摘要:
The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
摘要:
The present invention relates to antigen binding proteins comprising two Fc parts, methods for their production, pharmaceutical compositions containing said antigen binding proteins, and uses thereof.
摘要:
The present invention relates to nucleic acids which encode the heavy chains and light chains of a novel domain exchanged, bivalent, bispecific antibody, and vectors comprising the same.
摘要:
The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.
摘要:
The present invention relates to bispecific, bivalent antibodies against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要:
In a motion capture system having a depth camera, a physical interaction zone of a user is defined based on a size of the user and other factors. The zone is a volume in which the user performs hand gestures to provide inputs to an application. The shape and location of the zone can be customized for the user. The zone is anchored to the user so that the gestures can be performed from any location in the field of view. Also, the zone is kept between the user and the depth camera even as the user rotates his or her body so that the user is not facing the camera. A display provides feedback based on a mapping from a coordinate system of the zone to a coordinate system of the display. The user can move a cursor on the display or control an avatar.
摘要:
The present invention is directed to a pharmaceutical composition comprising: (A) a type II anti-CD20 antibody with increased antibody dependent cellular cytotoxicity (ADCC); and (B) a chemotherapeutic agent selected from the group consisting of: cyclophosphamide, vincristine and doxorubicine. The present invention is also directed to a method for the treatment of a CD20 expressing cancer, comprising administering to a patient in need of such treatment (i) an effective first amount of a type II anti-CD20 antibody with increased antibody dependent cellular cytotoxicity; and (ii) an effective second amount of one or more chemotherapeutic agents selected from the group consisting of cyclophosphamide, vincristine and doxorubicine.
摘要:
Apparatus and method are described, illustratively in an LVLS master/slave system, for detecting a circuit failure, shutting down the system as if a normal power down function has occurred, but restarting the system. Signals, including power and ground lines are monitors, mal-functions detected and the apparatus put into a power down sequence. Illustratively in the LVLS system, driving a signal line to either the power or ground rails is used as a signal to the apparatus to enter the power down sequence. The present invention, after a programmable time, then drives the signal line to the opposite rail thereby signaling the system to restart—a wake up mode. After a programmable time, the signal line is released and the system resumes normal operation.
摘要:
The present invention relates to bispecific, tetravalent antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.