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    RETROVIRAL VECTORS
    1.
    发明公开
    RETROVIRAL VECTORS 审中-公开

    公开(公告)号：US20240041957A1

    公开(公告)日：2024-02-08

    申请号：US18255444

    申请日：2021-12-03

    申请人： UCL Business LTD

    发明人： John Counsell ,  Guillaume DE BRABANDERE

    IPC分类号： A61K35/76 ,  C12N15/86

    CPC分类号： A61K35/76 ,  C12N15/86 ,  C12N2740/16043 ,  C12N2830/48 ,  C12N2740/16032

    摘要： There is provided a retroviral RNA vector comprising a 5′ cap, a transgene, a 3′ long terminal repeat (LTR) and an RNA packaging sequence, wherein translation of the transgene is initiated at the 5′ end of the transgene in a cap-dependent manner, and wherein the 3′ LTR and the RNA packaging sequence are located 3′ of the transgene. Also provided is a nucleotide sequence encoding a vector genome. In addition, there is provided a host cell, a virion and a pharmaceutical composition comprising the vector or nucleotide sequence, and the use of the vector in delivering a transgene to a cell or subject.

    Therapeutic Anti-Virus VLPS
    6.
    发明申请
    Therapeutic Anti-Virus VLPS 审中-公开
    治疗性抗病毒VLPS

    公开(公告)号：US20140030792A1

    公开(公告)日：2014-01-30

    申请号：US13940122

    申请日：2013-07-11

    申请人： Radhakrishnan Rathnachalam

    发明人： Radhakrishnan Rathnachalam

    IPC分类号： C12N7/00

    CPC分类号： C12N7/00 ,  C12N7/045 ,  C12N15/1131 ,  C12N2310/141 ,  C12N2740/16021 ,  C12N2740/16032 ,  C12N2740/16043 ,  C12N2740/16062

    摘要： This invention provides therapeutic viruses (TV) and methods to inhibit the propagation of a target virus. TVs can be rendered noninfectious by inactivating mutations, but also include sequences providing miRNA to inactivate essential mRNAs of the target virus. Methods can include provision of the TV and contact with a host cell harboring the target virus. The target virus providing the essential enzymes necessary to the replication of the TV and the TV disabling the target virus with the miRNA.

    摘要翻译： 本发明提供了治疗病毒（TV）和抑制靶病毒繁殖的方法。 电视可以通过灭活突变而变得非传染性，但也包括提供miRNA来灭活靶病毒的基本mRNA的序列。 方法可以包括提供电视并与携带目标病毒的宿主细胞接触。 提供复制电视和电视所需的必需酶的目标病毒能够使用miRNA抑制靶病毒。