公开(公告)号：US07432345B2

公开(公告)日：2008-10-07

申请号：US10127836

申请日：2002-04-22

申请人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

发明人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

IPC分类号： C07K1/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K1/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/70578 ,  C07K14/82 ,  C07K16/18 ,  C07K17/00 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N5/06 ,  C12N9/00 ,  C12N9/001 ,  C12N9/1051 ,  C12N15/00 ,  C12N2799/026 ,  C12P21/02 ,  C12P21/06 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/505 ,  G01N33/5061 ,  G01N33/53 ,  G01N33/574 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6845 ,  G01N2800/042 ,  Y10S530/828 ,  Y10S530/866

摘要： The present invention is directed to novel PRO1475 polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the PRO1475 polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the PRO1475 polypeptides of the present invention and to methods for producing the PRO1475 polypeptides of the present invention.

摘要翻译： 本发明涉及新型PRO1475多肽和编码那些多肽的核酸分子。 本文还提供了包含这些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的PRO1475多肽的嵌合多肽分子，与本发明的PRO1475多肽结合的抗体和用于产生PRO1475多肽的方法 的本发明。

公开(公告)号：US07408042B2

公开(公告)日：2008-08-05

申请号：US10145958

申请日：2002-05-14

申请人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

发明人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

IPC分类号： C07K16/18

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K1/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/70578 ,  C07K14/82 ,  C07K16/18 ,  C07K17/00 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N5/06 ,  C12N9/00 ,  C12N9/001 ,  C12N9/1051 ,  C12N15/00 ,  C12N2799/026 ,  C12P21/02 ,  C12P21/06 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/505 ,  G01N33/5061 ,  G01N33/53 ,  G01N33/574 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6845 ,  G01N2800/042 ,  Y10S530/828 ,  Y10S530/866

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07385031B2

公开(公告)日：2008-06-10

申请号：US10145632

申请日：2002-05-14

申请人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

发明人： Kevin P. Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  William I. Wood ,  Zemin Zhang

IPC分类号： C07K14/705

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K1/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/70578 ,  C07K14/82 ,  C07K16/18 ,  C07K17/00 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N5/06 ,  C12N9/00 ,  C12N9/001 ,  C12N9/1051 ,  C12N15/00 ,  C12N2799/026 ,  C12P21/02 ,  C12P21/06 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5014 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/505 ,  G01N33/5061 ,  G01N33/53 ,  G01N33/574 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6845 ,  G01N2800/042 ,  Y10S530/828 ,  Y10S530/866

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20070264686A1

公开(公告)日：2007-11-15

申请号：US11553810

申请日：2006-10-27

申请人： Kevin Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  Austin Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy Stewart ,  Daniel Tumas ,  Colin Watanabe ,  William Wood ,  Zemin Zhang

发明人： Kevin Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  Austin Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy Stewart ,  Daniel Tumas ,  Colin Watanabe ,  William Wood ,  Zemin Zhang

IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C07K14/47 ,  C07K16/18

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07285623B2

公开(公告)日：2007-10-23

申请号：US09981915

申请日：2001-10-16

申请人： Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  William I. Wood

发明人： Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  William I. Wood

IPC分类号： C07K14/475 ,  C07K16/46 ,  C07K19/00 ,  C12P21/06 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4702 ,  C07K14/4703 ,  C07K14/475 ,  C07K14/52 ,  C07K14/521 ,  C07K14/54 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/70578 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/00 ,  C12N2799/026 ,  C12N2799/027 ,  G01N33/573 ,  G01N33/57484 ,  G01N33/68 ,  G01N2333/99 ,  G01N2800/042

摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to human neurotrimin or DNA43316.

摘要翻译： 本发明涉及核苷酸序列，包括表达的序列标签（EST），寡核苷酸探针，多肽，载体和表达人免疫粘附的宿主细胞和抗人类神经定蛋白或DNA43316的抗体。

公开(公告)号：US20070077623A1

公开(公告)日：2007-04-05

申请号：US11518609

申请日：2006-09-07

申请人： Avi Ashkenazi ,  David Bolstein ,  Luc Desnoyers ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  Christopher Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Jennie Mather ,  James Pan ,  Nicholas Paoni ,  Margaret Roy ,  Timothy Stewart ,  Daniel Tumas ,  P. Williams ,  William Wood

发明人： Avi Ashkenazi ,  David Bolstein ,  Luc Desnoyers ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  Christopher Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Jennie Mather ,  James Pan ,  Nicholas Paoni ,  Margaret Roy ,  Timothy Stewart ,  Daniel Tumas ,  P. Williams ,  William Wood

IPC分类号： C12P21/06 ,  C07H21/04 ,  C12N9/00 ,  C07K14/705 ,  C07K16/18

CPC分类号： C07K14/47 ,  C07K14/705

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US06930172B2

公开(公告)日：2005-08-16

申请号：US10033301

申请日：2001-12-27

申请人： Napoleone Ferrara ,  Wei-Qiang Gao ,  Audrey Goddard ,  Austin L. Gurney ,  Colin K. Watanabe ,  William I. Wood

发明人： Napoleone Ferrara ,  Wei-Qiang Gao ,  Audrey Goddard ,  Austin L. Gurney ,  Colin K. Watanabe ,  William I. Wood

IPC分类号： A61K38/00 ,  C07H21/04 ,  C07K1/00 ,  C07K14/435 ,  C07K14/47 ,  C07K16/00 ,  C07K16/40 ,  C12N1/18 ,  C12N1/21 ,  C12N5/06 ,  C12N9/00 ,  C12N9/64 ,  C12N15/74 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US06927204B2

公开(公告)日：2005-08-09

申请号：US10458039

申请日：2003-06-09

申请人： Wei-Qiang Gao

发明人： Wei-Qiang Gao

IPC分类号： A61K38/18 ,  A61K38/30 ,  A61K38/00 ,  A61K38/28 ,  A61K39/395 ,  C07K16/00

CPC分类号： A61K38/1825 ,  A61K38/1841 ,  A61K38/30 ,  Y10S435/81 ,  A61K2300/00

摘要： Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.

摘要翻译： 提供了组合物，方法和装置，用于诱导或增强内耳组织，特别是内耳毛细胞的生长，增殖，再生。 此外，提供了通过施用治疗有效量的IGF-1来预防或治疗患有内耳障碍或病症的哺乳动物，特别是涉及毛细胞损伤，损失或变性的听力损伤的组合物和方法 或FGF-2，或其激动剂，单独或组合使用。

公开(公告)号：US06918771B2

公开(公告)日：2005-07-19

申请号：US10778833

申请日：2004-02-13

申请人： Michael L. Arington ,  Bradford E. Bailey ,  Bill B. Clark ,  Chen Yuanming ,  Qiang Gao ,  Dave Wilson ,  William E. Younkes

发明人： Michael L. Arington ,  Bradford E. Bailey ,  Bill B. Clark ,  Chen Yuanming ,  Qiang Gao ,  Dave Wilson ,  William E. Younkes

IPC分类号： G09B7/04 ,  G09B23/28

CPC分类号： G09B7/04 ,  G09B23/28 ,  G09B23/285

摘要： A simulation method and system based on a distributive processing model is used for training and educating healthcare teams. The system allows team members to be at the training facility or located remotely and connected via data communication links. The system allows multiple participants for individual team member roles at various connected simulation workstations. If simulation participants cannot man all the team roles, the system can provide virtual team members in their stead. The simulation server computer delivers to each workstation the particular programs and outputs required for any given simulation exercise.

摘要翻译： 基于分布式处理模型的模拟方法和系统用于培训和教育医疗团队。 该系统允许团队成员在培训设施中或远程定位并通过数据通信链接连接。 该系统允许多个参与者在各种连接的模拟工作站上进行各个团队成员的角色。 如果模拟参与者无法承担所有团队角色，系统可以提供虚拟团队成员。 模拟服务器计算机向每个工作站传送任何给定的模拟练习所需的特定程序和输出。

公开(公告)号：US20050084935A1

公开(公告)日：2005-04-21

申请号：US10897360

申请日：2004-07-21

申请人： Avi Ashkenazi ,  Kevin Baker ,  David Botstein ,  Luc Desnoyers ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Sophia Kuo ,  Mary Napier ,  James Pan ,  Nicholas Paoni ,  Margaret Roy ,  David Shelton ,  Timothy Stewart ,  Daniel Tumas ,  P. Williams ,  William Wood

发明人： Avi Ashkenazi ,  Kevin Baker ,  David Botstein ,  Luc Desnoyers ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Sophia Kuo ,  Mary Napier ,  James Pan ,  Nicholas Paoni ,  Margaret Roy ,  David Shelton ,  Timothy Stewart ,  Daniel Tumas ,  P. Williams ,  William Wood

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/50 ,  G01N33/574 ,  G01N33/68 ,  C12P21/02 ,  C07H21/04 ,  C12N9/00

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026 ,  C12N2799/027 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/57484 ,  G01N33/68 ,  G01N33/6845

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.