公开(公告)号：US20230295561A1

公开(公告)日：2023-09-21

申请号：US18006321

申请日：2021-07-23

Applicant: Paul WEISS ,  Ali TAMAYOL ,  Amir NASAJPOUR ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  Board of Regents of the University of Nebraska

Inventor： Paul Weiss ,  Ali Tamayol ,  Amir Nasajpour

IPC: C12N5/00 ,  C09K19/36

CPC classification number: C12N5/0068 ,  C09K19/36 ,  C12N2533/20

Abstract: The present invention provides liquid crystals and compositions thereof (e.g., liquid crystal-based scaffolds). The present invention also provides the methods for generating said liquid crystals and compositions thereof (e.g., liquid crystal-based scaffolds) as well as uses thereof in cell-culturing and tissue-generating.

公开(公告)号：US20230287362A1

公开(公告)日：2023-09-14

申请号：US18183815

申请日：2023-03-14

Applicant: The Regents of the University of Colorado, a body corporate ,  The Regents of the University of California

Inventor： Aaron Whiteley ,  Hannah Ledvina ,  Kevin Corbett ,  Qiaozhen Ye ,  Yajie Gu

IPC: C12N9/12 ,  C07K16/10 ,  C12N9/10

CPC classification number: C12N9/1241 ,  C07K16/10 ,  C12N9/1007 ,  C12Y201/01 ,  C12N9/1077 ,  C12Y204/02038 ,  C07K2319/30

Abstract: The invention describes the discovery and novel application of a bacterial ubiquitin transferase (Cap2). Specifically, the invention describes the novel activity of the enzyme Cap2 which is capable of creating a specific fusion between two proteins implementing a standalone catalytic mechanism to create the fusion.

公开(公告)号：US20230268483A1

公开(公告)日：2023-08-24

申请号：US18112130

申请日：2023-02-21

Applicant: Regents of the University of Minnesota ,  Board of Regents, The University of Texas System

Inventor： Christopher John Ellison ,  Charles Buddie Mullins ,  Samantha Nicole Lauro ,  Joshua Paul Pender ,  Han Xiao ,  Jason Alexander Weeks, JR. ,  James Norman Burrow, JR.

IPC: H01M4/1391 ,  H01M10/0525 ,  H01M4/131 ,  H01M4/04 ,  H01M4/62 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/36 ,  H01B1/18

CPC classification number: H01M4/1391 ,  H01M10/0525 ,  H01M4/131 ,  H01M4/0433 ,  H01M4/0485 ,  H01M4/0404 ,  H01M4/622 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/366 ,  H01M4/623 ,  H01B1/18

Abstract: A method of making a porous film includes disposing a slurry on a substrate, solidifying the slurry to yield a film on the substrate, and subliming the organic sublimable material to yield the porous film on the substrate. The slurry includes an electrochemically active material, an electrically conductive material, and a binder dispersed in an organic sublimable material. The electrochemically active material and the electrically conductive material are different.
A slurry includes a solid component including an electrochemically active material, an electrically conductive material, and a binder; and a liquid component including an organic sublimable material, wherein the electrochemically active material and the electrically conductive material are different, and the solid component is dispersed in the liquid component.

公开(公告)号：US20230140210A1

公开(公告)日：2023-05-04

申请号：US17969519

申请日：2022-10-19

Applicant: REGENTS OF THE UNIVERSITY OF MICHIGAN ,  The Regents of the University of California

Inventor： Michael Holinstat ,  Reheman Adili ,  Andrew White ,  Theodore R. Holman

IPC: C07D249/12 ,  A61P7/02 ,  C07D403/12

Abstract: Disclosed herein are small molecule inhibitors of platelet function, and methods of using the small molecules to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

公开(公告)号：US20220387969A1

公开(公告)日：2022-12-08

申请号：US17775992

申请日：2020-11-11

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE ,  ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Alan W. WEIMER ,  Annika LAI ,  Robert PFEFFER ,  Jerry LIN

IPC: B01J20/22 ,  B01J20/10 ,  B01J20/28 ,  B01J20/32 ,  B01D53/62 ,  B01D53/81

Abstract: A method for forming an amine-functionalized solid CO2 sorbent for carbon capture may include providing a support material and applying at least one cycle of molecular layer deposition (MLD) with an amine precursor onto the surface of the support material. An amine layer formed on the support material contains amine groups/amine-containing ligands to adsorb CO2 onto the support material in a low temperature operating window for adsorption and desorption without the loss of active sites.

公开(公告)号：US20210213031A1

公开(公告)日：2021-07-15

申请号：US15734254

申请日：2019-06-04

Applicant: The Regents of the University of California ,  The Regents of the University of Colorado

Inventor： Gerard Boss ,  Adriano Chan ,  Matthew Brenner ,  Sari Brenner Mahon ,  Vikhyat Bebarta

IPC: A61K31/555 ,  A61K9/00 ,  A61P39/02

Abstract: Methods and compositions for treating cyanide, sulfide, or methane-thiol exposure in a subject. The compositions may include one or more cobinamide compounds, such as an amino-tetrazole-cobinamide and/or a di-(amino-tetrazole)-cobinamide.

公开(公告)号：US20210130444A1

公开(公告)日：2021-05-06

申请号：US16877103

申请日：2020-05-18

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATION ,  The Regents of the University of California

Inventor： Jeffery L. BENNETT ,  Gregory P. OWENS ,  Alan S. VERKMAN

IPC: C07K16/18 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: The present invention is directed to antibodies binding to aquaporin 4 (AQP4) and methods of using such antibodies to treat neuromyelitis optica (NMO) either as a monotherapy or in combination with standard NMO therapies such as immunosuppressives or plasmaphersis.

公开(公告)号：US20210058229A1

公开(公告)日：2021-02-25

申请号：US16996061

申请日：2020-08-18

Applicant: The Board of Regents of The University of Texas System ,  The Regents of the University of California ,  Microsoft Technology Licensing, LLC

Inventor： Xiaoqian Jiang ,  Miran Kim ,  Yongsoo Song ,  Kristin Lauter

IPC: H04L9/00 ,  G06F21/60 ,  H04L9/06 ,  G06F21/62 ,  G06F17/16

Abstract: A method, system and computer program product for performing computations on sensitive data while guaranteeing privacy. A service provider receives a first and a second ciphertext from a medical provider that homomorphically encrypts matrices A and B, respectively, using an encryption key, where the matrices A and B include medical data encoded as vectors. The service provider performs a homomorphic matrix multiplication on the first and second ciphertexts without decrypting the first and second ciphertexts. An encrypted result from the performed homomorphic matrix multiplication on the first and second ciphertexts is generated and transmitted to the medical provider to decrypt which matches a result of performing a matrix multiplication on unencrypted matrices A and B thereby enabling computations to be performed on the medical data in a secure manner.

公开(公告)号：US10918657B2

公开(公告)日：2021-02-16

申请号：US14536176

申请日：2014-11-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE MARINE BIOLOGICAL LABORATORY ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jennifer R. Morgan ,  Gal Bitan ,  David J. Busch

IPC: A61K31/7088 ,  A61K31/6615 ,  A61K31/663 ,  A61K31/255 ,  A61K31/194 ,  C12N15/113 ,  A61K45/06

Abstract: Methods for the treatment of spinal cord injury or traumatic brain injury are provided. In certain embodiments, the methods include the use of a molecular tweezers and/or nucleobase oligomer capable of inhibiting the accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins. Examples of treatments that may inhibit accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins include treatment with a synuclein antisense nucleobase oligomer or treatment with the molecular tweezers CLR01. These treatments may improve outcomes of spinal cord surgery or traumatic brain injury, including, without limitation, neuronal survival, neuronal regeneration, and recovery of neuronal functions.

公开(公告)号：US20210022827A1

公开(公告)日：2021-01-28

申请号：US16317855

申请日：2017-07-17

Applicant: The Board Of Regents for Oklahoma State University ,  The Board of Regents of the University of Oklahoma

Inventor： DAQING PIAO ,  SANJAY PATEL

IPC: A61B90/00 ,  A61B34/37

Abstract: Taught herein is a new contact-based optical imaging technology, en-face differential optical topography (en-face DOT), which performs real-time visualization of subsurface tissue heterogeneity within a depth up to 3 mm and over a 9.5 mm diameter FOV with a modest mm-level lateral resolution. An embodiment of the probe fits in a 12 mm port and houses at its maximum 128 cop-per-coated 750 μm fibers that form radially alternating illumination (70 fibers) and detection (58 fibers) channels. By simultaneously illuminating the 70 source channels of the laparoscopic probe that is in contact with a scattering medium and concurrently measuring the light diffusely propagated to the 58 detector channels, the presence of near-surface optical heterogeneities can be resolved in an en-face 9.5 mm field-of-view in real-time. Visualization of subsurface margin of strong attenuation contrast at a depth up to 3 mm is demonstrated at one wavelength at a frame rate of 1.3 Hz.