公开(公告)号：US20060166924A1

公开(公告)日：2006-07-27

申请号：US11390345

申请日：2006-03-28

申请人： Ikunoshin Kato ,  Kiyozo Asada ,  Mitsuhiro Ueno ,  Kimikazu Hashino ,  Hirofumi Yoshioka ,  Keiji Tanaka

发明人： Ikunoshin Kato ,  Kiyozo Asada ,  Mitsuhiro Ueno ,  Kimikazu Hashino ,  Hirofumi Yoshioka ,  Keiji Tanaka

IPC分类号： A61K48/00

CPC分类号： A61K48/00 ,  C12N15/86 ,  C12N2710/10043 ,  C12N2740/13043 ,  C12N2810/40

摘要： Gene therapeutics to be used in treating diseases showing sensitivity to gene therapy, characterized by containing as the active ingredient an efficacious amount of a functional substance which has a function of having an affinity for a virus containing a gene usable in the gene therapy and another function of having an affinity specific for a target cell with a need for the gene transfer, or an efficacious amount of a functional substance which has an affinity for the above virus and an efficacious amount of another functional substance which has an affinity specific for the above cell.

摘要翻译： 用于治疗对基因治疗具有敏感性的疾病的基因疗法，其特征在于含有作为活性成分的有效量的具有对含有可用于基因治疗的基因的病毒具有亲和力的功能物质的功能物质，以及另一功能 对具有基因转移需要的靶细胞具有亲和力的特异性，或对上述病毒具有亲和力的有效量的功能性物质和对上述细胞具有亲和力的有效量的另一种功能性物质 。

公开(公告)号：US20050221360A1

公开(公告)日：2005-10-06

申请号：US11088843

申请日：2005-03-25

申请人： Sachiko Okamoto ,  Junichi Mineno ,  Kiyozo Asada ,  Ikunoshin Kato

发明人： Sachiko Okamoto ,  Junichi Mineno ,  Kiyozo Asada ,  Ikunoshin Kato

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6834 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6874 ,  C12Q2565/518 ,  C12Q2565/102 ,  C12Q2563/125 ,  C12Q2563/107 ,  C12Q2525/161 ,  C12Q2565/1025

摘要： A method for purifying a microbead having an immobilized nucleic acid, a kit for the method, a microbead array which is an array of microbeads each having an immobilized nucleic acid, and a kit for preparing the microbead array.

摘要翻译： 用于纯化具有固定化核酸的微珠的方法，该方法的试剂盒，作为各自具有固定化核酸的微珠阵列的微珠阵列和用于制备微珠阵列的试剂盒。

公开(公告)号：US06949634B2

公开(公告)日：2005-09-27

申请号：US10201314

申请日：2002-07-24

申请人： Junko Yamamoto ,  Kazue Miyake ,  Hiroyuki Mukai ,  Fumitsugu Hino ,  Ikunoshin Kato

发明人： Junko Yamamoto ,  Kazue Miyake ,  Hiroyuki Mukai ,  Fumitsugu Hino ,  Ikunoshin Kato

IPC分类号： C12N15/10 ,  C12Q1/68 ,  C07H19/00 ,  C12N9/00 ,  C12P19/34

CPC分类号： C12Q1/6844 ,  C12N15/10 ,  C12Q1/686 ,  C12Q2521/319 ,  C12Q2521/107

摘要： A method for synthesizing cDNA characterized by performing a reverse transcription reaction in the presence of an enzyme having a reverse transcriptional activity and another enzyme different from the former one which as a 3′-5′ exonuclease activity.

公开(公告)号：US06949623B2

公开(公告)日：2005-09-27

申请号：US09775964

申请日：2001-02-02

申请人： Kiyozo Asada ,  Takashi Uemori ,  Takashi Ueno ,  Nobuto Koyama ,  Kimikazu Hashino ,  Ikunoshin Kato

发明人： Kiyozo Asada ,  Takashi Uemori ,  Takashi Ueno ,  Nobuto Koyama ,  Kimikazu Hashino ,  Ikunoshin Kato

IPC分类号： A61K48/00 ,  C07K14/505 ,  C07K14/78 ,  C12N9/10 ,  C12N15/12 ,  C12N15/867 ,  C07K1/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/505 ,  C07K14/78 ,  C07K2319/00 ,  C12N9/1088 ,  C12N2740/13043 ,  C12N2740/13045

摘要： The present invention provides a method for increasing the efficiency of gene transfer into target cells with a retrovirus. The transduction is affected by infecting target cells with a retrovirus in the presence of a mixture of a functional material having a retrovirus binding domain, and a second functional material having target cell binding domain. The target cells may be selected from the group of unintentional hematopoietic progenitor cells and erythrocyte precursor, specifically pluripotent stem cells or embryopalstic stem cells.

摘要翻译： 本发明提供了用逆转录病毒提高基因转移到靶细胞的效率的方法。 在具有逆转录病毒结合域的功能材料和具有靶细胞结合结构域的第二功能材料的混合物存在下，用逆转录病毒感染靶细胞影响转导。 靶细胞可以选自无意造血祖细胞和红细胞前体，特别是多能干细胞或胚胎干细胞。

公开(公告)号：US06921656B1

公开(公告)日：2005-07-26

申请号：US10048621

申请日：2000-07-26

申请人： Nobuto Koyama ,  Toshitake Okui ,  Hikaru Takakura ,  Kiyozo Asada ,  Ikunoshin Kato

发明人： Nobuto Koyama ,  Toshitake Okui ,  Hikaru Takakura ,  Kiyozo Asada ,  Ikunoshin Kato

IPC分类号： C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N9/26 ,  C12N9/28 ,  C12N9/34 ,  C12N15/56 ,  C12P19/04 ,  C12P19/14 ,  C12P19/20 ,  C07H21/04 ,  C12N15/52

CPC分类号： C12N9/2428 ,  C12N9/2414 ,  C12N9/2417 ,  C12P19/04 ,  C12P19/14 ,  C12P19/20

摘要： Polypeptides having the amino acid sequence represented by SEQ ID NO:6 in Sequence Listing or an amino acid sequence derived from the above sequence by at least one of deletion, addition, insertion or substitution of one or more amino acids and showing a thermophilic glucoamylase activity.

摘要翻译： 或具有由序列表中SEQ ID NO：6表示的氨基酸序列的多肽或由上述序列衍生的氨基酸序列，通过至少一种缺失，添加，插入或取代一个或多个氨基酸并显示出嗜热葡糖淀粉酶活性 。

公开(公告)号：US06911432B2

公开(公告)日：2005-06-28

申请号：US10228195

申请日：2002-08-27

申请人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A23L1/30 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A61K31/341 ,  C07G99/00 ,  A01N43/04

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose are represented by formula (I): These compositions include foods, drinks, cosmetics, etc. containing as the active ingredient at least one such compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. These compounds show an apoptosis-inducing activity, carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes them useful also as the active ingredient of antioxidants and preservatives.

摘要翻译： 用于治疗，改善或预防对3,6-脱水吡喃半乳糖敏感的疾病的药物组合物由式（I）表示：这些组合物包括含有至少一种这样的化合物，其醛， 其水合物和2-O-甲基化衍生物和含有上述化合物的可溶性糖化合物。 这些化合物对活性氧，脂质过氧化物自由基和NO的生成表现出细胞凋亡诱导活性，制癌活性和抑制活性，这使得它们也可用作抗氧化剂和防腐剂的活性成分。

公开(公告)号：US06911208B2

公开(公告)日：2005-06-28

申请号：US10109670

申请日：2002-04-01

申请人： Kazutoh Takesako ,  Takashi Okado ,  Tomoko Yagihara ,  Masanobu Kuroda ,  Yoshimi Onishi ,  Ikunoshin Kato ,  Kazuo Akiyama ,  Hiroshi Yasueda ,  Hideyo Yamaguchi

发明人： Kazutoh Takesako ,  Takashi Okado ,  Tomoko Yagihara ,  Masanobu Kuroda ,  Yoshimi Onishi ,  Ikunoshin Kato ,  Kazuo Akiyama ,  Hiroshi Yasueda ,  Hideyo Yamaguchi

IPC分类号： A61K38/00 ,  C07K14/37 ,  C07K16/14 ,  C12N15/31 ,  C12P21/08 ,  A61K39/35 ,  A61K39/36 ,  C12N21/04 ,  C12N21/06

CPC分类号： A61K39/0002 ,  A61K38/00 ,  A61K39/00 ,  C07K14/37 ,  C07K16/14 ,  Y10S530/858

摘要： A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergies; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergies, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.

摘要翻译： 一种基本上纯的，分离的抗原蛋白，其来源于马拉色氏菌属的真菌，其特征在于所述抗原蛋白具有与过敏患者IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。 根据本发明，可以提供从马拉色霉属，其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。 此外，可以提供用于马拉色氏菌过敏症的诊断剂，治疗剂或预防药物，其中所述药剂包含抗原蛋白或其片段作为活性成分。

公开(公告)号：US20050124575A1

公开(公告)日：2005-06-09

申请号：US10507937

申请日：2003-04-14

申请人： Eiji Nishiyama ,  Nobuko Muraki ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Eiji Nishiyama ,  Nobuko Muraki ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A23K1/16 ,  A23L1/0532 ,  A23L1/30 ,  A61K31/715 ,  A61K31/729 ,  A61P29/00 ,  C08B37/00 ,  A23G3/00 ,  A61K47/00

CPC分类号： C08B37/0039 ,  A23K20/163 ,  A23L29/256 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/715 ,  A61K31/729 ,  A23V2250/5024 ,  A23V2250/1578 ,  A23V2250/5108 ,  A23V2250/616 ,  A23V2250/5118

摘要： Remedies or preventives, which are characterized by containing as the active ingredient at least one member selected from the group consisting of agar, agarose, high-molecular weight digestion products originating in agar and high-molecular weight digestion products originating in agarose, for diseases sensitive to the above active ingredients.

摘要翻译： 其特征在于含有选自琼脂，琼脂糖，源自琼脂的高分子量消化产物和起源于琼脂糖的高分子量消化产物中的至少一种成分为活性成分，用于疾病敏感性的补救剂或预防剂 以上活性成分。

公开(公告)号：US20050119191A1

公开(公告)日：2005-06-02

申请号：US11034243

申请日：2005-01-13

申请人： Tatsui Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Tatsui Enoki ,  Hiroaki Sagawa ,  Takanari Tominaga ,  Eiji Nishiyama ,  Nobuto Koyama ,  Takeshi Sakai ,  Fu-Gong Yu ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A23L1/30 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A61K31/341 ,  C07G99/00 ,  A61K31/70 ,  A61K31/335

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.

摘要翻译： 用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等， 所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。 该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。

公开(公告)号：US20050118578A1

公开(公告)日：2005-06-02

申请号：US10467325

申请日：2002-02-06

申请人： Junichi Mineno ,  Osamu Takeda ,  Masatomo Rokushima ,  Takashi Uemori ,  Shigekazu Hokazono ,  Hiroyuki Mukai ,  Shusaku Yamashita ,  Hiroaki Sagawa ,  Kiyozo Asada ,  Ikunoshin Kato

发明人： Junichi Mineno ,  Osamu Takeda ,  Masatomo Rokushima ,  Takashi Uemori ,  Shigekazu Hokazono ,  Hiroyuki Mukai ,  Shusaku Yamashita ,  Hiroaki Sagawa ,  Kiyozo Asada ,  Ikunoshin Kato

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6837 ,  C12Q2565/518 ,  C12Q2531/119

摘要： A nucleic acid, which is provided in a large amount through a nucleic acid amplification reaction with the use of chimeric oligonucleotide primers, is constructed in a state of containing a modified deoxyribonucleotide for immobilizing the nucleic acid to a solid phase and then immobilized to a solid phase at a high efficiency, thereby giving an immobilized nucleic acid product with excellent qualities.

摘要翻译： 通过使用嵌合寡核苷酸引物通过核酸扩增反应大量提供的核酸以含有修饰的脱氧核糖核苷酸的状态构建，用于将核酸固定至固相，然后固定于固体 相，从而得到具有优异品质的固定化核酸产物。