公开(公告)号：US20060079478A1

公开(公告)日：2006-04-13

申请号：US10833293

申请日：2004-04-26

申请人： Constantine Boojamra ,  Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Steven Krawczyk ,  Christopher Lee ,  Kuei-Ying Lin ,  Richard Mackman ,  David Markevitch ,  Peter Nelson ,  David Oare ,  Vidya Prasad ,  Hyung-Jung Pyun ,  Adrian Ray ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang ,  Lijun Zhang

发明人： Constantine Boojamra ,  Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Steven Krawczyk ,  Christopher Lee ,  Kuei-Ying Lin ,  Richard Mackman ,  David Markevitch ,  Peter Nelson ,  David Oare ,  Vidya Prasad ,  Hyung-Jung Pyun ,  Adrian Ray ,  Sundaramoorthi Swaminathan ,  William Watkins ,  Jennifer Zhang ,  Lijun Zhang

IPC分类号： A61K31/7076 ,  A61K31/7072 ,  C07H19/04 ,  A61K31/675

CPC分类号： A61K31/7076 ,  A61K31/675 ,  A61K31/7072 ,  A61K47/548 ,  C07H19/04

摘要： The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及磷取代的抗癌化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20060035866A1

公开(公告)日：2006-02-16

申请号：US10833295

申请日：2004-04-26

申请人： Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Manoj Desai ,  Maria Fardis ,  Alan Huang ,  Thorsten Kirschberg ,  Christopher Lee ,  Richard Mackman ,  Peter Nelson ,  Hyung-Jung Pyun ,  Adrian Ray ,  William Watkins ,  Jennifer Zhang ,  Sundaramoorthi Swaminathan

发明人： Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Manoj Desai ,  Maria Fardis ,  Alan Huang ,  Thorsten Kirschberg ,  Christopher Lee ,  Richard Mackman ,  Peter Nelson ,  Hyung-Jung Pyun ,  Adrian Ray ,  William Watkins ,  Jennifer Zhang ,  Sundaramoorthi Swaminathan

IPC分类号： A61K31/66

CPC分类号： A61K47/548 ,  A61K47/542

摘要： The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及具有免疫调节活性的膦酸酯取代的化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20050261237A1

公开(公告)日：2005-11-24

申请号：US10832810

申请日：2004-04-26

申请人： Constantine Boojamra ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Christopher Lee ,  David Oare ,  Vidya Prasad ,  Adrian Ray ,  Sundaramoorthi Swaminathan ,  William Watkins

发明人： Constantine Boojamra ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Maria Fardis ,  Alan Huang ,  Choung Kim ,  Thorsten Kirschberg ,  Christopher Lee ,  David Oare ,  Vidya Prasad ,  Adrian Ray ,  Sundaramoorthi Swaminathan ,  William Watkins

IPC分类号： A61K31/675 ,  A61K31/7072 ,  A61K31/7076

CPC分类号： C07F9/65616 ,  C07F9/65586 ,  C07F9/6561 ,  C07H7/04 ,  C07H19/056 ,  C07H19/06 ,  C07H19/14 ,  C07H19/173

摘要： The invention is related to phosphorus substituted nucleoside compounds and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及磷取代的核苷化合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US06723716B1

公开(公告)日：2004-04-20

申请号：US09668722

申请日：2000-09-21

申请人： Scott J. Hecker ,  Aesop Cho ,  Tomasz W. Glinka ,  Trevor Calkins ,  Ving J. Lee

发明人： Scott J. Hecker ,  Aesop Cho ,  Tomasz W. Glinka ,  Trevor Calkins ,  Ving J. Lee

IPC分类号： C07D50159

CPC分类号： C07D213/70 ,  C07D285/08 ,  C07D501/00 ,  C07F9/6506

摘要： The present invention relates to a cephem prodrug having formula III or formula IV: or a pharmaceutically acceptable salt thereof, wherein R′1 is selected from the group consisting of hydrogen and —C(O)CH(NH2)CH3 and R′2 is selected from the group consisting of hydrogen and an acyl group that is cleaved by an enzyme found in mammals, with the proviso that, when either R′1 or R′2 is hydrogen, the other is not. A, B, L, G, E, and J are each independently nitrogen or carbon such that the respective rings are selected from the group consisting of provided that the group —CH2—S—CH2CH2NHR′2 is attached only to a carbon atom of said heterocyclic group, and Q is selected from the group consisting of nitrogen and —CX, wherein X is selected from the group consisting of hydrogen and chlorine.

摘要翻译： 本发明涉及具有式III或式IV的头孢烯前药或其药学上可接受的盐，其中R'1选自氢和-C（O）CH（NH 2）CH 3和R' <2>选自氢和由哺乳动物中发现的酶切割的酰基，条件是当R'1或R'2都是氢时，另一个不是 。 A，B，L，G，E和J各自独立地为氮或碳，使得各个环选自提供基团-CH 2 -S-CH 2 CH 2 NHR'2仅与碳原子连接 的所述杂环基，Q选自氮和-CX，其中X选自氢和氯。

公开(公告)号：US06596723B1

公开(公告)日：2003-07-22

申请号：US09906864

申请日：2001-07-16

申请人： Will J. Watkins ,  Remy Lemoine ,  Aesop Cho ,  Thomas E. Renau

发明人： Will J. Watkins ,  Remy Lemoine ,  Aesop Cho ,  Thomas E. Renau

IPC分类号： A61K31495

CPC分类号： C07D401/12 ,  A61K31/33 ,  A61K31/495 ,  A61K31/517 ,  A61K45/06 ,  C07D239/92 ,  C07D311/96 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  A61K2300/00

摘要： This invention relates to compounds that are efflux pump inhibitors and therefore are useful as potentiators of anti-fungal agents for the treatment of infections caused by fungi that employ an efflux pump resistance mechanism.