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    DEVICE FOR CHARACTERIZING PARTICLES AND USES THEREOF
    823.
    发明申请
    DEVICE FOR CHARACTERIZING PARTICLES AND USES THEREOF 审中-公开

    公开(公告)号：US20200161110A1

    公开(公告)日：2020-05-21

    申请号：US16686203

    申请日：2019-11-17

    Applicant: Academia Sinica

    Inventor： Abdil OZDEMIR ,  Jung-Lee LIN ,  Chung-Hsuan CHEN

    IPC: H01J49/00 ,  H01J49/06 ,  H01J49/16

    Abstract: Disclosed herein is a device for characterizing a biological sample or an airborne sample. According to embodiments of the present disclosure, the device comprises an electrospray source, a mass analyzer, a charge detector, and optionally, an ion guide. The present device is useful in analyzing the particle population in the biological or airborne sample based on the mass to charge (m/z) ratio and the charge (z) of each particle. Also disclosed herein are the methods of making a diagnosis of cancer by use of the present device, and methods of determining the mass distribution of particles in an airborne sample.

    Multi-drug delivery system and use thereof
    829.
    发明授权
    Multi-drug delivery system and use thereof 有权

    公开(公告)号：US10532097B2

    公开(公告)日：2020-01-14

    申请号：US15325346

    申请日：2015-07-10

    Applicant: Academia Sinica

    Inventor： Patrick C. H. Hsieh ,  Pei-Jung Wu ,  Steve Roffler ,  Bill Cheng

    IPC: A61K39/395 ,  C07K16/44 ,  A61K9/00 ,  A61K47/36 ,  A61K47/42 ,  A61K9/06 ,  A61K47/60 ,  A61K47/68 ,  A61K38/00

    Abstract: Disclosed herein is a multiple drugs delivery system and its uses in treating diseases. The multiple drugs delivery system includes, an anti-PEG antibody for directing the PEGylated therapeutic to the treatment site; and a hydrogel for retaining the anti-PEG antibody and/or the PEGylated therapeutic at the treatment site for at least 3 days. The hydrogel is selected from the group consisting of hyaluronan (HA) or a derivative of HA, collagen, gelatin, fibronectin, fibrinogen, alginate, chitosan, and a synthetic biocompatible polymer. The anti-PEG antibody and the hydrogel are present in the mixture in a ratio from about 1:1 (v/v) to 1:100 (v/v). At least two dosages of the PEGylated therapeutic, which may be the same or different, are administered to the subject, with each dosage being given at about 1 hour to about 1 week apart. Accordingly, a novel method of treating a subject having cancer or ischemic disease is also provided.

    SYNTHETIC POLYPEPTIDES AND USES THEREOF
    830.
    发明申请
    SYNTHETIC POLYPEPTIDES AND USES THEREOF 审中-公开

    公开(公告)号：US20200000722A1

    公开(公告)日：2020-01-02

    申请号：US16455800

    申请日：2019-06-28

    Applicant: Academia Sinica

    Inventor： Hsien-Ming LEE ,  Hua-De GAO ,  Jia-Lin HONG ,  Chih-Yu KUO ,  Cheng-Bang JIAN

    IPC: A61K9/127 ,  C07K14/00 ,  A61K31/704 ,  A61K49/00 ,  C07K7/08 ,  A61K41/00

    Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.

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