公开(公告)号：US10551372B2

公开(公告)日：2020-02-04

申请号：US15234050

申请日：2016-08-11

Applicant: The Cleveland Clinic Foundation

Inventor： Stanley L. Hazen ,  Zeneng Wang ,  Bruce S. Levison

IPC: G01N24/00 ,  G01N33/49 ,  G01N33/92 ,  G01N33/493 ,  H01J49/00

Abstract: Methods of characterizing a test subject's risk of having or developing cardiovascular disease are provided. The methods include using an analytic device to determine levels of choline-related trimethylamine-containing compounds such as trimethylamine N-oxide, choline, or betaine in a biological sample obtained from the subject and comparing the levels of the choline-related trimethylamine-containing compound in the subject's biological sample to a control value. The test subject's risk of having cardiovascular disease is then characterized as higher if the levels of the choline-related trimethylamine-containing compound are higher than the control value. Also provided are methods of identifying a subject at risk of experiencing a complication of atherosclerotic cardiovascular disease, and methods of evaluating the efficacy of a cardiovascular therapeutic agent in a subject with cardiovascular disease using levels of choline-related trimethylamine-containing compounds.

公开(公告)号：US20200027209A1

公开(公告)日：2020-01-23

申请号：US16415833

申请日：2019-05-17

Applicant: Case Western Reserve University ,  The Cleveland Clinic Foundation

Inventor： Anant Madabhushi ,  Prateek Prasanna ,  Justis Ehlers

IPC: G06T7/00 ,  G06K9/62 ,  G06T7/32 ,  G06T7/11 ,  G06T5/50 ,  G06T5/20 ,  G06K9/46 ,  A61B3/12 ,  A61B5/00

Abstract: Embodiments facilitate prediction of anti-vascular endothelial growth (anti-VEGF) therapy response in DME patients. A first set of embodiments discussed herein relates to training of a machine learning classifier to determine a prediction for response to anti-VEGF therapy based on a set of graph-network features and a set of morphological features generated based on FA images of tissue demonstrating DME. A second set of embodiments discussed herein relates to determination of a prediction of response to anti-VEGF therapy for a DME patient (e.g., non-rebounder vs. rebounder, response vs. non-response) based on a set of graph-network features and a set of morphological features generated based on FA imagery of the patient.

公开(公告)号：US10537432B2

公开(公告)日：2020-01-21

申请号：US15677470

申请日：2017-08-15

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Jose L. Navia ,  Samir Kapadia ,  Marwane Berrada

IPC: A61F2/24

Abstract: An apparatus for partially supporting a leaflet of a regurgitant heart valve comprises at least one subvalvular device including a subvalvular supporting portion including a leaflet-contacting upper supporter surface longitudinally spaced from an oppositely facing lower supporter surface. A supporter perimeter wall extends longitudinally between the upper and lower supporter surfaces, with at least a portion contacting a subvalvular cardiac wall adjacent to the heart valve. An anchor portion is adjacent to, and longitudinally spaced from, the upper supporter surface. The anchor portion includes a leaflet-contacting lower anchor surface longitudinally spaced from an oppositely facing upper anchor surface. A connector neck is interposed longitudinally between, and is directly attached to both of, the upper supporter surface and the lower anchor surface. The connector neck penetrates longitudinally through at least one of a base of the leaflet and an annulus of the heart valve at a manufactured puncture site.

公开(公告)号：US10478255B2

公开(公告)日：2019-11-19

申请号：US15958770

申请日：2018-04-20

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Karl West ,  Jeffrey H. Yanof

IPC: A61B34/20 ,  A61B5/06 ,  A61B5/00 ,  G06T17/20 ,  G06T3/00 ,  G06T3/20 ,  G06F3/01 ,  G06T7/33 ,  A61B34/00 ,  A61B90/00 ,  A61B90/50 ,  G02B27/01 ,  G06T19/00

Abstract: Holographic image-guidance can be used to track an interventional device during an endovascular percutaneous procedure. The holographic image guidance can be provided by a head-mounted device by transforming tracking data and vasculature image data to a common coordinate system and creating a holographic display relative to a patient's vasculature to track the interventional device during the endovascular percutaneous procedure. The holographic display can also include graphics to provide guidance for the physical interventional device as it travels through the patient's anatomy (e.g., the vasculature).

公开(公告)号：US20190290185A1

公开(公告)日：2019-09-26

申请号：US16348766

申请日：2017-11-10

Applicant: The Johns Hopkins University ,  The Cleveland Clinic Foundation

Inventor： Sridevi SARMA ,  Adam LI ,  Jorge GONZALEZ-MARTINEZ

IPC: A61B5/00 ,  A61B5/0476

Abstract: A method of identifying an epileptogenic zone of a subjects brain includes: receiving a plurality N of physiological brain signals that extend over a duration, each of the plurality N of physiological brain signals acquired from the subjects brain; calculating within a time window a state transition matrix based on at least a portion of each of the plurality N of physiological brain signals, wherein the state transition matrix is a linear time invariant model of a network of N nodes corresponding to the plurality N of physiological brain signals; calculating a minimum norm of a perturbation on the state transition matrix that causes the network to transition from a stable state to an unstable state; and assigning a fragility metric to each of the plurality N of physiological brain signals based on the minimum norm of the perturbation for that physiological brain signal.

公开(公告)号：US20190281904A1

公开(公告)日：2019-09-19

申请号：US16427415

申请日：2019-05-31

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Jill Elizabeth Byrne

IPC: A41D13/005 ,  A41D27/20

Abstract: A temperature-regulating garment is provided for assisting a user with regulating body temperature. A garment body has first and second major garment body edges. The garment body has a neckline formed by a least a portion of the first major garment body edge. The garment body has a front right panel, a front left panel, and a back panel. At least one armhole is located laterally between the back panel and a selected one of the right front panel and the left front panel. First and second neck pockets are each configured to accept a temperature-regulating pack. The first neck pocket is disposed upon at least one of the right front panel and the back panel, spanning the first major garment body edge. The second neck pocket is disposed upon at least one of the left front panel and the back panel, spanning the first major garment body edge.

公开(公告)号：US10391285B2

公开(公告)日：2019-08-27

申请号：US14301770

申请日：2014-06-11

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Jamshid Karimov ,  Kiyotaka Fukamachi ,  Ray Dessoffy

IPC: A61M27/00 ,  A61M25/01 ,  A61M25/00 ,  A61B90/70

Abstract: Systems, devices and methods for minimizing or preventing catheter or other medical device occlusion. Mechanical motion is applied to the inner and outer walls of the catheter to minimize blood clots or other biological substances from obstructing the catheter and to help maintain catheter patency.

公开(公告)号：US20190247665A1

公开(公告)日：2019-08-15

申请号：US16396337

申请日：2019-04-26

Applicant: The Cleveland Clinic Foundation

Inventor： Cameron C. McIntyre ,  Christopher R. Butson ,  John D. Hall ,  Jaimie M. Henderson

IPC: A61N1/36 ,  A61B90/00 ,  G16H50/50

CPC classification number: A61N1/36146 ,  A61B90/37 ,  A61B2090/364 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36082 ,  A61N1/36135 ,  G06F19/321 ,  G16H30/20 ,  G16H50/50

Abstract: This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. A patient-specific brain atlas can be created using the inverse of the transformation to map the brain atlas data onto the volumetric imaging data and a volume of influence can be calculated using the patient-specific brain atlas. In certain examples, the volume of influence can include a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location.

公开(公告)号：US20190240465A1

公开(公告)日：2019-08-08

申请号：US16341975

申请日：2017-10-13

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Karunakaravel Karuppasamy

IPC: A61M29/00 ,  A61M25/09

CPC classification number: A61M29/00 ,  A61B2017/1205 ,  A61B2017/3425 ,  A61M25/09 ,  A61M25/104

Abstract: A modular dilation device (100) is provided for inserting multiple dilators into a target patient tissue site. The modular dilation device includes a first dilator (104) and a second dilator (530). The first dilator has a first dilator distal end (108) and a first dilator inner lumen (114). The first dilator has a first dilator side wall opening (118). The first dilator distal end has a first dilator open tip (116). The first dilator has a first dilator open slit (120). The first dilator open slit extends between the first dilator side wall opening and the first dilator open tip. The second dilator has a second dilator distal end and a second dilator inner lumen. The second dilator distal end has a second dilator open tip. When the second dilator is joined to the first dilator, the second dilator open tip is adjacent to the first dilator side wall opening.

公开(公告)号：US10368987B2

公开(公告)日：2019-08-06

申请号：US15177424

申请日：2016-06-09

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： A. Marc Gillinov ,  Michael K. Banbury ,  Jeremy Hemingway ,  Craig B. Berky ,  Jonathan Bauer

IPC: A61F2/24 ,  A61B17/064

Abstract: One aspect of the present disclosure includes a system comprising prosthetic chordae, at least one attachment member including a channel, a female securing member, and a papillary penetration member configured to pass through the channel, the chordae, and the securing member when implanted in a patient's heart. The penetration member includes an axis.