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公开(公告)号：US20190135873A1
公开(公告)日：2019-05-09
申请号：US16226283
申请日：2018-12-19
CPC分类号： C07K14/005 , A61K38/162 , A61K45/06 , A61K47/60 , A61K47/64 , A61K47/641 , A61K47/645 , C07K2319/035 , C07K2319/70 , C12N7/00 , C12N2740/16022 , C12N2740/16322
摘要： A method for treating a cancer comprises administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising an anti-cancer agent having at least one secretion modifying region (SMR) peptide from HIV-1 Nef fused to at least one cell-penetrating peptide (CPP) or at least one Clusterin (Clu)-binding peptide (Clu-BP).
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公开(公告)号：US20190134151A1
公开(公告)日：2019-05-09
申请号：US16226242
申请日：2018-12-19
摘要： Compositions and methods for reducing the growth of and/or preventing the formation of a microbial biofilm are disclosed. The composition comprises an antimicrobial SMR peptide comprising an HIV-1 SMRwt peptide and a cell penetrating peptide (CPP) domain. In some embodiments, the composition further comprises one or more other antimicrobial peptides (AMPs), antibiotics, matrix-inhibiting compounds, matrix-disaggregating compounds, quorum sensing inhibitors, or a combination thereof. In other embodiments, the compositions are used for impregnating or coating an article and/or material surface with the composition to render it less prone to microbial infections.
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公开(公告)号：US20180291317A1
公开(公告)日：2018-10-11
申请号：US16004954
申请日：2018-06-11
摘要： A method for formulating a cleaning composition contains the step of coating a granular absorbent material with a coating agent to produce a coated absorbent material and mixing the coated absorbent material with a sanitation agent, wherein the coated absorbent material absorbs the sanitation agent to form the cleaning composition. The resulting cleaning composition may be used for cleaning up pathogens or hazardous materials. The cleaning composition may also functions as a liquefiable dry cleaning powder for public areas in response to bodily fluid incidents. A coating method of a non-toxic bio static film on a high surface area solid is disclosed.
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公开(公告)号：US10040831B2
公开(公告)日：2018-08-07
申请号：US15383454
申请日：2016-12-19
IPC分类号： A61K38/16 , A61K47/64 , C07K14/00 , C07K19/00 , C07K14/005 , A61K47/48 , A61K45/06 , C12N7/00
CPC分类号： C07K14/005 , A61K38/162 , A61K45/06 , A61K47/60 , A61K47/64 , A61K47/641 , C07K2319/035 , C07K2319/70 , C12N7/00 , C12N2740/16022 , C12N2740/16322
摘要： A multipartite peptide that inhibits release of exosomes in a cell, comprising an N-terminal end and a C-terminal end and comprising at least one secretion modifying region (SMR) peptide from HIV-1 Nef and at least one Clusterin (Clu)-binding peptide (Clu-BP). Pharmaceutical compositions comprising these peptides alone or in synergistic combinations with other active agents in methods for treating cancers and/or infectious diseases are further provided herein.
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公开(公告)号：US20180170969A1
公开(公告)日：2018-06-21
申请号：US15383454
申请日：2016-12-19
IPC分类号： C07K14/005 , A61K38/16 , A61K45/06 , C12N7/00
CPC分类号： C07K14/005 , A61K38/162 , A61K45/06 , A61K47/48215 , A61K47/60 , A61K47/64 , C07K2319/035 , C07K2319/70 , C12N7/00 , C12N2740/16022
摘要： A multipartite peptide that inhibits release of exosomes in a cell, comprising an N-terminal end and a C-terminal end and comprising at least one secretion modifying region (SMR) peptide from HIV-1 Nef and at least one Clusterin (Clu)-binding peptide (Clu-BP). Pharmaceutical compositions comprising these peptides alone or in synergistic combinations with other active agents in methods for treating cancers and/or infectious diseases are further provided herein.
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公开(公告)号：US20170182041A1
公开(公告)日：2017-06-29
申请号：US15445833
申请日：2017-02-28
发明人： Zhigang XIONG , Roger P. SIMON
IPC分类号： A61K31/4965 , A61K9/00 , A61K31/155
CPC分类号： A61K31/4965 , A61K9/00 , A61K9/0019 , A61K9/0085 , A61K31/155 , A61K31/40 , A61K31/55 , C07K14/43518
摘要： This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US09629838B2
公开(公告)日：2017-04-25
申请号：US13972558
申请日：2013-08-21
发明人： Zhigang Xiong , Roger P. Simon
IPC分类号： A61K31/4965 , C07K14/435 , A61K9/00 , A61K31/155 , A61K31/40 , A61K31/55
CPC分类号： A61K31/4965 , A61K9/00 , A61K9/0019 , A61K9/0085 , A61K31/155 , A61K31/40 , A61K31/55 , C07K14/43518
摘要： This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US09556224B2
公开(公告)日：2017-01-31
申请号：US14156119
申请日：2014-01-15
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , C07K7/06 , C12N7/00 , C12N2740/16032 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
摘要翻译： 本申请公开了一种使用抗微生物组合物治疗微生物感染的方法，其包含含有至少一种VGFPV基序的抗微生物肽。
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89.发明授权Compositions and methods for treating AIDS or cancer by inhibiting the secretion of microparticles 有权通过抑制微粒分泌来治疗AIDS或癌症的组合物和方法公开(公告)号：US08871708B2
公开(公告)日：2014-10-28
申请号：US14015438
申请日：2013-08-30
发明人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
IPC分类号： A61P31/12 , A61P31/18 , A61P35/00 , A61K39/00 , A61K39/21 , C12N5/22 , C07K7/06 , C07K7/08 , C07K14/005 , A61K38/00
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
摘要翻译： 公开了抑制细胞释放微粒的新型肽。 肽在N-末端含有至少一个VGFPV基序，长度为10-100个氨基酸。 还公开了编码肽的多核苷酸，携带多核苷酸的表达载体，以及使用新肽治疗AIDS和肿瘤的方法。
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公开(公告)号：US20140155319A1
公开(公告)日：2014-06-05
申请号：US14156119
申请日：2014-01-15
IPC分类号： C07K7/06
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , C07K7/06 , C12N7/00 , C12N2740/16032 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
摘要翻译： 本申请公开了一种使用抗微生物组合物治疗微生物感染的方法，其包含含有至少一种VGFPV基序的抗微生物肽。
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