公开(公告)号：US20220213467A1

公开(公告)日：2022-07-07

申请号：US17702880

申请日：2022-03-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Roy BAR-ZIV ,  Shirley SHULMAN DAUBE ,  Michael LEVY ,  Reuven FALKOVICH ,  Ohad VONSHAK ,  Yiftach DIVON

IPC: C12N15/10 ,  G01N33/543

Abstract: A method of assembling and immobilizing proteinaceous complexes is disclosed. In addition, methods of generating functional RNA polymerase and ribosomal subunits are disclosed.

公开(公告)号：US20220170039A1

公开(公告)日：2022-06-02

申请号：US17676315

申请日：2022-02-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Avihai DANON ,  Erez ELIYAHU ,  Vivekanand TIWARI

IPC: C12N15/82 ,  C07K14/415 ,  C12N9/02

Abstract: The present invention provides compositions for attenuating the function of atypical CYS HIS rich thioredoxin 4 (ACHT4), a light-regulated protein expressed in plants and algae that controls starch storage in chloroplast, and methods for increasing plant and algae growth and yield.

公开(公告)号：US11324777B2

公开(公告)日：2022-05-10

申请号：US15825275

申请日：2017-11-29

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair Reisner ,  Yaki Eidelstein ,  Eran Ophir ,  Assaf Lask ,  Ran Afik ,  Noga Or-Geva ,  Esther Bachar-Lustig

IPC: A61K35/17 ,  A61K39/00 ,  C12N5/0783 ,  A61K35/22 ,  A61K35/26 ,  A61K35/28 ,  A61K35/34 ,  A61K35/36 ,  A61K35/38 ,  A61K35/39 ,  A61K35/407 ,  A61K35/42 ,  A61K35/12

Abstract: A method of generating an isolated population of cells comprising anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) contacting peripheral blood mononuclear cells (PBMC) with a third party antigen or antigens in the presence of IL-21 so as to allow enrichment of antigen reactive cells; and (b) culturing the cells resulting from step (a) in the presence of IL-21, IL-15 and IL-7 in an antigen free environment so as to allow proliferation of cells comprising the central memory T-lymphocyte (Tcm) phenotype.

公开(公告)号：US11278555B2

公开(公告)日：2022-03-22

申请号：US16092742

申请日：2017-04-10

Applicant: Yeda Research and Development Co. Ltd. ,  Memorial Sloan-Kettering Cancer Center

Inventor： Avigdor Scherz ,  Yoram Salomon ,  Lilach Agemy ,  Rachel Hamri ,  Dina Preise ,  Kwanghee Kim ,  Jonathan Coleman

IPC: A61K31/675 ,  A61K31/409 ,  A61K31/7068 ,  A61K31/7135 ,  A61K45/06 ,  A61P35/00

Abstract: An anti-myeloid-derived suppressor cells agent (“anti-MDSCs agent”) and a bacteriochlorophyll derivative (hereinafter “Bchl-D) for use in combination therapy for cancer, wherein the anti-MDSC agent and the Bchl-D are administered sequentially and the administration of the Bchl-D is followed by photodynamic therapy (PDT) or vascular targeted PDT (VTP).

公开(公告)号：US20220073344A1

公开(公告)日：2022-03-10

申请号：US17416772

申请日：2019-12-30

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： David MILSTEIN ,  You-Quan ZHOU ,  Aviel ANABY

IPC: C01B3/00 ,  B01J31/20 ,  B01J31/18 ,  B01J31/24

Abstract: This invention provides a reversible hydrogen loading and discharging system and a reversible method for loading and discharging hydrogen. The system and the methods of this invention comprise ethylene glycol as a liquid organic hydrogen carrier and at least one transition metal. By reacting ethylene glycol with at least one transition metal; at least one hydrogen molecule and at least one oligoester of ethylene glycol are formed (hydrogen releasing)⋅, and by reacting at least one oligoester of ethylene glycol with at least one transition metal and at least one hydrogen molecule, at least one ethylene glycol is formed (hydrogen loading).

公开(公告)号：US11262364B2

公开(公告)日：2022-03-01

申请号：US15744532

申请日：2016-07-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  Tamar Sternheimer

Inventor： Meir Shinitzky ,  Ludmila Schechtman

IPC: G01N33/68 ,  C07K14/47 ,  C07K7/04

Abstract: Provided is a composition including a combination of at least one short peptide and at least one peptide dimer, in defined ratio, to which autoantibodies found in elevated levels in schizophrenic patients bind.

公开(公告)号：US20220003762A1

公开(公告)日：2022-01-06

申请号：US17332178

申请日：2021-05-27

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Rachel SOREK ,  Keren JAKOBI ,  Pennina SAFER ,  Anat REINER-BENAIM ,  Irun R. COHEN

IPC: G01N33/564 ,  G01N33/68 ,  G16B40/20

Abstract: Methods and kits for diagnosing or monitoring systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to a specific antibody reactivity profile useful in diagnosing or monitoring SLE in a subject.

公开(公告)号：US20210379557A1

公开(公告)日：2021-12-09

申请号：US17288460

申请日：2019-10-23

Applicant: Yeda Research and Development Co. Ltd. ,  Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Inventor： Ron NAAMAN ,  Claudio FONTANESI ,  Francesco TASSINARI ,  Suryakant MISHRA ,  Eyal CAPUA ,  Yossef PALTIEL ,  Shira YOCHELIS ,  Tzuriel METZGER

IPC: B01J19/08 ,  B01J19/22 ,  C07C319/28 ,  C07C319/02

Abstract: A system and method for use in synthesis and promoting interactions of chiral molecules. The system can include: a container configured for containing fluid mixture comprising one or more reactant molecules and at least one surface comprising ferromagnetic or paramagnetic material located to be in at least partial contact with reactants in said container. The ferromagnetic of paramagnetic material can be magnetizable with magnetization direction perpendicular to said at least one surface, thereby providing chiral selective synthesis from said one or more reactant molecules. The technique can enable selective interactions of enantiomers of selected handedness of chiral molecules or formation of selected enantiomers from achiral molecule reactants.

公开(公告)号：US20210378960A1

公开(公告)日：2021-12-09

申请号：US17406168

申请日：2021-08-19

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob KLEIN ,  Ronit GOLDBERG ,  Jasmine SEROR

IPC: A61K9/127 ,  A61K9/00 ,  A61K47/32 ,  A61K47/10 ,  A61K47/36 ,  A61K9/08 ,  A61K31/728 ,  A61K31/77 ,  A61K31/79 ,  B65D35/00 ,  B65D75/36

Abstract: Formulations (e.g., solutions) comprising one or more water-soluble polymer(s), liposomes, and an aqueous carrier, are provided. The provided solutions are useful for rinsing, and/or immersing therein, a contact lens and/or in the treatment of ocular discomfort, for example, an ocular discomfort associated with a contact lens. Also provided are kits comprising the solution and a contact lens; articles-of-manufacturing comprising the solution and configured for dispending the solution; and methods utilizing the solution.

公开(公告)号：US20210355220A1

公开(公告)日：2021-11-18

申请号：US17278261

申请日：2019-09-20

Applicant: Tikcro Technologies Ltd. ,  Yeda Research and Development Co. Ltd.

Inventor： Ami Navon ,  Aviv Boim ,  Ariel Stanhill ,  Leehee Weinberger ,  Yuval Avnir

IPC: C07K16/28

Abstract: Disclosed herein are anti-CTLA-4 antibodies possessing superior binding and biological activities relative to ipibmumab and tremelimumab, pharmaceutical compositions comprising such. Also provided herein are therapeutic and diagnostic applications of such anti-CTLA-4 antibodies.