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102 条记录 (耗时 0.059 秒)

    Acylglycerol acyltransferase-like protein MGAT-X1 and uses thereof
    81.
    发明授权
    Acylglycerol acyltransferase-like protein MGAT-X1 and uses thereof 失效
    酰基甘油酰基转移酶样蛋白MGAT-X1及其用途

    公开(公告)号：US08343745B2

    公开(公告)日：2013-01-01

    申请号：US12854524

    申请日：2010-08-31

    申请人： Stefan Golz ,  Ulf Brüggemeier ,  Bernhard Weingartner ,  Andreas Geerts

    发明人： Stefan Golz ,  Ulf Brüggemeier ,  Bernhard Weingartner ,  Andreas Geerts

    IPC分类号： C12N9/10 ,  A61K38/00 ,  C07H21/04 ,  C07K1/00

    CPC分类号： C07K16/40 ,  C12N9/1029

    摘要： The present invention is directed to a polynucleotide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X1. The invention also provides the human MGAT-X1 associated with the dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases. The invention also provides assays for the identification of compounds useful for the modulation of dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases for treating of such diseases associated with expression of the MGAT-X1. The invention also features compounds which bind to and/or activate or inhibit the activity of MGAT-X1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明涉及新的酰基甘油酰基转移酶样蛋白MGAT-X1的多核苷酸序列。 本发明还提供了与皮肤病，泌尿疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或胃肠疾病有关的人MGAT-X1。 本发明还提供了用于鉴定可用于调节皮肤病，泌尿系统疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或用于治疗这些疾病的胃肠病学疾病的化合物的测定 与MGAT-X1的表达相关。 本发明还涉及结合和/或活化或抑制MGAT-X1的活性的化合物以及包含这些化合物的药物组合物。

    CRTAC AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET
    84.
    发明申请
    CRTAC AS A BIOMARKER, THERAPEUTIC AND DIAGNOSTIC TARGET 审中-公开
    CRTAC作为生物标志物，治疗和诊断目标

    公开(公告)号：US20100081136A1

    公开(公告)日：2010-04-01

    申请号：US12444227

    申请日：2007-10-02

    申请人： Stefan Golz ,  Holger Summer ,  Andreas Geerts ,  Ulf Bruggemeier ,  Barbara Albrecht-Kupper ,  Martina Klein

    发明人： Stefan Golz ,  Holger Summer ,  Andreas Geerts ,  Ulf Bruggemeier ,  Barbara Albrecht-Kupper ,  Martina Klein

    IPC分类号： G01N33/53 ,  C12Q1/68

    CPC分类号： G01N33/6887 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

    摘要： The invention provides CRTAC, which is associated with cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CRTAC as well as pharmaceutical compositions comprising such compounds. The invention also provides CRTAC as a biomarker for diseases such as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases.

    摘要翻译： 本发明提供了与心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系疾病有关的CRTAC。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液疾病，神经疾病，癌症，内分泌疾病和泌尿系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制CRTAC的活性的化合物以及包含这些化合物的药物组合物。 本发明还提供CRTAC作为心血管疾病，血液疾病，神经系统疾病，癌症，内分泌疾病和泌尿系疾病等疾病的生物标志物。

    Diagnostics and Therapeutics for Diseases Associated with Arginyl Aminopeptidase (Aminopeptidase B)-Like 1 (Rnpepl1)
    86.
    发明申请
    Diagnostics and Therapeutics for Diseases Associated with Arginyl Aminopeptidase (Aminopeptidase B)-Like 1 (Rnpepl1) 审中-公开
    与精氨酰氨肽酶（氨肽酶B）相关的疾病诊断和治疗 - 相似1（Rnpepl1）

    公开(公告)号：US20080248462A1

    公开(公告)日：2008-10-09

    申请号：US10575364

    申请日：2004-10-12

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andres Geerts

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andres Geerts

    IPC分类号： C12Q1/68 ,  G01N33/68 ,  G01N33/53 ,  C07K2/00 ,  C07K16/00 ,  C07H21/00 ,  G01N33/00

    CPC分类号： G01N33/57496 ,  C12Q1/37 ,  G01N2500/00 ,  Y10T436/143333

    摘要： The invention provides a human RNPEPL1 which is associated with the cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases, urological diseases and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases, urological diseases and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of RNPEPL1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液疾病，呼吸系统疾病，神经系统疾病，泌尿系疾病和繁殖障碍有关的人类RNPEPL1。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液疾病，呼吸系统疾病，神经疾病，泌尿系疾病和繁殖障碍的化合物的测定。 本发明还涉及结合和/或活化或抑制RNPEPL1的活性的化合物以及包含这些化合物的药物组合物。

    Organic anion transporting (oat)-like protein UST3-LIKE1 and uses thereof
    87.
    发明授权
    Organic anion transporting (oat)-like protein UST3-LIKE1 and uses thereof 失效
    有机阴离子输送（燕麦）样蛋白质UST3-LIKE1及其用途

    公开(公告)号：US07338781B2

    公开(公告)日：2008-03-04

    申请号：US10548420

    申请日：2004-03-04

    申请人： Stefan Golz ,  Ulf Brüggemeier ,  Andreas Geerts

    发明人： Stefan Golz ,  Ulf Brüggemeier ,  Andreas Geerts

    IPC分类号： C21P21/06 ,  C07K14/00

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The present invention is directed to a polynucleotide sequence of a novel organic anion transporting (OAT)-like protein UST3-likel. More particularly, the present invention provides a polynucleotide sequence comprising the nucleic acid sequence SEQ ID NO: 1 or nucleic acid sequences that hybridize to SEQ ID NO: 1 or its complimentary strand. The invention also provides the human UST3-LIKE1 associated with the gastrointestinal and liver diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders and cardiovascular diseases as a result of relative quantification of the mRNA distribution in different human tissues by expression profiling. The invention also provides assays for the identification of compounds useful for the modulation of said diseases. The methods of the invention involve cell-free and cell-based assays that identify compounds which bind to and/or activate or inhibit the activity of UST3-LIKE1, a organic anion transporting (OAT)-like protein, followed by an in vivo assay of the effect of the compound on said diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of UST3-LIKE1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明涉及新型有机阴离子转运（OAT）样蛋白UST3-可能的多核苷酸序列。 更具体地，本发明提供了包含核酸序列SEQ ID NO：1或与SEQ ID NO：1或其互补链杂交的核酸序列的多核苷酸序列。 本发明还提供了与胃肠和肝脏疾病，代谢疾病，血液学疾病，呼吸系统疾病，神经系统疾病，泌尿系统疾病和心血管疾病相关的人类UST3-LIKE1，其是通过表达相对定量不同人体组织中的mRNA分布的结果 剖析。 本发明还提供用于鉴定可用于调节所述疾病的化合物的测定。 本发明的方法包括无细胞和基于细胞的测定，其鉴定结合和/或活化或抑制UST3-LIKE1（有机阴离子转运（OAT）样蛋白）的活性的化合物，然后进行体内测定 化合物对所述疾病的作用。 本发明还涉及结合和/或活化或抑制UST3-LIKE1的活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and therapeutics for diseases associated with kallikrein 8 (klk8)
    90.
    发明申请
    Diagnostics and therapeutics for diseases associated with kallikrein 8 (klk8) 审中-公开
    与激肽释放酶8（klk8）相关疾病的诊断和治疗

    公开(公告)号：US20070196372A1

    公开(公告)日：2007-08-23

    申请号：US10568762

    申请日：2004-08-17

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

    IPC分类号： A61K39/395 ,  A61K48/00 ,  A61K38/55 ,  G01N33/53

    CPC分类号： C12Q1/37

    摘要： The invention provides a human KLK8 which is associated with the cardiovascular diseases, dermatological diseases, neurological diseases, metabolic diseases, cancer disorders, urological diseases, gastroenterological diseases and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, neurological diseases, metabolic diseases, cancer disorders, urological diseases, gastroenterological diseases and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK8 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，皮肤病，神经疾病，代谢疾病，癌症病症，泌尿科疾病，胃肠疾病和繁殖障碍有关的人类KLK8。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，神经疾病，代谢疾病，癌症疾病，泌尿科疾病，胃肠疾病和繁殖障碍的化合物的测定。 本发明还涉及结合和/或活化或抑制KLK8活性的化合物以及包含这些化合物的药物组合物。