conductivity aqueous solution in an affinity chromatography.

公开(公告)号：US20180179296A1

公开(公告)日：2018-06-28

申请号：US15896170

申请日：2018-02-14

申请人： Zymeworks Inc.

发明人： Adam Louis CORPER ,  Dunja Urosev ,  Stacey A.L. Tom-Yew ,  Dustin Weyland Blue Bleile ,  Thomas Spreter Von Kreudenstein ,  Surjit Dixit ,  Paula Irene Lario ,  Mario Sanches

IPC分类号： C07K16/36

CPC分类号： C07K16/36 ,  C07K2317/55 ,  C07K2317/94

摘要： The present invention provides heterodimer pairs comprising a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain. At least one of the heterodimers comprises amino acid modifications in the CH1 and/or CL domains, amino acid modifications in the VH and/or VL domains or a combination thereof. The modified amino acid residues are part of the interface between the light chain and heavy chain and are modified in order to create preferential pairing between each heavy chain and a desired light chain such that when the two heavy chains and two light chains of the heterodimer pair are co-expressed in a mammalian cell, the heavy chain of the first heterodimer preferentially pairs with one of the light chains rather than the other. Likewise, the heavy chain of the second heterodimer preferentially pairs with the second light chain rather than first.

公开(公告)号：US20180155443A1

公开(公告)日：2018-06-07

申请号：US15881055

申请日：2018-01-26

申请人： Ablynx N.V.

发明人： Christian DUBY

IPC分类号： C07K16/36 ,  A61K39/00

CPC分类号： C07K16/36 ,  A61K38/36 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/76

摘要： The present invention is based on the finding that administration of polypeptides comprising at least one Immunoglobulin single variable domains against vWF to human TTP patients provides a significant decrease in the time to response. The invention provides a polypeptide comprising at least one immunoglobulin single variable domain (ISVD) against von Willebrand Factor (vWF) for use in treating a vWF-related disease in a human in need thereof. The invention further relates to dosage unit forms, kits and medical uses for treating TTP.

公开(公告)号：US09987328B2

公开(公告)日：2018-06-05

申请号：US15141036

申请日：2016-04-28

申请人： CSL Behring GmbH

发明人： Stefan Zeitler ,  Marc Nolte ,  Stefan Schulte ,  Gerhard Dickneite ,  Ingo Pragst

IPC分类号： A61K9/00 ,  A61K38/17 ,  A61K38/55 ,  A61K38/57 ,  C07K16/36 ,  C07K16/40 ,  A61K31/727 ,  A61K38/16 ,  A61K38/58 ,  A61K39/395 ,  A61L33/00 ,  A61L33/12 ,  A61K47/65 ,  A61K47/64

CPC分类号： A61K38/1767 ,  A61K31/727 ,  A61K38/16 ,  A61K38/556 ,  A61K38/57 ,  A61K38/58 ,  A61K39/3955 ,  A61K47/643 ,  A61K47/65 ,  A61L33/0041 ,  A61L33/0082 ,  A61L33/128 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/42 ,  A61L2420/00 ,  C07K16/36 ,  C07K16/40 ,  C07K2317/76

摘要： An inhibitor of FXII/FXIIa for the prevention of the formation and/or stabilization of thrombi during and/or after a medical procedure performed on a human or animal subject comprising contacting blood of said human or animal subject with artificial surfaces, wherein said inhibitor of FXII/FXIIa is administered before and/or during and/or after said medical procedure.