公开(公告)号：US5958771A

公开(公告)日：1999-09-28

申请号：US205144

申请日：1998-12-03

申请人： C. Frank Bennett ,  Elizabeth J. Ackermann ,  Lex M. Cowsert

发明人： C. Frank Bennett ,  Elizabeth J. Ackermann ,  Lex M. Cowsert

IPC分类号： C12N15/09 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K31/713 ,  A61K38/00 ,  A61K48/00 ,  A61P35/00 ,  A61P37/00 ,  C12N15/113 ,  C07H21/04 ,  C12N15/85 ,  C12Q1/68

CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Cellular Inhibitor of Apoptosis-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Cellular Inhibitor of Apoptosis-2. Methods of using these compounds for modulation of Cellular Inhibitor of Apoptosis-2 expression and for treatment of diseases associated with expression of Cellular Inhibitor of Apoptosis-2 are provided.

公开(公告)号：US5955443A

公开(公告)日：1999-09-21

申请号：US44506

申请日：1998-03-19

申请人： C. Frank Bennett ,  Thomas P. Condon ,  Shin Cheng Flournoy ,  Hong Zhang

发明人： C. Frank Bennett ,  Thomas P. Condon ,  Shin Cheng Flournoy ,  Hong Zhang

IPC分类号： C12N15/09 ,  A61K31/711 ,  A61K38/00 ,  A61K48/00 ,  A61P1/04 ,  A61P9/00 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/06 ,  A61P43/00 ,  C12N15/113 ,  C12P19/34 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346

摘要： Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a nucleic acid encoding a platelet endothelial cell adhesion molecule-1 (PECAM-1; also known as CD31 antigen or endoCAM) protein are provided.

摘要翻译： 提供了用于治疗和诊断易于通过调节编码血小板内皮细胞粘附分子-1（PECAM-1;也称为CD31抗原或endoCAM）蛋白的核酸的表达进行治疗的疾病或病症的组合物和方法。

公开(公告)号：US5885970A

公开(公告)日：1999-03-23

申请号：US488177

申请日：1995-06-07

申请人： C. Frank Bennett ,  Nicholas Dean

发明人： C. Frank Bennett ,  Nicholas Dean

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/00 ,  C07K14/705 ,  C12N9/12 ,  C12N15/113 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/85

CPC分类号： A61K48/00 ,  C07H21/00 ,  C07K14/70564 ,  C12N15/1137 ,  C12N9/12 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Y207/11013 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3521 ,  C12N2310/3527 ,  C12N2310/3533 ,  C12Q2600/158

摘要： Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. Oligonucleotides specifically hybridizable with a translation initiation site, 5'-untranslated region or 3'-untranslated region are provided. Oligonucleotides specifically hybridizable with a particular PKC isozyme or set of isozymes are also provided. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide targeted to PKC are disclosed.

公开(公告)号：US5856099A

公开(公告)日：1999-01-05

申请号：US651692

申请日：1996-05-21

申请人： Loren Miraglia ,  C. Frank Bennett ,  Nicholas Dean ,  Thomas Geiger

发明人： Loren Miraglia ,  C. Frank Bennett ,  Nicholas Dean ,  Thomas Geiger

IPC分类号： A61K38/00 ,  C07H21/00 ,  C12N15/113 ,  C12Q1/68 ,  A61K48/00 ,  C07H21/04 ,  C12N15/86

CPC分类号： C12N15/1138 ,  C07H21/00 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322

摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of type I IL-1 receptor mRNA expression. In accordance with preferred embodiments, oligomers are provided which are specifically hybridizable with DNA or RNA encoding type I interleukin-1 receptor. Methods of modulating type I IL-1 receptor expression and of treating animals suffering from diseases amenable to therapeutic intervention by modulating the expression of type I interleukin-1 receptor with an oligomer specifically hybridizable with DNA or RNA encoding type I interleukin-1 receptor are disclosed.

摘要翻译： 提供组合物和方法用于治疗和诊断易于通过调节I型IL-1受体mRNA表达的治疗。 根据优选的实施方案，提供可与编码I型白细胞介素-1受体的DNA或RNA特异性杂交的寡聚体。 公开了调节I型IL-1受体表达的方法和通过用与编码I型白细胞介素-1受体的DNA或RNA特异性杂交的寡聚体调节I型白细胞介素-1受体的表达来治疗患有适于治疗性干预的疾病的动物的方法 。

公开(公告)号：US5703054A

公开(公告)日：1997-12-30

申请号：US89996

申请日：1993-07-09

申请人： C. Frank Bennett ,  Nicholas Dean

发明人： C. Frank Bennett ,  Nicholas Dean

IPC分类号： C12N15/09 ,  A61K31/70 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  A61P29/00 ,  A61P35/00 ,  C07H21/00 ,  C07H21/04 ,  C12N9/12 ,  C12N15/113 ,  C12Q1/68

CPC分类号： C12N15/1137 ,  A61K48/00 ,  C07H21/00 ,  C12N9/12 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Y207/11013 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3521 ,  C12N2310/3527 ,  C12N2310/3533 ,  C12Q2600/158

摘要： Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are specifically hybridizable with nucleic acid encoding PKC. Oligonucleotides specifically hybridizable with a translation initiation site, 5'-untranslated region or 3'-untranslated region are provided. Oligonucleotides specifically hybridizable with a particular PKC isozyme or set of isozymes are also provided. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to PKC are disclosed.

摘要翻译： 提供组合物和方法用于治疗和诊断与蛋白激酶C相关的疾病。提供与编码PKC的核酸特异性杂交的寡核苷酸。 提供了与翻译起始位点，5'-非翻译区或3'非翻译区特异性杂交的寡核苷酸。 还提供了与特定PKC同功酶或同功酶组特异性杂交的寡核苷酸。 公开了通过用与PKC相对应的RNA或DNA特异性杂交的寡核苷酸调节蛋白激酶C表达来治疗患有治疗性干预的疾病的方法。

公开(公告)号：US20120264806A1

公开(公告)日：2012-10-18

申请号：US13148291

申请日：2010-02-05

申请人： C. Frank Bennett ,  Richard S. Geary ,  Eric E. Swayze ,  Andrew M. Siwkowski

发明人： C. Frank Bennett ,  Richard S. Geary ,  Eric E. Swayze ,  Andrew M. Siwkowski

IPC分类号： A61K31/7088 ,  A61K31/713

CPC分类号： C12N15/113 ,  A61K9/0019 ,  A61K31/7088 ,  A61K31/721 ,  A61K47/36 ,  C12N15/111 ,  C12N2310/11 ,  C12N2320/30 ,  C12N2320/32

摘要： The present invention provides method of optimizing the efficacy and potency of antisense compounds. In certain embodiments, the invention provides assays useful for determining favorable oligonucleotide characteristics and excipients for improved cellular uptake.

摘要翻译： 本发明提供了优化反义化合物的功效和效力的方法。 在某些实施方案中，本发明提供可用于确定有利的寡核苷酸特征的测定和用于改善细胞摄取的赋形

公开(公告)号：US20110124715A1

公开(公告)日：2011-05-26

申请号：US12849886

申请日：2010-08-04

申请人： Ronnie C. Hanecak ,  Kevin P. Anderson ,  C. Frank Bennett ,  Ming-Yi Chiang ,  Vickie L. Brown-Driver ,  David J. Ecker ,  Timothy Vickers ,  Jacqueline R. Wyatt

发明人： Ronnie C. Hanecak ,  Kevin P. Anderson ,  C. Frank Bennett ,  Ming-Yi Chiang ,  Vickie L. Brown-Driver ,  David J. Ecker ,  Timothy Vickers ,  Jacqueline R. Wyatt

IPC分类号： A61K31/7088 ,  C12N7/00 ,  A61P31/16 ,  A61P31/18 ,  A61P31/22

CPC分类号： A61K31/70 ,  A61K38/00 ,  C07H21/00 ,  C12N15/1133 ,  C12N15/1137 ,  C12N15/115 ,  C12N15/117 ,  C12N2310/151 ,  C12N2310/18 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12Q1/701 ,  C12Y207/07049 ,  C12Y301/01004 ,  C12N2310/3521

摘要： Modified oligonucleotides having a conserved G4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus are provided. G4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases are also provided.

摘要翻译： 提供了具有保守的G4序列和足够数目的侧翼核苷酸以显着抑制病毒活性的修饰的寡核苷酸。 还提供了G4四重态寡核苷酸结构。 还提供了用于病毒相关疾病的预防，诊断和治疗方法。

公开(公告)号：US20090048435A1

公开(公告)日：2009-02-19

申请号：US10559401

申请日：2004-04-30

申请人： C. Frank Bennett ,  Thomas P. Condon

发明人： C. Frank Bennett ,  Thomas P. Condon

IPC分类号： C07H21/02

CPC分类号： C07H21/02 ,  C07H21/04 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3521

摘要： Compositions comprising oligonucleotides which are specifically hybridizable with nucleic acids encoding cellular adhesion molecules intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1) are disclosed. A series of double stranded RNA molecules targeting human ICAM-1 were designed and inhibition of RNA was measured. Oligonucleotides targeted to ICAM were effective in reducing airway hyperresponsiveness in mouse and monkey asthma models.

摘要翻译： 公开了包含与编码细胞粘附分子的核酸细胞内粘附分子-1（ICAM-1），血管细胞粘附分子-1（VCAM-1）和内皮细胞粘附分子-1（ELAM-1）特异性杂交的寡核苷酸的组合物 。 设计了靶向人ICAM-1的一系列双链RNA分子，并测定了RNA的抑制。 靶向ICAM的寡核苷酸有效减少小鼠和猴子哮喘模型中的气道高反应性。

公开(公告)号：US06849612B2

公开(公告)日：2005-02-01

申请号：US09982262

申请日：2001-10-18

申请人： C. Frank Bennett ,  Christopher Mirabelli

发明人： C. Frank Bennett ,  Christopher Mirabelli

IPC分类号： A01N1/02 ,  A01N43/04 ,  A61K38/00 ,  A61K48/00 ,  A61P1/16 ,  A61P27/02 ,  A61P29/00 ,  A61P31/00 ,  A61P31/14 ,  A61P31/18 ,  A61P35/00 ,  A61P43/00 ,  C07H21/02 ,  C07H21/04 ,  C12N5/22 ,  C12N15/113 ,  C12N15/12 ,  C12N15/63 ,  C12P19/34

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： Compositions and methods for the treatment of ophthalmic disorders, particularly preservation of corneal explants and prevention of corneal allograft rejection. These compositions comprise oligonucleotides which are specifically hybridizable with nucleic acids encoding the cellular adhesion molecules intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1).

摘要翻译： 用于治疗眼部疾病的组合物和方法，特别是保护角膜外植体和预防角膜同种异体移植排斥。 这些组合物包含与编码细胞粘附分子细胞间粘附分子-1（ICAM-1），血管细胞粘附分子-1（VCAM-1）和内皮细胞粘附分子-1（ELAM-1）的核酸特异性杂交的寡核苷酸， 。

公开(公告)号：US06632667B1

公开(公告)日：2003-10-14

申请号：US09429096

申请日：1999-10-28

申请人： C. Frank Bennett ,  Takashi Kei Kishimoto

发明人： C. Frank Bennett ,  Takashi Kei Kishimoto

IPC分类号： A61K3170

CPC分类号： C12N15/1137 ,  A61K31/00 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/40 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y304/24086 ,  Y02P20/582 ,  C12N2310/3525

摘要： The present invention provides methods of modulating the shedding of L-selectin in cells or tissues using an inhibitor of TACE expression or activity. Antisense oligonucleotides targeted to nucleic acids encoding TACE are preferred forms of TACE inhibitors. These methods are believed to be useful both therapeutically and diagnostically and as research tools. The present invention further comprises methods of treating conditions associated with altered L-selectin shedding or altered L-selectin levels.

摘要翻译： 本发明提供使用TACE表达或活性抑制剂调节细胞或组织中L-选择素脱落的方法。 靶向编码TACE的核酸的反义寡核苷酸是TACE抑制剂的优选形式。 认为这些方法在治疗和诊断上都是有用的，并且作为研究工具。 本发明还包括治疗与改变的L-选择蛋白脱落或改变的L-选择素水平相关的病症的方法。