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公开(公告)号：US20180148454A1
公开(公告)日：2018-05-31
申请号：US15577518
申请日：2016-05-30
Inventor： Honglin LI , Yufang XU , Zhenjiang ZHAO , Wei ZHOU , Yuqiong XU , Deheng SUN , Xia WANG , Zhuo CHEN
IPC: C07D487/04 , A61P35/00 , A61P35/02
CPC classification number: C07D487/04 , A61K31/519 , A61P35/00 , A61P35/02 , C07D475/00
Abstract: The present invention relates to a pteridinone derivative serving as an EGFR inhibitor and use thereof. Specifically, the present invention relates to a compound represented by the following formula I, pharmaceutical composition comprising the compound of the following formula I, and use of the compound in preparation of drugs for treating EGFR-mediated diseases or inhibiting EGFR.
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82.发明授权公开(公告)号：US09945860B2
公开(公告)日：2018-04-17
申请号：US15426621
申请日：2017-02-07
Inventor： Yi Yang , Yuzheng Zhao , Jing Jin , Qingxun Hu
IPC: C07K14/32 , G01N33/573 , G01N33/58 , G01N33/50
CPC classification number: G01N33/5735 , C07K14/195 , C07K14/32 , C07K2319/00 , C07K2319/60 , G01N33/5011 , G01N33/582 , G01N2500/02 , G01N2800/7028
Abstract: The invention relates to a genetically encoded fluorescent sensor for nicotinamide adenine dinucleotide, as well as methods of preparation and uses thereof. In one aspect, this invention relates to a sensor for detecting nicotinamide adenine dinucleotide, particularly, a recombinant fluorescent fusion protein sensor for detecting nicotinamide adenine dinucleotide. In one specific aspect, this invention relates to a recombinant fluorescent fusion protein sensor for detecting reduced nicotinamide adenine dinucleotide (NADH); in another specific aspect, this invention relates to a recombinant fluorescent fusion protein sensor for detecting oxidized nicotinamide adenine dinucleotide (NAD+); in yet another aspect, the invention relates to a recombinant fluorescent fusion protein sensor for detecting the ratio of reduced to oxidized nicotinamide adenine dinucleotide. This invention also relates to the method of preparing the sensors, and uses of the sensors in detecting NADH, NAD+, NADH/NAD+ ratio, screening drugs and measuring NADH metabolism.
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83.发明授权公开(公告)号：US09939359B2
公开(公告)日：2018-04-10
申请号：US14915659
申请日：2014-09-25
Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , SHANGHAI ELECTRIC POWER EQUIPMENT CO., LTD. SHANGHAI STEAM TURBINE FACTORY
Inventor： Fuzhen Xuan , Haitao Wang , Qiongqi Wang , Linbo Mei , Xia Liu , Yuhui Huang
CPC classification number: G01N3/18 , G01N3/00 , G01N3/08 , G01N3/28 , G01N2203/0017 , G01N2203/006 , G01N2203/0069
Abstract: Disclosed is a method of measurement and determination on fracture toughness of structural materials at high temperature, comprising: preliminary assessing the ductility of a material based on a high-temperature uniaxial tensile test and the fracture characteristic; designing and manufacturing a CT specimen; conducting a monotonic loading fracture test on the CT specimen at high temperature; modifying a load-displacement curve output by a testing machine; determining a passivation coefficient M for the crack of the structural material; reversely recursing instant load-displacement data pairs corresponding to the instant crack length; calculating a J_R crack extension resistance curve of the tensile test; examining the validity of the J_R crack extension resistance curve and the fracture toughness JIC; calculating the fracture toughness per equivalent of the structural material KIC. The present invention overcomes the difficulty of placing an extensometer inside a high-temperature furnace.
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84.发明申请公开(公告)号：US20180023009A1
公开(公告)日：2018-01-25
申请号：US15549385
申请日：2015-05-04
Inventor： Qiang YANG , Hao LU , Sen LIU , Chaoyang WANG , Xiao XU
Abstract: This invention involves a method and a device for enhanced oil-water separation and desalination in a low-pressure separator. The water-containing oil is mixed with desalted water in a countercurrent way at the entrance, wherein the desalted water accounts for 0-1% of the water-containing oil by volume. The resultant oil-water mixture then enters a T-shaped liquid-gas separator (3) for degassing treatment to quickly separate gas from the mixture. In a low-pressure separator, the oil-water mixture flows, from left to right, to a flow conditioner (4) to uniformly distribute the mixture in the transverse section, and then flows to a hydrophilic droplet agglomeration module (5) and a CPI fast separation module (6) to separate water from oil, wherein part of the separated water is discharged and the oil with a trace of water (0-0.01%) passes over a partition (18) to a deep separation segment. The oil is subjected to deep water removal by a conjugated fiber water removal module and then discharged, and the water captured by the conjugated fiber water removal module is subject to a conjugated fiber oil removal module for deep oil removal and then discharged.
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公开(公告)号：US09844742B2
公开(公告)日：2017-12-19
申请号：US14764179
申请日：2014-01-10
Inventor： Qiang Yang , Xiao Xu , Hao Lu , Chaoyang Wang
IPC: B01D19/00
CPC classification number: B01D19/0052 , B01D19/0036 , B01D19/0057
Abstract: The present invention relates to a device for liquid degassing by means of swirling or centrifugal force coupled with a pressure gradient. This device comprises a cavity. The cavity is furnished with an inlet for liquid-gas mixture, a gas outlet and a liquid outlet. The gas outlet is inserted into the cavity through the top end of the cavity and positioned around 0.1-3 times the maximum diameter of the cavity from the top of the cavity. Specifically, an overflow pipe with the diameter gradually increasing from the bottom to the top was used as the gas outlet. The overflow pipe is further furnished with a bell mouth at the bottom part.
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Patent Agency Ranking
86.发明申请公开(公告)号：US20170204309A1
公开(公告)日：2017-07-20
申请号：US15327920
申请日：2015-07-20
Applicant: KUNSHAN TIANYANG HOT MELT ADHESIVE CO., LTD. , SHANGHAI TIANYANG HOT MELT ADHESIVE CO., LTD. , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventor： Zhelong Li , Wanyu Zhu , Heji Lei , Fangqun Wu , Zuoxiang Zeng
IPC: C09J167/02 , C09J11/06
CPC classification number: C09J167/02 , C08G63/672 , C09J11/06 , C08K5/005 , C08K5/521 , C08K5/526 , C08K5/11
Abstract: A method for preparation of a high-viscosity polyester hot-melt adhesive with a partially sensitive viscosity-temperature property is disclosed, including the steps of: i) subjecting terephthalic acid, isophthalic acid, dodecanedioic acid, adipic acid, butanediol, dipropylene glycol and hexanediol to an esterification reaction in the presence of tetrabutyl titanate serving as a catalyst; and ii) adding an antioxidant to a product resulting from step i) to conduct a polycondensation reaction under a reduced pressure so as to obtain the high-viscosity polyester hot-melt adhesive which has a low melting point of 130° C.-135° C. and a partially sensitive viscosity-temperature property.
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公开(公告)号：US20170198416A1
公开(公告)日：2017-07-13
申请号：US15313702
申请日：2014-05-30
Inventor： Chongjun Zhao , Youfu Huang , Jianbo Dong , Xiuzhen Qian , Jinchao Zhang
CPC classification number: D01F9/12 , C08J11/04 , C08J99/00 , C08J2363/00 , H05B3/023 , H05B3/145 , Y02P20/143 , Y02W30/70
Abstract: Disclosed herein are methods and systems for recovering carbon fibers from objects. The object may include carbon fibers and resin. The object may be contacted with an electric current to separate the carbon fibers from the resin.
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88.发明授权公开(公告)号：US09677080B2
公开(公告)日：2017-06-13
申请号：US14413930
申请日：2012-11-15
Inventor： Xiangshan Zhou , Yuanxing Zhang , Jinjia Wang , Xiaolong Wang , Peng Bai , Ping Zhang
CPC classification number: C12N15/815 , C07K14/39 , C12N1/32 , C12P21/00
Abstract: Provided is a method of eliminating the dependence of methanol induced promoter on a single methanol carbon source for expressing foreign polypeptide. The method comprises activating the expression of the promoter requiring methanol induction by increasing the expression quantity of Mit1 polypeptide in cells of methylotrophic yeast, so that the promoter originally depending on methanol induction no longer depends on single methanol and can also express foreign polypeptide.
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89.发明授权公开(公告)号：US09499410B2
公开(公告)日：2016-11-22
申请号：US14431018
申请日：2012-09-29
Inventor： Chongjun Zhao
CPC classification number: C01D15/02 , B82Y30/00 , B82Y40/00 , C01B32/184 , C01B32/192 , C01B32/23 , H01G11/46 , H01M4/364 , H01M4/485 , H01M4/587 , Y02P70/54
Abstract: Methods of making a metal oxide-graphene composite are disclosed. The method can include, for example, providing a composition including graphene oxide and at least one elemental metal dispersed in a liquid medium, and heating the composition in a sealed chamber at a temperature above a nominal boiling point of the liquid medium to form the metal oxide-graphene composite. Compositions useful for performing the process and composites obtained by the process are also disclosed.
Abstract translation: 公开了制备金属氧化物 - 石墨烯复合材料的方法。 该方法可以包括例如提供包括氧化石墨烯和分散在液体介质中的至少一种元素金属的组合物，并且在高于液体介质的标称沸点的温度下在密封室中加热组合物以形成金属 氧化石墨烯复合材料。 还公开了用于执行由该方法获得的工艺和复合材料的组合物。
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90.发明申请METHODS FOR RECOVERING CARBON FIBER FROM CARBON-FIBER-REINFORCED POLYMER (CFRP) COMPOSITES 有权从碳纤维增强聚合物（CFRP）复合材料回收碳纤维的方法公开(公告)号：US20160115301A1
公开(公告)日：2016-04-28
申请号：US14889395
申请日：2013-05-08
Inventor： Chongjun ZHAO , Muzi SHITIAN , Weifeng MA , Xiuzhen QIAN , Jinchao ZHANG , Xin CHEN
CPC classification number: C08K7/06 , C08J11/08 , C08J2361/06 , C08J2363/00 , C08L61/06 , D01F9/12 , Y02W30/701
Abstract: Method for recovering carbon fibers from carbon fiber reinforced polymer composites is provided. The recovered carbon fibers can be separable and can be substantially free of thermosetting resins. Compositions comprising said recovered carbon fibers are also provided.
Abstract translation: 提供了从碳纤维增强聚合物复合材料中回收碳纤维的方法。 回收的碳纤维可以是可分离的，并且可以基本上不含热固性树脂。 还提供了包含所述回收的碳纤维的组合物。
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