公开(公告)号：US20230002502A1

公开(公告)日：2023-01-05

申请号：US17779908

申请日：2020-11-26

Applicant: South Australian Health and Medical Research Institute Limited ,  The Flinders University of South Australia

Inventor： David John Lynn ,  Stephen James Blake

IPC: C07K16/28 ,  C07K16/24

Abstract: The present disclosure relates to methods and products for reducing side effects associated with immunotherapy using immune agonist antibodies. In certain embodiments, the present disclosure provides a method of reducing one or more side effects associated with immunotherapy using an immune agonist antibody alone, or in combination with an immune checkpoint inhibitor, in a subject suffering from a cancer, the method comprising modifying the gut microbiota in the subject and thereby reducing the one or more side effects associated with the immunotherapy in the subject.

公开(公告)号：US11261496B2

公开(公告)日：2022-03-01

申请号：US15794270

申请日：2018-01-23

Applicant: UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Doug Brooks ,  Emma Parkinson-Lawrence ,  Ian R. D. Johnson ,  Lisa Butler

IPC: G01N33/574 ,  C12Q1/6886 ,  A61P35/00 ,  C07K16/30 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  A61N5/10

Abstract: Methods for detecting a prostate cancer in a subject comprise detecting a marker selected from an endosomal associated marker and/or a lysosomal associated marker from the subject.

公开(公告)号：US20210213053A1

公开(公告)日：2021-07-15

申请号：US17059221

申请日：2019-05-29

Applicant: The Flinders University of South Australia ,  The University of Melbourne

Inventor： Kelton Paul Tremellen ,  David K. Gardner ,  Alexandra J. Harvey

IPC: A61K33/34 ,  A61K33/30 ,  A61K47/38 ,  A61K47/10 ,  A61K9/08 ,  A61K9/14 ,  A61K9/06 ,  A61B17/43 ,  A61B17/435

Abstract: A method of enhancing embryo implantation in a subject is disclosed which comprises administering to the uterine cavity of the subject a formulation comprising copper and/or zinc in an amount effective to stimulate endometrial production of leukaemia inhibitory factor (LIF) and/or vascular endothelial growth factor (VEGF). Alternatively, a device may be inserted into the uterine cavity of the subject, wherein the device comprises copper and/or zinc, for a period of time that is effective to stimulate endometrial production of LIF and/or VEGF. The method is suitable for use with women undergoing treatment by any of the assisted reproductive technologies, such as those involving the transfer of embryos such as in vitro fertilisation (IVF) and variants including IVF-ICSI (intracytoplasmic sperm injection) and in vitro maturation (IVM) treatments, as well as intrauterine-insemination (IUI) therapy. However, the method is also applicable for women wanting to improve their prospects of pregnancy through natural conception.

公开(公告)号：US10596187B2

公开(公告)日：2020-03-24

申请号：US15034965

申请日：2014-11-07

Applicant: Yale University ,  Flinders University of South Australia ,  Balakrishnan Siddartha Ramakrishna

Inventor： Balakrishnan Siddartha Ramakrishna ,  Graeme Paul Young ,  Ian Lewis Brown ,  Henry Joseph Binder

IPC: A61K33/00 ,  A23L2/38 ,  A61K31/718 ,  A61K33/14 ,  A61K47/36 ,  A61K9/00 ,  A23L2/52 ,  A61K33/30 ,  A61K33/34 ,  A61K33/06 ,  A23L33/105 ,  A23L33/16 ,  A23L29/212 ,  A23L33/10 ,  A23L33/21 ,  A23L29/269 ,  A23L29/238 ,  A23L29/256 ,  A23L29/231 ,  A23L29/25 ,  A23L29/281 ,  A61K31/194 ,  A61K31/7004

Abstract: Provided herein are compositions, for example: oral rehydration compositions, beverages, food items, methods and uses, which utilise resistant starch to prevent or treat dehydration, including dehydration which is caused by diarrhoea. Beverages, food items and oral rehydration solutions including a resistant starch, which are suitable for aiding in the maintenance and restoration of hydration levels in individuals undertaking physical activities, including sports, are also disclosed.

公开(公告)号：US10590012B2

公开(公告)日：2020-03-17

申请号：US15521099

申请日：2015-10-13

Applicant: THE UNIVERSITY OF TULSA ,  FLINDERS UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Justin M. Chalker, Sr. ,  Michael P. Crockett ,  Austin M. Evans ,  Max Worthington

IPC: B01J20/22 ,  C02F1/28 ,  C07C319/22 ,  B01J20/30 ,  B01J20/26 ,  B01J20/32 ,  C07C321/22 ,  C02F101/20 ,  C02F103/00 ,  C02F101/10

Abstract: Disclosed is a limonene-sulfur polysulfide and methods for preparing the same. The polysulfide prepared according to these methods is flexible, moldable and otherwise capable of being formed in any manner consistent with a thermoplastic polymer. The limonene-sulfur polysulfide has been demonstrated to sequester inorganic palladium and inorganic mercury dissolved in water.

公开(公告)号：US20200079858A1

公开(公告)日：2020-03-12

申请号：US16493845

申请日：2018-03-14

Applicant: UNIVERSITY OF SOUTH AUSTRALIA ,  CENTRAL ADELAIDE LOCAL HEALTH NETWORK INC. ,  SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUEE SOCPRA SOCPRA SCIENCES SANTE ET

Inventor： Jeffrey Victor LEYTON ,  Eric MARSAULT ,  Simon BEAUDOIN ,  Pierre-Luc BOUDREAULT ,  Marc-André BONIN ,  Angel LOPEZ

IPC: C07K16/28 ,  G01N33/574 ,  A61K47/54 ,  A61K47/68 ,  A61K51/04 ,  A61K51/10

Abstract: The present description relates to a conjugated anti-interleukin-5 receptor α-subunit (IL-5Rα) compound comprising cholic acid (ChAc) or a variant thereof, the ChAc conjugated to a non-cell penetrating peptide comprising a nuclear localization sequence (NLS) conjugated to an anti-interleukin-5 receptor α-subunit (IL-5Rα) compound and further conjugated to chemotherapeutic agent and/or a radionuclide.

公开(公告)号：US20200045979A1

公开(公告)日：2020-02-13

申请号：US16608421

申请日：2018-04-27

Applicant: The Flinders University of South Australia

Inventor： Christopher Milton Mathew Franco

IPC: A01N63/02 ,  C12N1/20 ,  C12R1/465

Abstract: The present disclosure relates to bacterial inoculants, and methods for their use, to control a fungal root disease in a plant and promote plant growth in water limited conditions. In particular strains of Paenibacillus and Streptomyces are disclosed.

公开(公告)号：US10320469B2

公开(公告)日：2019-06-11

申请号：US15877246

申请日：2018-01-22

Applicant: UNIVERSITY OF SOUTH AUSTRALIA

Inventor： David Victor Lawrie Haley ,  John Lawrence Buetefuer ,  Alexander James Grant ,  William George Cowley ,  Gottfried Lechner ,  Ingmar Rudiger Land ,  Robert George McKilliam ,  Andre Pollok ,  Linda Mary Davis ,  Ricky Rocco Luppino ,  Sorin Adrian Barbulescu

IPC: H04B7/185 ,  H04B7/212 ,  H04W40/20

Abstract: A communication system is disclosed. In an embodiment, the communication system includes a user node for receiving data from a remote application program, the data including message data for communication to a central application program operatively associated with the remote application program; plurality of geographically distributed gateway nodes; one or more access nodes for receiving the message data from the user node via a first communications interface, and communicating the message data via a second communications interface to one or more of the plurality of geographically distributed gateway nodes; and a hub for communicating with the one or more of the plurality of geographically distributed gateway nodes to receive the message data for communication to the central application.

公开(公告)号：US10284286B2

公开(公告)日：2019-05-07

申请号：US14913339

申请日：2014-08-21

Applicant: University of South Australia

Inventor： Alexander James Grant ,  Gottfried Lechner ,  Andre Pollok ,  Robert George McKilliam ,  Ingmar Rudiger Land ,  David Victor Lawrie Haley ,  William George Cowley ,  Linda Mary Davis ,  Sorin Adrian Barbulescu ,  John Lawrence Buetefuer ,  Marc Pierre Denis Lavenant

IPC: H04B7/185 ,  H04B1/10 ,  H04W72/04 ,  H04W72/08 ,  H04W88/02 ,  H04B1/7107

Abstract: A multiuser communication system comprises multiple transmitters and a multiuser receiver that detects multiple transmissions via iterative soft interference cancellation. An initial acquisition module and single user decoder module are also described. The multiuser receiver acquires and subtracts known users in the residual signal before acquiring new users in the residual signal, which is performed iteratively until no new users are detected or a stopping criterion is met. To aid receiver acquisition, the transmitters insert discrete tones into the transmitted signals. These allow the multiuser receiver to obtain initial estimates of the frequency, time, gain, and/or phase offset for each user. To improve the quality of cancellation the receiver refines estimates of gain, time, frequency and phase offsets for each user after each iteration, and calculates time varying SINR estimates for each user. The multiuser receiver may be satellite based, may be a distributed receiver, or process users in parallel.

公开(公告)号：US20190112378A1

公开(公告)日：2019-04-18

申请号：US15753614

申请日：2015-11-26

Applicant: UNIVERSITY OF SOUTH AUSTRALIA ,  CENTRAL ADELAIDE LOCAL HEALTH NETWORK INC.

Inventor： Angel F. LOPEZ ,  Claudine S. BONDER ,  Emma THOMPSON

IPC: C07K16/28 ,  A61P35/04 ,  C07K16/24

Abstract: A method of treating or preventing breast cancer (eg invasive ductal carcinoma) and/or cancer associated with elevated levels of either one or both of the IL-3 receptor (IL-3R) and interleukin-3 (IL-3) is disclosed which comprises administering to a subject an IL-3 -inhibiting agent such as an agent which inhibits (eg by blocking) IL-3R.